메뉴 건너뛰기




Volumn 662, Issue , 2010, Pages 29-58

Systems biology approaches and tools for analysis of interactomes and multi-target drugs

Author keywords

Genomics; Interactome; Multi target drugs; Network; Posttranslational modification; Proteomics; Systems biology

Indexed keywords


EID: 84934438895     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-60761-800-3_2     Document Type: Article
Times cited : (48)

References (123)
  • 1
    • 34249041230 scopus 로고    scopus 로고
    • Exploring genetic interactions and networks with yeast
    • Boone C, Bussey H, Andrews BJ (2007) Exploring genetic interactions and networks with yeast. Nat Rev Genet 8:437-449
    • (2007) Nat Rev Genet , vol.8 , pp. 437-449
    • Boone, C.1    Bussey, H.2    Andrews, B.J.3
  • 5
    • 28944450579 scopus 로고    scopus 로고
    • Changing perspectives in yeast research nearly a decade after the genome sequence
    • Dolinski K, Botstein D (2005) Changing perspectives in yeast research nearly a decade after the genome sequence. Genome Res 15:1611-1619
    • (2005) Genome Res , vol.15 , pp. 1611-1619
    • Dolinski, K.1    Botstein, D.2
  • 6
    • 33746525415 scopus 로고    scopus 로고
    • Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways
    • Lehner B, Crombie C, Tischler J, Fortunato A, Fraser AG (2006) Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways. Nat Genet 38:896-903
    • (2006) Nat Genet , vol.38 , pp. 896-903
    • Lehner, B.1    Crombie, C.2    Tischler, J.3    Fortunato, A.4    Fraser, A.G.5
  • 10
    • 0036797562 scopus 로고    scopus 로고
    • Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans
    • Cordell HJ (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463-2468
    • (2002) Hum Mol Genet , vol.11 , pp. 2463-2468
    • Cordell, H.J.1
  • 18
    • 39449139597 scopus 로고    scopus 로고
    • Genetic interactions: The missing links for a better understanding of cancer susceptibility, progression and treatment
    • Maxwell CA, Moreno V, Sole X, Gomez L, Hernandez P, Urruticoechea A, Pujana MA (2008) Genetic interactions: the missing links for a better understanding of cancer susceptibility, progression and treatment. Mol Cancer 7:4
    • (2008) Mol Cancer , vol.7 , pp. 4
    • Maxwell, C.A.1    Moreno, V.2    Sole, X.3    Gomez, L.4    Hernandez, P.5    Urruticoechea, A.6    Pujana, M.A.7
  • 22
    • 34247578600 scopus 로고    scopus 로고
    • Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells
    • Burkard ME, Randall CL, Larochelle S, Zhang C, Shokat KM, Fisher RP, Jallepalli PV (2007) Chemical genetics reveals the requirement for Polo-like kinase 1 activity in positioning RhoA and triggering cytokinesis in human cells. Proc Natl Acad Sci USA 104:4383-4388
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 4383-4388
    • Burkard, M.E.1    Randall, C.L.2    Larochelle, S.3    Zhang, C.4    Shokat, K.M.5    Fisher, R.P.6    Jallepalli, P.V.7
  • 24
    • 47349124275 scopus 로고    scopus 로고
    • What does systems biology mean for drug development?
    • Schrattenholz A, Soskic V (2008) What does systems biology mean for drug development? Curr Top Med Chem 15:1520-1528
    • (2008) Curr Top Med Chem , vol.15 , pp. 1520-1528
    • Schrattenholz, A.1    Soskic, V.2
  • 25
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB (2004) Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov 3:673-683
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 26
    • 34447544101 scopus 로고    scopus 로고
    • Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease?
    • Youdim MB (2007) Magic bullets or novel multimodal drugs with various CNS targets for Parkinson's disease? Nat Rev Drug Discov 6:499-500
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 499-500
    • Youdim, M.B.1
  • 27
    • 34250638746 scopus 로고    scopus 로고
    • SiRNAs in drug discovery: Target validation and beyond
    • Natt F (2007) siRNAs in drug discovery: target validation and beyond. Curr Opin Mol Ther 9:242-24728.
