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Volumn 62, Issue S1, 2015, Pages S47-S64

NAFLD: A multisystem disease

Author keywords

Cardiac arrhythmias; Cardiac disease; Cardiovascular disease; Chronic kidney disease; Hepatocellular carcinoma; Insulin resistance; Non alcoholic fatty liver disease; Type 2 diabetes

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INSULIN;

EID: 84930656108     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.12.012     Document Type: Review
Times cited : (2232)

References (147)
  • 1
    • 84896690517 scopus 로고    scopus 로고
    • Extrahepatic complications of nonalcoholic fatty liver disease
    • M.J. Armstrong, L.A. Adams, A. Canbay, and W.K. Syn Extrahepatic complications of nonalcoholic fatty liver disease Hepatology 59 2014 1174 1197
    • (2014) Hepatology , vol.59 , pp. 1174-1197
    • Armstrong, M.J.1    Adams, L.A.2    Canbay, A.3    Syn, W.K.4
  • 2
    • 84875679556 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: An emerging threat to obese and diabetic individuals
    • H.C. Masuoka, and N. Chalasani Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals Ann N Y Acad Sci 1281 2013 106 122
    • (2013) Ann N y Acad Sci , vol.1281 , pp. 106-122
    • Masuoka, H.C.1    Chalasani, N.2
  • 4
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • J.D. Browning, L.S. Szczepaniak, R. Dobbins, P. Nuremberg, J.D. Horton, and J.C. Cohen Prevalence of hepatic steatosis in an urban population in the United States: impact of ethnicity Hepatology 40 2004 1387 1395
    • (2004) Hepatology , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 6
    • 80555136061 scopus 로고    scopus 로고
    • Meta-analysis: Natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity
    • G. Musso, R. Gambino, M. Cassader, and G. Pagano Meta-analysis: natural history of non-alcoholic fatty liver disease (NAFLD) and diagnostic accuracy of non-invasive tests for liver disease severity Ann Med 43 2011 617 649
    • (2011) Ann Med , vol.43 , pp. 617-649
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 7
    • 84905401784 scopus 로고    scopus 로고
    • Association of non-alcoholic fatty liver disease with chronic kidney disease: A systematic review and meta-analysis
    • G. Musso, R. Gambino, J.H. Tabibian, M. Ekstedt, S. Kechagias, M. Hamaguchi, and et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis PLoS Med 11 2014 e1001680
    • (2014) PLoS Med , vol.11 , pp. e1001680
    • Musso, G.1    Gambino, R.2    Tabibian, J.H.3    Ekstedt, M.4    Kechagias, S.5    Hamaguchi, M.6
  • 8
    • 84876473298 scopus 로고    scopus 로고
    • Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis
    • G. Musso, M. Cassader, C. Olivetti, F. Rosina, G. Carbone, and R. Gambino Association of obstructive sleep apnoea with the presence and severity of non-alcoholic fatty liver disease. A systematic review and meta-analysis Obes Rev 14 2013 417 431
    • (2013) Obes Rev , vol.14 , pp. 417-431
    • Musso, G.1    Cassader, M.2    Olivetti, C.3    Rosina, F.4    Carbone, G.5    Gambino, R.6
  • 9
    • 84902651902 scopus 로고    scopus 로고
    • Radiologic evaluation of nonalcoholic fatty liver disease
    • S.S. Lee, and S.H. Park Radiologic evaluation of nonalcoholic fatty liver disease World J Gastroenterol 20 2014 7392 7402
    • (2014) World J Gastroenterol , vol.20 , pp. 7392-7402
    • Lee, S.S.1    Park, S.H.2
  • 10
    • 31444437104 scopus 로고    scopus 로고
    • Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
    • H.B. Holt, S.H. Wild, P.J. Wood, J. Zhang, A.A. Darekar, K. Dewbury, and et al. Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects Diabetologia 49 2006 141 148
    • (2006) Diabetologia , vol.49 , pp. 141-148
    • Holt, H.B.1    Wild, S.H.2    Wood, P.J.3    Zhang, J.4    Darekar, A.A.5    Dewbury, K.6
  • 11
    • 84892881288 scopus 로고    scopus 로고
    • Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis
    • Y. Sumida, A. Nakajima, and Y. Itoh Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis World J Gastroenterol 20 2014 475 485
    • (2014) World J Gastroenterol , vol.20 , pp. 475-485
    • Sumida, Y.1    Nakajima, A.2    Itoh, Y.3
  • 12
    • 80052012241 scopus 로고    scopus 로고
    • Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: A meta-analysis
    • R. Hernaez, M. Lazo, S. Bonekamp, I. Kamel, F.L. Brancati, E. Guallar, and et al. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis Hepatology 54 2011 1082 1090
    • (2011) Hepatology , vol.54 , pp. 1082-1090
    • Hernaez, R.1    Lazo, M.2    Bonekamp, S.3    Kamel, I.4    Brancati, F.L.5    Guallar, E.6
  • 13
    • 80052996528 scopus 로고    scopus 로고
    • Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy
    • S.B. Reeder, I. Cruite, G. Hamilton, and C.B. Sirlin Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy J Magn Reson Imaging 34 2011 729 749
    • (2011) J Magn Reson Imaging , vol.34 , pp. 729-749
    • Reeder, S.B.1    Cruite, I.2    Hamilton, G.3    Sirlin, C.B.4
  • 14
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • L.S. Szczepaniak, P. Nurenberg, D. Leonard, J.D. Browning, J.S. Reingold, S. Grundy, and et al. Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population Am J Physiol Endocrinol Metab 288 2005 E462 E468
    • (2005) Am J Physiol Endocrinol Metab , vol.288 , pp. E462-E468
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3    Browning, J.D.4    Reingold, J.S.5    Grundy, S.6
  • 15
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • D.E. Kleiner, E.M. Brunt, N.M. Van, C. Behling, M.J. Contos, O.W. Cummings, and et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease Hepatology 41 2005 1313 1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van, N. M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 16
    • 34248213618 scopus 로고    scopus 로고
    • Hepatology outpatient service provision in secondary care: A study of liver disease incidence and resource costs
    • S. Whalley, P. Puvanachandra, A. Desai, and H. Kennedy Hepatology outpatient service provision in secondary care: a study of liver disease incidence and resource costs Clin Med 7 2007 119 124
    • (2007) Clin Med , vol.7 , pp. 119-124
    • Whalley, S.1    Puvanachandra, P.2    Desai, A.3    Kennedy, H.4
  • 17
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • S. Romeo, J. Kozlitina, C. Xing, A. Pertsemlidis, D. Cox, L.A. Pennacchio, and et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease Nat Genet 40 2008 1461 1465
    • (2008) Nat Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3    Pertsemlidis, A.4    Cox, D.5    Pennacchio, L.A.6
