Identification of the inflammasome Nlrp1b as the candidate gene conferring diabetes risk at the Idd4.1 locus in the nonobese diabetic mouse

Journal of Immunology

Volumn 194, Issue 12, 2015, Pages 5663-5673

  Motta, Vinicius N ^a   Markle, Janet G M ^a,b,d   Gulban, Omid ^a   Mortin Toth, Steven ^a   Liao, Kuo Chien ^b   Mogridge, Jeremy ^b   Steward, Charles A ^c   Danska, Jayne S ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; INFLAMMASOME; INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NLRP1B PROTEIN; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; NALP1B PROTEIN, MOUSE;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTOIMMUNITY; CHROMOSOME 11; CONTROLLED STUDY; CYTOKINE RELEASE; DIABETES MELLITUS; EXON SKIPPING; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HEMATOPOIETIC CELL; IMMUNE RESPONSE; IMMUNOREGULATION; INNATE IMMUNITY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; MOUSE MODEL; MULTIGENE FAMILY; NEXT GENERATION SEQUENCING; NONHUMAN; NONOBESE DIABETIC MOUSE; PANCREAS ISLET; PRIORITY JOURNAL; PROTEIN ASSEMBLY; RADIOSENSITIVITY; STOP CODON; ALTERNATIVE RNA SPLICING; ANIMAL; CHEMISTRY; CHROMOSOME MAP; DISEASE MODEL; FEMALE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN DOMAIN; QUANTITATIVE TRAIT LOCUS; SEQUENCE ALIGNMENT;

ALLELES; ALTERNATIVE SPLICING; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BASE SEQUENCE; CHROMOSOME MAPPING; DIABETES MELLITUS, TYPE 1; DISEASE MODELS, ANIMAL; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; INFLAMMASOMES; INTERFERON-BETA; MALE; MICE; MICE, INBRED NOD; MOLECULAR SEQUENCE DATA; PROTEIN INTERACTION DOMAINS AND MOTIFS; QUANTITATIVE TRAIT LOCI; SEQUENCE ALIGNMENT;

EID: 84931316311     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1400913     Document Type: Article

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