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 242-24728
    • Natt, F.1
  • 29
    • 34447288741 scopus 로고    scopus 로고
    • Towards drugs targeting multiple proteins in a systems biology approach
    • Keskin O, Gursoy A, Ma B, Nussinov R (2007) Towards drugs targeting multiple proteins in a systems biology approach. Curr Top Med Chem 7:943-951
    • (2007) Curr Top Med Chem , vol.7 , pp. 943-951
    • Keskin, O.1    Gursoy, A.2    Ma, B.3    Nussinov, R.4
  • 31
    • 0031304155 scopus 로고    scopus 로고
    • The role of innovation in drug development
    • Drews J, Ryser S (1997) The role of innovation in drug development. Nat Biotechnol 15:1318-1319
    • (1997) Nat Biotechnol , vol.15 , pp. 1318-1319
    • Drews, J.1    Ryser, S.2
  • 32
    • 33749234216 scopus 로고    scopus 로고
    • Drugs, their targets and the nature and number of drug targets
    • Imming P, Sinning C, Meyer A (2006) Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov 5:821-834
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 821-834
    • Imming, P.1    Sinning, C.2    Meyer, A.3
  • 33
    • 33646593147 scopus 로고    scopus 로고
    • NMDA receptors are not alone: Dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling
    • Schrattenholz A, Soskic V (2006) NMDA receptors are not alone: dynamic regulation of NMDA receptor structure and function by neuregulins and transient cholesterol-rich membrane domains leads to disease-specific nuances of glutamate-signalling. Curr Top Med Chem 6:663-686
    • (2006) Curr Top Med Chem , vol.6 , pp. 663-686
    • Schrattenholz, A.1    Soskic, V.2
  • 34
    • 14844289540 scopus 로고    scopus 로고
    • Illuminating drug discovery with biological pathways
    • Apic G, Ignjatovic T, Boyer S, Russell RB (2005) Illuminating drug discovery with biological pathways. FEBS Lett 579:1872-1877
    • (2005) FEBS Lett , vol.579 , pp. 1872-1877
    • Apic, G.1    Ignjatovic, T.2    Boyer, S.3    Russell, R.B.4
  • 35
    • 34247535888 scopus 로고    scopus 로고
    • A non-genetic basis for cancer progression and metastasis: Self-organizing attractors in cell regulatory networks
    • Huang S, Ingber DE (2006) A non-genetic basis for cancer progression and metastasis: self-organizing attractors in cell regulatory networks. Breast Dis 26:27-54
    • (2006) Breast Dis , vol.26 , pp. 27-54
    • Huang, S.1    Ingber, D.E.2
  • 36
    • 34447637467 scopus 로고    scopus 로고
    • Chaos reality in the brain
    • Tsuda I, Fujii H (2007) Chaos reality in the brain. J Integr Neurosci 6:309-326
    • (2007) J Integr Neurosci , vol.6 , pp. 309-326
    • Tsuda, I.1    Fujii, H.2
  • 37
    • 34548761352 scopus 로고    scopus 로고
    • Analyzing variance in multi-degree-of-freedom movements: Uncovering structure versus extracting correlations
    • Schoner G, Scholz JP (2007) Analyzing variance in multi-degree-of-freedom movements: uncovering structure versus extracting correlations. Mot Control 11:259-275
    • (2007) Mot Control , vol.11 , pp. 259-275
    • Schoner, G.1    Scholz, J.P.2
  • 39
    • 34548528157 scopus 로고    scopus 로고
    • Biochemical and statistical network models for systems biology
    • Price ND, Shmulevich I (2007) Biochemical and statistical network models for systems biology. Curr Opin Biotechnol 18:365-370
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 365-370
    • Price, N.D.1    Shmulevich, I.2
  • 40
    • 33947724147 scopus 로고    scopus 로고
    • Surrogacy theory and models of convoluted organic systems
    • Konopka AK (2007) Surrogacy theory and models of convoluted organic systems. Proteomics 7:846-856
    • (2007) Proteomics , vol.7 , pp. 846-856
    • Konopka, A.K.1
  • 42
    • 33947204690 scopus 로고    scopus 로고
    • Mitochondrial abnormalities - A link to idiosyncratic drug hepatotoxicity?
