Inhibition of murine skin carcinogenesis by freeze-dried grape powder and other grape-derived major antioxidants

Nutrition and Cancer

Volumn 63, Issue 1, 2011, Pages 28-38

  Hanausek, Margaret ^a   Spears, Erick ^b   Walaszek, Zbigniew ^a   Kowalczyk, Magdalena C ^a   Kowalczyk, Piotr ^a   Wendel, Courtney ^a   Slaga, Thomas J ^a  

^a Mays Cancer Center at UT Health San Antonio   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; CATECHIN; CYCLINE; CYCLOOXYGENASE 2; DEOXYGUANOSINE; DIMETHYLBENZ[A]ANTHRACENE; EPICATECHIN; GRAPE SEED EXTRACT; GRAPEFRUIT EXTRACT; HYDROXYL RADICAL; KAEMPFEROL; PEROXY RADICAL; PROANTHOCYANIDIN; PROANTHOCYANIDIN B 2,3 O GALLATE; QUERCETIN; RESVERATROL; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CANCER INHIBITION; CELL PROLIFERATION; CODON; CONTROLLED STUDY; DRUG POTENTIATION; EPIDERMIS HYPERPLASIA; FEMALE; FOOD INTAKE; FREEZE DRYING; GENE MUTATION; HYDROXYLATION; IC 50; IMMUNE SYSTEM; MOUSE; NONHUMAN; ONCOGENE H RAS; OXIDATIVE STRESS; POWDER; SKIN CARCINOGENESIS; SKIN INFLAMMATION; SKIN PAPILLOMA; SKINFOLD THICKNESS;

ANIMALS; ANTIOXIDANTS; BODY WEIGHT; CYCLOOXYGENASE 2; DEOXYGUANOSINE; EATING; FREEZE DRYING; GENES, RAS; MICE; MUTATION; POWDERS; SKIN NEOPLASMS; VITIS;

MURINAE; MUS; VITACEAE;

EID: 78751471087     PISSN: 01635581     EISSN: None     Source Type: Journal    
DOI: 10.1080/01635581.2010.516474     Document Type: Article

References (46)