  • 18
    • 84878930738 scopus 로고    scopus 로고
    • Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis
    • Q.M. Anstee, G. Targher, and C.P. Day Progression of NAFLD to diabetes mellitus, cardiovascular disease or cirrhosis Nat Rev Gastroenterol Hepatol 10 2013 330 344
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 330-344
    • Anstee, Q.M.1    Targher, G.2    Day, C.P.3
  • 19
    • 84896396831 scopus 로고    scopus 로고
    • A population-based study on the prevalence of NASH using scores validated against liver histology
    • J. Hyysalo, V.T. Mannisto, Y. Zhou, J. Arola, V. Karja, M. Leivonen, and et al. A population-based study on the prevalence of NASH using scores validated against liver histology J Hepatol 60 2013 839 846
    • (2013) J Hepatol , vol.60 , pp. 839-846
    • Hyysalo, J.1    Mannisto, V.T.2    Zhou, Y.3    Arola, J.4    Karja, V.5    Leivonen, M.6
  • 20
    • 84891810442 scopus 로고    scopus 로고
    • Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity
    • J. Hyysalo, P. Gopalacharyulu, H. Bian, T. Hyotylainen, M. Leivonen, N. Jaser, and et al. Circulating triacylglycerol signatures in nonalcoholic fatty liver disease associated with the I148M variant in PNPLA3 and with obesity Diabetes 63 2014 312 322
    • (2014) Diabetes , vol.63 , pp. 312-322
    • Hyysalo, J.1    Gopalacharyulu, P.2    Bian, H.3    Hyotylainen, T.4    Leivonen, M.5    Jaser, N.6
  • 21
    • 84891813794 scopus 로고    scopus 로고
    • Serum TAG analysis differentiates between genetic and obesity-associated NAFLD
    • D.G. Mashek, and A.S. Greenberg Serum TAG analysis differentiates between genetic and obesity-associated NAFLD Diabetes 63 2014 42 44
    • (2014) Diabetes , vol.63 , pp. 42-44
    • Mashek, D.G.1    Greenberg, A.S.2
  • 22
    • 84947050194 scopus 로고    scopus 로고
    • Hepatic fibrosis: Prospective comparison of MR elastography and US shear wave elastography for evaluation
    • J.H. Yoon, J.M. Lee, I. Joo, E.S. Lee, J.Y. Sohn, S.K. Jang, and et al. Hepatic fibrosis: prospective comparison of MR elastography and US shear wave elastography for evaluation Radiology 7 2014 132000
    • (2014) Radiology , vol.7 , pp. 132000
    • Yoon, J.H.1    Lee, J.M.2    Joo, I.3    Lee, E.S.4    Sohn, J.Y.5    Jang, S.K.6
  • 24
    • 84928209634 scopus 로고    scopus 로고
    • Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up
    • [Epub ahead of print]
    • M. Ekstedt, H. Hagstrom, P. Nasr, M. Fredrikson, P. Stal, S. Kechagias, and et al. Fibrosis stage is the strongest predictor for disease-specific mortality in NAFLD after up to 33 years of follow-up Hepatology 2014 10.1002/hep.27368 [Epub ahead of print]
    • (2014) Hepatology
    • Ekstedt, M.1    Hagstrom, H.2    Nasr, P.3    Fredrikson, M.4    Stal, P.5    Kechagias, S.6
  • 27
    • 1942454793 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis
    • E.M. Brunt Nonalcoholic steatohepatitis Semin Liver Dis 24 2004 3 20
    • (2004) Semin Liver Dis , vol.24 , pp. 3-20
    • Brunt, E.M.1
  • 30
    • 79953185045 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis
    • J. Ertle, A. Dechene, J.P. Sowa, V. Penndorf, K. Herzer, G. Kaiser, and et al. Non-alcoholic fatty liver disease progresses to hepatocellular carcinoma in the absence of apparent cirrhosis Int J Cancer 128 2011 2436 2443
    • (2011) Int J Cancer , vol.128 , pp. 2436-2443
    • Ertle, J.1    Dechene, A.2    Sowa, J.P.3    Penndorf, V.4    Herzer, K.5    Kaiser, G.6
  • 31
    • 77957200500 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: Mechanisms and implications
    • F. Stickel, and C. Hellerbrand Non-alcoholic fatty liver disease as a risk factor for hepatocellular carcinoma: mechanisms and implications Gut 59 2010 1303 1307
    • (2010) Gut , vol.59 , pp. 1303-1307
    • Stickel, F.1    Hellerbrand, C.2
  • 32
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: A weighty connection
    • B.Q. Starley, C.J. Calcagno, and S.A. Harrison Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection Hepatology 51 2010 1820 1832
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 34
    • 84893663418 scopus 로고    scopus 로고
    • Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance
    • B.C. Lee, and J. Lee Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance Biochim Biophys Acta 1842 2014 446 462
    • (2014) Biochim Biophys Acta , vol.1842 , pp. 446-462
    • Lee, B.C.1    Lee, J.2
  • 35
    • 61849170035 scopus 로고    scopus 로고
    • TLRs and innate immunity
    • B.A. Beutler TLRs and innate immunity Blood 113 2009 1399 1407
    • (2009) Blood , vol.113 , pp. 1399-1407
    • Beutler, B.A.1
  • 36
    • 84879888338 scopus 로고    scopus 로고
    • Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
    • S. Yoshimoto, T.M. Loo, K. Atarashi, H. Kanda, S. Sato, S. Oyadomari, and et al. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Nature 499 2013 97 101
    • (2013) Nature , vol.499 , pp. 97-101
    • Yoshimoto, S.1    Loo, T.M.2    Atarashi, K.3    Kanda, H.4    Sato, S.5    Oyadomari, S.6
  • 37
    • 84865409950 scopus 로고    scopus 로고
    • Diabetes and cause-specific mortality in a prospective cohort of one million U.S. Adults
    • P.T. Campbell, C.C. Newton, A.V. Patel, E.J. Jacobs, and S.M. Gapstur Diabetes and cause-specific mortality in a prospective cohort of one million U.S. Adults Diabetes Care 35 2012 1835 1844
    • (2012) Diabetes Care , vol.35 , pp. 1835-1844
    • Campbell, P.T.1    Newton, C.C.2    Patel, A.V.3    Jacobs, E.J.4    Gapstur, S.M.5
  • 39
    • 84920998988 scopus 로고    scopus 로고
    • The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease
    • M. Maximos, F. Bril, S.P. Portillo, R. Lomonaco, B. Orsak, D. Biernacki, and et al. The role of liver fat and insulin resistance as determinants of plasma aminotransferase elevation in nonalcoholic fatty liver disease Hepatology 61 2014 153 160
    • (2014) Hepatology , vol.61 , pp. 153-160
    • Maximos, M.1    Bril, F.2    Portillo, S.P.3    Lomonaco, R.4    Orsak, B.5    Biernacki, D.6
  • 40
    • 77953045389 scopus 로고    scopus 로고
    • Nine-year incident diabetes is predicted by fatty liver indices: The French D.E.S.I.R. Study
    • B. Balkau, C. Lange, S. Vol, F. Fumeron, and F. Bonnet Nine-year incident diabetes is predicted by fatty liver indices: the French D.E.S.I.R. Study BMC Gastroenterol 10 2010 56
    • (2010) BMC Gastroenterol , vol.10 , pp. 56
    • Balkau, B.1    Lange, C.2    Vol, S.3    Fumeron, F.4    Bonnet, F.5
  • 41
    • 2542612878 scopus 로고    scopus 로고
    • Is serum gamma glutamyltransferase a marker of oxidative stress?