    • Boelsterli UA, Lim PL (2007) Mitochondrial abnormalities - a link to idiosyncratic drug hepatotoxicity? Toxicol Appl Pharmacol 220:92-107
    • (2007) Toxicol Appl Pharmacol , vol.220 , pp. 92-107
    • Boelsterli, U.A.1    Lim, P.L.2
  • 43
    • 34047154993 scopus 로고    scopus 로고
    • Strategies to reduce late-stage drug attrition due to mitochondrial toxicity
    • Dykens JA, Marroquin LD, Will Y (2007) Strategies to reduce late-stage drug attrition due to mitochondrial toxicity. Expert Rev Mol Diagn 7:161-175
    • (2007) Expert Rev Mol Diagn , vol.7 , pp. 161-175
    • Dykens, J.A.1    Marroquin, L.D.2    Will, Y.3
  • 44
    • 34247886039 scopus 로고    scopus 로고
    • Genomic and proteomic screening of apoptosis mitochondrial regulators for drug target discovery
    • Lecellier G, Brenner C (2007) Genomic and proteomic screening of apoptosis mitochondrial regulators for drug target discovery. Curr Med Chem 14:875-881
    • (2007) Curr Med Chem , vol.14 , pp. 875-881
    • Lecellier, G.1    Brenner, C.2
  • 45
    • 33847293352 scopus 로고    scopus 로고
    • Complex disease-associated pharmacogenetics: Drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis Alzheimer's disease
    • Roses AD, Saunders AM, Huang Y, Strum J, Weisgraber KH, Mahley RW (2007) Complex disease-associated pharmacogenetics: drug efficacy, drug safety, and confirmation of a pathogenetic hypothesis (Alzheimer's disease). Pharmacogenomics J 7:10-28
    • (2007) Pharmacogenomics J , vol.7 , pp. 10-28
    • Roses, A.D.1    Saunders, A.M.2    Huang, Y.3    Strum, J.4    Weisgraber, K.H.5    Mahley, R.W.6
  • 47
    • 77049308856 scopus 로고
    • Aging: A theory based on free radical and radiation chemistry
    • Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298-300
    • (1956) J Gerontol , vol.11 , pp. 298-300
    • Harman, D.1
  • 48
    • 35148855604 scopus 로고    scopus 로고
    • Biomarkers for Alzheimer's disease
    • Ward M (2007) Biomarkers for Alzheimer's disease. Expert Rev Mol Diagn 7:635-646
    • (2007) Expert Rev Mol Diagn , vol.7 , pp. 635-646
    • Ward, M.1
  • 51
    • 34447316702 scopus 로고    scopus 로고
    • Genetics of Alzheimer's disease: A centennial review
    • Ertekin-Taner N (2007) Genetics of Alzheimer's disease: a centennial review. Neurol Clin 25:611-667
    • (2007) Neurol Clin , vol.25 , pp. 611-667
    • Ertekin-Taner, N.1
  • 52
    • 33847360433 scopus 로고    scopus 로고
    • The genetics of Alzheimer's disease
    • Chai CK (2007) The genetics of Alzheimer's disease. Am J Alzheimers Dis Other Demen 22:37-41
    • (2007) Am J Alzheimers Dis Other Demen , vol.22 , pp. 37-41
    • Chai, C.K.1
  • 53
    • 34648843067 scopus 로고    scopus 로고
    • Mitochondrial cascade hypothesis of Alzheimer's disease: Myth or reality?
