-
1
-
-
75549085755
-
Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
-
DeFronzo RA, Tripathy D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 2009; 32 (Suppl 2): S157-S163.
-
(2009)
Diabetes Care
, vol.32
, Issue.SUPPL. 2
-
-
Defronzo, R.A.1
Tripathy, D.2
-
2
-
-
80054942844
-
Mitochondrial dysfunction and insulin resistance from the outside in: Extracellular matrix, the cytoskeleton, and mitochondria
-
Coletta DK, Mandarino LJ. Mitochondrial dysfunction and insulin resistance from the outside in: extracellular matrix, the cytoskeleton, and mitochondria. Am J Physiol Endocrinol Metab 2011; 301: 749-755.
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
, pp. 749-755
-
-
Coletta, D.K.1
Mandarino, L.J.2
-
3
-
-
31044433308
-
Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin resistant offspring of type 2 diabetic parents
-
Morino K, Petersen KF, Dufour S, Befroy D, Frattini J, Shatzkes N, et al. Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin resistant offspring of type 2 diabetic parents. J Clin Invest 2005; 115: 3587-3593.
-
(2005)
J Clin Invest
, vol.115
, pp. 3587-3593
-
-
Morino, K.1
Petersen, K.F.2
Dufour, S.3
Befroy, D.4
Frattini, J.5
Shatzkes, N.6
-
4
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, et al. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A 2011; 108: 14608-14613.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
Emanuelli, B.2
Hirschey, M.D.3
Boucher, J.4
Lee, K.Y.5
Lombard, D.6
-
5
-
-
77952940043
-
Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle
-
Palacios OM, Carmona JJ, Michan S, Chen KY, Manabe Y, Ward JL III, et al. Diet and exercise signals regulate SIRT3 and activate AMPK and PGC-1alpha in skeletal muscle. Aging (Albany NY) 2009; 1: 771-783.
-
(2009)
Aging (Albany NY)
, vol.1
, pp. 771-783
-
-
Palacios, O.M.1
Carmona, J.J.2
Michan, S.3
Chen, K.Y.4
Manabe, Y.5
Ward III, J.L.6
-
6
-
-
84863086273
-
SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism
-
Hirschey MD, Shimazu T, Huang JY, Schwer B, Verdin E. SIRT3 regulates mitochondrial protein acetylation and intermediary metabolism. Cold Spring Harb Symp Quant Biol 2011; 76: 267-277.
-
(2011)
Cold Spring Harb Symp Quant Biol
, vol.76
, pp. 267-277
-
-
Hirschey, M.D.1
Shimazu, T.2
Huang, J.Y.3
Schwer, B.4
Verdin, E.5
-
7
-
-
84864062918
-
Sirtuin 1 and sirtuin 3: Physiological modulators of metabolism
-
Nogueiras R, Habegger KM, Chaudhary N, Finan B, Banks AS, Dietrich MO, et al. Sirtuin 1 and sirtuin 3: physiological modulators of metabolism. Physiol Rev 2012; 92: 1479-1514.
-
(2012)
Physiol Rev
, vol.92
, pp. 1479-1514
-
-
Nogueiras, R.1
Habegger, K.M.2
Chaudhary, N.3
Finan, B.4
Banks, A.S.5
Dietrich, M.O.6
-
8
-
-
84866365752
-
Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats
-
Pintana H, Apaijai N, Pratchayasakul W, Chattipakorn N, Chattipakorn SC. Effects of metformin on learning and memory behaviors and brain mitochondrial functions in high fat diet induced insulin resistant rats. Life Sciences 2012; 91: 409-414.
-
(2012)
Life Sciences
, vol.91
, pp. 409-414
-
-
Pintana, H.1
Apaijai, N.2
Pratchayasakul, W.3
Chattipakorn, N.4
Chattipakorn, S.C.5
-
9
-
-
84857955247
-
Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells
-
Sawada K, Kawabata K, Yamashita T, Kawasaki K, Yamamoto N, Ashida H. Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells. Lipids Health Dis 2012; 11: 36.
-
(2012)
Lipids Health Dis
, vol.11
, pp. 36
-
-
Sawada, K.1
Kawabata, K.2
Yamashita, T.3
Kawasaki, K.4
Yamamoto, N.5
Ashida, H.6
-
10
-
-
76349125988
-
Xiao. SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells
-
T Shi, GQ Fan, SD Xiao. SIRT3 reduces lipid accumulation via AMPK activation in human hepatic cells. Digest Dis 2010; 11: 55-62.