    • D.H. Lee, R. Blomhoff, and D.R. Jacobs Jr. Is serum gamma glutamyltransferase a marker of oxidative stress? Free Radic Res 38 2004 535 539
    • (2004) Free Radic Res , vol.38 , pp. 535-539
    • Lee, D.H.1    Blomhoff, R.2    Jacobs, D.R.3
  • 42
    • 76149092159 scopus 로고    scopus 로고
    • Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup
    • T. Yamada, M. Fukatsu, S. Suzuki, T. Wada, T. Yoshida, and T. Joh Fatty liver predicts impaired fasting glucose and type 2 diabetes mellitus in Japanese undergoing a health checkup J Gastroenterol Hepatol 25 2010 352 356
    • (2010) J Gastroenterol Hepatol , vol.25 , pp. 352-356
    • Yamada, T.1    Fukatsu, M.2    Suzuki, S.3    Wada, T.4    Yoshida, T.5    Joh, T.6
  • 43
    • 84862075971 scopus 로고    scopus 로고
    • Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes
    • K.C. Sung, W.S. Jeong, S.H. Wild, and C.D. Byrne Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for type 2 diabetes Diabetes Care 35 2012 717 722
    • (2012) Diabetes Care , vol.35 , pp. 717-722
    • Sung, K.C.1    Jeong, W.S.2    Wild, S.H.3    Byrne, C.D.4
  • 44
    • 36048934639 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men
    • M. Shibata, Y. Kihara, M. Taguchi, M. Tashiro, and M. Otsuki Nonalcoholic fatty liver disease is a risk factor for type 2 diabetes in middle-aged Japanese men Diabetes Care 30 2007 2940 2944
    • (2007) Diabetes Care , vol.30 , pp. 2940-2944
    • Shibata, M.1    Kihara, Y.2    Taguchi, M.3    Tashiro, M.4    Otsuki, M.5
  • 46
    • 41749083027 scopus 로고    scopus 로고
    • Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults
    • C.H. Kim, J.Y. Park, K.U. Lee, J.H. Kim, and H.K. Kim Fatty liver is an independent risk factor for the development of Type 2 diabetes in Korean adults Diabet Med 25 2008 476 481
    • (2008) Diabet Med , vol.25 , pp. 476-481
    • Kim, C.H.1    Park, J.Y.2    Lee, K.U.3    Kim, J.H.4    Kim, H.K.5
  • 47
    • 34347402532 scopus 로고    scopus 로고
    • Effects of nonalcoholic fatty liver disease on the development of metabolic disorders
    • J.G. Fan, F. Li, X.B. Cai, Y.D. Peng, Q.H. Ao, and Y. Gao Effects of nonalcoholic fatty liver disease on the development of metabolic disorders J Gastroenterol Hepatol 22 2007 1086 1091
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 1086-1091
    • Fan, J.G.1    Li, F.2    Cai, X.B.3    Peng, Y.D.4    Ao, Q.H.5    Gao, Y.6
  • 48
    • 79956074978 scopus 로고    scopus 로고
    • Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: A 4-year retrospective longitudinal study
    • J.C. Bae, E.J. Rhee, W.Y. Lee, S.E. Park, C.Y. Park, K.W. Oh, and et al. Combined effect of nonalcoholic fatty liver disease and impaired fasting glucose on the development of type 2 diabetes: a 4-year retrospective longitudinal study Diabetes Care 34 2011 727 729
    • (2011) Diabetes Care , vol.34 , pp. 727-729
    • Bae, J.C.1    Rhee, E.J.2    Lee, W.Y.3    Park, S.E.4    Park, C.Y.5    Oh, K.W.6
  • 49
    • 84876105171 scopus 로고    scopus 로고
    • The clinical availability of non-alcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in Korean men: 5-years' prospective cohort study
    • S.K. Park, M.H. Seo, H.C. Shin, and J.H. Ryoo The clinical availability of non-alcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5-years' prospective cohort study Hepatology 57 2012 1378 1383
    • (2012) Hepatology , vol.57 , pp. 1378-1383
    • Park, S.K.1    Seo, M.H.2    Shin, H.C.3    Ryoo, J.H.4
  • 51
    • 84889658153 scopus 로고    scopus 로고
    • Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population
    • Y. Chang, H.S. Jung, K.E. Yun, J. Cho, Y.K. Cho, and S. Ryu Cohort study of non-alcoholic fatty liver disease, NAFLD fibrosis score, and the risk of incident diabetes in a Korean population Am J Gastroenterol 108 2013 1861 1868
    • (2013) Am J Gastroenterol , vol.108 , pp. 1861-1868
    • Chang, Y.1    Jung, H.S.2    Yun, K.E.3    Cho, J.4    Cho, Y.K.5    Ryu, S.6
  • 52
    • 84883686923 scopus 로고    scopus 로고
    • Resolution of fatty liver and risk of incident diabetes
    • K.C. Sung, S.H. Wild, and C.D. Byrne Resolution of fatty liver and risk of incident diabetes J Clin Endocrinol Metab 98 2013 3637 3643
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 3637-3643
    • Sung, K.C.1    Wild, S.H.2    Byrne, C.D.3
  • 53
    • 84892527975 scopus 로고    scopus 로고
    • Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: The Edinburgh type 2 diabetes study
    • J.R. Morling, J.A. Fallowfield, I.N. Guha, L.D. Nee, S. Glancy, R.M. Williamson, and et al. Using non-invasive biomarkers to identify hepatic fibrosis in people with type 2 diabetes mellitus: the Edinburgh type 2 diabetes study J Hepatol 60 2014 384 391
    • (2014) J Hepatol , vol.60 , pp. 384-391
    • Morling, J.R.1    Fallowfield, J.A.2    Guha, I.N.3    Nee, L.D.4    Glancy, S.5    Williamson, R.M.6
  • 54
    • 84893091115 scopus 로고    scopus 로고
    • Ectopic fat, insulin resistance and non-alcoholic fatty liver disease
    • C.D. Byrne Ectopic fat, insulin resistance and non-alcoholic fatty liver disease Proc Nutr Soc 72 2013 412 419
    • (2013) Proc Nutr Soc , vol.72 , pp. 412-419
    • Byrne, C.D.1
  • 56
    • 79959355078 scopus 로고    scopus 로고
    • Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
    • Z. Gao, J. Zhang, I. Kheterpal, N. Kennedy, R.J. Davis, and J. Ye Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity J Biol Chem 24 2011 22227 22234
    • (2011) J Biol Chem , vol.24 , pp. 22227-22234
    • Gao, Z.1    Zhang, J.2    Kheterpal, I.3    Kennedy, N.4    Davis, R.J.5    Ye, J.6
  • 57
    • 3543029821 scopus 로고    scopus 로고
    • Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease
    • V.T. Samuel, Z.X. Liu, X. Qu, B.D. Elder, S. Bilz, D. Befroy, and et al. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J Biol Chem 30 2004 32345 32353
    • (2004) J Biol Chem , vol.30 , pp. 32345-32353
    • Samuel, V.T.1    Liu, Z.X.2    Qu, X.3    Elder, B.D.4    Bilz, S.5    Befroy, D.6
  • 58
    • 84865120793 scopus 로고    scopus 로고
    • Dorothy Hodgkin Lecture 2012: Non-alcoholic fatty liver disease, insulin resistance and ectopic fat: A new problem in diabetes management
    • C.D. Byrne Dorothy Hodgkin Lecture 2012: non-alcoholic fatty liver disease, insulin resistance and ectopic fat: a new problem in diabetes management Diabet Med 29 2012 1098 1107
    • (2012) Diabet Med , vol.29 , pp. 1098-1107
    • Byrne, C.D.1
  • 59
    • 84887318014 scopus 로고    scopus 로고
    • The Gordian Knot of dysbiosis, obesity and NAFLD
    • W.Z. Mehal The Gordian Knot of dysbiosis, obesity and NAFLD Nat Rev Gastroenterol Hepatol 10 2013 637 644
    • (2013) Nat Rev Gastroenterol Hepatol , vol.10 , pp. 637-644
    • Mehal, W.Z.1
  • 60
