Resveratrol, in its natural combination in whole grape, for health promotion and disease management

Annals of the New York Academy of Sciences

Volumn 1348, Issue 1, 2015, Pages 150-160

  Singh, Chandra K ^a   Liu, Xiaoqi ^b   Ahmad, Nihal ^a,c  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b PURDUE UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

clinical trials; grape; resveratrol

Indexed keywords

ANTIOXIDANT; BEVACIZUMAB; GRAPE SEED EXTRACT; LYCOPENE; MELATONIN; PLACEBO; PLANT MEDICINAL PRODUCT; POLYPHENOL; QUERCETIN; RANIBIZUMAB; RESVERATROL;

ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ASSAY; ARTICLE; CLINICAL TRIAL (TOPIC); DIET SUPPLEMENTATION; DRUG FORMULATION; DRUG SAFETY; EPIDEMIOLOGICAL DATA; FOOD INTAKE; GRAPE; GRAPEFRUIT; HEALTH PROMOTION; HUMAN; HYPERCHOLESTEROLEMIA; IN VIVO STUDY; METABOLIC SYNDROME X; NONHUMAN; OXIDATIVE STRESS; PHYTOCHEMISTRY; PREVENTIVE MEDICINE; TRADITIONAL MEDICINE; VASODILATATION;

EID: 84932149869     PISSN: 00778923     EISSN: 17496632     Source Type: Journal    
DOI: 10.1111/nyas.12798     Document Type: Article

References (52)

