Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity

Toxicology

Volumn 243, Issue 1-2, 2008, Pages 43-50

  Lee, Kyu Yong ^a   Koh, Seong Ho ^a   Noh, Min Young ^a   Kim, Seung Hyun ^a   Lee, Young Joo ^a  

^a Hanyang University   (South Korea)

Author keywords

Alzheimer's dementia; Amyloid beta; Neurotoxicity; Phosphatidylinositol 3 kinase

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; AMYLOID BETA PROTEIN; CASPASE 3; ENZYME ACTIVATOR; GLYCOGEN SYNTHASE KINASE 3BETA; HEAT SHOCK TRANSCRIPTION FACTOR 1; LYSYLLYSYLHISTIDYLTHREONYLASPARTYLASPARTYLGLYCYLTYROSYLMETHIONYLSERYLPROLYLGLYCYLVALYLALANINE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TAU PROTEIN; THREONINE; TRYPAN BLUE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMYLOID BETA-PROTEIN; ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FREE RADICALS; NEURONS; NEUROTOXICITY SYNDROMES; PEPTIDE FRAGMENTS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 37049008884     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2007.09.020     Document Type: Article

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