    • 84860497397 scopus 로고    scopus 로고
    • Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance
    • F.R. Jornayvaz, and G.I. Shulman Diacylglycerol activation of protein kinase Cepsilon and hepatic insulin resistance Cell Metab 15 2012 574 584
    • (2012) Cell Metab , vol.15 , pp. 574-584
    • Jornayvaz, F.R.1    Shulman, G.I.2
  • 61
    • 84857861919 scopus 로고    scopus 로고
    • Mechanisms for insulin resistance: Common threads and missing links
    • V.T. Samuel, and G.I. Shulman Mechanisms for insulin resistance: common threads and missing links Cell 148 2012 852 871
    • (2012) Cell , vol.148 , pp. 852-871
    • Samuel, V.T.1    Shulman, G.I.2
  • 62
    • 34250356015 scopus 로고    scopus 로고
    • Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis
    • K. Yamaguchi, L. Yang, S. McCall, J. Huang, X.X. Yu, S.K. Pandey, and et al. Inhibiting triglyceride synthesis improves hepatic steatosis but exacerbates liver damage and fibrosis in obese mice with nonalcoholic steatohepatitis Hepatology 45 2007 1366 1374
    • (2007) Hepatology , vol.45 , pp. 1366-1374
    • Yamaguchi, K.1    Yang, L.2    McCall, S.3    Huang, J.4    Yu, X.X.5    Pandey, S.K.6
  • 63
    • 51349156218 scopus 로고    scopus 로고
    • Insulin sensitivity: Modulation by nutrients and inflammation
    • S. Schenk, M. Saberi, and J.M. Olefsky Insulin sensitivity: modulation by nutrients and inflammation J Clin Invest 118 2008 2992 3002
    • (2008) J Clin Invest , vol.118 , pp. 2992-3002
    • Schenk, S.1    Saberi, M.2    Olefsky, J.M.3
  • 64
    • 84862669638 scopus 로고    scopus 로고
    • Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis
    • A. Leroux, G. Ferrere, V. Godie, F. Cailleux, M.L. Renoud, F. Gaudin, and et al. Toxic lipids stored by Kupffer cells correlates with their pro-inflammatory phenotype at an early stage of steatohepatitis J Hepatol 57 2012 141 149
    • (2012) J Hepatol , vol.57 , pp. 141-149
    • Leroux, A.1    Ferrere, G.2    Godie, V.3    Cailleux, F.4    Renoud, M.L.5    Gaudin, F.6
  • 65
    • 84901944641 scopus 로고    scopus 로고
    • The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes
    • R.J. Perry, V.T. Samuel, K.F. Petersen, and G.I. Shulman The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes Nature 510 2014 84 91
    • (2014) Nature , vol.510 , pp. 84-91
    • Perry, R.J.1    Samuel, V.T.2    Petersen, K.F.3    Shulman, G.I.4
  • 66
    • 84866058762 scopus 로고    scopus 로고
    • Regulation of plasma ceramide levels with fatty acid oversupply: Evidence that the liver detects and secretes de novo synthesised ceramide
    • M.J. Watt, A.C. Barnett, C.R. Bruce, S. Schenk, J.F. Horowitz, and A.J. Hoy Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide Diabetologia 55 2012 2741 2746
    • (2012) Diabetologia , vol.55 , pp. 2741-2746
    • Watt, M.J.1    Barnett, A.C.2    Bruce, C.R.3    Schenk, S.4    Horowitz, J.F.5    Hoy, A.J.6
  • 67
    • 67650096801 scopus 로고    scopus 로고
    • Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome
    • G. Yang, L. Badeanlou, J. Bielawski, A.J. Roberts, Y.A. Hannun, and F. Samad Central role of ceramide biosynthesis in body weight regulation, energy metabolism, and the metabolic syndrome Am J Physiol Endocrinol Metab 297 2009 E211 E224
    • (2009) Am J Physiol Endocrinol Metab , vol.297 , pp. E211-E224
    • Yang, G.1    Badeanlou, L.2    Bielawski, J.3    Roberts, A.J.4    Hannun, Y.A.5    Samad, F.6
  • 68
    • 0031919157 scopus 로고    scopus 로고
    • Regulation of ceramide production and apoptosis
    • R.N. Kolesnick, and M. Kronke Regulation of ceramide production and apoptosis Annu Rev Physiol 60 1998 643 665
    • (1998) Annu Rev Physiol , vol.60 , pp. 643-665
    • Kolesnick, R.N.1    Kronke, M.2
  • 69
    • 79959746261 scopus 로고    scopus 로고
    • Sphingolipids: Agents provocateurs in the pathogenesis of insulin resistance
    • C. Lipina, and H. Hundal Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance Diabetologia 1 2011 1596 1607
    • (2011) Diabetologia , vol.1 , pp. 1596-1607
    • Lipina, C.1    Hundal, H.2
  • 70
    • 84873178604 scopus 로고    scopus 로고
    • CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance
    • J.L. Cantley, T. Yoshimura, J.P. Camporez, D. Zhang, F.R. Jornayvaz, N. Kumashiro, and et al. CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance Proc Natl Acad Sci U S A 110 2013 1869 1874
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 1869-1874
    • Cantley, J.L.1    Yoshimura, T.2    Camporez, J.P.3    Zhang, D.4    Jornayvaz, F.R.5    Kumashiro, N.6
  • 71
    • 77950343252 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
    • G.S. Hotamisligil Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 2010 900 917
    • (2010) Cell , vol.140 , pp. 900-917
    • Hotamisligil, G.S.1
  • 72
    • 55649103668 scopus 로고    scopus 로고
    • Insulin resistance, inflammation, and non-alcoholic fatty liver disease
    • H. Tilg, and A.R. Moschen Insulin resistance, inflammation, and non-alcoholic fatty liver disease Trends Endocrinol Metab 19 2008 371 379
    • (2008) Trends Endocrinol Metab , vol.19 , pp. 371-379
    • Tilg, H.1    Moschen, A.R.2
  • 73
    • 84873637593 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: A novel cardiometabolic risk factor for type 2 diabetes and its complications
    • G. Targher, and C.D. Byrne Nonalcoholic fatty liver disease: a novel cardiometabolic risk factor for type 2 diabetes and its complications J Clin Endocrinol Metab 98 2013 483 495
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. 483-495
    • Targher, G.1    Byrne, C.D.2
  • 74
    • 77949882555 scopus 로고    scopus 로고
    • Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: The roles of fetuin-A, adiponectin, and AMPK
    • J.H. Ix, and K. Sharma Mechanisms linking obesity, chronic kidney disease, and fatty liver disease: the roles of fetuin-A, adiponectin, and AMPK J Am Soc Nephrol 21 2010 406 412
    • (2010) J Am Soc Nephrol , vol.21 , pp. 406-412
    • Ix, J.H.1    Sharma, K.2
  • 75
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • G. Targher, C.P. Day, and E. Bonora Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease N Engl J Med 363 2010 1341 1350
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 76
    • 84861417701 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: A new and important cardiovascular risk factor?
    • L.S. Bhatia, N.P. Curzen, P.C. Calder, and C.D. Byrne Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J 33 2012 1190 1200
    • (2012) Eur Heart J , vol.33 , pp. 1190-1200
    • Bhatia, L.S.1    Curzen, N.P.2    Calder, P.C.3    Byrne, C.D.4
  • 77
    • 84884508163 scopus 로고    scopus 로고
    • A systematic review: Burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; Should we care?
