Genetic interactions: The missing links for a better understanding of cancer susceptibility, progression and treatment

Molecular Cancer

Volumn 7, Issue , 2008, Pages

  Maxwell, Christopher A ^a   Moreno, Víctor ^a   Solé, Xavier ^a   Gómez, Laia ^a   Hernández, Pilar ^a   Urruticoechea, Ander ^a   Pujana, Miguel Angel ^a  

^a CATALAN INSTITUTE OF ONCOLOGY   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BRCA1 PROTEIN; BRCA2 PROTEIN; SMALL INTERFERING RNA;

ARTICLE; BREAST TUMOR; CANCER GROWTH; CANCER SUSCEPTIBILITY; CANCER THERAPY; CARCINOGENESIS; CHROMOSOME 20Q; CHROMOSOME 8Q; DNA DAMAGE; DNA REPAIR; FUNCTIONAL GENOMICS; FUNCTIONAL PROTEOMICS; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN GENOME; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE; RNA INTERFERENCE; CHROMOSOME 20; CHROMOSOME 8; DISEASE COURSE; EDITORIAL; GENE REGULATORY NETWORK; GENETIC PREDISPOSITION; GENETICS; GENOME; PROTEIN ANALYSIS;

BREAST NEOPLASMS; CHROMOSOMES, HUMAN, PAIR 20; CHROMOSOMES, HUMAN, PAIR 8; DISEASE PROGRESSION; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GENOME, HUMAN; HUMANS; PROTEIN INTERACTION MAPPING;

EID: 39449139597     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-7-4     Document Type: Article

References (80)

1. Hunter DJ Thomas G Hoover RN Chanock SJ Scanning the horizon: What is the future of genome-wide association studies in accelerating discoveries in cancer etiology and prevention? Cancer Causes Control 2007, 18(5):479-484 10.1007/s10552-007-0118-y 17440825
2. Kim SY Hahn WC Cancer genomics: Integrating form and function Carcinogenesis 2007, 28(7):1387-1392 10.1093/carcin/bgm086 17434922
3. Fan C Oh DS Wessels L Weigelt B Nuyten DS Nobel AB van't Veer LJ Perou CM Concordance among gene-expression-based predictors for breast cancer N Engl J Med 2006, 355(6):560-569 10.1056/NEJMoa052933 16899776
4. Rual JF Venkatesan K Hao T Hirozane-Kishikawa T Dricot A Li N Berriz GF Gibbons FD Dreze M Ayivi-Guedehoussou N Klitgord N Simon C Boxem M Milstein S Rosenberg J Goldberg DS Zhang LV Wong SL Franklin G Li S Albala JS Lim J Fraughton C Llamosas E Cevik S Bex C Lamesch P Sikorski RS Vandenhaute J Zoghbi HY Smolyar A Bosak S Sequerra R Doucette-Stamm L Cusick ME Hill DE Roth FP Vidal M Towards a proteome-scale map of the human protein-protein interaction network Nature 2005, 437(7062):1173-1178 10.1038/nature04209 16189514
5. Stelzl U Worm U Lalowski M Haenig C Brembeck FH Goehler H Stroedicke M Zenkner M Schoenherr A Koeppen S Timm J Mintzlaff S Abraham C Bock N Kietzmann S Goedde A Toksoz E Droege A Krobitsch S Korn B Birchmeier W Lehrach H Wanker EE A human protein-protein interaction network: A resource for annotating the proteome Cell 2005, 122(6):957-968 10.1016/ j.cell.2005.08.029 16169070
6. Rhodes DR Chinnaiyan AM Integrative analysis of the cancer transcriptome Nat Genet 2005, 37(Suppl):S31-7 10.1038/ng1570 15920528
7. Khalil IG Hill C Systems biology for cancer Curr Opin Oncol 2005, 17(1):44-48 10.1097/01.cco.0000150951.38222.16 15608512
8. Barabasi AL Oltvai ZN Network biology: Understanding the cell's functional organization Nat Rev Genet 2004, 5(2):101-113 10.1038/nrg1272 14735121
9. Hernandez P Huerta-Cepas J Montaner D Al-Shahrour F Valls J Gomez L Capella G Dopazo J Pujana MA Evidence for systems-level molecular mechanisms of tumorigenesis BMC Genomics 2007, 8:185 1929080 17584915 10.1186/1471-2164-8-185
