Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents

European Journal of Medicinal Chemistry

Volumn 85, Issue , 2014, Pages 65-76

  Pingaew, Ratchanok ^a   Saekee, Amporn ^a   Mandi, Prasit ^b   Nantasenamat, Chanin ^b   Prachayasittikul, Supaluk ^b   Ruchirawat, Somsak ^c,d,e   Prachayasittikul, Virapong ^b  

^a SRINAKHARINWIROT UNIVERSITY   (Thailand)

^b MAHIDOL UNIVERSITY   (Thailand)

^c CHULABHORN RESEARCH INSTITUTE   (Thailand)

^d Research and Innovation   (Thailand)

^e Thailand Ministry of Science and Technology   (Thailand)

Author keywords

Antimalarial activity; Chalcone; Coumarin; Cytotoxicity; Molecular docking; Triazole

Indexed keywords

4 ((1 (3 (3 (2,3 DIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 4 ((1 (3 (3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 4 ((1 (3 (3 (3,4 DIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 4 ((1 (4 (3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 4 ((1 (4 (3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YLL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (3 (3 (2,3 DIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (3 (3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (3 (3 (3,4 DIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1 H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (4 (3 (2,3 DIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (4 (3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; 7 ((1 (4 (3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL)PHENYL) 1H 1,2,3 TRIAZOL 4 YL)METHOXY) 2H CHROMEN 2 ONE; ALPHA TUBULIN; ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; BETA TUBULIN; CHALCONE DERIVATIVE; COUMARIN DERIVATIVE; ETOPOSIDE; FALCIPAIN 2; UNCLASSIFIED DRUG; 1,2,3 TRIAZOLE DERIVATIVE; 4 [[1 [3 [3 (2,3 DIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 4 [[1 [3 [3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 4 [[1 [3 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 4 [[1 [4 [3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 4 [[1 [4 [3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [3 [3 (2,3 DIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [3 [3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [3 [3 (3,4 DIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [4 [3 (2,3 DIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [4 [3 (2,3,4 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; 7 [[1 [4 [3 (3,4,5 TRIMETHOXYPHENYL)ACRYLOYL]PHENYL] 1H 1,2,3 TRIAZOL 4 YL]METHOXY] 2H CHROMEN 2 ONE; COLCHICINE; DIHYDROARTEMISININ; DOXORUBICIN; ELLIPTICINE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; TUBULIN; CHALCONE; COUMARIN; CYSTEINE PROTEINASE; TRIAZOLE DERIVATIVE;

ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL LINE; CARBON NUCLEAR MAGNETIC RESONANCE; CYCLOADDITION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; HEPG2 CELL LINE; HUMAN; HUMAN CELL; MOLECULAR DOCKING; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; A549 CELL LINE; AGMK CELL LINE; ANIMAL CELL; CHOLANGIOCARCINOMA CELL LINE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; HYDROGEN BOND; IC50; LEUKEMIA CELL LINE; LYMPHATIC LEUKEMIA; NONHUMAN; STRUCTURE ACTIVITY RELATION; VERO CELL LINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PROTEIN CONFORMATION; SYNTHESIS; TUMOR CELL LINE;

ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONE; CHEMISTRY TECHNIQUES, SYNTHETIC; COUMARINS; CYSTEINE ENDOPEPTIDASES; HUMANS; MOLECULAR DOCKING SIMULATION; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; TRIAZOLES; TUBULIN;

EID: 84905161366     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.07.087     Document Type: Article

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