    • E.T. Oni, A.S. Agatston, M.J. Blaha, J. Fialkow, R. Cury, A. Sposito, and et al. A systematic review: burden and severity of subclinical cardiovascular disease among those with nonalcoholic fatty liver; should we care? Atherosclerosis 230 2013 258 267
    • (2013) Atherosclerosis , vol.230 , pp. 258-267
    • Oni, E.T.1    Agatston, A.S.2    Blaha, M.J.3    Fialkow, J.4    Cury, R.5    Sposito, A.6
  • 78
    • 84947099886 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and carotid artery inflammation evaluated by 18F-fluorodeoxyglucose positron emission tomography
    • [Epub ahead of print]
    • S.H. Moon, T.S. Noh, Y.S. Cho, S.P. Hong, S.H. Hyun, J.Y. Choi, and et al. Association between nonalcoholic fatty liver disease and carotid artery inflammation evaluated by 18F-fluorodeoxyglucose positron emission tomography Angiology 2014 [Epub ahead of print]
    • (2014) Angiology
    • Moon, S.H.1    Noh, T.S.2    Cho, Y.S.3    Hong, S.P.4    Hyun, S.H.5    Choi, J.Y.6
  • 79
    • 84894234723 scopus 로고    scopus 로고
    • Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease
    • S. Ballestri, A. Lonardo, S. Bonapace, C.D. Byrne, P. Loria, and G. Targher Risk of cardiovascular, cardiac and arrhythmic complications in patients with non-alcoholic fatty liver disease World J Gastroenterol 20 2014 1724 1745
    • (2014) World J Gastroenterol , vol.20 , pp. 1724-1745
    • Ballestri, S.1    Lonardo, A.2    Bonapace, S.3    Byrne, C.D.4    Loria, P.5    Targher, G.6
  • 80
    • 84861329163 scopus 로고    scopus 로고
    • Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population
    • M. Stepanova, and Z.M. Younossi Independent association between nonalcoholic fatty liver disease and cardiovascular disease in the US population Clin Gastroenterol Hepatol 10 2012 646 650
    • (2012) Clin Gastroenterol Hepatol , vol.10 , pp. 646-650
    • Stepanova, M.1    Younossi, Z.M.2
  • 81
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients
    • G. Targher, L. Bertolini, R. Padovani, S. Rodella, R. Tessari, L. Zenari, and et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type 2 diabetic patients Diabetes Care 30 2007 1212 1218
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Tessari, R.5    Zenari, L.6
  • 82
    • 80655144446 scopus 로고    scopus 로고
    • Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease
    • V.W. Wong, G.L. Wong, G.W. Yip, A.O. Lo, J. Limquiaco, W.C. Chu, and et al. Coronary artery disease and cardiovascular outcomes in patients with non-alcoholic fatty liver disease Gut 60 2011 1721 1727
    • (2011) Gut , vol.60 , pp. 1721-1727
    • Wong, V.W.1    Wong, G.L.2    Yip, G.W.3    Lo, A.O.4    Limquiaco, J.5    Chu, W.C.6
  • 85
    • 84863148823 scopus 로고    scopus 로고
    • Natural course of nonalcoholic fatty liver disease in southern China: A prospective cohort study
    • Y.J. Zhou, Y.Y. Li, Y.Q. Nie, C.M. Huang, and C.Y. Cao Natural course of nonalcoholic fatty liver disease in southern China: a prospective cohort study J Dig Dis 13 2012 153 160
    • (2012) J Dig Dis , vol.13 , pp. 153-160
    • Zhou, Y.J.1    Li, Y.Y.2    Nie, Y.Q.3    Huang, C.M.4    Cao, C.Y.5
  • 87
    • 34547673500 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients
    • G. Targher, L. Bertolini, S. Rodella, R. Tessari, L. Zenari, G. Lippi, and et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients Diabetes Care 30 2007 2119 2121
    • (2007) Diabetes Care , vol.30 , pp. 2119-2121
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Tessari, R.4    Zenari, L.5    Lippi, G.6
  • 88
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • C. Soderberg, P. Stal, J. Askling, H. Glaumann, G. Lindberg, J. Marmur, and et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up Hepatology 51 2010 595 602
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3    Glaumann, H.4    Lindberg, G.5    Marmur, J.6
  • 91
    • 83755178774 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and mortality among US adults: Prospective cohort study
    • M. Lazo, R. Hernaez, S. Bonekamp, I.R. Kamel, F.L. Brancati, E. Guallar, and et al. Non-alcoholic fatty liver disease and mortality among US adults: prospective cohort study BMJ 343 2011 d6891
    • (2011) BMJ , vol.343 , pp. d6891
    • Lazo, M.1    Hernaez, R.2    Bonekamp, S.3    Kamel, I.R.4    Brancati, F.L.5    Guallar, E.6
  • 92
    • 84876130551 scopus 로고    scopus 로고
    • Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States
    • D. Kim, W.R. Kim, H.J. Kim, and T.M. Therneau Association between noninvasive fibrosis markers and mortality among adults with nonalcoholic fatty liver disease in the United States Hepatology 57 2013 1357 1365
    • (2013) Hepatology , vol.57 , pp. 1357-1365
    • Kim, D.1    Kim, W.R.2    Kim, H.J.3    Therneau, T.M.4
  • 94
    • 72949097025 scopus 로고    scopus 로고
    • Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels
    • R. Haring, H. Wallaschofski, M. Nauck, M. Dorr, S.E. Baumeister, and H. Volzke Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels Hepatology 50 2009 1403 1411
    • (2009) Hepatology , vol.50 , pp. 1403-1411
    • Haring, R.1    Wallaschofski, H.2    Nauck, M.3    Dorr, M.4    Baumeister, S.E.5    Volzke, H.6
  • 96
    • 84885172492 scopus 로고    scopus 로고
    • Hepatic steatosis in diabetic patients does not predict adverse liver-related or cardiovascular outcomes
    • M.A. Dunn, J. Behari, S.S. Rogal, M.R. O'Connell, A. Furlan, A. Aghayev, and et al. Hepatic steatosis in diabetic patients does not predict adverse liver-related or cardiovascular outcomes Liver Int 33 2013 1575 1582
    • (2013) Liver Int , vol.33 , pp. 1575-1582
    • Dunn, M.A.1    Behari, J.2    Rogal, S.S.3    O'Connell, M.R.4    Furlan, A.5    Aghayev, A.6
  • 98
    • 22344452893 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease: A population-based cohort study
    • L.A. Adams, J.F. Lymp, S.J. St, S.O. Sanderson, K.D. Lindor, A. Feldstein, and et al. The natural history of nonalcoholic fatty liver disease: a population-based cohort study Gastroenterology 129 2005 113 121
    • (2005) Gastroenterology , vol.129 , pp. 113-121
    • Adams, L.A.1    Lymp, J.F.2    St, S.J.3    Sanderson, S.O.4    Lindor, K.D.5    Feldstein, A.6
  • 99
    • 38649091680 scopus 로고    scopus 로고
    • Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver
    • G. Perseghin, G. Lattuada, C.F. De, A. Esposito, E. Belloni, G. Ntali, and et al. Increased mediastinal fat and impaired left ventricular energy metabolism in young men with newly found fatty liver Hepatology 47 2008 51 58
