Telomerase RNA levels limit the telomere length equilibrium

Cold Spring Harbor Symposia on Quantitative Biology

Volumn 71, Issue , 2006, Pages 225-229

  Greider, C W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RNA; TELOMERASE; TELOMERASE RNA; UNCLASSIFIED DRUG;

ANIMAL; APLASTIC ANEMIA; CELL DIVISION; DYSKERATOSIS CONGENITA; ENZYMOLOGY; FEMALE; GENETICS; HETEROZYGOTE; HUMAN; MALE; METABOLISM; MOUSE; MOUSE MUTANT; REVIEW; TELOMERE; ARTICLE; HAPLOINSUFFICIENCY; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; TELOMERE HOMEOSTASIS;

ANEMIA, APLASTIC; ANIMALS; CELL DIVISION; DYSKERATOSIS CONGENITA; FEMALE; HETEROZYGOTE; HUMANS; MALE; MICE; MICE, KNOCKOUT; RNA; TELOMERASE; TELOMERE;

EID: 34250647098     PISSN: 00917451     EISSN: None     Source Type: Book Series    
DOI: 10.1101/sqb.2006.71.063     Document Type: Conference Paper

References (44)

1. Blasco M.A., Lee H.-W., Hande M.P., Samper E., Lansdorp P.M., DePinho R.A., and Greider C.W. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25.
2. Chen J.L. and Greider C.W. 2004. Telomerase RNA structure and function: Implications for dyskeratosis congenita. Trends Biochem. Sci. 29: 183.
3. Craven R.J. and Petes T.D. 1999. Dependence of the regulation of telomere length on the type of subtelomeric repeat in the yeast Saccharomyces cerevisiae. Genetics 152: 1531.
4. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., and Jackson S.P. 2003. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194.
5. de Lange T. 1995. Telomere dynamics and genome instability in human cancer. In Telomeres (ed. E.H. Blackburn and C.W. Greider), p. 265. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
6. -. 2005. Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev. 19: 2100.
7. Enomoto S., Glowczewski L., and Berman J. 2002. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol. Biol. Cell 13: 2626.
8. Frank C.J., Hyde M., and Greider C.W. 2006. Regulation of telomere elongation by the cyclin-dependent kinase CDK1. Mol. Cell 24: 423.
9. Greenberg R.A., Chin L., Femino A., Lee K.H., Gottlieb G.J., Singer R.H., Greider C.W., and DePinho R.A. 1999. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse. Cell 97: 515.
10. Greider C.W. 1990. Telomeres, telomerase and senescence. Bioessays 12: 363.
11. -. 1991. Chromosome first aid. Cell 67: 645.
12. -. 1996. Telomere length regulation. Annu. Rev. Biochem. 65: 337.
13. Greider C.W. and Blackburn E.H. 1985. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43: 405.
14. -. 1989. A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis. Nature 337: 331.
15. Haber J.E. and Thorburn P.C. 1984. Healing of broken linear dicentric chromosomes in yeast. Genetics 106: 207.
16. Hao L.Y., Strong M., and Greider C.W. 2004. Phosphorylation of H2AX at short telomeres in T cells and fibroblasts. J. Biol. Chem. 279: 45148.
17. Hao L.Y., Armanios M., Strong M.A., Karim B., Feldser D.M., Huso D., and Greider C.W. 2005. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123: 1121.
18. Harley C.B., Futcher A.B., and Greider C.W. 1990. Telomeres shorten during ageing of human fibroblasts. Nature 345: 458. Hathcock K.S., Hemann M.T., Opperman K.K., Strong M.A., Greider C.W., and Hodes R.J. 2002. Haploinsufficiency of mTR results in defects in telomere elongation. Proc. Natl. Acad. Sci. 99: 3591.
19. Hemann M.T. and Greider C.W. 2000. Wild-derived inbred mouse strains have short telomeres. Nucleic Acids Res. 28: 4474.
20. Hemann M.T., Hackett J., IJpma A., and Greider C.W. 2000. Telomere length, telomere binding proteins and DNA damage signaling. Cold Spring Harbor Symp. Quant. Biol. 65: 275.
