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Volumn 11, Issue 3, 2015, Pages 175-181

Molecular action of metformin in hepatocytes: An updated insight

Author keywords

Amp activated protein kinase; Cyclase adenylate; Gluconeogenesis; Metformin; Mitochondrial glycerophosphate dehydrogenase; Respiratory complex I

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LACTATE DEHYDROGENASE; LACTIC ACID; METFORMIN; PROTEIN KINASE C; PYRUVIC ACID; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SIRTUIN 1; ANTIDIABETIC AGENT; DIHYDROXYACETONE PHOSPHATE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE;

EID: 84931836592     PISSN: 15733998     EISSN: 18756417     Source Type: Journal    
DOI: 10.2174/1573399811666150325233108     Document Type: Article
Times cited : (28)

References (75)
  • 1
    • 0029819936 scopus 로고    scopus 로고
    • Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus
    • Cusi K, Consoli A, DeFronzo RA. Metabolic effects of metformin on glucose and lactate metabolism in noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1996; 81: 4059-67.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 4059-4067
    • Cusi, K.1    Consoli, A.2    DeFronzo, R.A.3
  • 2
    • 0033673203 scopus 로고    scopus 로고
    • Mechanism by which metformin reduces glucose production in type 2 diabetes
    • Hundal RS, Krssak M, Dufour S, et al. Mechanism by which metformin reduces glucose production in type 2 diabetes. Diabetes 2000; 49: 2063-9.
    • (2000) Diabetes , vol.49 , pp. 2063-2069
    • Hundal, R.S.1    Krssak, M.2    Dufour, S.3
  • 3
    • 0030749042 scopus 로고    scopus 로고
    • Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver
    • Radziuk J, Zhang Z, Wiernsperger N, Pye S. Effects of metformin on lactate uptake and gluconeogenesis in the perfused rat liver. Diabetes 1997; 46: 1406-13.
    • (1997) Diabetes , vol.46 , pp. 1406-1413
    • Radziuk, J.1    Zhang, Z.2    Wiernsperger, N.3    Pye, S.4
  • 4
    • 84903524608 scopus 로고    scopus 로고
    • Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase
    • Madiraju AK, Erion DM, Rahimi Y, et al. Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature 2014; 510: 542-6.
    • (2014) Nature , vol.510 , pp. 542-546
    • Madiraju, A.K.1    Erion, D.M.2    Rahimi, Y.3
  • 5
    • 84873707522 scopus 로고    scopus 로고
    • Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP
    • Miller RA, Chu Q, Xie J, Foretz M, Viollet B, Birnbaum MJ. Biguanides suppress hepatic glucagon signalling by decreasing production of cyclic AMP. Nature 2013; 494: 256-60.
    • (2013) Nature , vol.494 , pp. 256-260
    • Miller, R.A.1    Chu, Q.2    Xie, J.3    Foretz, M.4    Viollet, B.5    Birnbaum, M.J.6
  • 6
    • 77954933558 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state
    • Foretz M, Hebrard S, Leclerc J, et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. J Clin Invest 2010; 120: 2355-69.
    • (2010) J Clin Invest , vol.120 , pp. 2355-2369
    • Foretz, M.1    Hebrard, S.2    Leclerc, J.3
  • 7
  • 8
    • 84885220015 scopus 로고    scopus 로고
    • Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program
    • Goldberg R, Temprosa M, Otvos J, et al. Lifestyle and metformin treatment favorably influence lipoprotein subfraction distribution in the Diabetes Prevention Program. J Clin Endocrinol Metab 2013; 98: 3989-98.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3989-3998
    • Goldberg, R.1    Temprosa, M.2    Otvos, J.3
  • 9
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet 1998; 352: 854-65.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 11
    • 85027943540 scopus 로고    scopus 로고
    • Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome
    • Fitch K, Abbara S, Lee H, Stavrou E, Sacks R, Michel T, Hemphill L, Torriani M, Grinspoon S. Effects of lifestyle modification and metformin on atherosclerotic indices among HIV-infected patients with the metabolic syndrome. AIDS 2012; 26: 587-97.
