The Hippo Pathway and YAP/TAZ-TEAD Protein-Protein Interaction as Targets for Regenerative Medicine and Cancer Treatment

Journal of Medicinal Chemistry

Volumn 58, Issue 12, 2015, Pages 4857-4873

  Santucci, Matteo ^a   Vignudelli, Tatiana ^a   Ferrari, Stefania ^a   Mor, Marco ^b   Scalvini, Laura ^b   Bolognesi, Maria Laura ^c   Uliassi, Elisa ^c   Costi, Maria Paola ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^b UNIVERSITY OF PARMA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR; G PROTEIN COUPLED RECEPTOR; PDZ PROTEIN; PEPTIDE FRAGMENT; PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TEAD; TRANSCRIPTION FACTOR TEAD4; TRANSCRIPTIONAL COACTIVATOR WITH PDZ BINDING MOTIF; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; YES ASSOCIATED PROTEIN; DNA BINDING PROTEIN; HIPPO PROTEIN, HUMAN; NUCLEAR PROTEIN; PHOSPHOPROTEIN; PROTEIN SERINE THREONINE KINASE; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAZ PROTEIN, HUMAN; TEAD1 PROTEIN, HUMAN; YAP1 (YES-ASSOCIATED) PROTEIN, HUMAN;

CANCER CELL; CANCER THERAPY; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; DNA BINDING; DROSOPHILA MELANOGASTER; EMBRYONIC STEM CELL; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; HEART MUSCLE STEM CELL; HIPPO PATHWAY; HUMAN; LIVER STEM CELL; NEURAL STEM CELL; NONHUMAN; ORGAN SIZE; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REGENERATIVE MEDICINE; REGULATORY MECHANISM; REVIEW; SECOND MESSENGER; SKIN STEM CELL; SMALL INTESTINE STEM CELL; STEM CELL; WNT SIGNALING PATHWAY; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; METABOLISM; MOLECULAR GENETICS; MOLECULARLY TARGETED THERAPY; NEOPLASMS; PROCEDURES; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; DNA-BINDING PROTEINS; DRUG DISCOVERY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR TARGETED THERAPY; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROTEIN INTERACTION MAPS; PROTEIN-SERINE-THREONINE KINASES; REGENERATIVE MEDICINE; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; STEM CELLS; TRANSCRIPTION FACTORS;

EID: 84933056597     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501615v     Document Type: Review

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