Determining the origins of superoxide and hydrogen peroxide in the mammalian NADH:ubiquinone oxidoreductase

Free Radical Biology and Medicine

Volumn 77, Issue , 2014, Pages 121-129

  Bazil, Jason N ^a   Pannala, Venkat R ^b   Dash, Ranjan K ^b   Beard, Daniel A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Complex I; Electron transport chain; Mathematical model; Mitochondrial metabolism; NADH:ubiquinone oxidoreductase; Reactive oxygen species

Indexed keywords

FLAVINE MONONUCLEOTIDE; HYDROGEN PEROXIDE; MALONIC ACID; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); ROTENONE; SEMIQUINONE; SUCCINIC ACID; SUPEROXIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL EXPERIMENT; ARTICLE; ELECTRON; ELECTRON TRANSPORT; KINETICS; MASS ACTION; MEMBRANE POTENTIAL; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATION REDUCTION STATE; OXIDATIVE PHOSPHORYLATION; PH; PROTON MOTIVE FORCE; RAT; REACTION ANALYSIS; SKELETAL MUSCLE; SUBMITOCHONDRIAL PARTICLE; ULTRASOUND; ANIMAL; CHEMISTRY; COMPUTER SIMULATION; HUMAN;

ANIMALS; COMPUTER SIMULATION; ELECTRON TRANSPORT COMPLEX I; HUMANS; HYDROGEN PEROXIDE; HYDROGEN-ION CONCENTRATION; KINETICS; NAD; OXIDATION-REDUCTION; SUPEROXIDES;

EID: 84908306065     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.08.023     Document Type: Article

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