    • (2012) AIDS , vol.26 , pp. 587-597
    • Fitch, K.1    Abbara, S.2    Lee, H.3    Stavrou, E.4    Sacks, R.5    Michel, T.6    Hemphill, L.7    Torriani, M.8    Grinspoon, S.9
  • 12
    • 79959554252 scopus 로고    scopus 로고
    • The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis
    • Van Wagner L,B, Rinnela ME. The role of insulin-sensitizing agents in the treatment of nonalcoholic steatohepatitis. Therap Adv Gastroenterol 2011; 4: 249-63.
    • (2011) Therap Adv Gastroenterol , vol.4 , pp. 249-263
    • Van Wagner, L.B.1    Rinnela, M.E.2
  • 14
    • 0042168646 scopus 로고    scopus 로고
    • Effects of withdrawal from metformin on the development of diabetes in the diabetes prevention program
    • Diabetes Prevention Program Research Group. Effects of withdrawal from metformin on the development of diabetes in the diabetes prevention program. Diabetes Care. 2003; 26: 977-80.
    • (2003) Diabetes Care , vol.26 , pp. 977-980
  • 15
    • 84887429519 scopus 로고    scopus 로고
    • Metformin, an antidiabetic molecule with anticancer properties
    • Beck E, Scheen A. Metformin, an antidiabetic molecule with anticancer properties. Rev Med Lieg. 2013; 68: 444-9.
    • (2013) Rev Med Lieg , vol.68 , pp. 444-449
    • Beck, E.1    Scheen, A.2
  • 16
    • 84881614717 scopus 로고    scopus 로고
    • Sakamoto K:Molecular mechanism of action of metformin: Old or new insights?
    • Rena G, Pearson ER, Sakamoto K:Molecular mechanism of action of metformin: old or new insights? Diabetologia 2013; 56: 1898- 906.
    • (2013) Diabetologia , vol.56 , pp. 1898-1906
    • Rena, G.1    Pearson, E.R.2
  • 17
    • 34248156160 scopus 로고    scopus 로고
    • Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action
    • Shu Y, Sheardown SA, Brown C, et al. Effect of genetic variation in the organic cation transporter 1 (OCT1) on metformin action. J Clin Invest 2007; 117: 1422-31.
    • (2007) J Clin Invest , vol.117 , pp. 1422-1431
    • Shu, Y.1    Sheardown, S.A.2    Brown, C.3
  • 18
    • 78649646556 scopus 로고    scopus 로고
    • Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy
    • Nies A., Koepsell H., Damme K., Schwab M. Organic cation transporters (OCTs, MATEs), in vitro and in vivo evidence for the importance in drug therapy. Handb Exp Pharmacol 2011; 201: 105-67
    • (2011) Handb Exp Pharmacol , vol.201 , pp. 105-167
    • Nies, A.1    Koepsell, H.2    Damme, K.3    Schwab, M.4
  • 19
    • 0028158709 scopus 로고
    • Accumulation of metformin by tissues of the normal and diabetic mouse
    • Wilcock C, Bailey CJ. Accumulation of metformin by tissues of the normal and diabetic mouse. Xenobiotica 1994; 24: 49-57.
    • (1994) Xenobiotica , vol.24 , pp. 49-57
    • Wilcock, C.1    Bailey, C.J.2
  • 20
    • 84907370814 scopus 로고    scopus 로고
    • Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria
    • Bridges HR, Jones AJ, Pollak MN, Hirst J. Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria. Biochem J 2014; 462: 475-87.
    • (2014) Biochem J , vol.462 , pp. 475-487
    • Bridges, H.R.1    Jones, A.J.2    Pollak, M.N.3    Hirst, J.4
  • 21
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen MR, Doran E, Halestrap AP. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem J 2000; 348: 607-14.