10. Pujana MA Han JD Starita LM Stevens KN Tewari M Ahn JS Rennert G Moreno V Kirchhoff T Gold B Assmann V Elshamy WM Rual JF Levine D Rozek LS Gelman RS Gunsalus KC Greenberg RA Sobhian B Bertin N Venkatesan K Ayivi-Guedehoussou N Sole X Hernandez P Lazaro C Nathanson KL Weber BL Cusick ME Hill DE Offit K Livingston DM Gruber SB Parvin JD Vidal M Network modeling links breast cancer susceptibility and centrosome dysfunction Nat Genet 2007, 39(11):1338-1349 10.1038/ng.2007.2 17922014
11. Kelley R Ideker T Systematic interpretation of genetic interactions using protein networks Nat Biotechnol 2005, 23(5):561-566 10.1038/ nbt1096 15877074
12. Boone C Bussey H Andrews BJ Exploring genetic interactions and networks with yeast Nat Rev Genet 2007, 8(6):437-449 10.1038/nrg2085 17510664
13. Hartman JL Garvik B Hartwell L Principles for the buffering of genetic variation Science 2001, 291(5506):1001-1004 10.1126/ science.291.5506.1001 11232561
14. Lehner B Modelling genotype-phenotype relationships and human disease with genetic interaction networks J Exp Biol 2007, 210(Pt 9):1559-1566 10.1242/jeb.002311 17449820
15. Goffeau A Barrell BG Bussey H Davis RW Dujon B Feldmann H Galibert F Hoheisel JD Jacq C Johnston M Louis EJ Mewes HW Murakami Y Philippsen P Tettelin H Oliver SG Life with 6000 genes Science 1996, 274(5287):546, 563-7 10.1126/science.274.5287.546
16. Hughes TR Robinson MD Mitsakakis N Johnston M The promise of functional genomics: Completing the encyclopedia of a cell Curr Opin Microbiol 2004, 7(5):546-554 10.1016/j.mib.2004.08.015 15451511
17. Tong AH Lesage G Bader GD Ding H Xu H Xin X Young J Berriz GF Brost RL Chang M Chen Y Cheng X Chua G Friesen H Goldberg DS Haynes J Humphries C He G Hussein S Ke L Krogan N Li Z Levinson JN Lu H Menard P Munyana C Parsons AB Ryan O Tonikian R Roberts T Sdicu AM Shapiro J Sheikh B Suter B Wong SL Zhang LV Zhu H Burd CG Munro S Sander C Rine J Greenblatt J Peter M Bretscher A Bell G Roth FP Brown GW Andrews B Bussey H Boone C Global mapping of the yeast genetic interaction network Science 2004, 303(5659):808-813 10.1126/science.1091317 14764870
18. Cordell HJ Epistasis: What it means, what it doesn't mean, and statistical methods to detect it in humans Hum Mol Genet 2002, 11(20):2463-2468 10.1093/hmg/11.20.2463 12351582
19. Fisher RA The correlation between relatives on the supposition of Mendelian inheritance Trans R Soc Edinb 1918, 52:399-433
20. Bateson W Mendel's Principles of Heredity Cambridge University Press, Cambridge 1909
21. Waddington CH Canalization of development and the inheritance of acquired characters. 1942, 150(3811):563-565
22. Drees BL Thorsson V Carter GW Rives AW Raymond MZ Avila-Campillo I Shannon P Galitski T Derivation of genetic interaction networks from quantitative phenotype data Genome Biol 2005, 6(4):R38 1088966 15833125 10.1186/gb-2005-6-4-r38
23. Moore JH The ubiquitous nature of epistasis in determining susceptibility to common human diseases Hum Hered 2003, 56(1-3):73-82 10.1159/000073735 14614241
24. Avery L Wasserman S Ordering gene function: The interpretation of epistasis in regulatory hierarchies Trends Genet 1992, 8(9):312-316 10.1016/0168-9525(92)90263-4 1365397
25. Tong AH Evangelista M Parsons AB Xu H Bader GD Page N Robinson M Raghibizadeh S Hogue CW Bussey H Andrews B Tyers M Boone C Systematic genetic analysis with ordered arrays of yeast deletion mutants Science 2001, 294(5550):2364-2368 10.1126/science.1065810 11743205
