Evidence for organic cation transporter-mediated metformin transport and 5′-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles

Metabolism: Clinical and Experimental

Volumn 64, Issue 2, 2015, Pages 296-304

  Oshima, Rieko ^a   Yamada, Mayumi ^a   Kurogi, Eriko ^a   Ogino, Yohei ^a   Serizawa, Yasuhiro ^a   Tsuda, Satoshi ^a   Ma, Xiao ^b   Egawa, Tatsuro ^c   Hayashi, Tatsuya ^a  

^a KYOTO UNIVERSITY   (Japan)

^b YUNNAN AGRICULTURAL UNIVERSITY   (China)

^c TOYOHASHI SOZO UNIVERSITY   (Japan)

Author keywords

5 adenosine monophosphate activated; Glucose transport; Metformin; Organic cation transporter; protein kinase; Skeletalmuscle

Indexed keywords

3 METHYLGLUCOSE; CIMETIDINE; CREATINE PHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE 1 ALPHA; CYCLIC AMP DEPENDENT PROTEIN KINASE 2 ALPHA; GLUCOSE; GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3BETA; INITIATION FACTOR 4E BINDING PROTEIN 1; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; ORGANIC CATION TRANSPORTER 2; ORGANIC CATION TRANSPORTER 3; PROTEIN KINASE B; S6 KINASE; UNCLASSIFIED DRUG; AGENTS AFFECTING WATER, MOLECULE OR ION TRANSPORT; AMP-ACTIVATED PROTEIN KINASE ALPHA1 PROTEIN, RAT; ANTIDIABETIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; ORGANIC CATION TRANSPORTER; PRKAA2 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; EPITROCHLEARIS MUSCLE; GLUCOSE BLOOD LEVEL; GLUCOSE TRANSPORT; GLYCOGEN ANALYSIS; IN VITRO STUDY; MALE; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SOLEUS MUSCLE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ENERGY METABOLISM; ENZYMOLOGY; FAST MUSCLE FIBER; METABOLISM; PHOSPHORYLATION; PROTEIN PROCESSING; RANDOMIZATION; SLOW MUSCLE FIBER; TRANSPORT AT THE CELLULAR LEVEL; WISTAR RAT;

3-O-METHYLGLUCOSE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; BIOLOGICAL TRANSPORT; CIMETIDINE; ENERGY METABOLISM; ENZYME ACTIVATION; HYPOGLYCEMIC AGENTS; IN VITRO TECHNIQUES; MALE; MEMBRANE TRANSPORT MODULATORS; METFORMIN; MUSCLE FIBERS, FAST-TWITCH; MUSCLE FIBERS, SLOW-TWITCH; ORGANIC CATION TRANSPORT PROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANDOM ALLOCATION; RATS, WISTAR;

EID: 84920568734     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2014.10.037     Document Type: Article

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