    • Mancuso M, Coppede F, Murri L, Siciliano G (2007) Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality? Antioxid Redox Signal 9:1631-1646
    • (2007) Antioxid Redox Signal , vol.9 , pp. 1631-1646
    • Mancuso, M.1    Coppede, F.2    Murri, L.3    Siciliano, G.4
  • 54
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: Cholesterol, membrane rafts, isoprenoids and statins
    • Reid PC, Urano Y, Kodama T, Hamakubo T (2007) Alzheimer's disease: cholesterol, membrane rafts, isoprenoids and statins. J Cell Mol Med 11:383-392
    • (2007) J Cell Mol Med , vol.11 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 55
    • 45949109970 scopus 로고    scopus 로고
    • From viruses to cancer stem cells: Dissecting the pathways to malignancy
    • Argyle DJ, Blacking T (2008) From viruses to cancer stem cells: dissecting the pathways to malignancy. Vet J 177:311-323
    • (2008) Vet J , vol.177 , pp. 311-323
    • Argyle, D.J.1    Blacking, T.2
  • 58
    • 35348952095 scopus 로고    scopus 로고
    • Cancer: A matter of life cycle?
    • Erenpreisa J, Cragg MS (2007) Cancer: a matter of life cycle? Cell Biol Int 31:1507-1510
    • (2007) Cell Biol Int , vol.31 , pp. 1507-1510
    • Erenpreisa, J.1    Cragg, M.S.2
  • 60
  • 61
    • 35748935235 scopus 로고    scopus 로고
    • Proteins, drug targets and the mechanisms they control: The simple truth about complex networks
    • Araujo RP, Liotta LA, Petricoin EF (2007) Proteins, drug targets and the mechanisms they control: the simple truth about complex networks. Nat Rev Drug Discov 6:871-880
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 871-880
    • Araujo, R.P.1    Liotta, L.A.2    Petricoin, E.F.3
  • 63
    • 20144365155 scopus 로고    scopus 로고
    • Inhibitors of the arachidonic acid pathway and peroxisome proliferator- activated receptor ligands have superadditive effects on lung cancer growth inhibition
    • Avis I, Martinez A, Tauler J, Zudaire E, Mayburd A, Abu-Ghazaleh R, Ondrey F, Mulshine JL (2005) Inhibitors of the arachidonic acid pathway and peroxisome proliferator- activated receptor ligands have superadditive effects on lung cancer growth inhibition. Cancer Res 65:4181-4190
    • (2005) Cancer Res , vol.65 , pp. 4181-4190
    • Avis, I.1    Martinez, A.2    Tauler, J.3    Zudaire, E.4    Mayburd, A.5    Abu-Ghazaleh, R.6    Ondrey, F.7    Mulshine, J.L.8
  • 64
    • 34247526984 scopus 로고    scopus 로고
    • Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer
    • Liby KT, Yore MM, Sporn MB (2007) Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer. Nat Rev Cancer 7:357-369
    • (2007) Nat Rev Cancer , vol.7 , pp. 357-369
    • Liby, K.T.1    Yore, M.M.2    Sporn, M.B.3
  • 65
    • 31044441042 scopus 로고    scopus 로고
    • Biological basis for the cardiovascular consequences of COX-2 inhibition: Therapeutic challenges and opportunities
    • Grosser T, Fries S, FitzGerald GA (2006) Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest 116:4-15
    • (2006) J Clin Invest , vol.116 , pp. 4-15
    • Grosser, T.1    Fries, S.2    Fitzgerald, G.A.3
  • 66
    • 27144443099 scopus 로고    scopus 로고
    • Drug discovery: Playing dirty
    • Frantz S (2005) Drug discovery: playing dirty. Nature 437:942-943
    • (2005) Nature , vol.437 , pp. 942-943
    • Frantz, S.1
  • 67
    • 33645452696 scopus 로고    scopus 로고
    • Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application
    • Millan MJ (2006) Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol Ther 110:135-370
    • (2006) Pharmacol Ther , vol.110 , pp. 135-370
    • Millan, M.J.1
  • 69
    • 4644271084 scopus 로고    scopus 로고
    • Magic shotguns versus magic bullets: Selectively non-selective drugs for mood disorders and schizophrenia
    • Roth BL, Sheffler DJ, Kroeze WK (2004) Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia. Nat Rev Drug Discov 3:353-359
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 353-359
    • Roth, B.L.1    Sheffler, D.J.2    Kroeze, W.K.3
  • 70
    • 0031821056 scopus 로고    scopus 로고
    • What makes an antipsychotic atypical?
