Effect of muscadine grape seed supplementation on vascular function in subjects with or at risk for cardiovascular disease: A randomized crossover trial

Journal of the American College of Nutrition

Volumn 29, Issue 5, 2010, Pages 469-475

  Mellen, Philip B ^a   Daniel, Kurt R ^b   Brosnihan, K Bridget ^b   Hansen, Kim J ^b   Herrington, David M ^b  

^a Hattiesburg Clinic   (United States)

^b WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Cardiovascular disease; Dietary supplements; Endothelial function

Indexed keywords

GRAPE SEED EXTRACT; MUSCADINE GRAPE SEED EXTRACT; PLACEBO; UNCLASSIFIED DRUG; ANTIOXIDANT; BIOLOGICAL MARKER; FLAVONOID; PHENOL DERIVATIVE; PLANT EXTRACT; POLYPHENOLS;

ADULT; ANTIOXIDANT ACTIVITY; ARTERY BLOOD FLOW; ARTERY DIAMETER; ARTICLE; BRACHIAL ARTERY; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR RISK; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CROSSOVER PROCEDURE; DIET SUPPLEMENTATION; FEMALE; HUMAN; INFLAMMATION; LIPID PEROXIDATION; MALE; RANDOMIZED CONTROLLED TRIAL; VASCULAR ENDOTHELIUM; ADOLESCENT; AGED; BLOOD; CARDIOVASCULAR DISEASE; CHEMISTRY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DOUBLE BLIND PROCEDURE; DRUG EFFECT; GRAPE; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; PLANT SEED; RISK FACTOR; VASODILATATION;

ADOLESCENT; ADULT; AGED; ANTIOXIDANTS; BIOLOGICAL MARKERS; BRACHIAL ARTERY; CARDIOVASCULAR DISEASES; CORONARY DISEASE; CROSS-OVER STUDIES; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FLAVONOIDS; HUMANS; MALE; MIDDLE AGED; PHENOLS; PLANT EXTRACTS; RISK FACTORS; SEEDS; VASODILATION; VITIS; YOUNG ADULT;

EID: 80052815353     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.2010.10719883     Document Type: Article

References (34)

