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Volumn 13, Issue 1, 2008, Pages 62-71

Development of a fission yeast-based high-throughput screen to identify chemical regulators of cAMP phosphodiesterases

Author keywords

cAMP; High throughput; Inhibitors; Phosphodiesterase; Schizosaccharomyces pombe

Indexed keywords

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR; ENZYME INHIBITOR; FURANOCOUMARIN IMPERATORIN; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 37749012052     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057107312127     Document Type: Article
Times cited : (35)

References (41)
  • 1
    • 33748329399 scopus 로고    scopus 로고
    • Molecular details of cAMP generation in mammalian cells: A tale of two systems
    • Kamenetsky M., Middelhaufe S., Bank EM, Levin LR, Buck J., Steegborn C.: Molecular details of cAMP generation in mammalian cells: a tale of two systems. J Mol Biol 2006 ; 362 (4). 623-639.
    • (2006) J Mol Biol , vol.362 , Issue.4 , pp. 623-639
    • Kamenetsky, M.1    Middelhaufe, S.2    Bank, E.M.3    Levin, L.R.4    Buck, J.5    Steegborn, C.6
  • 2
    • 33748686575 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases: Molecular regulation to clinical use
    • Bender AT, Beavo JA: Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev 2006 ; 58 (3). 488-520.
    • (2006) Pharmacol Rev , vol.58 , Issue.3 , pp. 488-520
    • Bender, A.T.1    Beavo, J.A.2
  • 3
    • 30044446499 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies
    • Lerner A., Epstein PM: Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies. Biochem J 2006 ; 393 (pt 1). 21-41.
    • (2006) Biochem J , vol.393 , Issue.1 , pp. 21-41
    • Lerner, A.1    Epstein, P.M.2
  • 4
    • 33845927898 scopus 로고    scopus 로고
    • Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A
    • Vasta V., Shimizu-Albergine M., Beavo JA: Modulation of Leydig cell function by cyclic nucleotide phosphodiesterase 8A. Proc Natl Acad Sci U S A 2006 ; 103: 19925-19930.
    • (2006) Proc Natl Acad Sci U S a , vol.103 , pp. 19925-19930
    • Vasta, V.1    Shimizu-Albergine, M.2    Beavo, J.A.3
  • 5
    • 0036139840 scopus 로고    scopus 로고
    • Update on the therapeutic potential of PDE4 inhibitors
    • Dyke HJ, Montana JG: Update on the therapeutic potential of PDE4 inhibitors. Expert Opin Investig Drugs 2002 ; 11 (1). 1-13.
    • (2002) Expert Opin Investig Drugs , vol.11 , Issue.1 , pp. 1-13
    • Dyke, H.J.1    Montana, J.G.2
  • 7
    • 1342264246 scopus 로고    scopus 로고
    • Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4)
    • O'Donnell JM, Zhang HT: Antidepressant effects of inhibitors of cAMP phosphodiesterase (PDE4). Trends Pharmacol Sci 2004 ; 25 (3). 158-163.
    • (2004) Trends Pharmacol Sci , vol.25 , Issue.3 , pp. 158-163
    • O'Donnell, J.M.1    Zhang, H.T.2
  • 8
    • 31144433061 scopus 로고    scopus 로고
    • Cyclic nucleotide phosphodiesterase (PDE) superfamily: A new target for the development of specific therapeutic agents
    • Lugnier C.: Cyclic nucleotide phosphodiesterase (PDE) superfamily: a new target for the development of specific therapeutic agents. Pharmacol Ther 2006 ; 109 (3). 366-398.
    • (2006) Pharmacol Ther , vol.109 , Issue.3 , pp. 366-398
    • Lugnier, C.1
  • 9
    • 33846975147 scopus 로고    scopus 로고
    • Role of phosphodiesterases in neurological and psychiatric disease
    • Hebb AL, Robertson HA: Role of phosphodiesterases in neurological and psychiatric disease. Curr Opin Pharmacol 2007 ; 7 (1). 86-92.