    • (2000) Biochem J , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 22
    • 0020608149 scopus 로고
    • Photoaffinity cross-linking of oligomycin-sensitive ATPase from beef heart mitochondria by 3ʹ-arylazido-8-azido ATP
    • Schafer HJ, Mainka L, Rathgeber G, Zimmer G. Photoaffinity cross-linking of oligomycin-sensitive ATPase from beef heart mitochondria by 3ʹ-arylazido-8-azido ATP. Biochem Biophys Res Commun 1983; 111: 732-9.
    • (1983) Biochem Biophys Res Commun , vol.111 , pp. 732-739
    • Schafer, H.J.1    Mainka, L.2    Rathgeber, G.3    Zimmer, G.4
  • 23
    • 33744801418 scopus 로고    scopus 로고
    • Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria
    • Lamhonwah AM, Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun 2006; 345: 1315-25.
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1315-1325
    • Lamhonwah, A.M.1    Tein, I.2
  • 24
    • 84876488863 scopus 로고    scopus 로고
    • Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria
    • Shitara Y, Nakamichi N, Norioka M, Shima H, Kato Y, Horie T. Role of organic cation/carnitine transporter 1 in uptake of phenformin and inhibitory effect on complex I respiration in mitochondria. Toxicol Sci 2013; 132: 32-42.
    • (2013) Toxicol Sci , vol.132 , pp. 32-42
    • Shitara, Y.1    Nakamichi, N.2    Norioka, M.3    Shima, H.4    Kato, Y.5    Horie, T.6
  • 25
    • 77954964776 scopus 로고    scopus 로고
    • An energetic tale of AMPK-independent effects of metformin
    • Miller RA, Birnbaum MJ. An energetic tale of AMPK-independent effects of metformin. J Clin Invest. 2010; 120: 2267-70.
    • (2010) J Clin Invest , vol.120 , pp. 2267-2270
    • Miller, R.A.1    Birnbaum, M.J.2
  • 26
    • 0004122931 scopus 로고    scopus 로고
    • Brooks/Cole
    • Garrett & Grisham. Biochemistry. Brooks/Cole 2010; pp 598-611.
    • (2010) Biochemistry , pp. 598-611
    • Garrett1    Grisham2
  • 30
    • 84861887451 scopus 로고    scopus 로고
    • Cellular responses to the metalbinding properties of metformin
    • Logie L, Harthill J, Patel K, et al. Cellular responses to the metalbinding properties of metformin. Diabetes 2012; 61: 1423-33.
    • (2012) Diabetes , vol.61 , pp. 1423-1433
    • Logie, L.1    Harthill, J.2    Patel, K.3
  • 31
    • 84856743909 scopus 로고    scopus 로고
    • Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration
    • Larsen S, Rabøl R, Hansen CN, Madsbad S, Helge JW, Dela F. Metformin-treated patients with type 2 diabetes have normal mitochondrial complex I respiration. Diabetologia 2012; 55: 443-9.
    • (2012) Diabetologia , vol.55 , pp. 443-449
    • Larsen, S.1    Rabøl, R.2    Hansen, C.N.3    Madsbad, S.4    Helge, J.W.5    Dela, F.6
  • 33
    • 84905404389 scopus 로고    scopus 로고
    • Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK)
    • Cao J, Meng S, Chang E, et al. Low concentrations of metformin suppress glucose production in hepatocytes through AMP-activated protein kinase (AMPK). J Biol Chem 2014; 289: 20435-46.
    • (2014) J Biol Chem , vol.289 , pp. 20435-20446
    • Cao, J.1    Meng, S.2    Chang, E.3
  • 34
    • 0034773404 scopus 로고    scopus 로고
    • Role of AMP-activated protein kinase in mechanism of metformin action
    • Zhou G, Myers R, Li Y, et al. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108: 1167-74.