26. Winzeler EA Shoemaker DD Astromoff A Liang H Anderson K Andre B Bangham R Benito R Boeke JD Bussey H Chu AM Connelly C Davis K Dietrich F Dow SW El Bakkoury M Foury F Friend SH Gentalen E Giaever G Hegemann JH Jones T Laub M Liao H Liebundguth N Lockhart DJ Lucau-Danila A Lussier M M'Rabet N Menard P Mittmann M Pai C Rebischung C Revuelta JL Riles L Roberts CJ Ross-MacDonald P Scherens B Snyder M Sookhai-Mahadeo S Storms RK Veronneau S Voet M Volckaert G Ward TR Wysocki R Yen GS Yu K Zimmermann K Philippsen P Johnston M Davis RW Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis Science 1999, 285(5429):901-906 10.1126/science.285.5429.901 10436161
27. Davierwala AP Haynes J Li Z Brost RL Robinson MD Yu L Mnaimneh S Ding H Zhu H Chen Y Cheng X Brown GW Boone C Andrews BJ Hughes TR The synthetic genetic interaction spectrum of essential genes Nat Genet 2005, 37(10):1147-1152 10.1038/ng1640 16155567
28. Segre D Deluna A Church GM Kishony R Modular epistasis in yeast metabolism Nat Genet 2005, 37(1):77-83 15592468
29. Myers CL Robson D Wible A Hibbs MA Chiriac C Theesfeld CL Dolinski K Troyanskaya OG Discovery of biological networks from diverse functional genomic data Genome Biol 2005, 6(13):R114 1414113 16420673 10.1186/ gb-2005-6-13-r114
30. Wong SL Zhang LV Tong AH Li Z Goldberg DS King OD Lesage G Vidal M Andrews B Bussey H Boone C Roth FP Combining biological networks to predict genetic interactions Proc Natl Acad Sci U S A 2004, 101(44):15682-15687 524818 15496468 10.1073/pnas.0406614101
31. Zhong W Sternberg PW Genome-wide prediction of C. elegans genetic interactions Science 2006, 311(5766):1481-1484 10.1126/science.1123287 16527984
32. Mika S Rost B Protein-protein interactions more conserved within species than across species PLoS Comput Biol 2006, 2(7):e79 1513270 16854211 10.1371/journal.pcbi.0020079
33. Sharan R Suthram S Kelley RM Kuhn T McCuine S Uetz P Sittler T Karp RM Ideker T Conserved patterns of protein interaction in multiple species Proc Natl Acad Sci U S A 2005, 102(6):1974-1979 548573 15687504 10.1073/ pnas.0409522102
34. Lehner B Crombie C Tischler J Fortunato A Fraser AG Systematic mapping of genetic interactions in Caenorhabditis elegans identifies common modifiers of diverse signaling pathways Nat Genet 2006, 38(8):896-903 10.1038/ng1844 16845399
35. Echeverri CJ Beachy PA Baum B Boutros M Buchholz F Chanda SK Downward J Ellenberg J Fraser AG Hacohen N Hahn WC Jackson AL Kiger A Linsley PS Lum L Ma Y Mathey-Prevot B Root DE Sabatini DM Taipale J Perrimon N Bernards R Minimizing the risk of reporting false positives in large-scale RNAi screens Nat Methods 2006, 3(10):777-779 10.1038/ nmeth1006-777 16990807
36. Hunter DJ Kraft P Jacobs KB Cox DG Yeager M Hankinson SE Wacholder S Wang Z Welch R Hutchinson A Wang J Yu K Chatterjee N Orr N Willett WC Colditz GA Ziegler RG Berg CD Buys SS McCarty CA Feigelson HS Calle EE Thun MJ Hayes RB Tucker M Gerhard DS Fraumeni JF Jr. Hoover RN Thomas G Chanock SJ A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer Nat Genet 2007, 39(7):870-874 10.1038/ng2075 17529973
37. Easton DF Pooley KA Dunning AM Pharoah PDP Thompson D Ballinger DG Struewing JP Morrison J Field H Luben R Wareham N Ahmed S Healey CS Bowman R Meyer KB Haiman CA Kolonel LK Henderson BE Le Marchand L Brennan P Sangrajrang S Gaborieau V Odefrey F Shen CY Wu PE Wang HC Eccles D Evans DG Peto J Fletcher O Johnson N Seal S Stratton MR Rahman N Chenevix-Trench G Bojesen SE Nordestgaard BG Axelsson CK Garcia-Closas M Brinton L Chanock S Lissowska J Peplonska B Nevanlinna H Fagerholm R Eerola H Kang D Yoo KY Noh DY Ahn SH Hunter DJ Hankinson SE Cox DG Hall P Wedren S Liu J Low YL Bogdanova N Schurmann