Synthesis of 2,2,4-trimethyl-1,2-dihydroquinolinyl substituted 1,2,3-triazole derivatives: Their evaluation as potential PDE 4B inhibitors possessing cytotoxic properties against cancer cells

Bioorganic Chemistry

Volumn 53, Issue , 2014, Pages 8-14

  Praveena, K S S ^a   Durgadas, Shylaprasad ^b   Suresh Babu, N ^c   Akkenapally, Surekha ^d   Ganesh Kumar, C ^d   Deora, Girdhar Singh ^e   Murthy, N Y S ^f   Mukkanti, Khagga ^c   Pal, Sarbani ^a  

^a MNR Degree and PG College   (India)

^b MSN Pharmachem Pvt Ltd   (India)

^c JAWAHARLAL NEHRU TECHNOLOGICAL UNIVERSITY   (India)

^d INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^e UNIVERSITY OF QUEENSLAND   (Australia)

^f ANURAG UNIVERSITY   (India)

Author keywords

1,2,3 Triazole; Cycloaddition; Cytotoxic activities; Nimesulide; PDE4B

Indexed keywords

1,2,3 TRIAZOLE DERIVATIVE; ALKYNE; AMINE; AMMONIUM NITRATE; AZIDE; COPPER; DOXORUBICIN; N (4 METHOXYPHENYL) 2 [4 [[N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHYSULFONAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N 3 TOLYL 2 [4 [[N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHYLSULFONAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N 4 TOLYL 2 [4 [[N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHYLSULFONAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N [4 (METHYLSULFONAMIDO) 3 PHENOXYPHENYL] 2 [4 [[N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHYLSULFONAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; N [[1 [(2 CHLORO 6 METHOXYQUINOLIN 3 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHANESULFONAMIDE; N [[1 [(2 CHLORO 6 METHYLQUINOLIN 3 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHANESULFONAMIDE; N [[1 [(2 CHLORO 7 METHYLQUINOLIN 3 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHANESULFONAMIDE; N [[1 [(2 CHLOROQUINOLIN 3 YL)METHYL] 1H 1,2,3 TRIAZOL 4 YL]METHYL] N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHANESULFONAMIDE; N PHENYL 2 [4 [[N (2,2,4 TRIMETHYL 7 PHENOXY 1,2 DIHYDROQUINOLIN 6 YL)METHYLSULFONAMIDO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETAMIDE; NIMESULIDE; NITRO DERIVATIVE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; QUINOLINE DERIVATIVE; ROLIPRAM; UNCLASSIFIED DRUG; TRIAZOLE DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; CANCER CELL; CATALYSIS; COMPUTER MODEL; CONTROLLED STUDY; CYCLOADDITION; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; LIVER CANCER; LUNG CANCER; MALE; MOLECULAR DOCKING; PRIORITY JOURNAL; PROSTATE CANCER; SKRAUP REACTION; UTERINE CERVIX CANCER; BINDING SITE; CELL SURVIVAL; CHEMISTRY; DRUG EFFECTS; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

ALKYNES; AZIDES; BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CELL LINE, TUMOR; CELL SURVIVAL; COPPER; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOADDITION REACTION; HUMANS; MOLECULAR DOCKING SIMULATION; PHOSPHODIESTERASE 4 INHIBITORS; TRIAZOLES;

EID: 84893132567     PISSN: 00452068     EISSN: 10902120     Source Type: Journal    
DOI: 10.1016/j.bioorg.2013.12.002     Document Type: Article

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