The P2X7 receptor antagonist Brilliant Blue G attenuates contralateral rotations in a rat model of Parkinsonism through a combined control of synaptotoxicity, neurotoxicity and gliosis

Neuropharmacology

Volumn 81, Issue , 2014, Pages 142-152

  Carmo, Marta R S ^a,b   Menezes, Ana Paula F ^a   Nunes, Ana Carla L ^a   Pliássova, Anna ^b,e   Rolo, Anabela P ^b,c   Palmeira, Carlos M ^b,d   Cunha, Rodrigo A ^b,e   Canas, Paula M ^b   Andrade, Geanne M ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c UNIVERSITY OF AVEIRO   (Portugal)

^d UNIVERSITY OF COIMBRA   (Portugal)

^e UNIVERSITY OF COIMBRA   (Portugal)

Author keywords

Astrocytes; ATP; Dopamine; Microglia; Neuroprotection; P2X7 receptor; Parkinson's disease; Synaptotoxicity

Indexed keywords

3 [[5 (2,3 DICHLOROPHENYL) 1H TETRAZOL 1 YL]METHYL]PYRIDINE; BRILLIANT BLUE G; DOPAMINE; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; COOMASSIE BRILLIANT BLUE; FUCHSINE; OXIDOPAMINE; PURINERGIC P2X RECEPTOR ANTAGONIST;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; BRAIN SYNAPTOSOME; CIRCLING BEHAVIOR; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINE BRAIN LEVEL; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; GLIOSIS; IN VITRO STUDY; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; NEUROTOXICITY; NONHUMAN; PARKINSONISM; PASSIVE AVOIDANCE; PATHOGENESIS; PRIORITY JOURNAL; RAT; SHORT TERM MEMORY; ANIMAL; AVOIDANCE BEHAVIOR; BRAIN; CHEMICALLY INDUCED; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; HEMISPHERIC DOMINANCE; MAZE TEST; MEMORY DISORDERS; METABOLISM; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; PARKINSONIAN DISORDERS; PATHOPHYSIOLOGY; REACTION TIME; TOXICITY; TUMOR CELL LINE; WISTAR RAT;

ANIMALS; AVOIDANCE LEARNING; BRAIN; CELL LINE, TUMOR; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FUNCTIONAL LATERALITY; GLIOSIS; MALE; MAZE LEARNING; MEMORY DISORDERS; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; OXIDOPAMINE; PARKINSONIAN DISORDERS; PURINERGIC P2X RECEPTOR ANTAGONISTS; RATS; RATS, WISTAR; REACTION TIME; ROSANILINE DYES;

EID: 84894441295     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.01.045     Document Type: Article

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