1. Slaga TJ, Hanausek M, Morizot D, and Walaszek Z: Importance of animal models in understanding human carcinogenesis and its chemoprevention. Cancer Bull 47, 438-444, 1995.
2. Boutwell RK: Some biological aspects of skin carcinogenisis. Prog Exp Tumor Res 4, 207-250, 1964.
3. DiGiovanni J, Slaga TJ, and Boutwell RK: Comparison of the tumorinitiating activity of 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene in female SENCAR and CS-1 mice. Carcinogenesis 1, 381-389, 1980.
4. DiGiovanni J: Multistage carcinogenesis in mouse skin. Pharmacol Ther 54, 63-128, 1992.
5. Dipple A, Moschel RC, and Bigger CAH: Polynuclear aromatic carcinogens. In Searle CE (ed.), 2nd ed. Chemical Carcinogens 1, 41-163, 1992.
6. Vericat JA, Cheng SC, and Dipple A: Absolute configuration of 7,12- dimethylbenz[a]anthracene-DNA adducts in mouse epidermis. Cancer Lett 57, 237-242, 1991.
7. Tang MS, Vulimiri SV, Viaje A, Chen JX, Bilolikar DS, et al.: Both (+/?)syn- and (+/?)anti-7,12-dimethylbenz[a]anthracene-3,4-diol- 1,2-epoxides initiate tumors in mouse skin that possess -CAA- to -CTAmutatioms at codon 61 of c-H-ras. Cancer Research 60, 5688-5695, 2000.
8. Slaga TJ and Klein-Szanto AJ: Initiation-promotion versus complete skin carcinogenesis in mice: importance of dark basal keratinocytes (stem cells). Cancer Invest 1, 425-436, 1983.
9. Prasad S, Kalra N, Srivastava S, and Shukla Y: Regulation of oxidative stress-mediated apoptosis by diallyl sulfide in DMBA-exposed Swiss mice. Hum Exp Toxicol 27, 55-63, 2008.
10. Nuttall SL, Kendall MJ, Bombardelli E, andMorazzoni P: An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 23, 385-389, 1998.
11. HanausekMandWalaszek Z: Intermediate biomarkers in cancer prevention and their application in clinical oncology. Cancer Bull 47, 445-448, 1995.
12. Pezzuto JM: Grapes and human health: a perspective. J Agric Food Chem 56, 6777-6784, 2008.
13. Pezzuto JM, Kosmeder JW, Park EJ, Lee SK, Cuendet M, et al.: Cancer Chemoprevention, Vol. 2: Strategies for Cancer Chemoprevention. Characterization of Natural Product Chemopreventive Agents. Totowa, NJ: Humana Press, Inc., 2005.
14. Zykova TA, Zhu F, Zhai X, Ma WY, Ermakova SP, et al.: Resveratrol directly targets COX-2 to inhibit carcinogenesis. Mol Carcinog 47, 797-805, 2008.
15. Kundu JK, Shin YK, Kim SH, and Surh YJ: Resveratrol inhibits phorbol ester-induced expression of COX-2 and activation of NF-kappaB in mouse skin by blocking IkappaB kinase activity. Carcinogenesis 27, 1465-1474, 2006.
16. Kapadia GJ, Azuine MA, Tokuda H, Takasaki M, Mukainaka T, et al.: Chemopreventive effect of resveratrol, sesamol, sesame oil and sunflower oil in the Epstein-Barr virus early antigen activation assay and the mouse skin two-stage carcinogenesis. Pharmacol Res 45, 499-505, 2002.
17. Pryor WA, Cornicelli JA, Devall LJ, Tait B, Trivedi BK, et al.: A rapid screening-test to determine the antioxidant potencies of natural and synthetic antioxidants. J Org Chem 58, 3521-3532, 1993.
18. Bagchi D, Garg A, Krohn RL, Bagchi M, Tran MX, et al.: Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res CommunMol Pathol Pharmacol 95, 179-189, 1997.
19. Floyd RA, Watson JJ, and Wong PK: Sensitive assay of hydroxyl free radical formation utilizing high pressure liquid chromatography with electrochemical detection of phenol and salicylate hydroxylation products. J Biochem Biophys Methods 10, 221-235, 1984.
20. Ghiselli A: Aromatic hydroxylation. Salicylic acid as a probe formeasuring hydroxyl radical production. Methods Mol Biol 108, 89-100, 1998.
21. Hanausek M, Ganesh P,Walaszek Z, Arntzen CJ, Slaga TJ, et al.: Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc Natl Acad Sci USA 98, 11551-11556, 2001.
22. Bradley PP, Priebat DA, Christensen RD, and Rothstein G: Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Invest Dermatol 78, 206-209, 1982.
23. KasaiH,Crain PF,KuchinoY,Nishimura S, Ootsuyama A, et al.: Formation of 8-hydroxyguanine moiety in cellular DNA by agents producing oxygen radicals and evidence for its repair. Carcinogenesis 7, 1849-1851, 1986.
24. Floyd RA: Serendipitous findings while researching oxygen free radicals. Free Radic Biol Med 46, 1004-1013, 2009.
25. McCabe DR, Hensley K, and Acworth IN: Method for the detection of nucleosides, bases, and hydroxylated adducts using gradient HPLC with coulometric array and ultraviolet detection. J Med Food 2, 209-214, 1999.
26. Finch JS, Albino HE, and Bowden GT: Quantitation of early clonal expansion of two mutant 61st codon c-Ha-ras alleles in DMBA/TPA treated mouse skin by nested PCR/RFLP. Carcinogenesis 17, 2551-2557, 1996.
27. Nelson MA, FutscherBW, Kinsella T,Wymer J, and Bowden GT:Detection of mutant Ha-ras genes in chemically initiated mouse skin epidermis before the development of benign tumors. Proc Natl Acad Sci USA 89, 6398-6402, 1992.
28. Nomoto M, Yamaguchi R, Kawamura M, Kohno K, and Kasai H: Analysis of 8-hydroxyguanine in rat kidney genomic DNA after administration of a renal carcinogen, ferric nitrilotriacetate. Carcinogenesis 20, 837-841, 1999.
29. Zar JH: Biostatistical Analysis. Englewood Cliffs, NJ: Prentice Hall, 1996.
30. Boutwell RK: The function and mechanism of promoters of carcinogenesis. CRC Crit Rev Toxicol 2, 419-443, 1974.
31. Halliwell B: The chemistry of free radicals. Toxicol Ind Health 9, 1-21, 1993.
32. Quintanilla M, Brown K, Ramsden M, and Balmain A: Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322, 78-80, 1986.
33. Ross JA and Nesnow S: Polycyclic aromatic hydrocarbons: correlations between DNA adducts and ras oncogene mutations. Mutat Res 424, 155-166, 1999.
34. Balmain A and Harris CC: Carcinogenesis in mouse and human cells: parallels and paradoxes. Carcinogenesis 21, 371-377, 2000.
35. Haridas V, Hanausek M, Nishimura G, Soehnge H, Gaikwad A, et al.: Triterpenoid electrophiles (avicins) activate the innate stress response by redox regulation of a gene battery. J Clin Invest 113, 65-73, 2004.
36. Lengauer C, Kinzler KW, and Vogelstein B: Genetic instabilities in human cancers. Nature 396, 643-649, 1998.
37. Marshall HE,Merchant K, and Stamler JS: Nitrosation and oxidation in the regulation of gene expression. FASEB J 14, 1889-1900, 2000.
38. Marnett LJ: Oxyradicals and DNA damage. Carcinogenesis 21, 361-370, 2000.
39. Muller-Decker K, Neufang G, Berger I, Neumann M, Marks F, et al.: Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis. Proc Natl Acad Sci USA 99, 12483-12488, 2002.
40. Bishop JM: Molecular themes in oncogenesis. Cell 64, 235-248, 1991.
41. Marshall CJ: Tumor suppressor genes. Cell 64, 313-326, 1991.
42. Kowalczyk MC, Walaszek Z, Kowalczyk P, Kinjo T, Hanausek M, et al.: Differential effects of several phytochemicals and their derivatives on murine keratinocytes in vitro and in vivo: implications for skin cancer prevention. Carcinogenesis 30, 1008-1015, 2009.
43. Walaszek Z, Hanausek M, and Slaga TJ: Mechanisms of chemoprevention. Chest 125, 128S-1233S, 2004.
44. KowalczykMC, Kowalczyk P, Tolstykh O, Hanausek M,Walaszek Z, et al.: Synergistic effects of combined phytochemicals and skin cancer prevention in SENCAR mice. Cancer Prev Res 3, 170-178, 2010.
45. Gusman J, Malonne H, and Atassi G: A reappraisal of the potential chemopreventive and chemotherapeutic properties of resveratrol. Carcinogenesis 22, 1111-1117, 2001.
46. Aziz MH, Reagan-Shaw S, Wu J, Longley BJ, and Ahmad N: Chemoprevention of skin cancer by grape constituent resveratrol: relevance to human disease? FASEB J 19, 1193-1195, 2005.