    • Stahl SM (1998) What makes an antipsychotic atypical? J Clin Psychiatry 59:403-404
    • (1998) J Clin Psychiatry , vol.59 , pp. 403-404
    • Stahl, S.M.1
  • 71
    • 0031444312 scopus 로고    scopus 로고
    • Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells
    • Ahmad N, Feyes DK, Nieminen AL, Agarwal R, Mukhtar H (1997) Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J Natl Cancer Inst 89: 1881-1886
    • (1997) J Natl Cancer Inst , vol.89 , pp. 1881-1886
    • Ahmad, N.1    Feyes, D.K.2    Nieminen, A.L.3    Agarwal, R.4    Mukhtar, H.5
  • 72
    • 33645094927 scopus 로고    scopus 로고
    • Targeting multiple signaling pathways by green tea polyphenol (?)-epigallocatechin-3-gallate
    • Khan N, Afaq F, Saleem M, Ahmad N, Mukhtar H (2006) Targeting multiple signaling pathways by green tea polyphenol (?)-epigallocatechin-3-gallate. Cancer Res 66:2500-2505
    • (2006) Cancer Res , vol.66 , pp. 2500-2505
    • Khan, N.1    Afaq, F.2    Saleem, M.3    Ahmad, N.4    Mukhtar, H.5
  • 73
    • 33847284555 scopus 로고    scopus 로고
    • Apoptosis by dietary factors: The suicide solution for delaying cancer growth
    • Khan N, Afaq F, Mukhtar H (2007) Apoptosis by dietary factors: the suicide solution for delaying cancer growth. Carcinogenesis 28:233-239
    • (2007) Carcinogenesis , vol.28 , pp. 233-239
    • Khan, N.1    Afaq, F.2    Mukhtar, H.3
  • 74
    • 54249155522 scopus 로고    scopus 로고
    • Network pharmacology: The next paradigm in drug discovery
    • Hopkins AL (2008) Network pharmacology: the next paradigm in drug discovery. Nat Chem Biol 4:682-690
    • (2008) Nat Chem Biol , vol.4 , pp. 682-690
    • Hopkins, A.L.1
  • 75
    • 48249130117 scopus 로고    scopus 로고
    • On the paradigm shift towards multitarget selective drug design
    • Dessalew N, Workalemahu M (2008) On the paradigm shift towards multitarget selective drug design. Curr Comput Aided Drug Des 4:76-90
    • (2008) Curr Comput Aided Drug des , vol.4 , pp. 76-90
    • Dessalew, N.1    Workalemahu, M.2
  • 77
    • 0038483826 scopus 로고    scopus 로고
    • Emergence of scaling in random networks
    • Barabasi AL, Albert R (1999) Emergence of scaling in random networks. Science 286:509-512
    • (1999) Science , vol.286 , pp. 509-512
    • Barabasi, A.L.1    Albert, R.2
  • 78
    • 20444504323 scopus 로고    scopus 로고
    • Uncovering the overlapping community structure of complex networks in nature and society
    • Palla G, Derenyi I, Farkas I, Vicsek T (2005) Uncovering the overlapping community structure of complex networks in nature and society. Nature 435:814-818
    • (2005) Nature , vol.435 , pp. 814-818
    • Palla, G.1    Derenyi, I.2    Farkas, I.3    Vicsek, T.4
  • 79
    • 42349096647 scopus 로고    scopus 로고
    • A global view of drug-therapy interactions
    • Nacher JC, Schwartz JM (2008) A global view of drug-therapy interactions. BMC Pharmacol 8:5
    • (2008) BMC Pharmacol , vol.8 , pp. 5
    • Nacher, J.C.1    Schwartz, J.M.2
  • 80
    • 15044349115 scopus 로고    scopus 로고
    • The efficiency of multi-target drugs: The network approach might help drug design
    • Csermely P, Agoston V, Pongor S (2005) The efficiency of multi-target drugs: the network approach might help drug design. Trends Pharmacol Sci 26:178-182
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 178-182
    • Csermely, P.1    Agoston, V.2    Pongor, S.3
  • 81
    • 33846919627 scopus 로고    scopus 로고
    • The protein network as a tool for finding novel drug targets
    • Strong M, Eisenberg D (2007) The protein network as a tool for finding novel drug targets. Prog Drug Res 64:191, 193-215