    • (2007) Curr Opin Pharmacol , vol.7 , Issue.1 , pp. 86-92
    • Hebb, A.L.1    Robertson, H.A.2
  • 10
    • 0025215701 scopus 로고
    • Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe
    • Hoffman CS, Winston F.: Isolation and characterization of mutants constitutive for expression of the fbp1 gene of Schizosaccharomyces pombe. Genetics 1990 ; 124 (4). 807-816.
    • (1990) Genetics , vol.124 , Issue.4 , pp. 807-816
    • Hoffman, C.S.1    Winston, F.2
  • 11
    • 14644435106 scopus 로고    scopus 로고
    • Glucose sensing via the protein kinase a pathway in Schizosaccharomyces pombe
    • Hoffman CS: Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem Soc Trans 2005 ; 33 (pt 1). 257-260.
    • (2005) Biochem Soc Trans , vol.33 , Issue.1 , pp. 257-260
    • Hoffman, C.S.1
  • 12
    • 15244359991 scopus 로고    scopus 로고
    • Except in every detail: Comparing and contrasting G protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryotic
    • Hoffman CS: Except in every detail: comparing and contrasting G protein signaling in Saccharomyces cerevisiae and Schizosaccharomyces pombe. Eukaryotic Cell 2005 ; 4: 495-503.
    • (2005) Cell , vol.4 , pp. 495-503
    • Hoffman, C.S.1
  • 13
    • 0029954766 scopus 로고    scopus 로고
    • Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe
    • Degols G., Shiozaki K., Russell P.: Activation and regulation of the Spc1 stress-activated protein kinase in Schizosaccharomyces pombe. Mol Cell Biol 1996 ; 16 (6). 2870-2877.
    • (1996) Mol Cell Biol , vol.16 , Issue.6 , pp. 2870-2877
    • Degols, G.1    Shiozaki, K.2    Russell, P.3
  • 14
    • 0029997856 scopus 로고    scopus 로고
    • The wis1 signal transduction pathway is required for expression of cAMP- repressed genes in fission yeast
    • Stettler S., Warbrick E., Prochnik S., Mackie S., Fantes P.: The wis1 signal transduction pathway is required for expression of cAMP- repressed genes in fission yeast. J Cell Sci 1996 ; 109 (pt 7). 1927-1935.
    • (1996) J Cell Sci , vol.109 , Issue.7 , pp. 1927-1935
    • Stettler, S.1    Warbrick, E.2    Prochnik, S.3    MacKie, S.4    Fantes, P.5
  • 15
    • 2942670792 scopus 로고    scopus 로고
    • Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe. Eukaryotic
    • Stiefel J., Wang L., Kelly DA, Janoo RTK, Seitz J., Whitehall SK,, et al. Suppressors of an adenylate cyclase deletion in the fission yeast Schizosaccharomyces pombe. Eukaryotic Cell 2004 ; 3 (3). 610-619.
    • (2004) Cell , vol.3 , Issue.3 , pp. 610-619
    • Stiefel, J.1    Wang, L.2    Kelly, D.A.3    Rtk, J.4    Seitz, J.5    Whitehall, S.K.6
  • 16
    • 29144469377 scopus 로고    scopus 로고
    • Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling
    • Wang L., Griffiths K., Zhang YH, Ivey FD, Hoffman CS: Schizosaccharomyces pombe adenylate cyclase suppressor mutations suggest a role for cAMP phosphodiesterase regulation in feedback control of glucose/cAMP signaling. Genetics 2005 ; 171: 1523-1533.
    • (2005) Genetics , vol.171 , pp. 1523-1533
    • Wang, L.1    Griffiths, K.2    Zhang, Y.H.3    Ivey, F.D.4    Hoffman, C.S.5
  • 17
    • 0026742292 scopus 로고
    • Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast
    • Mochizuki N., Yamamoto M.: Reduction in the intracellular cAMP level triggers initiation of sexual development in fission yeast. Mol Gen Genet 1992 ; 233 (1-2). 17-24.