P Dork T Tollenaar RAEM Jacobi CE Devilee P Klijn JGM Sigurdson AJ Doody MM Alexander BH Zhang J Cox A Brock IW MacPherson G Reed MWR Couch FJ Goode EL Olson JE Meijers-Heijboer H van den Ouweland A Uitterlinden A Rivadeneira F Milne RL Ribas G Gonzalez-Neira A Benitez J Hopper JL McCredie M Southey M Giles GG Schroen C Justenhoven C Brauch H Hamann U Ko YD Spurdle AB Beesley J Chen X Mannermaa A Kosma VM Kataja V et al Genome-wide association study identifies novel breast cancer susceptibility loci Nature 2007, 447(7148):1087-1093 10.1038/ nature05887 17529967
38. Ritchie MD Hahn LW Roodi N Bailey LR Dupont WD Parl FF Moore JH Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer Am J Hum Genet 2001, 69(1):138-147 1226028 11404819 10.1086/321276
39. Zhang Y Liu JS Bayesian inference of epistatic interactions in case-control studies Nat Genet 2007, 39(9):1167-1173 10.1038/ng2110 17721534
40. Zondervan KT Cardon LR The complex interplay among factors that influence allelic association Nat Rev Genet 2004, 5(2):89-100 10.1038/ nrg1270 14735120
41. Wang S Zhao H Sample size needed to detect gene-gene interactions using association designs Am J Epidemiol 2003/10/31 2003, 158(9):899-914 10.1093/aje/kwg233 14585768
42. Gauderman WJ Sample size requirements for association studies of gene-gene interaction Am J Epidemiol 2002/02/28 2002, 155(5):478-484 10.1093/aje/155.5.478 11867360
43. Hahn LW Ritchie MD Moore JH Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions Bioinformatics 2003/02/14 2003, 19(3):376-382 10.1093/bioinformatics/ btf869 12584123
44. Manuguerra M Matullo G Veglia F Autrup H Dunning AM Garte S Gormally E Malaveille C Guarrera S Polidoro S Saletta F Peluso M Airoldi L Overvad K Raaschou-Nielsen O Clavel-Chapelon F Linseisen J Boeing H Trichopoulos D Kalandidi A Palli D Krogh V Tumino R Panico S Bueno-De-Mesquita HB Peeters PH Lund E Pera G Martinez C Amiano P Barricarte A Tormo MJ Quiros JR Berglund G Janzon L Jarvholm B Day NE Allen NE Saracci R Kaaks R Ferrari P Riboli E Vineis P Multi-factor dimensionality reduction applied to a large prospective investigation on gene-gene and gene-environment interactions Carcinogenesis 2006/09/08 2007, 28(2):414-422 10.1093/carcin/bgl159 16956909
45. Culverhouse R Klein T Shannon W Detecting epistatic interactions contributing to quantitative traits Genet Epidemiol 2004/08/12 2004, 27(2):141-152 10.1002/gepi.20006 15305330
46. Sha Q Zhu X Zuo Y Cooper R Zhang S A combinatorial searching method for detecting a set of interacting loci associated with complex traits Ann Hum Genet 2006/08/16 2006, 70(Pt 5):677-692 10.1111/ j.1469-1809.2006.00262.x 16907712
47. Hunter DJ Kraft P Drinking from the fire hose - statistical issues in genomewide association studies N Engl J Med 2007, 357(5):436-439 10.1056/ NEJMp078120 17634446
48. Hanahan D Weinberg RA The hallmarks of cancer Cell 2000, 100(1):57-70 10.1016/S0092-8674(00)81683-9 10647931
49. Green DR Evan GI A matter of life and death Cancer Cell 2002, 1(1):19-30 10.1016/S1535-6108(02)00024-7 12086884
50. Kitano H Cancer as a robust system: Implications for anticancer therapy Nat Rev Cancer 2004, 4(3):227-235 10.1038/nrc1300 14993904
51. Sancho E Batlle E Clevers H Signaling pathways in intestinal development and cancer Annu Rev Cell Dev Biol 2004, 20:695-723 10.1146/ annurev.cellbio.20.010403.092805 15473857
52. Ma L Teruya-Feldstein J Behrendt N Chen Z Noda T Hino O Cordon-Cardo C Pandolfi PP Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression Genes Dev 2005, 19(15):1779-1786 1182340 16027168 10.1101/gad.1314405