21. Hemann M.T., Strong M., Hao L.Y., and Greider C.W. 2001a. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107: 67.
22. Hemann M.T., Rudolph L., Strong M., DePinho R.A., Chin L., and Greider C.W. 2001b. Telomere dysfunction triggers developmentally regulated germ cell apoptosis. Mol. Biol. Cell 12: 2023.
23. IJpma A. and Greider C.W. 2003. Short telomeres induce a DNA damage response in Saccharomyces cerevisiae. Mol. Biol. Cell 14: 987.
24. Lamb J., Harris P.C., Wilkie A.O., Wood W.G., Dauwerse J.G., and Higgs D.R. 1993. De novo truncation of chromosome 16p and healing with (TTAGGG)n in the alpha-thalassemia/mental retardation syndrome (ATR-16). Am. J. Hum. Genet. 52: 668.
25. Lee H.-W., Blasco M.A., Gottlieb G.J., Horner J.W., Greider C.W., and DePinho R.A. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392: 569.
26. Lingner J., Hughes T.R., Shevchenko A., Mann M., Lundblad V., and Cech T.R. 1997. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276: 561.
27. Lundblad V. and Szostak J.W. 1989. A mutant with a defect in telomere elongation leads to senescence in yeast. Cell 57: 633.
28. Mozdy A.D. and Cech T.R. 2006. Low abundance of telomerase in yeast: Implications for telomerase haploinsufficiency. RNA 12: 1721.
29. Naito T., Matsuura A., and Ishikawa F. 1998. Circular chromosome formation in a fission yeast mutant defective in two ATM homologues. Nat. Genet. 20: 203.
30. Olovnikov A.M. 1973. A theory of marginotomy. J. Theor. Biol. 41: 181.
31. Qi L., Strong M.A., Karim B.O., Armanios M., Huso D.L., and Greider C.W. 2003. Short telomeres and ataxia-telangiectasia mutated deficiency cooperatively increase telomere dysfunction and suppress tumorigenesis. Cancer Res. 63: 8188.
32. Ritchie K.B., Mallory J.C., and Petes T.D. 1999. Interactions of TLC1 (which encodes the RNA subunit of telomerase), TEL1, and MEC1 in regulating telomere length in the yeast Saccharomyces cerevisiae. Mol. Cell. Biol. 19: 6065.
33. Rudolph K.L., Millard M., Bosenberg M.W., and DePinho R.A. 2001. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28: 155.
34. Shay J.W. and Wright W.E. 2002. Telomerase: A target for cancer therapeutics. Cancer Cell 2: 257.
35. Shore D. 1997a. Telomerase and telomere-binding proteins: Controlling the endgame. Trends Biochem. Sci. 22: 233.
36. -. 1997b. Telomere length regulation: Getting the measure of chromosome ends. Biol. Chem. 378: 591.
37. Singer M.S. and Gottschling D.E. 1994. TLC1: Template RNA component of Saccharomyces cerevisiae telomerase. Science 266: 404.
38. Smogorzewska A. and de Lange T. 2004. Regulation of telomerase by telomeric proteins. Annu. Rev. Biochem. 73: 177.
39. Viprakasit V., Kidd A.M., Ayyub H., Horsley S., Hughes J., and Higgs D.R. 2003. De novo deletion within the telomeric region flanking the human alpha globin locus as a cause of alpha thalassaemia. Br. J. Haematol. 120: 867.
40. Vodenicharov M.D. and Wellinger R.J. 2006. DNA degradation at unprotected telomeres in yeast is regulated by the CDK1 (Cdc28/Clb) cell-cycle kinase. Mol. Cell 24: 127.
41. Vulliamy T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P.J., and Dokal I. 2001. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature 413: 432.
42. Watson J.D. 1972. Origin of concatameric T7 DNA. Nat. New Biol. 239: 197.
43. Wilkie A.O., Lamb J., Harris P.C., Finney R.D., and Higgs D.R. 1990. A truncated human chromosome 16 associated with alpha thalassaemia is stabilized by addition of telomeric repeat (TTAGGG)n. Nature 346: 868.
44. Wong K.K., Maser R.S., Bachoo R.M., Menon J., Carrasco D.R., Gu Y., Alt F.W., and DePinho R.A. 2003. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421: 643.