Assembly defects induce oxidative stress in inherited mitochondrial complex I deficiency

International Journal of Biochemistry and Cell Biology

Volumn 65, Issue , 2015, Pages 91-103

  Leman, Géraldine ^a,c   Gueguen, Naïg ^a,b,c   Desquiret Dumas, Valérie ^a,b,c   Kane, Mariame Selma ^a,c   Wettervald, Céline ^b   Chupin, Stéphanie ^b   Chevrollier, Arnaud ^a,c   Lebre, Anne Sophie ^d   Bonnefont, Jean Paul ^e   Barth, Magalie ^a,b   Amati Bonneau, Patrizia ^a,b,c   Verny, Christophe ^a,c   Henrion, Daniel ^a,c   Bonneau, Dominique ^a,b,c   Reynier, Pascal ^a,b,c   Procaccio, Vincent ^a,b,c  

^a UNIVERSITÉ D'ANGERS   (France)

^b ANGERS UNIVERSITY HOSPITAL   (France)

^c INSERM   (France)

^d REIMS UNIVERSITY HOSPITAL   (France)

^e HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Assembly defects; Complex I; FMN site; Mitochondria; Mitochondrial diseases; Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CELL NUCLEUS DNA; FLAVINE MONONUCLEOTIDE; MITOCHONDRIAL DNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

ARTICLE; CATALYSIS; CELL FUNCTION; CELL GROWTH; CELL MUTANT; CELL PROLIFERATION; CLINICAL ARTICLE; COMPLEX I DEFICIENCY; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; FIBROBLAST CULTURE; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MUTATION; NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; OXIDATION; OXIDATIVE STRESS; PROTEIN ASSEMBLY; CASE CONTROL STUDY; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DEFICIENCY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; GENETICS; METABOLISM; PHYSIOLOGY;

ADENOSINE TRIPHOSPHATE; CASE-CONTROL STUDIES; CELLS, CULTURED; DNA, MITOCHONDRIAL; ELECTRON TRANSPORT COMPLEX I; FIBROBLASTS; HUMANS; MITOCHONDRIAL DISEASES; MODELS, MOLECULAR; MUTATION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES;

EID: 84930941222     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2015.05.017     Document Type: Article

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