53. Xu X Qiao W Linke SP Cao L Li WM Furth PA Harris CC Deng CX Genetic interactions between tumor suppressors Brca1 and p53 in apoptosis, cell cycle and tumorigenesis Nat Genet 2001, 28(3):266-271 10.1038/90108 11431698
54. Takahashi C Ewen ME Genetic interaction between Rb and N-ras: differentiation control and metastasis Cancer Res 2006, 66(19):9345-9348 10.1158/0008-5472.CAN-06-1250 17018584
55. Forbes S Clements J Dawson E Bamford S Webb T Dogan A Flanagan A Teague J Wooster R Futreal PA Stratton MR Cosmic 2005 Br J Cancer 2006, 94(2):318-322 10.1038/sj.bjc.6602928 16421597
56. Greenman C Stephens P Smith R Dalgliesh GL Hunter C Bignell G Davies H Teague J Butler A Stevens C Edkins S O'Meara S Vastrik I Schmidt EE Avis T Barthorpe S Bhamra G Buck G Choudhury B Clements J Cole J Dicks E Forbes S Gray K Halliday K Harrison R Hills K Hinton J Jenkinson A Jones D Menzies A Mironenko T Perry J Raine K Richardson D Shepherd R Small A Tofts C Varian J Webb T West S Widaa S Yates A Cahill DP Louis DN Goldstraw P Nicholson AG Brasseur F Looijenga L Weber BL Chiew YE DeFazio A Greaves MF Green AR Campbell P Birney E Easton DF Chenevix-Trench G Tan MH Khoo SK Teh BT Yuen ST Leung SY Wooster R Futreal PA Stratton MR Patterns of somatic mutation in human cancer genomes Nature 2007, 446(7132):153-158 10.1038/nature05610 17344846
57. Thomas RK Baker AC Debiasi RM Winckler W Laframboise T Lin WM Wang M Feng W Zander T MacConaill L Lee JC Nicoletti R Hatton C Goyette M Girard L Majmudar K Ziaugra L Wong KK Gabriel S Beroukhim R Peyton M Barretina J Dutt A Emery C Greulich H Shah K Sasaki H Gazdar A Minna J Armstrong SA Mellinghoff IK Hodi FS Dranoff G Mischel PS Cloughesy TF Nelson SF Liau LM Mertz K Rubin MA Moch H Loda M Catalona W Fletcher J Signoretti S Kaye F Anderson KC Demetri GD Dummer R Wagner S Herlyn M Sellers WR Meyerson M Garraway LA High-throughput oncogene mutation profiling in human cancer Nat Genet 2007, 39(3):347-351 10.1038/ng1975 17293865
58. Boehm JS Zhao JJ Yao J Kim SY Firestein R Dunn IF Sjostrom SK Garraway LA Weremowicz S Richardson AL Greulich H Stewart CJ Mulvey LA Shen RR Ambrogio L Hirozane-Kishikawa T Hill DE Vidal M Meyerson M Grenier JK Hinkle G Root DE Roberts TM Lander ES Polyak K Hahn WC Integrative genomic approaches identify IKBKE as a breast cancer oncogene Cell 2007, 129(6):1065-1079 10.1016/j.cell.2007.03.052 17574021
59. Garraway LA Widlund HR Rubin MA Getz G Berger AJ Ramaswamy S Beroukhim R Milner DA Granter SR Du J Lee C Wagner SN Li C Golub TR Rimm DL Meyerson ML Fisher DE Sellers WR Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma Nature 2005, 436(7047):117-122 10.1038/nature03664 16001072
60. Chin K DeVries S Fridlyand J Spellman PT Roydasgupta R Kuo WL Lapuk A Neve RM Qian Z Ryder T Chen F Feiler H Tokuyasu T Kingsley C Dairkee S Meng Z Chew K Pinkel D Jain A Ljung BM Esserman L Albertson DG Waldman FM Gray JW Genomic and transcriptional aberrations linked to breast cancer pathophysiologies Cancer Cell 2006, 10(6):529-541 10.1016/ j.ccr.2006.10.009 17157792
61. Kitano H Cancer robustness: Tumour tactics Nature 2003, 426(6963):125 10.1038/426125a 14614483
62. Kitano H Systems biology: A brief overview Science 2002, 295(5560):1662-1664 10.1126/science.1069492 11872829
63. Albert R Jeong H Barabasi AL Error and attack tolerance of complex networks Nature 2000, 406(6794):378-382 10.1038/35019019 10935628