    • (2007) Prog Drug Res , vol.64 , Issue.191 , pp. 193-215
    • Strong, M.1    Eisenberg, D.2
  • 82
    • 33846574259 scopus 로고    scopus 로고
    • Fragments, network biology and designing multiple ligands
    • Morphy R, Rankovic Z (2007) Fragments, network biology and designing multiple ligands. Drug Discov Today 12:156-160
    • (2007) Drug Discov Today , vol.12 , pp. 156-160
    • Morphy, R.1    Rankovic, Z.2
  • 83
    • 34347250494 scopus 로고    scopus 로고
    • Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in
    • Hyduke DR, Jarboe LR, Tran LM, Chou KJ, Liao JC (2007) Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli. Proc Natl Acad Sci USA 104:8484-8489
    • (2007) Escherichia Coli. Proc Natl Acad Sci USA , vol.104 , pp. 8484-8489
    • Hyduke, D.R.1    Jarboe, L.R.2    Tran, L.M.3    Chou, K.J.4    Liao, J.C.5
  • 84
    • 34447283809 scopus 로고    scopus 로고
    • What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers
    • Schrattenholz A, Groebe K (2007) What does it need to be a biomarker? Relationships between resolution, differential quantification and statistical validation of protein surrogate biomarkers. Electrophoresis 28:1970-1979
    • (2007) Electrophoresis , vol.28 , pp. 1970-1979
    • Schrattenholz, A.1    Groebe, K.2
  • 85
    • 17644413780 scopus 로고    scopus 로고
    • Water and molecular chaperones act as weak links of protein folding networks: Energy landscape and punctuated equilibrium changes point towards a game theory of proteins
    • Kovacs IA, Szalay MS, Csermely P (2005) Water and molecular chaperones act as weak links of protein folding networks: energy landscape and punctuated equilibrium changes point towards a game theory of proteins. FEBS Lett 579:2254-2260
    • (2005) FEBS Lett , vol.579 , pp. 2254-2260
    • Kovacs, I.A.1    Szalay, M.S.2    Csermely, P.3
  • 87
    • 33745433838 scopus 로고    scopus 로고
    • Network motif identification in stochastic networks
    • Jiang R, Tu Z, Chen T, Sun F (2006) Network motif identification in stochastic networks. Proc Natl Acad Sci USA 103:9404-9409
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 9404-9409
    • Jiang, R.1    Tu, Z.2    Chen, T.3    Sun, F.4
  • 90
    • 26944477318 scopus 로고    scopus 로고
    • Multiple weak hits confuse complex systems: A transcriptional regulatory network as an example
    • Agoston V, Csermely P, Pongor S (2005) Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example. Phys Rev E Stat Nonlin Soft Matter Phys 71:051909
    • (2005) Phys Rev e Stat Nonlin Soft Matter Phys , vol.71 , pp. 051909
    • Agoston, V.1    Csermely, P.2    Pongor, S.3
  • 91
    • 33847150075 scopus 로고    scopus 로고
    • Pathway analysis software as a tool for drug target selection, prioritization and validation of drug mechanism
    • Sivachenko AY, Yuryev A (2007) Pathway analysis software as a tool for drug target selection, prioritization and validation of drug mechanism. Expert Opin Ther Targets 11:411-421
    • (2007) Expert Opin Ther Targets , vol.11 , pp. 411-421
    • Sivachenko, A.Y.1    Yuryev, A.2
  • 92
    • 33750579472 scopus 로고    scopus 로고
    • Expression profiling of drug response - From genes to pathways
    • Herwig R, Lehrach H (2006) Expression profiling of drug response - from genes to pathways. Dialogues Clin Neurosci 8:283-293
    • (2006) Dialogues Clin Neurosci , vol.8 , pp. 283-293
    • Herwig, R.1    Lehrach, H.2
  • 95
    • 34147172388 scopus 로고    scopus 로고
