Blockade of Kv1.3 channels ameliorates radiation-induced brain injury

Neuro-Oncology

Volumn 16, Issue 4, 2014, Pages 528-539

  Peng, Ying ^a   Lu, Kui ^a   Li, Zichen ^a   Zhao, Yaodong ^b   Wang, Yiping ^a   Hu, Bin ^a   Xu, Pengfei ^a   Shi, Xiaolei ^a   Zhou, Bin ^b   Pennington, Michael ^c   Chandy, K George ^d   Tang, Yamei ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^c Peptides International   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Kv1.3; Microglia; Radiation; ShK

Indexed keywords

CYCLOOXYGENASE 2; INTERLEUKIN 6; MESSENGER RNA; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KV1.3; RADIOPROTECTIVE AGENT; STICHODACTYLA HELIANTHUS 170; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN INJURY; BRAIN PROTECTION; BRAIN RADIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE SILENCING; IMMUNOFLUORESCENCE; MACROPHAGE ACTIVATION; MALE; MEDIATOR RELEASE; MEMORY; MICROGLIA; MORRIS WATER MAZE TEST; MOUSE; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NEUROPATHOLOGY; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PATCH CLAMP TECHNIQUE; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RADIATION INDUCED BRAIN INJURY; RADIATION PROTECTION; RADIATION SICKNESS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT COURSE THERAPY; SPATIAL LEARNING; STICHODACTYLA HELIANTHUS; WESTERN BLOTTING;

KV1.3; MICROGLIA; RADIATION; SHK;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; BRAIN; BRAIN INJURIES; CNIDARIAN VENOMS; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; KV1.3 POTASSIUM CHANNEL; MALE; MICE; MICE, INBRED BALB C; MICROGLIA; NEURONS; POTASSIUM CHANNEL BLOCKERS; RADIATION INJURIES; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING;

EID: 84897003333     PISSN: 15228517     EISSN: 15235866     Source Type: Journal    
DOI: 10.1093/neuonc/not221     Document Type: Article

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