-
(2010)
Digest Dis
, vol.11
, pp. 55-62
-
-
Shi, T.1
Fan, G.Q.2
Xiao, S.D.3
-
11
-
-
19444380162
-
Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells
-
Ouslimani N, Peynet J, Bonnefont-Rousselot D, Thérond P, Legrand A, Beaudeux JL. Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells. Metab Clin Exp 2005; 54: 829-834.
-
(2005)
Metab Clin Exp
, vol.54
, pp. 829-834
-
-
Ouslimani, N.1
Peynet, J.2
Bonnefont-Rousselot, D.3
Thérond, P.4
Legrand, A.5
Beaudeux, J.L.6
-
12
-
-
64849117472
-
Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation
-
Huang NL, Chiang SH, Hsueh CH, Liang YJ, Chen YJ, Lai LP. Metformin inhibits TNF-alpha-induced IkappaB kinase phosphorylation, IkappaB-alpha degradation and IL-6 production in endothelial cells through PI3K-dependent AMPK phosphorylation. Int J Cardiol 2009; 134: 169-175.
-
(2009)
Int J Cardiol
, vol.134
, pp. 169-175
-
-
Huang, N.L.1
Chiang, S.H.2
Hsueh, C.H.3
Liang, Y.J.4
Chen, Y.J.5
Lai, L.P.6
-
13
-
-
77649187908
-
Metformin induces suppression of NAD(P)H oxidase activity in podocytes
-
Piwkowska A, Rogacka D, Jankowski M, Dominiczak MH, Stepiński JK, Angielski S. Metformin induces suppression of NAD(P)H oxidase activity in podocytes. Biochem Biophys Res Commun 2010; 393: 268-273.
-
(2010)
Biochem Biophys Res Commun
, vol.393
, pp. 268-273
-
-
Piwkowska, A.1
Rogacka, D.2
Jankowski, M.3
Dominiczak, M.H.4
Stepiński, J.K.5
Angielski, S.6
-
14
-
-
79961041348
-
Metformin improves cardiac function in a non-diabetic rat model of post-MI heart failure
-
Yin M, van der Horst IC, van Melle JP, Qian C, van Gilst WH, Sillje HH, et al. Metformin improves cardiac function in a non-diabetic rat model of post-MI heart failure. Am J Physiol Heart Circ Physiol 2011; 301: H459-H468.
-
(2011)
Am J Physiol Heart Circ Physiol
, vol.301
-
-
Yin, M.1
van der Horst, I.C.2
van Melle, J.P.3
Qian, C.4
van Gilst, W.H.5
Sillje, H.H.6
-
15
-
-
33644763280
-
Diet-induced obesity and acute hyperlipidemia reduce I kappa Balpha levels in rat skeletal muscle in a fiber-type dependent manner
-
Bhatt BA, Dube JJ, Dedousis N, Reider JA, O'Doherty RM. Diet-induced obesity and acute hyperlipidemia reduce I kappa Balpha levels in rat skeletal muscle in a fiber-type dependent manner. Am J Physiol Regul Integr Comp Physiol 2006; 290: R233-R240.
-
(2006)
Am J Physiol Regul Integr Comp Physiol
, vol.290
-
-
Bhatt, B.A.1
Dube, J.J.2
Dedousis, N.3
Reider, J.A.4
O'Doherty, R.M.5
-
16
-
-
80052291180
-
Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production
-
Jing E, Emanuelli B, Hirschey MD, Boucher J, Lee KY, Lombard D, et al. Sirtuin-3 (Sirt3) regulates skeletal muscle metabolism and insulin signaling via altered mitochondrial oxidation and reactive oxygen species production. Proc Natl Acad Sci U S A 2011; 108: 14608-14613.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 14608-14613
-
-
Jing, E.1
Emanuelli, B.2
Hirschey, M.D.3
Boucher, J.4
Lee, K.Y.5
Lombard, D.6
-
17
-
-
0035083645
-
Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity
-
He J, Watkins S, Kelley DE. Skeletal muscle lipid content and oxidative enzyme activity in relation to muscle fiber type in type 2 diabetes and obesity. Diabetes 2004; 50: 817-823.
-
(2004)
Diabetes
, vol.50
, pp. 817-823
-
-
He, J.1
Watkins, S.2
Kelley, D.E.3
-
18
-
-
34248141686
-
Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
-
Befroy DE, Petersen KF, Dufour S, Mason GF, de Graaf RA, Rothman DL, et al. Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients. Diabetes 2007; 56: 1376-1381.
-
(2007)
Diabetes
, vol.56
, pp. 1376-1381
-
-
Befroy, D.E.1
Petersen, K.F.2
Dufour, S.3
Mason, G.F.4
de Graaf, R.A.5
Rothman, D.L.6
-
19
-
-
84861589885
-
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis
-
Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, et al. Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis. Sci Rep 2012; 2: 425.
