Synthesis of 1 H -1,2,3-triazole linked aryl(arylamidomethyl) - dihydrofurocoumarin hybrids and analysis of their cytotoxicity

European Journal of Medicinal Chemistry

Volumn 100, Issue , 2015, Pages 119-128

  Lipeeva, Alla V ^a   Pokrovsky, Mikhail A ^b   Baev, Dmitry S ^a   Shakirov, Makhmut M ^a   Bagryanskaya, Irina Y ^a,b   Tolstikova, Tatijana G ^a,b   Pokrovsky, Andrey G ^b   Shults, Elvira E ^a,b  

^a N N VOROZHTSOV NOVOSIBIRSK INSTITUTE OF ORGANIC CHEMISTRY   (Russian Federation)

^b NOVOSIBIRSK STATE UNIVERSITY   (Russian Federation)

Author keywords

1,2,3 Triazoles; Alkynes; Azides; Click chemistry; Cytotoxicity

Indexed keywords

1 ETHYNYL 4 (BENZYLOXY) 3 METHOXYBENZENE; 1,2,3 TRIAZOLE DERIVATIVE; 2 AZIDO 2 ISOPROPYL 9 (4 METHYLPIPERAZIN 1 YL) 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 AZIDOOREOSELONE; 2 ISOPROPYL 2 [4 (2,3,4 TRIMETHOXYPHENYL) 1H 1,2,3 TRIAZOL 1 YL) 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 ISOPROPYL 9 [(4 METHYLPIPERAZIN 1 YL)METHYL] 2 (4 PHENYL 1H 1,2,3 TRIAZOL 1 YL) 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 (2 HYDROXY 5 NITROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 (2 HYDROXY 5 NITROPHENYL) 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 9 [(4 METHYLPIPERAZIN 1 YL)METHYL] 3,7 DIHYDRO 2H FURO [3,2 G]CHROMENE 3,7 DIONE; 2 [4 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 (2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL) 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 9 [(4 METHYLPIPERAZIN 1 YL)METHYL] 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(3,4,5 TRIHYDROXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(3,5 DIHYDROXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(3,5 DIMETHOXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(4 ACETYLAMINO 2 HYDROXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(4 AMINO 2 HYDROXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [(4 HYDROXY 3 METHOXYBENZAMIDO)METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [4 (BENZYLOXY) 3 METHOXYPHENYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 2H FURO[3,2 G]CHROMENE 3,7 DIONE; 2 [4 [[3 (2,4 DIMETHOXYPHENYL)ACRYLAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL] 2 ISOPROPYL 3,7 DIHYDRO 2H FURO[3,2 G]CHROMENE 3,7 DIONE 24; 3 [2,4 DIMETHOXYPHENYL N (PROP 2 YN 1 YL)ACRYLAMIDE; 3,4,5 TRIHYDROXY N (PROP 2 YN 1 YL)BENZAMIDE; 3,5 DIMETHOXY N (PROP 2 YN 1 YL)BENZAMIDE; 4 AMINO 2 HYDROXY N (PROP 2 YN 1 YL)BENZAMIDE; 6 ETHYNYL 2,3 DIHYDROBENZO[B][1,4]DIOXINE; ALKYNE DERIVATIVE; AZIDE; CYTOTOXIC AGENT; DOXORUBICIN; FUROCOUMARIN DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; ROLIPRAM; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; TRIAZOLE DERIVATIVE;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL LINE; CEM 13 CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYCLOADDITION; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MT 4 CELL LINE; MTT ASSAY; STRUCTURE ACTIVITY RELATION; U937 CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; SYNTHESIS; TUMOR CELL CULTURE;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FUROCOUMARINS; HUMANS; MOLECULAR DOCKING SIMULATION; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES; TUMOR CELLS, CULTURED;

EID: 84931260603     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2015.05.016     Document Type: Article

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