Melatonin ameliorates amyloid beta-induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI3/Akt/GSk3β pathway in the mouse hippocampus

Journal of Pineal Research

Volumn 59, Issue 1, 2015, Pages 47-59

  Ali, Tahir ^a   Kim, Myeong Ok ^a  

^a Gyeongsang National University   (South Korea)

Author keywords

A 1 42; melatonin; neurodegeneration; PI3 Akt GSK3 signaling; synaptic disorder; Tau hyperphosphorylation

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BETA SECRETASE 1; CASPASE 3; CASPASE 7; CASPASE 9; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MELATONIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PHOSPHATIDYLINOSITOL 3 KINASE; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE B; SYNAPTOPHYSIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 23; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; TAU PROTEIN; AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL VIABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VITRO STUDY; LATENT PERIOD; LEARNING; MALE; MEMORY DISORDER; MORRIS WATER MAZE TEST; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NISSL STAINING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SHORT TERM MEMORY; SIGNAL TRANSDUCTION; WESTERN BLOTTING; WORKING MEMORY; Y-MAZE TEST; ANIMAL; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; MEMORY DISORDERS; METABOLISM; NEURODEGENERATIVE DISEASES; PHOSPHORYLATION;

AMYLOID BETA-PEPTIDES; ANIMALS; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; MALE; MELATONIN; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; NEURODEGENERATIVE DISEASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; TAU PROTEINS;

EID: 84934293109     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12238     Document Type: Article

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