    • (2001) J Clin Invest , vol.108 , pp. 1167-1174
    • Zhou, G.1    Myers, R.2    Li, Y.3
  • 35
    • 84858782079 scopus 로고    scopus 로고
    • AMPK: A nutrient and energy sensor that maintains energy homeostasis
    • Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol 2012; 13: 251-62.
    • (2012) Nat Rev Mol Cell Biol , vol.13 , pp. 251-262
    • Hardie, D.G.1    Ross, F.A.2    Hawley, S.A.3
  • 36
    • 55949132861 scopus 로고    scopus 로고
    • AMP-activated protein kinase: Structure and regulation
    • Sanz P. AMP-activated protein kinase: structure and regulation. Curr Protein Pept Sci 2008; 9: 478-92.
    • (2008) Curr Protein Pept Sci , vol.9 , pp. 478-492
    • Sanz, P.1
  • 37
    • 63849206613 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the regulation of hepatic energy metabolism: From physiology to therapeutic perspectives
    • Viollet B, Guigas B, Leclerc J, et al. AMP-activated protein kinase in the regulation of hepatic energy metabolism: from physiology to therapeutic perspectives. Acta Physiol (Oxf) 2009; 196: 81-98.
    • (2009) Acta Physiol (Oxf) , vol.196 , pp. 81-98
    • Viollet, B.1    Guigas, B.2    Leclerc, J.3
  • 38
    • 79959338922 scopus 로고    scopus 로고
    • AMPK is a direct adenylate charge-regulated protein kinase
    • Oakhill JS, Steel R, Chen ZP, et al. AMPK is a direct adenylate charge-regulated protein kinase. Science 2011; 332: 1433-5.
    • (2011) Science , vol.332 , pp. 1433-1435
    • Oakhill, J.S.1    Steel, R.2    Chen, Z.P.3
  • 39
    • 28844433635 scopus 로고    scopus 로고
    • The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
    • Shaw RJ, Lamia KA, Vasquez D, et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 2005; 310: 1642-6.
    • (2005) Science , vol.310 , pp. 1642-1646
    • Shaw, R.J.1    Lamia, K.A.2    Vasquez, D.3
  • 40
    • 84922359822 scopus 로고    scopus 로고
    • Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex
    • Meng S, Cao J, He Q, et al. Metformin Activates AMP-activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex. J Biol Chem 2015; 290: 3793-802.
    • (2015) J Biol Chem , vol.290 , pp. 3793-3802
    • Meng, S.1    Cao, J.2    He, Q.3
  • 41
    • 79954517977 scopus 로고    scopus 로고
    • Structure of mammalian AMPK and its regulation by ADP
    • Xiao B, Sanders MJ, Underwood E, et al. Structure of mammalian AMPK and its regulation by ADP. Nature 2011; 472: 230-3.
    • (2011) Nature , vol.472 , pp. 230-233
    • Xiao, B.1    Sanders, M.J.2    Underwood, E.3
  • 42
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    • Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D. Dissecting the role of 5'-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 2006; 281: 32207-16.
    • (2006) J Biol Chem , vol.281 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 43
    • 79951962147 scopus 로고    scopus 로고
    • CREB and the CRTC co-activators: Sensors for hormonal and metabolic signals
    • Altarejos JY, Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat Rev Mol Cell Biol 2011; 12: 141-51.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 141-151
    • Altarejos, J.Y.1    Montminy, M.2
  • 44
    • 27144506185 scopus 로고    scopus 로고
    • The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism
    • Koo SH, Flechner L, Qi L, et al. The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 2005; 437: 1109-11.
    • (2005) Nature , vol.437 , pp. 1109-1111
    • Koo, S.H.1    Flechner, L.2    Qi, L.3
  • 45
    • 34548831102 scopus 로고    scopus 로고
    • Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2
    • Dentin R, Liu Y, Koo SH, et al. 3rd, Montminy M. Insulin modulates gluconeogenesis by inhibition of the coactivator TORC2. Nature 2007; 449: 366-9.
