NOD Idd5 locus controls insulitis and diabetes and overlaps the orthologous CTLA4/IDDM12 and NRAMP1 loci in humans

Diabetes

Volumn 49, Issue 10, 2000, Pages 1744-1747

  Hill, Natasha J ^a   Lyons, Paul A ^a   Armitage, Nicola ^a   Todd, John A ^a   Wicker, Linda S ^b   Peterson, Laurence B ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; INTERLEUKIN 8 RECEPTOR; PROTEIN BCL 2; STAT1 PROTEIN; STAT4 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHROMOSOME 1; CHROMOSOME 3; CONGENIC STRAIN; CONTROLLED STUDY; DNA POLYMORPHISM; GENE LOCUS; GENE MAPPING; GENE SEQUENCE; GENETIC LINKAGE; GENETIC RESISTANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULITIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

EID: 0033820560     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.49.10.1744     Document Type: Article

References (22)

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10. Susceptibility to leprosy is linked to the human NRAMP1 gene
11. Linkage of rheumatoid arthritis to the candidate gene NRAMP1 on 2q35
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13. Apoptosis resistance of nonobese diabetic peripheral lymphocytes linked to the Idd5 diabetes susceptibility region
14. CTLA-4 gene polymorphism associated with Graves' disease in a Caucasian population
15. The CTLA-4 gene region of chromosome 2q33 is linked to, and associated with, type 1 diabetes
16. Resistance alleles at two non-major histocompatibility complex-linked insulin-dependent diabetes loci on chromosome 3, Idd3 and Idd10, protect nonobese diabetic mice from diabetes
17. Localization of two insulin-dependent diabetes (Idd) genes to the Idd10 region on mouse chromosome 3
18. Congenic mapping of the type 1 diabetes locus, Idd3, to a 780-kb region of mouse chromosome 3: Identification of a candidate segment of ancestral DNA by haplotype mapping
19. Congenic mapping of the insulin-dependent diabetes (Idd) gene, Idd10, localizes two genes mediating the Idd10 effect and eliminates the candidate Fcgrl
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21. Mapping of the IDDM locus Idd3 to a 0.35-cM interval containing the interleukin-2 gene
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