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Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 24, 2013, Pages 6721-6727

Synthesis and biological evaluation of nimesulide based new class of triazole derivatives as potential PDE4B inhibitors against cancer cells

(7) Mareddy, Jyoti a,b Nallapati, Suresh Babu b Anireddy, Jayasree b Devi, Yumnam Priyadarshini b Mangamoori, Lakshmi Narasu b Kapavarapu, Ravikumar c Pal, Sarbani a

a MNR Degree and PG College (India)

b JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY (India)

c UNIVERSITY OF COIMBRA (Portugal)

Author keywords

1,2,3 Triazole; Cycloaddition; Cytotoxic activities; Nimesulide; PDE4B

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; NIMESULIDE; PHOSPHODIESTERASE IV INHIBITOR;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL REACTION; CONTROLLED STUDY; CYCLOADDITION; DRUG CYTOTOXICITY; DRUG MECHANISM; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

RUMEX;

1,2,3-TRIAZOLE; CYCLOADDITION; CYTOTOXIC ACTIVITIES; NIMESULIDE; PDE4B;

ALKYNES; APOPTOSIS; AZIDES; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; COPPER; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOADDITION REACTION; ENZYME ACTIVATION; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHODIESTERASE 4 INHIBITORS; SULFONAMIDES; TRIAZOLES;

EID: 84888877713 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.10.035 Document Type: Article

Times cited : (46)

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