Towards a mechanism-based analysis of pharmacodynamic drug-drug interactions in vivo

Pharmacology and Therapeutics

Volumn 106, Issue 1, 2005, Pages 1-18

  Jonker, Daniël M ^a,b   Visser, Sandra A G ^a   Van Der Graaf, Piet H ^c   Voskuyl, Rob A ^a,b   Danhof, Meindert ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b STICHTING EPILEPSIE INSTELLINGEN NEDERLAND SEIN   (Netherlands)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Drug combination; Mechanism based pharmacodynamic interaction model; Operational model of pharmacological agonism; Response surface analysis; Synergy

Indexed keywords

ALPHA HYDROXYMIDAZOLAM; AMOXICILLIN; ANTICONVULSIVE AGENT; ANTIFUNGAL AGENT; ANTIHYPERTENSIVE AGENT; ANTINEOPLASTIC AGENT; BENZODIAZEPINE DERIVATIVE; CLAVULANIC ACID; CLONAZEPAM; LAMOTRIGINE; MIDAZOLAM; OXCARBAZEPINE; PLACEBO; TIAGABINE; VALPROIC ACID;

DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG RESPONSE; GABAERGIC SYSTEM; HUMAN; IN VIVO STUDY; MATHEMATICAL MODEL; MEDICAL PRACTICE; MONTE CARLO METHOD; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RECEPTOR BINDING; REVIEW; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

EID: 15244352983     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2004.10.014     Document Type: Review

References (62)

