Development of a novel furocoumarin derivative inhibiting NF-κB dependent biological functions: Design, synthesis and biological effects

European Journal of Medicinal Chemistry

Volumn 46, Issue 10, 2011, Pages 4870-4877

  Borgatti, Monica ^a   Chilin, Adriana ^b   Piccagli, Laura ^a   Lampronti, Ilaria ^a   Bianchi, Nicoletta ^a   Mancini, Irene ^a   Marzaro, Giovanni ^b   Francesco Dall'Acqua, ^b   Guiotto, Adriano ^b   Gambari, Roberto ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b UNIVERSITY OF PADOVA   (Italy)

Author keywords

Cystic fibrosis; Docking; Furocoumarin; Interleukin 8; TNF ; Virtual screening

Indexed keywords

ANGELICIN; DEXTRO LEVO 2 [2' (3'' TERT BUTYL 5'' METHYL 7'' OXO 7H FURO[3,2 G] [1]BENZOPYRAN 6'' YL) ACETYL AMINO] 3 PHENYLPROPIONIC ACID; DEXTRO LEVO 2 [2' (3'' TERT BUTYL 5'', 9'' METHYL 7'' OXO 7H FURO[3,2 G] [1]BENZOPYRAN 6'' YL) ACETYL AMINO] 3 PHENYLPROPIONIC ACID; DOUBLE STRANDED DNA; FUROCOUMARIN DERIVATIVE; I KAPPA B KINASE BETA; INTERLEUKIN 8; LEVO 2 [2' (3'' TERT BUTYL 5'' METHYL 7'' OXO 7H FURO[3,2 G] [1]BENZOPYRAN 6'' YL) ACETYL AMINO] 3 PHENYLPROPIONIC ACID; PROTEIN P50; PSORALEN; TRIMETHYLPSORALEN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL GROWTH; COMPETITIVE INHIBITION; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME BINDING; ENZYME INHIBITION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; MOLECULAR DOCKING; MOLECULAR INTERACTION; PROTEIN DNA INTERACTION;

CELL LINE; CYSTIC FIBROSIS; DNA; DRUG DESIGN; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-8; MODELS, MOLECULAR; NF-KAPPA B; PROTEIN BINDING; PSORALENS; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80053182568     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.07.032     Document Type: Article

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