    • (1992) Mol Gen Genet , vol.233 , Issue.1-2 , pp. 17-24
    • Mochizuki, N.1    Yamamoto, M.2
  • 18
    • 8844221233 scopus 로고    scopus 로고
    • Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space
    • Kim YK, Arai MA, Arai T., Lamenzo JO, Dean EF III, Patterson N.,, et al. Relationship of stereochemical and skeletal diversity of small molecules to cellular measurement space. J Am Chem Soc 2004 ; 126 (45). 14740-14745.
    • (2004) J Am Chem Soc , vol.126 , Issue.45 , pp. 14740-14745
    • Kim, Y.K.1    Ma, A.2    Arai, T.3    Lamenzo, J.O.4    Dean III, E.F.5    Patterson, N.6
  • 19
    • 33846842437 scopus 로고    scopus 로고
    • Synthesis and cellular profiling of diverse organosilicon small molecules
    • Franz AK, Dreyfuss PD, Schreiber SL: Synthesis and cellular profiling of diverse organosilicon small molecules. J Am Chem Soc 2007 ; 129 (5). 1020-1021.
    • (2007) J Am Chem Soc , vol.129 , Issue.5 , pp. 1020-1021
    • Franz, A.K.1    Dreyfuss, P.D.2    Schreiber, S.L.3
  • 20
    • 0035911641 scopus 로고    scopus 로고
    • Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse
    • Cherry JA, Thompson BE, Pho V.: Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. Biochim Biophys Acta 2001 ; 1518 (1-2). 27-35.
    • (2001) Biochim Biophys Acta , vol.1518 , Issue.1-2 , pp. 27-35
    • Cherry, J.A.1    Thompson, B.E.2    Pho, V.3
  • 21
    • 0032555138 scopus 로고    scopus 로고
    • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase
    • Soderling SH, Bayuga SJ, Beavo JA: Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc Natl Acad Sci U S A 1998 ; 95 (15). 8991-8996.
    • (1998) Proc Natl Acad Sci U S a , vol.95 , Issue.15 , pp. 8991-8996
    • Sh, S.1    Bayuga, S.J.2    Beavo, J.A.3
  • 22
    • 4444349218 scopus 로고    scopus 로고
    • Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A
    • Wu AY, Tang XB, Martinez SE, Ikeda K., Beavo JA: Molecular determinants for cyclic nucleotide binding to the regulatory domains of phosphodiesterase 2A. J Biol Chem 2004 ; 279 (36). 37928-37938.
    • (2004) J Biol Chem , vol.279 , Issue.36 , pp. 37928-37938
    • Wu, A.Y.1    Tang, X.B.2    Martinez, S.E.3    Ikeda, K.4    Beavo, J.A.5
  • 23
    • 0025944872 scopus 로고
    • Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis
    • DeVoti J., Seydoux G., Beach D., McLeod M.: Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis. EMBO J 1991 ; 10 (12). 3759-3768.
    • (1991) EMBO J , vol.10 , Issue.12 , pp. 3759-3768
    • Devoti, J.1    Seydoux, G.2    Beach, D.3    McLeod, M.4
  • 24
    • 17844378717 scopus 로고    scopus 로고
    • Direct activation of fission yeast adenylate cyclase by the Gpa2 Gα of the glucose signaling pathway
    • Ivey FD, Hoffman CS Direct activation of fission yeast adenylate cyclase by the Gpa2 Gα of the glucose signaling pathway. Proc Natl Acad Sci U S A 2005 ; 102 (17). 6108-6113.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , Issue.17 , pp. 6108-6113
    • Ivey, F.D.1    Hoffman, C.S.2
  • 25
    • 0028100448 scopus 로고
    • Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein α subunit encoded by gpa2 (git8)
    • Nocero M., Isshiki T., Yamamoto M., Hoffman CS: Glucose repression of fbp1 transcription of Schizosaccharomyces pombe is partially regulated by adenylate cyclase activation by a G protein α subunit encoded by gpa2 (git8). Genetics 1994 ; 138 (1). 39-45.
