Metformin, an antidiabetic molecule with anti-cancerproperties;La metformine : Une molécule antidiabétique dotée de propriétés anti-cancéreuses

Revue Medicale de Liege

Volumn 68, Issue 9, 2013, Pages 444-449

  Beck, E ^b   Scheen, A J ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b CHU de Liège ^*

Author keywords

Cancer; Metformin; Mortality; Prevention; Type 2 diabetes

Indexed keywords

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CANCER; CANCER INCIDENCE; CANCER MORTALITY; CANCER RISK; COHORT ANALYSIS; COLORECTAL CANCER; DIABETIC PATIENT; DRUG EFFECT; LIVER CELL CARCINOMA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBSERVATIONAL STUDY;

ANTINEOPLASTIC AGENTS; DIABETES MELLITUS, TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; METFORMIN; NEOPLASMS;

EID: 84887429519     PISSN: 0370629X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Giovannucci E, Harlan DM, Archer MC, et al.- Diabetes and cancer : a consensus report. Diabetes Care, 2010, 33, 1674-1685.
2. Scheen AJ, Beck E, De Flines J, et al.- Obésité, insulinorésistance et diabéte de type 2 : facteurs de risque du cancer du sein. Rev Med Liege, 2011, 66, 238-244.
3. Godsland IF.- Insulin resistance and hyperinsulinaemia in the development and progression of cancer. Clin Sci, 2010, 118, 315-332.
4. Wysocki PJ, Wierusz-Wysocka B.- Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. Exp Rev Mol Diagn, 2010, 10, 509-519.
5. Cohen DH, LeRoith D.- Obesity, type 2 diabetes, and cancer: the insulin and IGF connection. Endocr Relat Cancer, 2012, 19, 27-45.
6. Smith U, Gale EA.- Does diabetes therapy influence the risk of cancer? Diabetologia, 2009, 52, 1699-1708.
7. Currie CJ, Poole CD, Gale EA.- The influence of glucose-lowering therapies on cancer risk in type 2 diabetes. Diabetologia, 2009, 52, 1766-1777.
8. Onitilo AA, Engel JM, Glurich I, et al.- Diabetes and cancer II: role of diabetes medications and influence of shared risk factors. Cancer Causes Control, 2012, 23, 991-1008.
9. Scheen AJ, Mathieu C.- Recommandations 2012 en diabétologie. Prise en charge de l'hyperglycémie dans le diabéte de type 2 : une approche centrée sur le patient. Rev Med Liége, 2012, 67, 623-631.
10. Scheen AJ, Lefebvre PJ.- Insuline glargine et cancer: une tempête dans un verre d'eau ? Rev Med Liege, 2009, 64, 440-445.
11. Beck E, Scheen AJ.- Activité anticancéreuse de la metformine : nouvelles perspectives pour une vieille molécule. Rev Med Suisse, 2010, 6, 1601-1607.
12. Feng YH, Velazquez-Torres G, Gully C, et al.- The impact of type 2 diabetes and antidiabetic drugs on cancer cell growth. J Cell Mol Med, 2011, 15, 825-836.
13. Emami Riedmaier A, Fisel P, Nies AT, et al.- Metformin and cancer : from the old medicine cabinet to pharmacological pitfalls and prospects. Trends Pharmacol Sci, 2013, 34, 126-135.
14. Pollak MN.- Investigating metformin for cancer prevention and treatment : the end of the beginning. Cancer Discovery, 2012, 2, 778-790.
15. Beck E, Scheen AJ.- Quels bénéfices anti-tumoraux attendre de la metformine ? Ann Endocrinol, 2013, 74, 137-147.
16. Scheen AJ, Ernest P, Jandrain B.- Comment j'explore... une différence de risque de survenue d'un événement dans les études cliniques. Rev Med Liege, 2012, 67, 597-602.
17. Stevens RJ, Ali R, Bankhead CR, et al.- Cancer outcomes and all-cause mortality in adults allocated to metformin: systematic review and collaborative meta-analysis of randomised clinical trials. Diabetologia, 2012, 55, 2593-2603.
18. Decensi A, Puntoni M, Goodwin P, et al.- Metformin and cancer risk in diabetic patients : a systematic review and meta-analysis. Cancer Prev Res, 2010, 3, 1451-1461.
19. Noto H, Goto A, Tsujimoto T, et al.- Cancer risk in diabetic patients treated with metformin : a systematic review and meta-analysis. PLoS One, 2012, 7, e33411.
20. Soranna D, Scotti L, Zambon A, et al.- Cancer risk associated with use of metformin and sulfonylurea in type 2 diabetes : a meta-analysis. Oncologist, 2012, 17, 813-822.
21. Col NF, Ochs L, Springmann V, et al.- Metformin and breast cancer risk : a meta-analysis and critical literature review. Breast Cancer Res Treat, 2012, 135, 639-646.
22. Zhang ZJ, Zheng ZJ, Kan H, et al.- Reduced risk of colorectal cancer with metformin therapy in patients with type 2 diabetes : a meta-analysis. Diabetes Care, 2011, 34, 2323-2328.
23. Wang P, Kang D, Cao W, et al.- Diabetes mellitus and risk of hepatocellular carcinoma : a systematic review and meta-analysis. Diabetes Metab Res Rev, 2012, 28, 109-122.
24. Zhang H, Gao C, Fang L, et al.- Metformin and reduced risk of hepatocellular carcinoma in diabetic patients : a meta-analysis. Scand J Gastroenterol, 2013, 48, 78-87.
25. Zhang ZJ, Zheng ZJ, Shi R, et al.- Metformin for liver cancer prevention in patients with type 2 diabetes : a systematic review and meta-analysis. J Clin Endocrinol Metab, 2012, 97, 2347-2353.
26. Suissa S, Azoulay L.- Metformin and the risk of cancer : time-related biases in observational studies. Diabetes Care, 2012, 35, 2665-2673.
27. Duncan BB, Schmidt MI.- Metformin, cancer, alphabet soup, and the role of epidemiology in etiologic research. Diabetes Care, 2009, 32, 1748-1750.
28. Dowling RJ, Niraula S, Stambolic V, et al.- Metformin in cancer: translational challenges. J Mol Endocrinol, 2012, 48, R31-43.
29. Gallagher EJ, LeRoith D.- Diabetes, cancer, and metformin: connections of metabolism and cell proliferation. Ann N Y Acad Sci, 2011, 1243, 54-68.
30. Ben Sahra I, Le Marchand-Brustel Y, Tanti JF, et al. - Metformin in cancer therapy : a new perspective for an old antidiabetic drug? Mol Cancer Ther, 2010, 9, 1092-1099.
31. Chong CR, Chabner BA.- Mysterious metformin. Oncologist, 2009, 14, 1178-1181.
32. Papanas N, Maltezos E, Mikhailidis DP.- Metformin and cancer : licence to heal? Expert Opin Investig Drugs, 2010, 19, 913-917.
33. Martin M, Marais R.- Metformin : a diabetes drug for cancer, or a cancer drug for diabetics? J Clin Oncol, 2012, 30, 2698-2700.
34. Goodwin PJ, Stambolic V, Lemieux J, et al.- Evaluation of metformin in early breast cancer : a modification of the traditional paradigm for clinical testing of anti-cancer agents. Breast Cancer Res Treat, 2011, 126, 215-220.
35. Zhang P, Li H, Tan X, et al.- Association of metformin use with cancer incidence and mortality : a meta-analysis. Cancer Epidemiol, 2013, 37, 207-218.