    • (2008) Hepatology , vol.47 , pp. 51-58
    • Perseghin, G.1    Lattuada, G.2    De, C. F.3    Esposito, A.4    Belloni, E.5    Ntali, G.6
  • 100
    • 33745856570 scopus 로고    scopus 로고
    • Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes
    • R. Lautamaki, R. Borra, P. Iozzo, M. Komu, T. Lehtimaki, M. Salmi, and et al. Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes Am J Physiol Endocrinol Metab 291 2006 E282 E290
    • (2006) Am J Physiol Endocrinol Metab , vol.291 , pp. E282-E290
    • Lautamaki, R.1    Borra, R.2    Iozzo, P.3    Komu, M.4    Lehtimaki, T.5    Salmi, M.6
  • 102
    • 55949119360 scopus 로고    scopus 로고
    • Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus
    • L.J. Rijzewijk, R.W. van der Meer, J.W. Smit, M. Diamant, J.J. Bax, S. Hammer, and et al. Myocardial steatosis is an independent predictor of diastolic dysfunction in type 2 diabetes mellitus J Am Coll Cardiol 52 2008 1793 1799
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1793-1799
    • Rijzewijk, L.J.1    Van Der Meer, R.W.2    Smit, J.W.3    Diamant, M.4    Bax, J.J.5    Hammer, S.6
  • 104
    • 84859048319 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes
    • S. Bonapace, G. Perseghin, G. Molon, G. Canali, L. Bertolini, G. Zoppini, and et al. Nonalcoholic fatty liver disease is associated with left ventricular diastolic dysfunction in patients with type 2 diabetes Diabetes Care 35 2012 389 395
    • (2012) Diabetes Care , vol.35 , pp. 389-395
    • Bonapace, S.1    Perseghin, G.2    Molon, G.3    Canali, G.4    Bertolini, L.5    Zoppini, G.6
  • 105
    • 84901485469 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population
    • N.H. Kim, J. Park, S.H. Kim, Y.H. Kim, D.H. Kim, G.Y. Cho, and et al. Non-alcoholic fatty liver disease, metabolic syndrome and subclinical cardiovascular changes in the general population Heart 100 2014 938 943
    • (2014) Heart , vol.100 , pp. 938-943
    • Kim, N.H.1    Park, J.2    Kim, S.H.3    Kim, Y.H.4    Kim, D.H.5    Cho, G.Y.6
  • 106
    • 84882893767 scopus 로고    scopus 로고
    • Association between nonalcoholic fatty liver disease and cardiovascular risk in obese children and adolescents
    • H. Alp, S. Karaarslan, E.B. Selver, M.E. Atabek, H. Altin, and T. Baysal Association between nonalcoholic fatty liver disease and cardiovascular risk in obese children and adolescents Can J Cardiol 29 2013 1118 1125
    • (2013) Can J Cardiol , vol.29 , pp. 1118-1125
    • Alp, H.1    Karaarslan, S.2    Selver, E.B.3    Atabek, M.E.4    Altin, H.5    Baysal, T.6
  • 107
    • 84880573350 scopus 로고    scopus 로고
    • Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease
    • 1168
    • G.K. Singh, B.E. Vitola, M.R. Holland, T. Sekarski, B.W. Patterson, F. Magkos, and et al. Alterations in ventricular structure and function in obese adolescents with nonalcoholic fatty liver disease J Pediatr 162 2013 1160 1168 1168
    • (2013) J Pediatr , vol.162 , pp. 1160-1168
    • Singh, G.K.1    Vitola, B.E.2    Holland, M.R.3    Sekarski, T.4    Patterson, B.W.5    Magkos, F.6
  • 108
    • 84880331841 scopus 로고    scopus 로고
    • Left ventricular function by echocardiography, tissue Doppler imaging, and carotid intima-media thickness in obese adolescents with nonalcoholic fatty liver disease
    • A. Sert, E. Aypar, O. Pirgon, H. Yilmaz, D. Odabas, and I. Tolu Left ventricular function by echocardiography, tissue Doppler imaging, and carotid intima-media thickness in obese adolescents with nonalcoholic fatty liver disease Am J Cardiol 112 2013 436 443
    • (2013) Am J Cardiol , vol.112 , pp. 436-443
    • Sert, A.1    Aypar, E.2    Pirgon, O.3    Yilmaz, H.4    Odabas, D.5    Tolu, I.6
  • 110
    • 84893637026 scopus 로고    scopus 로고
    • Left ventricular dysfunction in obese children and adolescents with nonalcoholic fatty liver disease
    • L. Pacifico, M.M. Di, M.A. De, M. Bezzi, J.F. Osborn, C. Catalano, and et al. Left ventricular dysfunction in obese children and adolescents with nonalcoholic fatty liver disease Hepatology 59 2014 461 470
    • (2014) Hepatology , vol.59 , pp. 461-470
    • Pacifico, L.1    Di, M.M.2    De, M. A.3    Bezzi, M.4    Osborn, J.F.5    Catalano, C.6
  • 113
    • 84872045804 scopus 로고    scopus 로고
    • Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation
    • M.F. Sinner, N. Wang, C.S. Fox, J.D. Fontes, M. Rienstra, J.W. Magnani, and et al. Relation of circulating liver transaminase concentrations to risk of new-onset atrial fibrillation Am J Cardiol 111 2013 219 224
    • (2013) Am J Cardiol , vol.111 , pp. 219-224
    • Sinner, M.F.1    Wang, N.2    Fox, C.S.3    Fontes, J.D.4    Rienstra, M.5    Magnani, J.W.6
  • 114
    • 84921626718 scopus 로고    scopus 로고
    • Circulating levels of liver enzymes and incidence of atrial fibrillation: The Atherosclerosis Risk in Communities cohort
    • A. Alonso, J.R. Misialek, M.A. Amiin, R.C. Hoogeveen, L.Y. Chen, S.K. Agarwal, and et al. Circulating levels of liver enzymes and incidence of atrial fibrillation: the Atherosclerosis Risk in Communities cohort Heart 100 2014 1151 1156
    • (2014) Heart , vol.100 , pp. 1151-1156
    • Alonso, A.1    Misialek, J.R.2    Amiin, M.A.3    Hoogeveen, R.C.4    Chen, L.Y.5    Agarwal, S.K.6
  • 115
    • 84878632572 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes
    • G. Targher, A. Mantovani, I. Pichiri, R. Rigolon, M. Dauriz, G. Zoppini, and et al. Non-alcoholic fatty liver disease is associated with an increased prevalence of atrial fibrillation in hospitalized patients with type 2 diabetes Clin Sci (Lond) 125 2013 301 309
    • (2013) Clin Sci (Lond) , vol.125 , pp. 301-309
    • Targher, G.1    Mantovani, A.2    Pichiri, I.3    Rigolon, R.4    Dauriz, M.5    Zoppini, G.6
  • 116
    • 84874317741 scopus 로고    scopus 로고
    • Non-alcoholic Fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes
    • G. Targher, F. Valbusa, S. Bonapace, L. Bertolini, L. Zenari, S. Rodella, and et al. Non-alcoholic Fatty liver disease is associated with an increased incidence of atrial fibrillation in patients with type 2 diabetes PLoS One 8 2013 e57183
    • (2013) PLoS One , vol.8 , pp. e57183
    • Targher, G.1    Valbusa, F.2    Bonapace, S.3    Bertolini, L.4    Zenari, L.5    Rodella, S.6
  • 117
    • 84901478944 scopus 로고    scopus 로고
    • Association of nonalcoholic fatty liver disease with QTc interval in patients with type 2 diabetes
    • G. Targher, F. Valbusa, S. Bonapace, L. Bertolini, L. Zenari, I. Pichiri, and et al. Association of nonalcoholic fatty liver disease with QTc interval in patients with type 2 diabetes Nutr Metab Cardiovasc Dis 24 2014 663 669
