Metabolically induced heteroplasmy shifting and l-arginine treatment reduce the energetic defect in a neuronal-like model of MELAS

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 6, 2012, Pages 1019-1029

  Desquiret Dumas, Valerie ^a,b   Gueguen, Naig ^a,b   Barth, Magalie ^a   Chevrollier, Arnaud ^a,b   Hancock, Saege ^c   Wallace, Douglas C ^c   Amati Bonneau, Patrizia ^a,b   Henrion, Daniel ^b   Bonneau, Dominique ^a,b   Reynier, Pascal ^a,b   Procaccio, Vincent ^a,b  

^a ANGERS UNIVERSITY HOSPITAL   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

L arginine; MELAS; Mitochondria; Mitochondrial disorder; MtDNA; Neuronal cell

Indexed keywords

ARGININE; GLUCOSE; NITRIC OXIDE;

ARTICLE; BIOENERGY; CELL METABOLISM; CHEMICAL ANALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; GLYCOLYSIS; HETEROPLASMY; HUMAN; HUMAN CELL; MELAS SYNDROME; MITOCHONDRION; MUTATIONAL ANALYSIS; OXIDATIVE STRESS; OXYGEN CONSUMPTION; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RESPIRATORY CHAIN;

ARGININE; CELL LINE, TUMOR; DNA, MITOCHONDRIAL; GLUCOSE; GLYCOLYSIS; HUMANS; HYBRID CELLS; MELAS SYNDROME; MITOCHONDRIA; MUTATION; NEUROBLASTOMA; NEURONS; RNA, TRANSFER, LEU;

EID: 84859034463     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2012.01.010     Document Type: Article

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