1. D.R. Anderson, C. Gennings, W.H. Carter, L.W. Harris, W.J. Lennox, and S.L. Bowersox Efficacy comparison of scopolamine and diazepam against soman-induced debilitation in guinea pigs Fundam Appl Toxicol 22 1994 588 593
2. E.J. Ariëns, J.M. van Rossum, and AM. Simonis A theoretical basis of molecular pharmacology: Part I. Interactions of one or two compounds with one receptor system Arzneimittelforschung 6 1956 282 293
3. E.J. Ariëns, J.M. van Rossum, and A.M. Simonis A theoretical basis of molecular pharmacology: Part II. Interactions of one or two compounds with two interdependent receptor systems Arzneimittelforschung 6 1956 611 621
4. E.J. Ariëns, J.M. van Rossum, and A.M. Simonis A theoretical basis of molecular pharmacology: Part III. Interactions of one or two compounds with two independent receptor systems Arzneimittelforschung 6 1956 737 746
5. V.J. Barrett, P. Leff, G.R. Martin, and P.J. Richardson Pharmacological analysis of the interaction between Bay K 8644 and 5-HT in rabbit aorta Br J Pharmacol 87 1986 487 494
6. M.C. Berenbaum What is synergy? Pharmacol Rev 41 1989 93 141
7. J.W. Black, and P. Leff Operational models of pharmacological agonism Proc R Soc Lond B Biol Sci 220 1983 141 162
8. C.I. Bliss The toxicity of poisons applied jointly Ann Appl Biol 26 1939 585 615
9. C.J.J.G. Bol, J.P.W. Vogelaar, J.P. Tang, and J.W. Mandema Quantification of pharmacodynamic interactions between dexmedetomidine and midazolam in the rat J Pharmacol Exp Ther 294 2000 437 455
10. T. Bouillon, C. Schmidt, G. Garstka, D. Heimbach, D. Stafforst, and H. Schwilden Pharmacokinetic-pharmacodynamic modeling of the respiratory depressant effect of alfentanil Anesthesiology 91 1999 144 155
11. B.F. Bourgeois, and N. Wad Combined administration of carbamazepine and phenobarbital: effect on anticonvulsant activity and neurotoxicity Epilepsia 29 1988 482 487
12. W.H. Carter Jr. Relating isobolograms to response surfaces Toxicology 105 1995 181 188
13. G.J. Christ, J. Goldfarb, and S. Maayani Receptor-mediated mutual-effect amplification elicited by phenylephrine and serotonin in isolated rabbit aorta J Pharmacol Exp Ther 252 1990 500 506
14. M. Corsi, P. Fina, and D.G. Trist Co-agonism in drug-receptor interaction: illustrated by the NMDA receptors Trends Pharmacol Sci 17 1996 220 222
15. A. Dahan, D. Nieuwenhuijs, E. Olofsen, E. Sarton, R. Romberg, and L. Teppema Response surface modeling of alfentanil-sevoflurane interaction on cardiorespiratory control and bispectral index Anesthesiology 94 2001 982 991
16. M. Déciga-Campos, U. Guevara López, M.I. Díaz Reval, and F.J. López-Muñoz Enhancement of antinociception by co-administration of an opioid drug (morphine) and a preferential cyclooxygenase-2 inhibitor (rofecoxib) in rats Eur J Pharmacol 460 2003 99 107
17. G.L. Drusano, D.Z. D'Argenio, S.L. Preston, C. Barone, W. Symonds, and S. LaFon Use of drug effect interaction modeling with Monte Carlo simulation to examine the impact of dosing interval on the projected antiviral activity of the combination of abacavir and amprenavir Antimicrob Agents Chemother 44 2000 1655 1659
18. G.L. Drusano, D.Z. D'Argenio, W. Symonds, P.A. Bilello, J. McDowell, and B. Sadler Nucleoside analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro Antimicrob Agents Chemother 42 1998 2153 2159
19. F.J. Ehlert Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods Mol Pharmacol 33 1988 187 194
20. G.M. Ferron, and W.J. Jusko Species- and gender-related differences in cyclosporine/prednisolone/sirolimus interactions in whole blood lymphocyte proliferation assays J Pharmacol Exp Ther 286 1998 191 200
21. C. Gennings On testing for drug/chemical interactions: definitions and inference J Biopharm Stat 10 2000 457 467
22. C. Gennings, W.H. Carter Jr., E.W. Carney, G.D. Charles, B.B. Gollapudi, and R.A. Carchman A novel flexible approach for evaluating fixed ratio mixtures of full and partial agonists Toxicol Sci 80 2004 134 150
23. C. Gennings, R.D. Sofia, R.A. Carchman, W.H. Carter Jr., and E.A. Swinyard Analysis of anticonvulsant and neurotoxic responses to combination therapy with carbamazepine, felbamate and phenytoin by response-surface modeling Arzneimittelforschung 45 1995 739 748
24. M. Germani, P. Magni, G. De Nicolao, I. Poggesi, A. Marsiglio, and D. Ballinari In vitro cell growth pharmacodynamic studies: a new nonparametric approach to determining the relative importance of drug concentration and treatment time Cancer Chemother Pharmacol 52 2003 507 513
25. W.R. Greco, G. Bravo, and J.C. Parsons The search for synergy: a critical review from a response surface perspective Pharmacol Rev 47 1995 331 385
26. W.R. Greco, H.S. Park, and Y.M. Rustum Application of a new approach for the quantitation of drug synergism to the combination of cis- diamminedichloroplatinum and 1-β-d-arabinofuranosylcytosine Cancer Res 50 1990 5318 5327
27. G.B. Grindey, R.G. Moran, and W.C. Werkheiser Approaches to the rational combination of antimetabolites for cancer chemotherapy E.J. Ariëns Drug design 1975 Academic Press New York 169 249
28. N.H. Holford, and L.B. Sheiner Kinetics of pharmacologic response Pharmacol Ther 16 1982 143 166
29. D.M. Jonker, T.A.C. Vermeij, P.M. Edelbroek, R.A. Voskuyl, V.K. Piotrovsky, and M. Danhof Pharmacodynamic analysis of the interaction between tiagabine and midazolam with an allosteric model that incorporates signal transduction Epilepsia 44 2003 329 338
30. D.M. Jonker, R.A. Voskuyl, and M. Danhof Pharmacodynamic analysis of the anticonvulsant effects of tiagabine and lamotrigine in combination in the rat Epilepsia 45 2004 424 435
31. M. Kochar, R. Guthrie, J. Triscari, K. Kassler-Taub, and R.A. Reeves Matrix study of irbesartan with hydrochlorothiazide in mild-to-moderate hypertension Am J Hypertens 12 1999 797 805
