Ca2+-dependent reduction of glutamate aspartate transporter GLAST expression in astrocytes by P2X7 receptor-mediated phosphoinositide 3-kinase signaling

Journal of Neurochemistry

Volumn 113, Issue 1, 2010, Pages 213-227

  Liu, Yu Peng ^a   Yang, Chung Shi ^b,c   Chen, Mei Chun ^a   Sun, Synthia H ^d   Tzeng, Shun Fen ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c NATIONAL CHI NAN UNIVERSITY   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Astrocyte; ATP; GLAST; Glutamate transporter; P2X7R; Purinergic

Indexed keywords

1,4,5 TRIPHOSPHATE RECEPTOR; 2' 3' O (4 BENZOYLBENZOYL)ATP; ADENOSINE TRIPHOSPHATE; CALCIUM CALMODULIN DEPENDENT PHOSPHOINOSITIDE 3 KINASE PHOSPHOLIPASE C GAMMA; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM ION; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMIC ACID; LENTIVIRUS VECTOR; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE; PROTEIN KINASE C; PURINERGIC P2X7 RECEPTOR; PURINERGIC RECEPTOR STIMULATING AGENT; RECEPTOR; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CONTROLLED STUDY; EXCITOTOXICITY; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; NEUROPROTECTION; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RNA DEGRADATION; RNA STABILITY; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; TRANSCRIPTION REGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID; ASTROCYTES; BENZOXAZOLES; CALCIUM; CELLS, CULTURED; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; EXCITATORY AMINO ACID TRANSPORTER 1; FEMALE; GENE EXPRESSION REGULATION; GLUTAMIC ACID; HUMANS; INJECTIONS, SPINAL; NEURONS; PLATELET AGGREGATION INHIBITORS; PYRIDOXAL PHOSPHATE; QUINOLINIUM COMPOUNDS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; RNA, MESSENGER; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SPINAL CORD INJURIES; TRANSFECTION;

LENTIVIRUS;

EID: 77749243037     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2010.06589.x     Document Type: Article

References (45)