    • (2007) Nature , vol.449 , pp. 366-369
    • Dentin, R.1    Liu, Y.2    Koo, S.H.3    Montminy, M.4
  • 46
    • 40449128605 scopus 로고    scopus 로고
    • Hepatic glucose sensing via the CREB coactivator CRTC2
    • Dentin R, Hedrick S, Xie J, Yates J, 3rd, Montminy M. Hepatic glucose sensing via the CREB coactivator CRTC2. Science 2008; 319: 1402-5.
    • (2008) Science , vol.319 , pp. 1402-1405
    • Dentin, R.1    Hedrick, S.2    Xie, J.3    Yates, J.4    Montminy, M.5
  • 48
    • 56249100986 scopus 로고    scopus 로고
    • A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
    • Liu Y, Dentin R, Chen D, et al. 3rd, Olefsky J, Guarente L, Montminy M. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature 2008; 456: 269-73.
    • (2008) Nature , vol.456 , pp. 269-273
    • Liu, Y.1    Dentin, R.2    Chen, D.3    Olefsky, J.4    Guarente, L.5    Montminy, M.6
  • 49
    • 65549136655 scopus 로고    scopus 로고
    • Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein
    • He L, Sabet A, Djedjos S, et al. Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell 2009; 137: 635-46.
    • (2009) Cell , vol.137 , pp. 635-646
    • He, L.1    Sabet, A.2    Djedjos, S.3
  • 50
    • 40749116561 scopus 로고    scopus 로고
    • Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP
    • Kim YD, Park KG, Lee YS, et al. Metformin inhibits hepatic gluconeogenesis through AMP-activated protein kinase-dependent regulation of the orphan nuclear receptor SHP. Diabetes 2008; 57: 306-14.
    • (2008) Diabetes , vol.57 , pp. 306-314
    • Kim, Y.D.1    Park, K.G.2    Lee, Y.S.3
  • 52
    • 77954282799 scopus 로고    scopus 로고
    • Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action
    • Takashima M, Ogawa W, Hayashi K, et al. Role of KLF15 in regulation of hepatic gluconeogenesis and metformin action. Diabetes 2010; 59: 1608-15.
    • (2010) Diabetes , vol.59 , pp. 1608-1615
    • Takashima, M.1    Ogawa, W.2    Hayashi, K.3
  • 53
    • 0036324142 scopus 로고    scopus 로고
    • The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
    • Hawley SA, Gadalla AE, Olsen GS, Hardie DG. The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism. Diabetes 2002; 51: 2420-5.
    • (2002) Diabetes , vol.51 , pp. 2420-2425
    • Hawley, S.A.1    Gadalla, A.E.2    Olsen, G.S.3    Hardie, D.G.4
  • 54
    • 84866656158 scopus 로고    scopus 로고
    • Glucagon and cyclic AMP: Time to turn the page?
    • Rodgers RL. Glucagon and cyclic AMP: time to turn the page? Curr Diabetes Rev 2012; 8: 362-81.
    • (2012) Curr Diabetes Rev , vol.8 , pp. 362-381
    • Rodgers, R.L.1
  • 55
    • 0023041534 scopus 로고
    • Activation of two signal-transduction systems in hepatocytes by glucagon
    • Wakelam M, Murphy GJ, Hruby VJ, Houslay MD. Activation of two signal-transduction systems in hepatocytes by glucagon. Nature 1986; 323: 68-71.
    • (1986) Nature , vol.323 , pp. 68-71
    • Wakelam, M.1    Murphy, G.J.2    Hruby, V.J.3    Houslay, M.D.4
  • 57
    • 0029133235 scopus 로고
    • Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
    • Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE. Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 1995; 333: 550-4.