-
(2012)
Sci Rep
, vol.2
, pp. 425
-
-
Fernandez-Marcos, P.J.1
Jeninga, E.H.2
Canto, C.3
Harach, T.4
de Boer, V.C.5
Andreux, P.6
-
20
-
-
84872308934
-
SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB
-
Chen CJ, Fu YC, Yu W, Wang W. SIRT3 protects cardiomyocytes from oxidative stress-mediated cell death by activating NF-κB. Biochem Biophys Res Commun 2013; 430: 798-803.
-
(2013)
Biochem Biophys Res Commun
, vol.430
, pp. 798-803
-
-
Chen, C.J.1
Fu, Y.C.2
Yu, W.3
Wang, W.4
-
21
-
-
0037341552
-
Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2
-
Gunton JE, Delhanty PJ, Takahashi S, Baxter RC. Metformin rapidly increases insulin receptor activation in human liver and signals preferentially through insulin-receptor substrate-2. J Clin Endocrinol Metab 2003; 88: 1323-1332.
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 1323-1332
-
-
Gunton, J.E.1
Delhanty, P.J.2
Takahashi, S.3
Baxter, R.C.4
-
22
-
-
61949300140
-
Activation of AMP activated protein kinase by metformin improves left ventricular function and survival in heart failure
-
Gundewar S, Calvert JW, Jha S, Toedt-Pingel I, Ji SY, Nunez D, et al. Activation of AMP activated protein kinase by metformin improves left ventricular function and survival in heart failure. Circ Res 2009; 104: 403-411.
-
(2009)
Circ Res
, vol.104
, pp. 403-411
-
-
Gundewar, S.1
Calvert, J.W.2
Jha, S.3
Toedt-Pingel, I.4
Ji, S.Y.5
Nunez, D.6
-
23
-
-
33644749330
-
Activation of AMP activated protein kinase reduces hyperglycemia induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells
-
Kukidome D, Nishikawa T, Sonoda K, Imoto K, Fujisawa K, Yano M, et al. Activation of AMP activated protein kinase reduces hyperglycemia induced mitochondrial reactive oxygen species production and promotes mitochondrial biogenesis in human umbilical vein endothelial cells. Diabetes 2006; 55: 120-127.
-
(2006)
Diabetes
, vol.55
, pp. 120-127
-
-
Kukidome, D.1
Nishikawa, T.2
Sonoda, K.3
Imoto, K.4
Fujisawa, K.5
Yano, M.6
-
24
-
-
79957979314
-
Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS
-
Chen Y, Zhang J, Lin Y, Lei Q, Guan KL, Zhao S, et al. Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS. Embo Rep 2011; 12: 534-541.
-
(2011)
Embo Rep
, vol.12
, pp. 534-541
-
-
Chen, Y.1
Zhang, J.2
Lin, Y.3
Lei, Q.4
Guan, K.L.5
Zhao, S.6
-
25
-
-
84875270581
-
Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial
-
Esteghamati A, Eskandari D, Mirmiranpour H, Noshad S, Mousavizadeh M, Hedayati M, et al. Effects of metformin on markers of oxidative stress and antioxidant reserve in patients with newly diagnosed type 2 diabetes: A randomized clinical trial. Clin Nutr 2012; 32: 179-185.
-
(2012)
Clin Nutr
, vol.32
, pp. 179-185
-
-
Esteghamati, A.1
Eskandari, D.2
Mirmiranpour, H.3
Noshad, S.4
Mousavizadeh, M.5
Hedayati, M.6
-
26
-
-
84863915541
-
Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets
-
Piro S, Rabuazzo AM, Renis M, Purrello F. Effects of metformin on oxidative stress, adenine nucleotides balance, and glucose-induced insulin release impaired by chronic free fatty acids exposure in rat pancreatic islets. J Endocrinol Invest 2012; 35: 504-510.
-
(2012)
J Endocrinol Invest
, vol.35
, pp. 504-510
-
-
Piro, S.1
Rabuazzo, A.M.2
Renis, M.3
Purrello, F.4
-
27
-
-
18144436363
-
Del Prato S. Reducing insulin resistance with metformin: The evidence today
-
Giannarelli R, Aragona M, Coppelli A, Del Prato S. Reducing insulin resistance with metformin: the evidence today. Diabetes Metab 2003; 29: 6S28-6S35.
-
(2003)
Diabetes Metab
, vol.29
-
-
Giannarelli, R.1
Aragona, M.2
Coppelli, A.3
-
28
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature 2002; 420: 333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
|