1. Abbracchio M. P. Ceruti S. (2006) Roles of P2 receptors in glial cells: focus on astrocytes. Purinergic Signal. 2, 595 604.
2. Basso D. M., Beattie M. S. Bresnahan J. C. (1995) A sensitive and reliable locomotor rating scale for open field testing in rats. J. Neurotrauma 12, 1 21.
3. Berridge M. J., Bootman M. D. Roderick H. L. (2003) Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4, 517 529.
4. Beschorner R., Dietz K., Schauer N., Mittelbronn M., Schluesener H. J., Trautmann K., Meyermann R. Simon P. (2007) Expression of EAAT1 reflects a possible neuroprotective function of reactive astrocytes and activated microglia following human traumatic brain injury. Histol. Histopathol. 22, 515 526.
5. Cheng H., Wu J. P. Tzeng S. F. (2002) Neuroprotection of glial cell line-derived neurotrophic factor in damaged spinal cords following contusive injury. J. Neurosci. Res. 69, 397 405.
6. Colbran R. J. (2004) Targeting of calcium/calmodulin-dependent protein kinase II. Biochem. J. 378, 1 16.
7. Constantini S. Young W. (1994) The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J. Neurosurg. 80, 97 111.
8. Doyle K. P., Simon R. P. Stenzel-Poore M. P. (2008) Mechanisms of ischemic brain damage. Neuropharmacology.
9. Duan S. Neary J. T. (2006) P2X(7) receptors: properties and relevance to CNS function. Glia 54, 738 746.
10. Fields R. D. Burnstock G. (2006) Purinergic signalling in neuron-glia interactions. Nat. Rev. Neurosci. 7, 423 436.
11. Fields R. D. Stevens B. (2000) ATP: an extracellular signaling molecule between neurons and glia. Trends Neurosci. 23, 625 633.
12. Franke H., Krugel U. Illes P. (1999) P2 receptor-mediated proliferative effects on astrocytes in vivo. Glia 28, 190 200.
13. Franke H., Krugel U., Schmidt R., Grosche J., Reichenbach A. Illes P. (2001) P2 receptor-types involved in astrogliosis in vivo. Br. J. Pharmacol. 134, 1180 1189.
14. Frizzo M. E., Frizzo J. K., Amadio S., Rodrigues J. M., Perry M. L., Bernardi G. Volonte C. (2007) Extracellular adenosine triphosphate induces glutamate transporter-1 expression in hippocampus. Hippocampus 17, 305 315.
15. Fukamachi S., Furuta A., Ikeda T., Ikenoue T., Kaneoka T., Rothstein J. D. Iwaki T. (2001) Altered expressions of glutamate transporter subtypes in rat model of neonatal cerebral hypoxia-ischemia. Brain Res. Dev. Brain Res. 132, 131 139.
16. Gegelashvili G., Dehnes Y., Danbolt N. C. Schousboe A. (2000) The high-affinity glutamate transporters GLT1, GLAST, and EAAT4 are regulated via different signalling mechanisms. Neurochem. Int. 37, 163 170.
17. Gong Q. J., Li Y. Y., Xin W. J., Zang Y., Ren W. J., Wei X. H., Li Y. Y., Zhang T. Liu X. G. (2008) ATP induces long-term potentiation of C-fiber-evoked field potentials in spinal dorsal horn: the roles of P2X(4) receptors and p38 MAPK in microglia. Glia.
18. He X., Yang F., Xie Z. Lu B. (2000) Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3. J. Cell Biol. 149, 783 792.
19. Hsiao H. Y., Mak O. T., Yang C. S., Liu Y. P., Fang K. M. Tzeng S. F. (2007) TNF-alpha/IFN-gamma-induced iNOS expression increased by prostaglandin E2 in rat primary astrocytes via EP2-evoked cAMP/PKA and intracellular calcium signaling. Glia 55, 214 223.
20. Iglesias R., Dahl G., Qiu F., Spray D. C. Scemes E. (2009) Pannexin 1: the molecular substrate of astrocyte "hemichannels". J. Neurosci. 29, 7092 7097.
21. Inoue K., Koizumi S. Tsuda M. (2007) The role of nucleotides in the neuron-glia communication responsible for the brain functions. J. Neurochem. 102, 1447 1458.
22. James G. Butt A. M. (2001) P2X and P2Y purinoreceptors mediate ATP-evoked calcium signalling in optic nerve glia in situ. Cell Calcium 30, 251 259.
23. Korn T., Magnus T. Jung S. (2005) Autoantigen specific T cells inhibit glutamate uptake in astrocytes by decreasing expression of astrocytic glutamate transporter GLAST: a mechanism mediated by tumor necrosis factor-alpha. FASEB J. 19, 1878 1880.
24. Krugel U., Schraft T., Regenthal R., Illes P. Kittner H. (2004) Purinergic modulation of extracellular glutamate levels in the nucleus accumbens in vivo. Int. J. Dev. Neurosci. 22, 565 570.