    • (1994) Genetics , vol.138 , Issue.1 , pp. 39-45
    • Nocero, M.1    Isshiki, T.2    Yamamoto, M.3    Hoffman, C.S.4
  • 26
    • 0033786755 scopus 로고    scopus 로고
    • Glucose monitoring in fission yeast via the gpa2 Gα, the git5 Gβ, and the git3 putative glucose receptor
    • Welton RM, Hoffman CS: Glucose monitoring in fission yeast via the gpa2 Gα, the git5 Gβ, and the git3 putative glucose receptor. Genetics 2000 ; 156: 513-521.
    • (2000) Genetics , vol.156 , pp. 513-521
    • Welton, R.M.1    Hoffman, C.S.2
  • 27
    • 0032523783 scopus 로고    scopus 로고
    • Regulation of the fission yeast transcription factor Pap1 by oxidative stress: Requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1
    • Toone WM, Kuge S., Samuels M., Morgan BA, Toda T., Jones N.: Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1. Genes Dev 1998 ; 12 (10). 1453-1463.
    • (1998) Genes Dev , vol.12 , Issue.10 , pp. 1453-1463
    • Toone, W.M.1    Kuge, S.2    Samuels, M.3    Morgan, B.A.4    Toda, T.5    Jones, N.6
  • 28
    • 0025977196 scopus 로고
    • Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases
    • Toda T., Shimanuki M., Yanagida M.: Fission yeast genes that confer resistance to staurosporine encode an AP-1-like transcription factor and a protein kinase related to the mammalian ERK1/MAP2 and budding yeast FUS3 and KSS1 kinases. Genes Dev 1991 ; 5 (1). 60-73.
    • (1991) Genes Dev , vol.5 , Issue.1 , pp. 60-73
    • Toda, T.1    Shimanuki, M.2    Yanagida, M.3
  • 29
    • 0033003760 scopus 로고    scopus 로고
    • A simple statistical parameter for use in evaluation and validation of high throughput screening assays
    • Zhang JH, Chung TD, Oldenburg KR: A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J Biomol Screen 1999 ; 4 (2). 67-73.
    • (1999) J Biomol Screen , vol.4 , Issue.2 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.2    Oldenburg, K.R.3
  • 30
    • 0025771976 scopus 로고
    • Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae
    • Colicelli J., Nicolette C., Birchmeier C., Rodgers L., Riggs M., Wigler M.: Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 1991 ; 88 (7). 2913-2917.
    • (1991) Proc Natl Acad Sci U S a , vol.88 , Issue.7 , pp. 2913-2917
    • Colicelli, J.1    Nicolette, C.2    Birchmeier, C.3    Rodgers, L.4    Riggs, M.5    Wigler, M.6
  • 31
    • 0027138677 scopus 로고
    • Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase
    • Pillai R., Kytle K., Reyes A., Colicelli J.: Use of a yeast expression system for the isolation and analysis of drug-resistant mutants of a mammalian phosphodiesterase. Proc Natl Acad Sci U S A 1993 ; 90 (24). 11970-11974.
    • (1993) Proc Natl Acad Sci U S a , vol.90 , Issue.24 , pp. 11970-11974
    • Pillai, R.1    Kytle, K.2    Reyes, A.3    Colicelli, J.4
  • 33
    • 0020000847 scopus 로고
    • Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3′, 5′-monophosphate phosphodiesterase inhibitors
    • Wachtel H.: Characteristic behavioural alterations in rats induced by rolipram and other selective adenosine cyclic 3′, 5′-monophosphate phosphodiesterase inhibitors. Psychopharmacology (Berl) 1982 ; 77 (4). 309-316.
    • (1982) Psychopharmacology (Berl) , vol.77 , Issue.4 , pp. 309-316
    • Wachtel, H.1
  • 34
    • 0020693045 scopus 로고
    • Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors
    • Wachtel H.: Potential antidepressant activity of rolipram and other selective cyclic adenosine 3′,5′-monophosphate phosphodiesterase inhibitors. Neuropharmacology 1983 ; 22 (3). 267-272.