1. Manach C, Mazur A, Scalbert A: Polyphenols and prevention of cardiovascular diseases. Curr Opin Lipidol 16:77–84, 2005.
2. Vita JA: Polyphenols and cardiovascular disease: effects on endothelial and platelet function. Am J Clin Nutr 81:292S–297S, 2005.
3. Agewall S, Wright S, Doughty RN, Whalley GA, Duxbury M, Sharpe N: Does a glass of red wine improve endothelial function? Eur Heart J 21:74–78, 2000.
4. Hashimoto M, Kim S, Eto M, Iijima K, Ako J, Yoshizumi M, Akishita M, Kondo K, Itakura H, Hosoda K, Toba K, Ouchi Y: Effect of acute intake of red wine on flow-mediated vasodilatation of the brachial artery. Am J Cardiol 88:1457–1160, 2001.
5. Boban M, Modun D, Music I, Vukovic J, Brizic I, Salamunic I, Obad A, Palada I, Dujic Z: Red wine induced modulation of vascular function: separating the role of polyphenols, ethanol, and urates. J Cardiovasc Pharmacol 47:695–701, 2006.
6. Lekakis J, Rallidis LS, Andreadou I, Vamvakou G, Kazantzoglou G, Magiatis P, Skaltsounis AL, Kremastinos DT: Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur J Cardiovasc Prev Rehabil 12:596–600, 2005.
7. Stein JH, Keevil JG, Wiebe DA, Aeschlimann S, Folts JD: Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 100:1050–1055, 1999.
8. Clifton PM: Effect of grape seed extracts and quercetin on cardiovascular and endothelial parameters in high-risk subjects. J Biomed Biotech 5:272–278, 2004.
9. Karatzi K, Papamichael C, Karatzis E, Papaioannou TG, Voidonikola PT, Vamvakou GD, Lekakis J, Zampelas A: Postprandial improvement of endothelial function by red wine and olive oil antioxidants: a synergistic effect of components of the Mediterranean diet. J Am Coll Nutr 27:448–453, 2008.
10. Chou EJ, Keevil JG, Aeschlimann S, Wiebe DA, Folts JD, Stein JH: Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol l88:553–555, 2001.
11. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R: Guidelines for the ultrasound assessment of endothelial-dependent flowmediated vasodilation of the brachial artery. J Am Coll Cardiol 39:257–265, 2002.
12. Fitzpatrick DF, Hirschfield SL, Coffey RG: Endothelium-dependent vasorelaxing activity of wine and other grape products. Am J Physiol 265:H774–H778, 1993.
13. Flesch M, Schwarz A, Bohm M: Effects of red and white wine on endothelium-dependent vasorelaxation of rat aorta and human coronary arteries. Am J Physiol 275:H1183–H1190, 1998.
14. Andriambeloson E, Stoclet JC, Andriantsitohaina R: Mechanism of endothelial nitric oxide-dependent vasorelaxation induced by wine polyphenols in rat thoracic aorta. J Cardiovasc Pharmacol 33:248–254, 1999.
15. de Moura RS, Miranda DZ, Pinto AC, Sicca RF, Souza MA, Rubenich LM, Carvalho LC, Rangel BM, Tano T, Madeira SV, Resende AC: Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine. J Cardiovasc Pharmacol 44:302–309, 2004.
16. Leikert JF, Räthel TR, Wohlfart P, Cheynier V, Vollmar AM, Dirsch VM: Red wine polyphenols enhance endothelial nitric oxide synthase expression and subsequent nitric oxide release from endothelial cells. Circulation 106:1614–1617, 2002.
17. Wallerath T, Poleo D, Li H, Förstermann U: Red wine increases the expression of human endothelial nitric oxide synthase: a mechanism that may contribute to its beneficial cardiovascular effects. J Am Coll Cardiol 41:471–478, 2003.
18. Wallerath T, Poleo D, Li H, Förstermann U: Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 106:1652–1658, 2002.
19. Spanier G, Xu H, Xia N, Tobias S, Deng S, Wojnowski L, Forstermann U, Li H: Resveratrol reduces endothelial oxidative stress by modulating the gene expression of superoxide dismutase 1 (SOD1), glutathione peroxidase 1 (GPx1) and NADPH oxidase subunit (Nox4). J Physiol Pharmacol 60:111–116, 2009.
20. St Leger AS, Cochrane AL, Moore F: Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet 1:1017–1020, 1979.
21. Ector B, Magee J, Hegwood C, Coign M: Resveratrol concentration in muscadine berries, juice, pomace, purees, seeds, and wines. Am J Enol Vitic 47:57–62, 1996.
22. Pastrana-Bonilla E, Akoh C, Sellappan S, Krewer G: Phenolic content and antioxidant capacity of muscadine grapes. J Agric Food Chem 51:5497–5503, 2003.
23. Yilmaz Y, Toledo RT: Major flavonoids in grape seeds and skins: antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem 52:255–260, 2004.
24. Sandhu AK, Gu L: Antioxidant capacity, phenolic content, and profiling of phenolic compounds in the seeds, skin, and pulp of Vitis rotundifolia (muscadine grapes) as determined by HPLCDAD-ESI-Msn J Agric. Food Chem 58:4681–4692, 2010.
25. Herrington DM, Fan L, Drum M, Riley WA, Pusser BE, Crouse JR, Burke GL, McBurnie MA, Morgan TM, Espeland MA: Brachial flow-mediated vasodilator responses in population-based research: methods, reproducibility and effects of age, gender and baseline diameter. J Cardiovasc Risk 8:319–328, 2001.
26. Yeboah J, Folsom AR, Burke GL, Johnson C, Polak JF, Post W, Lima JA, Crouse JR, Herrington DM: Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the Multi-Ethnic Study of Atherosclerosis. Circulation 120:502–509, 2009.
27. Esterbauer H, Schaur RJ, Zollner H: Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad Biol Med 11:81–128, 1991.
28. Longmire AW, Swift LL, Roberts LJ II, Awad JA, Burk RF, Morrow JD: Effect of oxygen tension on the generation of F2-isoprostanes and malondialdehyde in peroxidizing rat liver microsomes. Biochem Pharmacol 47:1173–1177, 1994.
29. Schewe T, Steffen Y, Sies H: How do dietary flavanols improve vascular function? A position paper. Arch Biochem Biophys 476:102–106, 2008.
30. Plantinga Y, Ghiadoni L, Magagna A, Giannarelli C, Franzoni F, Taddei S, Salvetti A: Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens 20:392–397, 2007.
31. Chau NP, Simon A, Vilar J, Cabrera-Fischer E, Pithois-Merli I, Levenson J: Active and passive effects of antihypertensive drugs on large artery diameter and elasticity in human essential hypertension. J Cardiovasc Pharmacol 19:78–85, 1992.
32. Safar ME, Laurent S, Bouthier JA, London GM: Comparative effects of captopril and isosorbide dinitrate on the arterial wall of hypertensive human brachial arteries. J Cardiovasc Pharmacol 8:1257–1261, 1986.
33. Heinonen IM, Lehtonen PJ, Hopia AI: Antioxidant activity of berry and fruit wines and liquors. J Agric Food Chem 46:25–31, 1998.
34. Korkmaz H, Onalan O: Evaluation of endothelial dysfunction: flow-mediated dilation. Endothelium 15:157–163, 2008.