    • (1995) N Engl J Med , vol.333 , pp. 550-554
    • Stumvoll, M.1    Nurjhan, N.2    Perriello, G.3    Dailey, G.4    Gerich, J.E.5
  • 58
    • 84920568734 scopus 로고    scopus 로고
    • Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate- activated protein kinase activation in rat skeletal muscles
    • Oshima R, Yamada M, Kurogi E, et al. Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate- activated protein kinase activation in rat skeletal muscles. Metabolism 2015; 64: 296-304.
    • (2015) Metabolism , vol.64 , pp. 296-304
    • Oshima, R.1    Yamada, M.2    Kurogi, E.3
  • 59
    • 0036299982 scopus 로고    scopus 로고
    • Metformin increases AMPactivated protein kinase activity in skeletal muscle of subjects with type 2 diabetes
    • Musi N, Hirshman MF, Nygren J, et al. Metformin increases AMPactivated protein kinase activity in skeletal muscle of subjects with type 2 diabetes. Diabetes 2002; 51: 2074-81.
    • (2002) Diabetes , vol.51 , pp. 2074-2081
    • Musi, N.1    Hirshman, M.F.2    Nygren, J.3
  • 60
    • 84898859036 scopus 로고    scopus 로고
    • Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3
    • Song Y, Shi J, Wu Y, et al. Metformin ameliorates insulin resistance in L6 rat skeletal muscle cells through upregulation of SIRT3. Chin Med J (Engl) 2014; 127: 1523-9.
    • (2014) Chin Med J (Engl) , vol.127 , pp. 1523-1529
    • Song, Y.1    Shi, J.2    Wu, Y.3
  • 61
    • 0027303172 scopus 로고
    • In vivo metformin treatment ameliorates insulin resistance: Evidence for potentiation of insulin- induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes
    • Matthaei S, Reibold JP, Hamann A, et al. In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin- induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes. Endocrinology 1993; 133: 304-11.
    • (1993) Endocrinology , vol.133 , pp. 304-311
    • Matthaei, S.1    Reibold, J.P.2    Hamann, A.3
  • 62
    • 0018859690 scopus 로고
    • The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects
    • Molloy AM, Ardill J, Tomkin GH.The effect of metformin treatment on gastric acid secretion and gastrointestinal hormone levels in normal subjects. Diabetologia 1980; 19: 93-6.
    • (1980) Diabetologia , vol.19 , pp. 93-96
    • Molloy, A.M.1    Ardill, J.2    Tomkin, G.H.3
  • 63
    • 0035097211 scopus 로고    scopus 로고
    • Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects
    • Mannucci E, Ognibene A, Cremasco F, et al. Effect of metformin on glucagon-like peptide 1 (GLP-1) and leptin levels in obese nondiabetic subjects. Diabetes Care 2001; 24: 489-94.
    • (2001) Diabetes Care , vol.24 , pp. 489-494
    • Mannucci, E.1    Ognibene, A.2    Cremasco, F.3
  • 64
    • 22344448987 scopus 로고    scopus 로고
    • Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without type 2 diabetes
    • Mannucci E, Tesi F, Bardini G, et al. Effects of metformin on glucagon-like peptide-1 levels in obese patients with and without type 2 diabetes. Diabetes Nutr Metab 2004; 17: 336-42.
    • (2004) Diabetes Nutr Metab , vol.17 , pp. 336-342
    • Mannucci, E.1    Tesi, F.2    Bardini, G.3
  • 66
    • 66449129517 scopus 로고    scopus 로고
    • Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in type 2 diabetes
    • Cuthbertson J, Patterson S, O'Harte FP, Bell PM. Investigation of the effect of oral metformin on dipeptidylpeptidase-4 (DPP-4) activity in type 2 diabetes. Diabet Med 2009; 26: 649-54.