    • (2014) Nutr Metab Cardiovasc Dis , vol.24 , pp. 663-669
    • Targher, G.1    Valbusa, F.2    Bonapace, S.3    Bertolini, L.4    Zenari, L.5    Pichiri, I.6
  • 118
    • 0025814624 scopus 로고
    • QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest
    • A. Algra, J.G. Tijssen, J.R. Roelandt, J. Pool, and J. Lubsen QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest Circulation 83 1991 1888 1894
    • (1991) Circulation , vol.83 , pp. 1888-1894
    • Algra, A.1    Tijssen, J.G.2    Roelandt, J.R.3    Pool, J.4    Lubsen, J.5
  • 119
    • 0347418230 scopus 로고    scopus 로고
    • The association between the length of the QT interval and mortality in the Cardiovascular Health Study
    • J. Robbins, J.C. Nelson, P.M. Rautaharju, and J.S. Gottdiener The association between the length of the QT interval and mortality in the Cardiovascular Health Study Am J Med 115 2003 689 694
    • (2003) Am J Med , vol.115 , pp. 689-694
    • Robbins, J.1    Nelson, J.C.2    Rautaharju, P.M.3    Gottdiener, J.S.4
  • 120
    • 70449526204 scopus 로고    scopus 로고
    • Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease
    • J.L. Newton, J. Pairman, K. Wilton, D.E. Jones, and C. Day Fatigue and autonomic dysfunction in non-alcoholic fatty liver disease Clin Auton Res 19 2009 319 326
    • (2009) Clin Auton Res , vol.19 , pp. 319-326
    • Newton, J.L.1    Pairman, J.2    Wilton, K.3    Jones, D.E.4    Day, C.5
  • 121
    • 84907363577 scopus 로고    scopus 로고
    • Aortic-valve stenosis-from patients at risk to severe valve obstruction
    • C.M. Otto, and B. Prendergast Aortic-valve stenosis-from patients at risk to severe valve obstruction N Engl J Med 371 2014 744 756
    • (2014) N Engl J Med , vol.371 , pp. 744-756
    • Otto, C.M.1    Prendergast, B.2
  • 122
    • 84864388596 scopus 로고    scopus 로고
    • Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes
    • A. Rossi, G. Targher, G. Zoppini, M. Cicoira, S. Bonapace, C. Negri, and et al. Aortic and mitral annular calcifications are predictive of all-cause and cardiovascular mortality in patients with type 2 diabetes Diabetes Care 35 2012 1781 1786
    • (2012) Diabetes Care , vol.35 , pp. 1781-1786
    • Rossi, A.1    Targher, G.2    Zoppini, G.3    Cicoira, M.4    Bonapace, S.5    Negri, C.6
  • 123
    • 84879078941 scopus 로고    scopus 로고
    • Hepatic steatosis is associated with aortic valve sclerosis in the general population: The Study of Health in Pomerania (SHIP)
    • M.R. Markus, S.E. Baumeister, J. Stritzke, M. Dorr, H. Wallaschofski, H. Volzke, and et al. Hepatic steatosis is associated with aortic valve sclerosis in the general population: the Study of Health in Pomerania (SHIP) Arterioscler Thromb Vasc Biol 33 2013 1690 1695
    • (2013) Arterioscler Thromb Vasc Biol , vol.33 , pp. 1690-1695
    • Markus, M.R.1    Baumeister, S.E.2    Stritzke, J.3    Dorr, M.4    Wallaschofski, H.5    Volzke, H.6
  • 124
    • 84895526205 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus
    • S. Bonapace, F. Valbusa, L. Bertolini, I. Pichiri, A. Mantovani, A. Rossi, and et al. Nonalcoholic fatty liver disease is associated with aortic valve sclerosis in patients with type 2 diabetes mellitus PLoS One 9 2014 e88371
    • (2014) PLoS One , vol.9 , pp. e88371
    • Bonapace, S.1    Valbusa, F.2    Bertolini, L.3    Pichiri, I.4    Mantovani, A.5    Rossi, A.6
  • 125
    • 79954662342 scopus 로고    scopus 로고
    • Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: Is there a link?
    • G. Targher, M. Chonchol, G. Zoppini, C. Abaterusso, and E. Bonora Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: is there a link? J Hepatol 54 2011 1020 1029
    • (2011) J Hepatol , vol.54 , pp. 1020-1029
    • Targher, G.1    Chonchol, M.2    Zoppini, G.3    Abaterusso, C.4    Bonora, E.5
  • 127
    • 39049102073 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients
    • G. Targher, L. Bertolini, S. Rodella, G. Zoppini, G. Lippi, C. Day, and et al. Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients Diabetologia 51 2008 444 450
    • (2008) Diabetologia , vol.51 , pp. 444-450
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Zoppini, G.4    Lippi, G.5    Day, C.6
  • 128
    • 77955665639 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients
    • G. Targher, L. Bertolini, M. Chonchol, S. Rodella, G. Zoppini, G. Lippi, and et al. Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and retinopathy in type 1 diabetic patients Diabetologia 53 2010 1341 1348
    • (2010) Diabetologia , vol.53 , pp. 1341-1348
    • Targher, G.1    Bertolini, L.2    Chonchol, M.3    Rodella, S.4    Zoppini, G.5    Lippi, G.6
  • 129
    • 77953838107 scopus 로고    scopus 로고
    • Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes
    • S.T. Hwang, Y.K. Cho, J.W. Yun, J.H. Park, H.J. Kim, D.I. Park, and et al. Impact of non-alcoholic fatty liver disease on microalbuminuria in patients with prediabetes and diabetes Intern Med J 40 2010 437 442
    • (2010) Intern Med J , vol.40 , pp. 437-442
    • Hwang, S.T.1    Cho, Y.K.2    Yun, J.W.3    Park, J.H.4    Kim, H.J.5    Park, D.I.6
  • 130
    • 84855812468 scopus 로고    scopus 로고
    • Increased prevalence of chronic kidney disease in patients with Type 1 diabetes and non-alcoholic fatty liver
    • G. Targher, I. Pichiri, G. Zoppini, M. Trombetta, and E. Bonora Increased prevalence of chronic kidney disease in patients with Type 1 diabetes and non-alcoholic fatty liver Diabet Med 29 2012 220 226
    • (2012) Diabet Med , vol.29 , pp. 220-226
    • Targher, G.1    Pichiri, I.2    Zoppini, G.3    Trombetta, M.4    Bonora, E.5
  • 131
    • 84863023329 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease associated with impairment of kidney function in nondiabetes population
    • G. Li, W. Shi, H. Hug, Y. Chen, L. Liu, and D. Yin Nonalcoholic fatty liver disease associated with impairment of kidney function in nondiabetes population Biochem Med (Zagreb) 22 2012 92 99
    • (2012) Biochem Med (Zagreb) , vol.22 , pp. 92-99
    • Li, G.1    Shi, W.2    Hug, H.3    Chen, Y.4    Liu, L.5    Yin, D.6
  • 132
    • 84881536928 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and chronic kidney disease in Koreans aged 50 years or older
    • A.L. Ahn, J.K. Choi, M.N. Kim, S.A. Kim, E.J. Oh, H.J. Kweon, and et al. Non-alcoholic fatty liver disease and chronic kidney disease in Koreans aged 50 years or older Korean J Fam Med 34 2013 199 205
    • (2013) Korean J Fam Med , vol.34 , pp. 199-205
