YAP1 is amplified and up-regulated in hedgehog-associated medulloblastomas and mediates Sonic hedgehog-driven neural precursor proliferation

Genes and Development

Volumn 23, Issue 23, 2009, Pages 2729-2741

  Fernandez L, Africa ^a   Northcott, Paul A ^b   Dalton, James ^c   Fraga, Charles ^c   Ellison, David ^c   Angers, Stephane ^b   Taylor, Michael D ^a   Kenney, Anna Marie ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

Cerebellum; Hippo; Medulloblastoma; Sonic hedgehog; TEAD1; YAP1

Indexed keywords

SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR YAP1;

ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CARCINOGENESIS; CELL POPULATION; CELL PROLIFERATION; CEREBELLUM; CONTROLLED STUDY; GENE AMPLIFICATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IRRADIATION; MEDULLOBLASTOMA; MOLECULAR MECHANICS; MOUSE; NERVE CELL; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; ONCOGENE; POPULATION DYNAMICS; PRECURSOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR RECURRENCE; UPREGULATION;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CEREBELLAR NEOPLASMS; HEDGEHOG PROTEINS; HUMANS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MEDULLOBLASTOMA; MICE; NEURONS; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; UP-REGULATION;

ERINACEIDAE;

EID: 72549090299     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1824509     Document Type: Article

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