    • Neuronal cell culture from human embryonic stem cells as in vitro model for neuroprotection
    • Schrattenholz A, Klemm M (2007) Neuronal cell culture from human embryonic stem cells as in vitro model for neuroprotection. ALTEX 24:9-15
    • (2007) ALTEX , vol.24 , pp. 9-15
    • Schrattenholz, A.1    Klemm, M.2
  • 96
    • 34548522775 scopus 로고    scopus 로고
    • Advances in proteomic workflows for systems biology
    • Malmstrom J, Lee H, Aebersold R (2007) Advances in proteomic workflows for systems biology. Curr Opin Biotechnol 18:378-384
    • (2007) Curr Opin Biotechnol , vol.18 , pp. 378-384
    • Malmstrom, J.1    Lee, H.2    Aebersold, R.3
  • 97
    • 33746350163 scopus 로고    scopus 로고
    • Comparison of different separation technologies for proteome analyses: Isoform resolution as a prerequisite for the definition of protein biomarkers on the level of posttranslational modifications
    • Hunzinger C, Schrattenholz A, Poznanovic S, Schwall GP, Stegmann W (2006) Comparison of different separation technologies for proteome analyses: isoform resolution as a prerequisite for the definition of protein biomarkers on the level of posttranslational modifications. J Chromatogr A 1123:170-181
    • (2006) J Chromatogr A , vol.1123 , pp. 170-181
    • Hunzinger, C.1    Schrattenholz, A.2    Poznanovic, S.3    Schwall, G.P.4    Stegmann, W.5
  • 98
    • 38649099068 scopus 로고    scopus 로고
    • Interactive three-dimensional visualization and contextual analysis of protein interaction networks
    • Ho E, Webber R, Wilkins MR (2007) Interactive three-dimensional visualization and contextual analysis of protein interaction networks. J Proteome Res 7:104-112
    • (2007) J Proteome Res , vol.7 , pp. 104-112
    • Ho, E.1    Webber, R.2    Wilkins, M.R.3
  • 99
    • 33751413608 scopus 로고    scopus 로고
    • Aging and the ubiquitinome: Traditional and non-traditional functions of ubiquitin in aging cells and tissues
    • Grillari J, Katinger H, Voglauer R (2006) Aging and the ubiquitinome: traditional and non-traditional functions of ubiquitin in aging cells and tissues. Exp Gerontol 41:1067-1079
    • (2006) Exp Gerontol , vol.41 , pp. 1067-1079
    • Grillari, J.1    Katinger, H.2    Voglauer, R.3
  • 100
    • 59249084491 scopus 로고    scopus 로고
    • The proteasome: Overview of structure and functions
    • Tanaka K (2009) The proteasome: overview of structure and functions. Proc Jpn Acad B Phys Biol Sci 85:12-36
    • (2009) Proc Jpn Acad B Phys Biol Sci , vol.85 , pp. 12-36
    • Tanaka, K.1
  • 101
    • 59149107480 scopus 로고    scopus 로고
    • The SUMO system: An overview
    • Ulrich HD (2009) The SUMO system: an overview. Methods Mol Biol 497:3-16
    • (2009) Methods Mol Biol , vol.497 , pp. 3-16
    • Ulrich, H.D.1
  • 102
    • 77953224213 scopus 로고    scopus 로고
    • Synchronisation of posttranslational modifications during ageing: Time is a crucial biological dimension
    • Schrattenholz A, Šoškic V, Groebe K (2010) Synchronisation of posttranslational modifications during ageing: time is a crucial biological dimension. Ann NY Acad Sci 1197:118-128
    • (2010) Ann NY Acad Sci , vol.1197 , pp. 118-128
    • Schrattenholz, A.1    Šoškic, V.2    Groebe, K.3
  • 107
    • 0037012884 scopus 로고    scopus 로고
    • Proteomics Public-private group maps out initiatives
    • Kaiser J (2002) Proteomics. Public-private group maps out initiatives. Science 296:827
    • (2002) Science , vol.296 , pp. 827
    • Kaiser, J.1
  • 111
    • 33645241830 scopus 로고    scopus 로고
    • VANTED: A system for advanced data analysis and visualization in the context of biological networks