    • (2009) Diabet Med , vol.26 , pp. 649-654
    • Cuthbertson, J.1    Patterson, S.2    O'Harte, F.P.3    Bell, P.M.4
  • 67
    • 33748531290 scopus 로고    scopus 로고
    • Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
    • Green BD, Irwin N, Duffy NA, Gault VA, O'harte FP, Flatt PR. Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1. Eur J Pharmacol 2006; 547: 192-9.
    • (2006) Eur J Pharmacol , vol.547 , pp. 192-199
    • Green, B.D.1    Irwin, N.2    Duffy, N.A.3    Gault, V.A.4    O'harte, F.P.5    Flatt, P.R.6
  • 69
    • 0036435607 scopus 로고    scopus 로고
    • Enhanced secretion of glucagon- like peptide 1 by biguanide compounds
    • Yasuda N, Inoue T, Nagakura T, et al. Enhanced secretion of glucagon- like peptide 1 by biguanide compounds. Biochem Biophys Res Commun 2002; 298: 779-84.
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 779-784
    • Yasuda, N.1    Inoue, T.2    Nagakura, T.3
  • 70
    • 82355165097 scopus 로고    scopus 로고
    • Mechanisms underlying metformin-induced secretion of glucagonlike peptide-1 from the intestinal L cell
    • Mulherin AJ, Oh AH, Kim H, Grieco A, Lauffer LM, Brubaker PL. Mechanisms underlying metformin-induced secretion of glucagonlike peptide-1 from the intestinal L cell. Endocrinology 2011; 152: 4610-9.
    • (2011) Endocrinology , vol.152 , pp. 4610-4619
    • Mulherin, A.J.1    Oh, A.H.2    Kim, H.3    Grieco, A.4    Lauffer, L.M.5    Brubaker, P.L.6
  • 71
    • 17844368938 scopus 로고    scopus 로고
    • Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver
    • Foretz M, Ancellin N, Andreelli F, et al. Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 2005; 54: 1331-9.
    • (2005) Diabetes , vol.54 , pp. 1331-1339
    • Foretz, M.1    Ancellin, N.2    Andreelli, F.3
  • 72
    • 0035914324 scopus 로고    scopus 로고
    • Regulation of transcription by AMP-activated protein kinase: Phosphorylation of p300 blocks its interaction with nuclear receptors
    • Yang W, Hong YH, Shen XQ, Frankowski C, Camp HS, Leff T. Regulation of transcription by AMP-activated protein kinase: phosphorylation of p300 blocks its interaction with nuclear receptors. J Biol Chem 2001; 276: 38341-4.
    • (2001) J Biol Chem , vol.276 , pp. 38341-38344
    • Yang, W.1    Hong, Y.H.2    Shen, X.Q.3    Frankowski, C.4    Camp, H.S.5    Leff, T.6
  • 73
    • 9144271181 scopus 로고    scopus 로고
    • AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulinresistant human HepG2 cells
    • Zang M, Zuccollo A, Hou X, et al. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulinresistant human HepG2 cells. J Biol Chem 2004; 279: 47898-905.
    • (2004) J Biol Chem , vol.279 , pp. 47898-47905
    • Zang, M.1    Zuccollo, A.2    Hou, X.3
  • 74
    • 84889887123 scopus 로고    scopus 로고
    • Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulinsensitizing effects of metformin
    • Fullerton MD, Galic S, Marcinko K, et al. Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulinsensitizing effects of metformin. Nat Med 2013; 19: 1649-54.
    • (2013) Nat Med , vol.19 , pp. 1649-1654
    • Fullerton, M.D.1    Galic, S.2    Marcinko, K.3
  • 75
    • 79959459359 scopus 로고    scopus 로고
    • Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity
    • Kim E, Liu NC, Yu IC, et al. Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes 2011; 60: 1493-503.
    • (2011) Diabetes , vol.60 , pp. 1493-1503
    • Kim, E.1    Liu, N.C.2    Yu, I.C.3


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