Melatonin alleviates secondary brain damage and neurobehavioral dysfunction after experimental subarachnoid hemorrhage: Possible involvement of TLR4-mediated inflammatory pathway

Journal of Pineal Research

Volumn 55, Issue 4, 2013, Pages 399-408

  Wang, Zhong ^a   Wu, Lingyun ^a   You, Wanchun ^a   Ji, Chengyuan ^a   Chen, Gang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

brain injury; melatonin; subarachnoid hemorrhage

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MELATONIN; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BRAIN DAMAGE; BRAIN NECROSIS; COGNITION; COGNITIVE DEFECT; COMPARATIVE STUDY; CONTROLLED STUDY; MAZE TEST; MORRIS WATER MAZE; NEUROBEHAVIORAL DYSFUNCTION; NEUROPROTECTION; NONHUMAN; PROTEIN EXPRESSION; RAT; SPATIAL LEARNING; SUBARACHNOID HEMORRHAGE;

BRAIN INJURY; MELATONIN; SUBARACHNOID HEMORRHAGE;

ANIMALS; BLOTTING, WESTERN; BRAIN INJURIES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; MELATONIN; MEMORY; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; SPATIAL BEHAVIOR; SUBARACHNOID HEMORRHAGE; TOLL-LIKE RECEPTOR 4;

EID: 84885607449     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12087     Document Type: Article

References (27)

1. de Rooij NK, Rinkel GJ, Dankbaar JW, et al. Delayed cerebral ischemia after subarachnoid hemorrhage: a systematic review of clinical, laboratory, and radiological predictors. Stroke 2013; 44: 43-54.
2. Wang Z, Ma C, Meng CJ, et al. Melatonin activates the Nrf2-ARE pathway when it protects against early brain injury in a subarachnoid hemorrhage model. J Pineal Res 2012; 53: 129-137.
3. Ersahin M, Toklu HZ, Cetinel S, et al. Melatonin reduces experimental subarachnoid hemorrhage-induced oxidative brain damage and neurological symptoms. J Pineal Res 2009; 46: 324-332.
4. Ayer RE, Sugawara T, Chen W, et al. Melatonin decreases mortality following severe subarachnoid hemorrhage. J Pineal Res 2008; 44: 197-204.
5. Provencio JJ,. Inflammation in subarachnoid hemorrhage and delayed deterioration associated with vasospasm: a review. Acta Neurochir Suppl 2013; 115: 233-238.
6. You WC, Wang CX, Pan YX, et al. Activation of nuclear factor-κB in the brain after experimental subarachnoid hemorrhage and its potential role in delayed brain injury. PLoS One 2013; 8: e60290.
7. Zhou ML, Shi JX, Hang CH, et al. Expression of Toll-like receptor 4 in the brain in a rabbit experimental subarachnoid haemorrhage model. Inflamm Res 2007; 56: 93-97.
8. Chahal N, Barker-Collo S, Feigin V,. Cognitive and functional outcomes of 5-year subarachnoid haemorrhage survivors: comparison to matched healthy controls. Neuroepidemiology 2011; 37: 31-38.
9. Chen G, Shi JX, Hang CH, et al. Inhibitory effect on cerebral inflammatory agents that accompany traumatic brain injury in a rat model: a potential neuroprotective mechanism of recombinant human erythropoietin (rhEPO). Neurosci Lett 2007; 425: 177-182.
10. Jeon H, Ai J, Sabri M, et al. Learning deficits after experimental subarachnoid hemorrhage in rats. Neuroscience 2010; 169: 1805-1814.
11. Mauriz JL, Collado PS, Veneroso C, et al. A review of the molecular aspects of melatonin's anti-inflammatory actions: recent insights and new perspectives. J Pineal Res 2013; 54: 1-14.
12. Fischer TW, Kleszczyński K, Hardkop LH, et al. Melatonin enhances antioxidative enzyme gene expression (CAT, GPx, SOD), prevents their UVR-induced depletion, and protects against the formation of DNA damage (8-hydroxy-2'-deoxyguanosine) in ex vivo human skin. J Pineal Res 2013; 54: 303-312.
13. Rodriguez C, Mayo JC, Sainz RM, et al. Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 2004; 36: 1-9.
14. Galano A, Tan DX, Reiter RJ,. On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 2013; 54: 245-257.
15. Pei Z, Cheung RT,. Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model. J Pineal Res 2004; 37: 85-91.
16. Shinozuka K, Staples M, Borlongan CV,. Melatonin-based therapeutics for neuroprotection in stroke. Int J Mol Sci 2013; 14: 8924-8947.
17. Lee MY, Kuan YH, Chen HY, et al. Intravenous administration of melatonin reduces the intracerebral cellular inflammatory response following transient focal cerebral ischemia in rats. J Pineal Res 2007; 42: 297-309.
18. Peri F, Piazza M,. Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists. Biotechnol Adv 2012; 30: 251-260.
19. Murakami K, Koide M, Dumont TM, et al. Subarachnoid hemorrhage induces gliosis and increased expression of the pro-inflammatory cytokine high mobility group box 1 protein. Transl Stroke Res 2011; 2: 72-79.
20. Ma CX, Yin WN, Cai BW, et al. Toll-like receptor 4/nuclear factor-kappa B signaling detected in brain after early subarachnoid hemorrhage. Chin Med J (Engl) 2009; 122: 1575-1581.
21. Sun Q, Dai Y, Zhang X, et al. Expression and cell distribution of myeloid differentiation primary response protein 88 in the cerebral cortex following experimental subarachnoid hemorrhage in rats: a pilot study. Brain Res 2013; 1520: 134-144.
22. Kang JW, Koh EJ, Lee SM,. Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. J Pineal Res 2011; 50: 403-411.
23. Kang JW, Lee SM,. Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. J Pineal Res 2012; 53: 67-76.
24. Wang Z, Zuo G, Shi XY, et al. Progesterone administration modulates cortical TLR4/NF-κB signaling pathway after subarachnoid hemorrhage in male rats. Mediators Inflamm 2011; 2011: 848309.
25. Fang Q, Chen G, Zhu W, et al. Influence of melatonin on cerebrovascular proinflammatory mediators expression and oxidative stress following subarachnoid hemorrhage in rabbits. Mediators Inflamm 2009; 2009: 426346.
26. Frontera JA, Aledort L, Gordon E, et al. Early platelet activation, inflammation and acute brain injury after a subarachnoid hemorrhage: a pilot study. J Thromb Haemost 2012; 10: 711-713.
27. Pradilla G, Chaichana KL, Hoang S, et al. Inflammation and cerebral vasospasm after subarachnoid hemorrhage. Neurosurg Clin N Am 2010; 21: 365-379.