Ubiquitin ligase MKRN1 modulates telomere length homeostasis through a proteolysis of hTERT

Genes and Development

Volumn 19, Issue 7, 2005, Pages 776-781

  Kim, Jim Hyun ^a   Park, Sun Mi ^a   Kang, Mi Ran ^a   Oh, Sue Young ^a   Lee, Tae H ^a   Muller, Mark T ^b   Chung, In Kwon ^a  

^a Yonsei University   (South Korea)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

Hsp90; hTERT; Proteolysis; Telomere; Ubiquitin

Indexed keywords

GELDANAMYCIN; PROTEIN MKRN1; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME REGULATION; GENE; GENE IDENTIFICATION; GENE OVEREXPRESSION; HOMEOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; PROTEIN STABILITY; RING FINGER GENE; TELOMERE; TWO HYBRID SYSTEM; UBIQUITINATION;

BENZOQUINONES; DNA-BINDING PROTEINS; HOMEOSTASIS; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; NERVE TISSUE PROTEINS; PROTEASOME ENDOPEPTIDASE COMPLEX; QUINONES; RIBONUCLEOPROTEINS; TELOMERASE; TELOMERE; UBIQUITIN;

EID: 17044367499     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1289405     Document Type: Article

References (26)

1. Blackburn, E.H. 1992. Telomerases. Annu. Rev. Biochem. 61: 113-129.
2. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., and Greider, C.W. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
3. Connell, P., Ballinger, C.A., Jiang, J., Wu, Y., Thompson, L.J., Hohfeld, J., and Patterson, C. 2001. The co-chaperone CHIP regulates protein triage decisions mediated by heat-shock proteins. Nat. Cell Biol. 3: 93-96.
4. Forsythe, H.L., Jarvis, J.L., Turner, J.W., Elmore, L.W., and Holt, S.E. 2001. Stable association of hsp90 and p23, but Not hsp70, with active human telomerase. J. Biol. Chem. 276: 15571-15574.
5. Girnita, L., Girnita, A., and Larsson, O. 2003. Mdm2-dependent ubiquitination and degradation of the insulin-like growth factor 1 receptor. Proc. Natl. Acad. Sci. 100: 8247-8252.
6. Goetz, M.P., Toft, D.O., Ames, M.M., and Erlichman, C. 2003. The Hsp90 chaperone complex as a novel target for cancer therapy. Ann. Oncol. 14: 1169-1176.
7. Gray, T.A., Hernandez, L., Carey, A.H., Schaldach, M.A., Smithwick, M.J., Rus, K., Marshall Graves, J.A., Stewart, C.L., and Nicholls, R.D. 2000. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Genomics 66: 76-86.
8. Greider, C.W. 1996. Telomere length regulation. Annu. Rev. Biochem. 65: 337-365.
9. Harley, C.B. 1991. Telomere loss: Mitotic clock or genetic time bomb? Mutat. Res. 256: 271-282.
10. Holt, S.E., Aisner, D.L., Baur, J., Tesmer, V.M., Dy, M., Ouellette, M., Trager, J.B., Morin, G.B., Toft, D.O., Shay, J.W., et al. 1999. Functional requirement of p23 and Hsp90 in telomerase complexes. Genes & Dev. 13: 817-826.
11. Isaacs, J.S., Jung, Y.J., Mimnaugh, E.G., Martinez, A., Cuttitta, F., and Neckers, L.M. 2002. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 α-degradative pathway. J. Biol. Chem. 277: 29936-29944.
12. Joazeiro, C.A. and Weissman, A.M. 2000. RING finger proteins: Mediators of ubiquitin ligase activity. Cell 102: 549-552.
13. Joazeiro, C.A., Wing, S.S., Huang, H., Leverson, J.D., Hunter, T., and Liu, Y.C. 1999. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science 286: 309-312.
14. Kim, N.W. and Wu, F. 1997. Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25: 2595-2597.
15. Kim, J.H., Lee, G.E., Kim, J.C., Lee, J.H., and Chung, I.K. 2002. A novel telomere elongation in an adriamycin-rcsistant stomach cancer cell line with decreased telomerase activity. Mol. Cell 13: 228-236.
16. Kim, S.H., Kaminker, P., and Campisi, J. 2002. Telomeres, aging and cancer: In search of a happy ending. Oncogene 21: 503-511.
17. Kim, J.H., Kim, J.H., Lee, G.E., Lee, J.E., and Chung, I.K. 2003. Potent inhibition of human telomerase by nitrostyrene derivatives. Mol. Pharmacol. 63: 1117-11124.
18. Lee, G.E., Yu, E.Y., Cho, C.H., Lee, J., Muller, M.T., and Chung, I.K. 2004. DNA-protein kinase catalytic subunit-interacting protein KIP binds telomerase by interacting with human telomerase reverse transcriptase. J. Biol. Chem. 289: 34750-34755.
19. Lee, J.S., Hong, U.S., Lee, T.H., Yoon, S.K., and Yoon, J.B. 2004. Mass spectrometric analysis of tumor necrosis factor receptor-associated factor 1 ubiquitination mediated by cellular inhibitor of apoptosis 2. Proteomics 4: 3376-3382.
20. Lingner, J., Cooper, J.P., and Cech, T.R. 1995. Telomerase and DNA end replication: No longer a lagging strand problem? Science 269: 1533-1534.
21. Nakamura, T.M. and Cech, T.R. 1998. Reversing time: Origin of telomerase. Cell 92: 587-590.
22. Park, S.M., Yoon, J.B., and Lee, T.H. 2004. Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and C-IAP2) in vitro. FEBS Lett. 566: 151-156.
23. Pickart, C.M. 2001. Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70: 503-533.
24. Seimiya, H., Sawada, H., Muramatsu, Y., Shimizu, M., Ohko, K., Yamane, K., and Tsuruo, T. 2000. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 19: 2652-2661.
25. Wang, J., Xie, L.Y., Allan, S., Beach, D., and Hannon, G.J. 1998. Myc activates telomerase. Genes & Dev. 12: 1769-1774.
26. Zhou, X.Z. and Lu, K.P. 2001. The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell 107: 347-359.