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Volumn 57, Issue , 2014, Pages 1-4

Novel furocoumarins as potential HIV-1 integrase inhibitors

(7) Olomola, Temitope O a Mosebi, Salerwe b Klein, Rosalyn a Traut Johnstone, Telisha b Coates, Judy b Hewer, Raymond b Kaye, Perry T a

a RHODES UNIVERSITY (South Africa)

b MINTEK (South Africa)

Author keywords

Furocoumarins; HIV 1 integrase; Rational design; Strand transfer inhibitors

Indexed keywords

3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL] N PROPYLPROPANAMIDE; 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL] N [(FURAN 2 YL)METHYL]PROPANAMIDE; 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL] N [(PYRIDIN 2 YL)METHYL]PROPANAMIDE; 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL] N [(PYRIDIN 3 YL)METHYL]PROPANAMIDE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; FUROCOUMARIN DERIVATIVE; INTEGRASE; INTEGRASE INHIBITOR; N BENZYL 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL]PROPANAMIDE; N TERT BUTYL 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL]PROPANAMIDE; N [5 (DIETHYLAMINO)PENT 2 YL] 3 [3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL]PROPANAMIDE; RALTEGRAVIR; RESORCINOL; UNCLASSIFIED DRUG; P31 INTEGRASE PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; 3 (3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL) N PROPYLPROPANAMIDE; 3 (3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL) N [(FURAN 2 YL)METHYLPROPANAMIDE; 3 (3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL) N [(PYRIDIN 3 YL)METHYL]PROPANAMIDE; 3 (3,5 DIMETHYLFURO[3,2G]COUMARIN 6 YL) N [(PYRIDIN 2 YL)METHYL]PROPANAMIDE; DIETHYL 2 ACETYLGLUTARATE; METAL ION; N BENZYL 3 (3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL)PROPANAMIDE; N TERT BUTYL 3 (3,5 DIMETHYLFURO[3,2 G]COUMARIN 6 YL)PROPANAMIDE; N [5 (DIETHYLAMINO)PENT 2 YL] 3 [3,5 DIMETHYLFURO[3,2G]COUMARIN 6 YL]PROPANAMIDE;

ALKYLATION; ARTICLE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INHIBITION; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; PRIORITY JOURNAL; PROTON TRANSPORT; SAPONIFICATION; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; HIV INFECTIONS; HUMAN; METABOLISM; STRUCTURE ACTIVITY RELATION; VIROLOGY; X RAY CRYSTALLOGRAPHY; COMPUTER MODEL;

CRYSTALLOGRAPHY, X-RAY; FUROCOUMARINS; HIV INFECTIONS; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84906549441 PISSN: 00452068 EISSN: 10902120 Source Type: Journal
DOI: 10.1016/j.bioorg.2014.07.008 Document Type: Article

Times cited : (39)

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