32. R.A. Larsen, M. Bauer, A.M. Thomas, and J.R. Graybill Amphotericin B and fluconazole, a potent combination therapy for cryptococcal meningitis Antimicrob Agents Chemother 48 2004 985 991
33. P. Leff An analysis of amplifying and potentiating interactions between agonists J Pharmacol Exp Ther 243 1987 1035 1042
34. P. Leff, I.G. Dougall, and D. Harper Estimation of partial agonist affinity by interaction with a full agonist: a direct operational model-fitting approach Br J Pharmacol 110 1993 239 244
35. S. Loewe The problem of synergism and antagonism of combined drugs Arzneimittelforschung 3 1953 285 290
36. J.J. Luszczki, and S.J. Czuczwar Isobolographic and subthreshold methods in the detection of interactions between oxcarbazepine and conventional antiepileptics-a comparative study Epilepsy Res 56 2003 27 42
37. J.J. Luszczki, M. Czuczwar, J. Kis, J. Krysa, I. Pasztelan, and M. Swiader Interactions of lamotrigine with topiramate and first-generation antiepileptic drugs in the maximal electroshock test in mice: an isobolographic analysis Epilepsia 44 2003 1003 1013
38. D. Mackay An analysis of functional antagonism and synergism Br J Pharmacol 73 1981 127 134
39. J.B. McGill, and P.A. Reilly Telmisartan plus hydrochlorothiazide versus telmisartan or hydrochlorothiazide monotherapy in patients with mild to moderate hypertension: a multicenter, randomized, double-blind, placebo-controlled, parallel-group trial Clin Ther 23 2001 833 850
40. J. Meletiadis, J.W. Mouton, J.F. Meis, and P.E. Verweij In vitro drug interaction modeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates Antimicrob Agents Chemother 47 2003 106 117
41. M.J. Mertens, E. Olofsen, F.H. Engbers, A.G. Burm, J.G. Bovill, and J. Vuyk Propofol reduces perioperative remifentanil requirements in a synergistic manner: response surface modeling of perioperative remifentanil-propofol interactions Anesthesiology 99 2003 347 359
42. C.F. Minto, T.W. Schnider, T.G. Short, K.M. Gregg, A. Gentilini, and S.L. Shafer Response surface model for anesthetic drug interactions Anesthesiology 92 2000 1603 1616
43. V.C. Moser, R.C. MacPhail, and C. Gennings Neurobehavioral evaluations of mixtures of trichloroethylene, heptachlor, and di(2-ethylhexyl)phthlate in a full-factorial design Toxicology 188 2003 125 137
44. D.J. Nieuwenhuijs, E. Olofsen, R.R. Romberg, E. Sarton, D. Ward, and F. Engbers Response surface modeling of remifentanil-propofol interaction on cardiorespiratory control and bispectral index Anesthesiology 98 2003 312 322
45. G. Pöch, and S. Holzmann Quantitative estimation of overadditive and underadditive drug effects by means of theoretical, additive dose-response curves J Pharmacol Methods 4 1980 179 188
46. J.L. Pool, W.C. Cushman, R.K. Saini, C.E. Nwachuku, and J.P. Battikha Use of the factorial design and quadratic response surface models to evaluate the fosinopril and hydrochlorothiazide combination therapy in hypertension Am J Hypertens 10 1997 117 123
47. R.B. Raffa, D.J. Stone, and R.J. Tallarida Discovery of "self-synergistic" spinal/supraspinal antinociception produced by acetaminophen (paracetamol) J Pharmacol Exp Ther 295 2000 291 294
48. A. Roca-Cusachs, F. Torres, M. Horas, J. Rios, G. Calvo, and J. Delgadillo Nitrendipine and enalapril combination therapy in mild to moderate hypertension: assessment of dose-response relationship by a clinical trial of factorial design J Cardiovasc Pharmacol 38 2001 840 849
49. C. Scaramellini, G. Bennett, and P. Leff Analysis of agonist-agonist interactions: the crucial influence of curve shape J Pharmacol Toxicol Methods 37 1997 167 178
50. J. Scholze, P. Zilles, and D. Compagnone Verapamil SR and trandolapril combination therapy in hypertension-a clinical trial of factorial design Br J Clin Pharmacol 45 1998 491 495
51. L.B. Sheiner Modeling pharmacodynamics: parametric and non-parametric approaches M. Rowland L.B. Sheiner J.L. Steimer Variability in drug therapy: description, estimation and control 1985 Raven Press New York 139 152
52. M. Shih, C. Gennings, V.M. Chinchilli, and W.H. Carter Jr. Titrating and evaluating multi-drug regimens within subjects Stat Med 22 2003 2257 2279
53. T.G. Short, Ho T. Yuk, C.F. Minto, T.W. Schnider, and S.L. Shafer Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs Anesthesiology 96 2002 400 408
54. M. Sun, C.M. van Rijn, Y. Liu, and M. Wang Combination of carbamazepine and valproate in different dose proportions in maximal electroshock seizure model in mice Epilepsy Res 51 2002 5 11
55. R.J. Tallarida Drug synergism: its detection and applications J Pharmacol Exp Ther 298 2001 865 872
56. R.J. Tallarida, F. Porreca, and A. Cowan Statistical analysis of drug-drug and site-site interactions with isobolograms Life Sci 45 1989 947 961
57. U. Trendelenburg The action of acetylcholine on the nictitating membrane of the spinal cat J Pharmacol Exp Ther 135 1962 39 44
58. B. Tuk, M.F. van Oostenbruggen, V.M. Herben, J.W. Mandema, and M. Danhof Characterization of the pharmacodynamic interaction between parent drug and active metabolite in vivo: midazolam and alpha-OH-midazolam J Pharmacol Exp Ther 289 1999 1067 1074
59. P.H. Van der Graaf, and M. Danhof Analysis of drug-receptor interactions in vivo: a new approach in pharmacokinetic-pharmacodynamic modelling Int J Clin Pharmacol Ther 35 1997 442 446
60. D.B. White, H.K. Slocum, Y. Brun, C. Wrzosek, and W.R. Greco A new nonlinear mixture response surface paradigm for the study of synergism: a three drug example Curr Drug Metab 4 2003 399 409
61. A receptor modulators: in vitro-in vivo correlation J Pharmacol Exp Ther 304 2003 88 101
62. G. Zernig, T. Issaevitch, and J.H. Woods Calculation of agonist efficacy, apparent affinity, and receptor population changes after administration of insurmountable antagonists: comparison of different analytical approaches J Pharmacol Toxicol Methods 35 1996 223 237