    • Junker BH, Klukas C, Schreiber F (2006) VANTED: a system for advanced data analysis and visualization in the context of biological networks. BMC Bioinform 7:109
    • (2006) BMC Bioinform , vol.7 , pp. 109
    • Junker, B.H.1    Klukas, C.2    Schreiber, F.3
  • 113
    • 0347511691 scopus 로고    scopus 로고
    • Next generation simulation tools: The Systems Biology Workbench and BioSPICE integration
    • Sauro HM, Hucka M, Finney A, Wellock C, Bolouri H, Doyle J, Kitano H (2003) Next generation simulation tools: the Systems Biology Workbench and BioSPICE integration. OMICS 7:355-372
    • (2003) OMICS , vol.7 , pp. 355-372
    • Sauro, H.M.1    Hucka, M.2    Finney, A.3    Wellock, C.4    Bolouri, H.5    Doyle, J.6    Kitano, H.7
  • 115
    • 34249915403 scopus 로고    scopus 로고
    • Prediction of enzyme kinetic parameters based on statistical learning
    • Borger S, Liebermeister W, Klipp E (2006) Prediction of enzyme kinetic parameters based on statistical learning. Genome Inform 17:80-87
    • (2006) Genome Inform , vol.17 , pp. 80-87
    • Borger, S.1    Liebermeister, W.2    Klipp, E.3
  • 116
    • 54249100907 scopus 로고    scopus 로고
    • Challenges for the 'chemical-systems' biologist
    • Simon GM, Cravatt BF (2008) Challenges for the 'chemical-systems' biologist. Nat Chem Biol 4:639-642
    • (2008) Nat Chem Biol , vol.4 , pp. 639-642
    • Simon, G.M.1    Cravatt, B.F.2
  • 117
    • 39549102872 scopus 로고    scopus 로고
    • Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes
    • Salisbury CM, Cravatt BF (2008) Optimization of activity-based probes for proteomic profiling of histone deacetylase complexes. J Am Chem Soc 130:2184-2194
    • (2008) J Am Chem Soc , vol.130 , pp. 2184-2194
    • Salisbury, C.M.1    Cravatt, B.F.2
  • 118
    • 38349064791 scopus 로고    scopus 로고
    • Chemical approaches to understanding O-GlcNAc glycosylation in the brain
    • Rexach JE, Clark PM, Hsieh-Wilson LC (2008) Chemical approaches to understanding O-GlcNAc glycosylation in the brain. Nat Chem Biol 4:97-106
    • (2008) Nat Chem Biol , vol.4 , pp. 97-106
    • Rexach, J.E.1    Clark, P.M.2    Hsieh-Wilson, L.C.3
  • 119
    • 59349119386 scopus 로고    scopus 로고
    • Large-scale profiling of protein palmitoylation in mammalian cells
    • Martin BR, Cravatt BF (2009) Large-scale profiling of protein palmitoylation in mammalian cells. Nat Methods 6:135-138
    • (2009) Nat Methods , vol.6 , pp. 135-138
    • Martin, B.R.1    Cravatt, B.F.2
  • 120
    • 50249085119 scopus 로고    scopus 로고
    • Second-generation difluorinated cyclooctynes for copper-free click chemistry
    • Codelli JA, Baskin JM, Agard NJ, Bertozzi CR (2008) Second-generation difluorinated cyclooctynes for copper-free click chemistry. J Am Chem Soc 130:11486-11493
    • (2008) J Am Chem Soc , vol.130 , pp. 11486-11493
    • Codelli, J.A.1    Baskin, J.M.2    Agard, N.J.3    Bertozzi, C.R.4
  • 122
    • 66349100804 scopus 로고    scopus 로고
    • New era of personalized medicine: A 10-year anniversary
    • Jorgensen JT (2009) New era of personalized medicine: a 10-year anniversary. Oncologist 14:557-558
    • (2009) Oncologist , vol.14 , pp. 557-558
    • Jorgensen, J.T.1
  • 123
    • 61349200075 scopus 로고    scopus 로고
    • Bioorthogonal ligation in the spotlight
    • Kurpiers T, Mootz HD (2009) Bioorthogonal ligation in the spotlight. Angew Chem Int Ed Engl 48:1729-1731
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 1729-1731
    • Kurpiers, T.1    Mootz, H.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.