1. Csiszar, A. et al. 2012. Age-associated proinflammatory secretory phenotype in vascular smooth muscle cells from the non-human primate Macaca mulatta: reversal by resveratrol treatment. J. Gerontol A Biol. Sci. Med. Sci. 67: 811–820.
2. Singh, C.K., M.A. Ndiaye & N. Ahmad. 2014. Resveratrol and cancer: challenges for clinical translation. Biochim. Biophys. Acta 1852: 1178–1185
3. Zordoky, B.N., I.M. Robertson & J.R. Dyck. 2014. Preclinical and clinical evidence for the role of resveratrol in the treatment of cardiovascular diseases. Biochim. Biophys. Acta 852: 1155–1177.
4. Kopp, P. 1998. Resveratrol, a phytoestrogen found in red wine: a possible explanation for the conundrum of the ‘French paradox’? Eur. J. Endocrinol. 138: 619–620.
5. Catalgol, B. et al. 2012. Resveratrol: French paradox revisited. Front. Pharmacol. 3: 141.
6. Mattivi, F. 1993. Solid phase extraction of trans-resveratrol from wines for HPLC analysis. Z. Lebensm. Unters. Forsch. 196: 522–525.
7. Jang, M. et al. 1997. Cancer chemopreventive activity of resveratrol: a natural product derived from grapes. Science 275: 218–220.
8. Howitz, K.T. et al. 2003. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191–196.
9. Singh, C.K., J. George & N. Ahmad. 2013. Resveratrol-based combinatorial strategies for cancer management. Ann. N. Y. Acad. Sci. 1290: 113–121.
10. Scalbert, A. et al. 2005. Dietary polyphenols and the prevention of diseases. Crit. Rev. Food Sci. Nutr. 45: 287–306.
11. Pollan, M. 2008. In Defense of Food: An Eater's Manifesto. Penguin Press.
12. Jacobs, D.R., Jr., M.D. Gross & L.C. Tapsell. 2009. Food synergy: an operational concept for understanding nutrition. Am. J. Clin. Nutr. 89: 1543S–1548S.
13. McGovern, P.E. 2003. Ancient Wine: The Search for the Origins of Viniculture. Princeton University Press.
14. Li, X. et al. 2006. Extractable amounts of trans-resveratrol in seed and berry skin in Vitis evaluated at the germplasm level. J. Agric. Food Chem. 54: 8804–8811.
15. Tříska,J., Houška M. 2012. Physical methods of resveratrol induction in grapes and grape products: a review. Czech. J. Food Sci. 30: 489–502.
16. Pezzuto, J.M. 2008. Grapes and human health: a perspective. J. Agric. Food Chem. 56: 6777–6784.
17. DeSanti, C. et al. 2000. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica 30: 857–866.
18. Zunino, S. 2009. Type 2 diabetes and glycemic response to grapes or grape products. J. Nutr. 139: 1794S–1800S.
19. Sekar, S. & S. Mariappan. 2008. Traditionally fermented biomedicines, arishtas and asavas from Ayurveda. Indian J. Trad. Know. 7: 548–556.
20. Thakkur, C.G. 1974. Introduction to Ayurveda, the Science of Life. ASI Publishers.
21. Paul, B. et al. 1999. Occurrence of resveratrol and pterostilbene in age-old darakchasava, an ayurvedic medicine from India. J. Ethnopharmacol. 68: 71–76.
22. Brandt, J. 2011 (first time published in 1928). The Grape Cure. Yonkers, NY: Ehret 10701–2714.
23. Renaud, S. & M. deLorgeril. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 339: 1523–1526.
24. Simini, B. 2000. Serge Renaud: from French paradox to Cretan miracle. Lancet 355: 48.
25. Choi, C.S. et al. 2010. Effects of grape pomace on the antioxidant defense system in diet-induced hypercholesterolemic rabbits. Nutr. Res. Pract. 4: 114–120.
26. Nayak, B.S. et al. 2010. Wound-healing activity of the skin of the common grape (Vitis vinifera) variant, Cabernet Sauvignon. Phytother. Res. 24: 1151–1157.
27. Rho, K.A. & M.K. Kim. 2006. Effects of different grape formulations on antioxidative capacity, lipid peroxidation and oxidative DNA damage in aged rats. J. Nutr. Sci. Vitaminol. (Tokyo) 52: 33–46.
28. Hanausek, M. et al. 2011. Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants. Nutr. Cancer 63: 28–38.
29. Allam, F. et al. 2013. Grape powder supplementation prevents oxidative stress-induced anxiety-like behavior, memory impairment, and high blood pressure in rats. J. Nutr. 143: 835–842.
30. Patki, G. et al. 2013. Grape powder intake prevents ovariectomy-induced anxiety-like behavior, memory impairment and high blood pressure in female Wistar rats. PLoS One 8: e74522.
31. Solanki, N. et al. 2015. Grape powder prevents cognitive, behavioral, and biochemical impairments in a rat model of posttraumatic stress disorder. Nutr. Res. 35: 65–75.
32. Seymour, E.M. et al. 2008. Chronic intake of a phytochemical-enriched diet reduces cardiac fibrosis and diastolic dysfunction caused by prolonged salt-sensitive hy-pertension. J. Gerontol. A Biol. Sci. Med. Sci. 63: 1034–1042.
33. Seymour, E.M. et al. 2010. Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction. Hypertension 55: 1179–1185.
34. Thandapilly, S.J. et al. 2012. Vascular and cardiac effects of grape powder in the spontaneously hypertensive rat. Am. J. Hypertens. 25: 1070–1076.
35. Kanavi, M.R. et al. 2014. The sustained delivery of resveratrol or a defined grape powder inhibits new blood vessel formation in a mouse model of choroidal neovascularization. Molecules 19: 17578–17603.
36. Chuang, C.C. et al. 2012. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J. Agric. Food Chem. 60: 12458–12468.
37. Zunino, S.J., D.H. Storms & C.B. Stephensen. 2007. Diets rich in polyphenols and vitamin A inhibit the development of type I autoimmune diabetes in nonobese diabetic mice. J. Nutr. 137: 1216–1221.
38. Fuhrman, B. et al. 2005. Grape powder polyphenols attenuate atherosclerosis development in apolipoprotein E deficient (E0) mice and reduce macrophage atherogenicity. J. Nutr. 135: 722–728.
39. Hohman, E.E. & C.M. Weaver. 2015. A grape-enriched diet increases bone calcium retention and cortical bone properties in ovariectomized rats. J. Nutr. 145: 253–259.
40. Wang, Q. et al. 2005. Dietary grape supplement ameliorates cerebral ischemia-induced neuronal death in gerbils. Mol. Nutr. Food Res. 49: 443–451.
41. Lin, A.D. et al. 2005. Protective effects of grape suspension on in vivo ischaemia/reperfusion of the rabbit bladder. BJU Int. 96: 1397–1402.
42. Nguyen, A.V. et al. 2009. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag. Res. 1: 25–37.
43. Prior, R.L. et al. 2007. Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. J. Am. Coll. Nutr. 26: 170–181.
44. Janiques, A.G. et al. 2014. Effects of grape powder supplementation on inflammatory and antioxidant markers in hemodialysis patients: a randomized double-blind study. J. Bras. Nefrol. 36: 496–501.
45. Mellen, P.B. et al. 2010. Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: a randomized crossover trial. J. Am. Coll. Nutr. 29: 469–475.
46. Vaisman, N. & E. Niv. 2015. Daily consumption of red grape cell powder in a dietary dose improves cardiovascular parameters: a double blind, placebo-controlled, randomized study. Int. J. Food Sci. Nutr. 1–8.
47. Zunino, S.J. et al. 2014. Dietary grape powder increases IL-1beta and IL-6 production by lipopolysaccharide-activated monocytes and reduces plasma concentrations of large LDL and large LDL-cholesterol particles in obese humans. Br. J. Nutr. 112: 369–380.
48. Barona, J. et al. 2012. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients 4: 1945–1957.
49. Barona, J. et al. 2012. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J. Nutr. 142: 1626–1632.
50. Zern, T.L. et al. 2005. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J. Nutr. 135: 1911–1917.
51. Allen, S.V. et al. 2014. Evaluation of the aromatase inhibition potential of freeze-dried grape powder. J. Diet. Suppl. DOI: 10.3109/19390211.2014.952863.
52. Popat, R. et al. 2013. A phase 2 study of SRT501 (resveratrol) with bortezomib for patients with relapsed and or refractory multiple myeloma. Br. J. Haematol. 160: 714–717.