    • Ahn, A.L.1    Choi, J.K.2    Kim, M.N.3    Kim, S.A.4    Oh, E.J.5    Kweon, H.J.6
  • 133
    • 78650323871 scopus 로고    scopus 로고
    • Relationship between kidney function and liver histology in subjects with nonalcoholic steatohepatitis
    • G. Targher, L. Bertolini, S. Rodella, G. Lippi, G. Zoppini, and M. Chonchol Relationship between kidney function and liver histology in subjects with nonalcoholic steatohepatitis Clin J Am Soc Nephrol 5 2010 2166 2171
    • (2010) Clin J Am Soc Nephrol , vol.5 , pp. 2166-2171
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Lippi, G.4    Zoppini, G.5    Chonchol, M.6
  • 134
    • 77956625813 scopus 로고    scopus 로고
    • Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: Association with liver fibrosis
    • Y. Yilmaz, Y.O. Alahdab, O. Yonal, R. Kurt, A.E. Kedrah, C.A. Celikel, and et al. Microalbuminuria in nondiabetic patients with nonalcoholic fatty liver disease: association with liver fibrosis Metabolism 59 2010 1327 1330
    • (2010) Metabolism , vol.59 , pp. 1327-1330
    • Yilmaz, Y.1    Alahdab, Y.O.2    Yonal, O.3    Kurt, R.4    Kedrah, A.E.5    Celikel, C.A.6
  • 135
    • 79955026956 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis and increased risk of chronic kidney disease
    • K. Yasui, Y. Sumida, Y. Mori, H. Mitsuyoshi, M. Minami, Y. Itoh, and et al. Nonalcoholic steatohepatitis and increased risk of chronic kidney disease Metabolism 60 2011 735 739
    • (2011) Metabolism , vol.60 , pp. 735-739
    • Yasui, K.1    Sumida, Y.2    Mori, Y.3    Mitsuyoshi, H.4    Minami, M.5    Itoh, Y.6
  • 136
    • 84855547156 scopus 로고    scopus 로고
    • Impaired renal function in morbid obese patients with nonalcoholic fatty liver disease
    • M.V. Machado, S. Goncalves, F. Carepa, J. Coutinho, A. Costa, and H. Cortez-Pinto Impaired renal function in morbid obese patients with nonalcoholic fatty liver disease Liver Int 32 2012 241 248
    • (2012) Liver Int , vol.32 , pp. 241-248
    • Machado, M.V.1    Goncalves, S.2    Carepa, F.3    Coutinho, J.4    Costa, A.5    Cortez-Pinto, H.6
  • 137
    • 49649090452 scopus 로고    scopus 로고
    • Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease
    • G. Targher, M. Chonchol, L. Bertolini, S. Rodella, L. Zenari, G. Lippi, and et al. Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease J Am Soc Nephrol 19 2008 1564 1570
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1564-1570
    • Targher, G.1    Chonchol, M.2    Bertolini, L.3    Rodella, S.4    Zenari, L.5    Lippi, G.6
  • 138
    • 40049095342 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men
    • Y. Chang, S. Ryu, E. Sung, H.Y. Woo, E. Oh, K. Cha, and et al. Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men Metabolism 57 2008 569 576
    • (2008) Metabolism , vol.57 , pp. 569-576
    • Chang, Y.1    Ryu, S.2    Sung, E.3    Woo, H.Y.4    Oh, E.5    Cha, K.6
  • 139
    • 79957619541 scopus 로고    scopus 로고
    • The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease
    • Y. Arase, F. Suzuki, M. Kobayashi, Y. Suzuki, Y. Kawamura, N. Matsumoto, and et al. The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease Intern Med 50 2011 1081 1087
    • (2011) Intern Med , vol.50 , pp. 1081-1087
    • Arase, Y.1    Suzuki, F.2    Kobayashi, M.3    Suzuki, Y.4    Kawamura, Y.5    Matsumoto, N.6
  • 140
    • 84901462957 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes
    • G. Targher, A. Mantovani, I. Pichiri, L. Mingolla, V. Cavalieri, W. Mantovani, and et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes Diabetes Care 37 2014 1729 1736
    • (2014) Diabetes Care , vol.37 , pp. 1729-1736
    • Targher, G.1    Mantovani, A.2    Pichiri, I.3    Mingolla, L.4    Cavalieri, V.5    Mantovani, W.6
  • 141
    • 33744958852 scopus 로고    scopus 로고
    • Assessing kidney function-measured and estimated glomerular filtration rate
    • L.A. Stevens, J. Coresh, T. Greene, and A.S. Levey Assessing kidney function-measured and estimated glomerular filtration rate N Engl J Med 354 2006 2473 2483
    • (2006) N Engl J Med , vol.354 , pp. 2473-2483
    • Stevens, L.A.1    Coresh, J.2    Greene, T.3    Levey, A.S.4
  • 142
    • 84863489710 scopus 로고    scopus 로고
    • Increased risk of cardiovascular disease and chronic kidney disease in NAFLD
    • E. Bonora, and G. Targher Increased risk of cardiovascular disease and chronic kidney disease in NAFLD Nat Rev Gastroenterol Hepatol 9 2012 372 381
    • (2012) Nat Rev Gastroenterol Hepatol , vol.9 , pp. 372-381
    • Bonora, E.1    Targher, G.2
  • 143
    • 34247857663 scopus 로고    scopus 로고
    • Obesity, inflammation, and insulin resistance
    • S.E. Shoelson, L. Herrero, and A. Naaz Obesity, inflammation, and insulin resistance Gastroenterology 132 2007 2169 2180
    • (2007) Gastroenterology , vol.132 , pp. 2169-2180
    • Shoelson, S.E.1    Herrero, L.2    Naaz, A.3
  • 144
    • 84875549943 scopus 로고    scopus 로고
    • The role of hepatokines in metabolism
    • N. Stefan, and H.U. Haring The role of hepatokines in metabolism Nat Rev Endocrinol 9 2013 144 152
    • (2013) Nat Rev Endocrinol , vol.9 , pp. 144-152
    • Stefan, N.1    Haring, H.U.2
  • 145
    • 84901480586 scopus 로고    scopus 로고
    • Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: Implications for cardiovascular disease
    • C.D. Byrne, and G. Targher Ectopic fat, insulin resistance, and nonalcoholic fatty liver disease: implications for cardiovascular disease Arterioscler Thromb Vasc Biol 34 2014 1155 1161
    • (2014) Arterioscler Thromb Vasc Biol , vol.34 , pp. 1155-1161
    • Byrne, C.D.1    Targher, G.2
  • 146
    • 84874193542 scopus 로고    scopus 로고
    • Diagnosis and management of nonalcoholic Fatty liver disease and its hemostatic/thrombotic and vascular complications
    • G. Targher, and C.D. Byrne Diagnosis and management of nonalcoholic Fatty liver disease and its hemostatic/thrombotic and vascular complications Semin Thromb Hemost 39 2013 214 228
    • (2013) Semin Thromb Hemost , vol.39 , pp. 214-228
    • Targher, G.1    Byrne, C.D.2
  • 147
    • 84928560778 scopus 로고    scopus 로고
    • Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease
    • A. Lonardo, S. Ballestri, G. Targher, and P. Loria Diagnosis and management of cardiovascular risk in nonalcoholic fatty liver disease Expert Rev Gastroenterol Hepatol 20 2014 1 22
    • (2014) Expert Rev Gastroenterol Hepatol , vol.20 , pp. 1-22
    • Lonardo, A.1    Ballestri, S.2    Targher, G.3    Loria, P.4


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