25. Lee M., Lee S. J., Choi H. J., Jung Y. W., Frokiaer J., Nielsen S. Kwon T. H. (2008) Regulation of AQP4 protein expression in rat brain astrocytes: role of P2X7 receptor activation. Brain Res. 1195, 1 11.
26. Li L. B., Toan S. V., Zelenaia O., Watson D. J., Wolfe J. H., Rothstein J. D. Robinson M. B. (2006) Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. J. Neurochem. 97, 759 771.
27. Liu Y. P., Yang C. S. Tzeng S. F. (2008) Inhibitory regulation of glutamate aspartate transporter (GLAST) expression in astrocytes by cadmium-induced calcium influx. J. Neurochem. 105, 137 150.
28. Lo J. C., Huang W. C., Chou Y. C., Tseng C. H., Lee W. L. Sun S. H. (2008) Activation of P2X(7) receptors decreases glutamate uptake and glutamine synthetase activity in RBA-2 astrocytes via distinct mechanisms. J. Neurochem. 105, 151 164.
29. McCarthy K. D. de Vellis J. (1980) Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue. J. Cell Biol. 85, 890 902.
30. Morioka N., Abdin M. J., Kitayama T., Morita K., Nakata Y. Dohi T. (2008) P2X(7) receptor stimulation in primary cultures of rat spinal microglia induces downregulation of the activity for glutamate transport. Glia 56, 528 538.
31. Neary J. T., Baker L., Jorgensen S. L. Norenberg M. D. (1994) Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol. 87, 8 13.
32. Neary J. T., Rathbone M. P., Cattabeni F., Abbracchio M. P. Burnstock G. (1996) Trophic actions of extracellular nucleotides and nucleosides on glial and neuronal cells. Trends Neurosci. 19, 13 18.
33. O-Uchi J., Komukai K., Kusakari Y., Obata T., Hongo K., Sasaki H. Kurihara S. (2005) Alpha1-adrenoceptor stimulation potentiates L-type Ca2+ current through Ca2+/calmodulin-dependent PK II (CaMKII) activation in rat ventricular myocytes. Proc. Natl Acad. Sci. USA 102, 9400 9405.
34. Panenka W., Jijon H., Herx L. M., Armstrong J. N., Feighan D., Wei T., Yong V. W., Ransohoff R. M. MacVicar B. A. (2001) P2X7-like receptor activation in astrocytes increases chemokine monocyte chemoattractant protein-1 expression via mitogen-activated protein kinase. J. Neurosci. 21, 7135 7142.
35. Prow N. A. Irani D. N. (2008) The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. J. Neurochem. 105, 1276 1286.
36. Schlag B. D., Vondrasek J. R., Munir M., Kalandadze A., Zelenaia O. A., Rothstein J. D. Robinson M. B. (1998) Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons. Mol. Pharmacol. 53, 355 369.
37. Swanson R. A., Liu J., Miller J. W., Rothstein J. D., Farrell K., Stein B. A. Longuemare M. C. (1997) Neuronal regulation of glutamate transporter subtype expression in astrocytes. J. Neurosci. 17, 932 940.
38. Takenouchi T., Ogihara K., Sato M. Kitani H. (2005) Inhibitory effects of U73122 and U73343 on Ca2+ influx and pore formation induced by the activation of P2X7 nucleotide receptors in mouse microglial cell line. Biochim. Biophys. Acta 1726, 177 186.
39. Tilleux S. Hermans E. (2007) Neuroinflammation and regulation of glial glutamate uptake in neurological disorders. J. Neurosci. Res. 85, 2059 2070.
40. Tran M. D., Wanner I. B. Neary J. T. (2008) Purinergic receptor signaling regulates N-cadherin expression in primary astrocyte cultures. J. Neurochem. 105, 272 286.
41. Virginio C., MacKenzie A., North R. A. Surprenant A. (1999) Kinetics of cell lysis, dye uptake and permeability changes in cells expressing the rat P2X7 receptor. J. Physiol. 519 (Pt 2 335 346.
42. Wang X., Arcuino G., Takano T. et al. (2004) P2X7 receptor inhibition improves recovery after spinal cord injury. Nat. Med. 10, 821 827.
43. Waxham M. N. Aronowski J. (1993) Ca2+/calmodulin-dependent protein kinase II is phosphorylated by protein kinase C in vitro. Biochemistry 32, 2923 2930.
44. Wayman G. A., Lee Y. S., Tokumitsu H., Silva A. Soderling T. R. (2008) Calmodulin-kinases: modulators of neuronal development and plasticity. Neuron 59, 914 931.
45. Zhou J. Sutherland M. L. (2004) Glutamate transporter cluster formation in astrocytic processes regulates glutamate uptake activity. J. Neurosci. 24, 6301 6306.