    • (1983) Neuropharmacology , vol.22 , Issue.3 , pp. 267-272
    • Wachtel, H.1
  • 35
    • 0035976546 scopus 로고    scopus 로고
    • Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey
    • Lamontagne S., Meadows E., Luk P., Normandin D., Muise E., Boulet L.,, et al. Localization of phosphodiesterase-4 isoforms in the medulla and nodose ganglion of the squirrel monkey. Brain Res 2001 ; 920 (1-2). 84-96.
    • (2001) Brain Res , vol.920 , Issue.1-2 , pp. 84-96
    • Lamontagne, S.1    Meadows, E.2    Luk, P.3    Normandin, D.4    Muise, E.5    Boulet, L.6
  • 36
    • 0037105945 scopus 로고    scopus 로고
    • Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization
    • Miro X., Perez-Torres S., Puigdomenech P., Palacios JM, Mengod G.: Differential distribution of PDE4D splice variant mRNAs in rat brain suggests association with specific pathways and presynaptical localization. Synapse 2002 ; 45 (4). 259-269.
    • (2002) Synapse , vol.45 , Issue.4 , pp. 259-269
    • Miro, X.1    Perez-Torres, S.2    Puigdomenech, P.3    Palacios, J.M.4    Mengod, G.5
  • 37
    • 33748324543 scopus 로고    scopus 로고
    • Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver
    • Maywood)
    • Peluso MR: Flavonoids attenuate cardiovascular disease, inhibit phosphodiesterase, and modulate lipid homeostasis in adipose tissue and liver. Exp Biol Med (Maywood) 2006 ; 231 (8). 1287-1299.
    • (2006) Exp Biol Med , vol.231 , Issue.8 , pp. 1287-1299
    • Peluso, M.R.1
  • 38
    • 0032889828 scopus 로고    scopus 로고
    • Effects of visnagin on cyclic nucleotide phosphodiesterases and their role in its inhibitory effects on vascular smooth muscle contraction
    • Duarte J., Lugnier C., Torres AI, Perez-Vizcaino F., Zarzuelo A., Tamargo J.: Effects of visnagin on cyclic nucleotide phosphodiesterases and their role in its inhibitory effects on vascular smooth muscle contraction. Gen Pharmacol 1999 ; 32 (1). 71-74.
    • (1999) Gen Pharmacol , vol.32 , Issue.1 , pp. 71-74
    • Duarte, J.1    Lugnier, C.2    Torres, A.I.3    Perez-Vizcaino, F.4    Zarzuelo, A.5    Tamargo, J.6
  • 40
    • 4444368819 scopus 로고    scopus 로고
    • Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway
    • Sancho R., Marquez N., Gomez-Gonzalo M., Calzado MA, Bettoni G., Coiras MT,, et al. Imperatorin inhibits HIV-1 replication through an Sp1-dependent pathway. J Biol Chem 2004 ; 279 (36). 37349-37359.
    • (2004) J Biol Chem , vol.279 , Issue.36 , pp. 37349-37359
    • Sancho, R.1    Marquez, N.2    Gomez-Gonzalo, M.3    Ma, C.4    Bettoni, G.5    Coiras, M.T.6
  • 41
    • 0029127229 scopus 로고
    • Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication
    • Angel JB, Saget BM, Walsh SP, Greten TF, Dinarello CA, Skolnik PR,, et al. Rolipram, a specific type IV phosphodiesterase inhibitor, is a potent inhibitor of HIV-1 replication. AIDS 1995 ; 9 (10). 1137-1144.
    • (1995) AIDS , vol.9 , Issue.10 , pp. 1137-1144
    • Angel, J.B.1    Saget, B.M.2    Walsh, S.P.3    Greten, T.F.4    Dinarello, C.A.5    Skolnik, P.R.6


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