64. Csete ME Doyle JC Reverse engineering of biological complexity Science 2002, 295(5560):1664-1669 10.1126/science.1069981 11872830
65. Farmer H McCabe N Lord CJ Tutt AN Johnson DA Richardson TB Santarosa M Dillon KJ Hickson I Knights C Martin NM Jackson SP Smith GC Ashworth A Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy Nature 2005, 434(7035):917-921 10.1038/nature03445 15829967
66. Bryant HE Schultz N Thomas HD Parker KM Flower D Lopez E Kyle S Meuth M Curtin NJ Helleday T Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase Nature 2005, 434(7035):913-917 10.1038/nature03443 15829966
67. Miki Y Swensen J Shattuck-Eidens D Futreal PA Harshman K Tavtigian S Liu Q Cochran C Bennett LM Ding W A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1 Science 1994, 266(5182):66-71 10.1126/science.7545954 7545954
68. Futreal PA Liu Q Shattuck-Eidens D Cochran C Harshman K Tavtigian S Bennett LM Haugen-Strano A Swensen J Miki Y BRCA1 mutations in primary breast and ovarian carcinomas Science 1994, 266(5182):120-122 10.1126/ science.7939630 7939630
69. Wooster R Bignell G Lancaster J Swift S Seal S Mangion J Collins N Gregory S Gumbs C Micklem G Identification of the breast cancer susceptibility gene BRCA2 Nature 1995, 378(6559):789-792 10.1038/ 378789a0 8524414
70. Deng CX Wang RH Roles of BRCA1 in DNA damage repair: A link between development and cancer Hum Mol Genet 2003, 12(Spec No 1):R113-23 10.1093/ hmg/ddg082 12668603
71. Hudis CA Trastuzumab - mechanism of action and use in clinical practice N Engl J Med 2007, 357(1):39-51 10.1056/NEJMra043186 17611206
72. Rubin BP Heinrich MC Corless CL Gastrointestinal stromal tumour Lancet 2007, 369(9574):1731-1741 10.1016/S0140-6736(07)60780-6 17512858
73. Deininger MW Optimizing therapy of chronic myeloid leukemia Exp Hematol 2007, 35(4 Suppl 1):144-154 10.1016/j.exphem.2007.01.023 17379100
74. Whitehurst AW Bodemann BO Cardenas J Ferguson D Girard L Peyton M Minna JD Michnoff C Hao W Roth MG Xie XJ White MA Synthetic lethal screen identification of chemosensitizer loci in cancer cells Nature 2007, 446(7137):815-819 10.1038/nature05697 17429401
75. Stommel JM Kimmelman AC Ying H Nabioullin R Ponugoti AH Wiedemeyer R Stegh AH Bradner JE Ligon KL Brennan C Chin L Depinho RA Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies Science 2007 17872411
76. Paddison PJ Silva JM Conklin DS Schlabach M Li M Aruleba S Balija V O'Shaughnessy A Gnoj L Scobie K Chang K Westbrook T Cleary M Sachidanandam R McCombie WR Elledge SJ Hannon GJ A resource for large-scale RNA-interference-based screens in mammals Nature 2004, 428(6981):427-431 10.1038/nature02370 15042091
77. Silva JM Li MZ Chang K Ge W Golding MC Rickles RJ Siolas D Hu G Paddison PJ Schlabach MR Sheth N Bradshaw J Burchard J Kulkarni A Cavet G Sachidanandam R McCombie WR Cleary MA Elledge SJ Hannon GJ Second-generation shRNA libraries covering the mouse and human genomes Nat Genet 2005, 37(11):1281-1288 16200065
78. Hoeijmakers JH Genome maintenance mechanisms for preventing cancer Nature 2001, 411(6835):366-374 10.1038/35077232 11357144
79. Ashburner M Ball CA Blake JA Botstein D Butler H Cherry JM Davis AP Dolinski K Dwight SS Eppig JT Harris MA Hill DP Issel-Tarver L Kasarskis A Lewis S Matese JC Richardson JE Ringwald M Rubin GM Sherlock G Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium Nat Genet 2000, 25(1):25-29 10.1038/75556 10802651
80. Woerner SM Kloor M von Knebel Doeberitz M Gebert JF Microsatellite instability in the development of DNA mismatch repair deficient tumors Cancer Biomark 2006, 2(1-2):69-86 17192061