Regulation of plasma ceramide levels with fatty acid oversupply: Evidence that the liver detects and secretes de novo synthesised ceramide

Diabetologia

Volumn 55, Issue 10, 2012, Pages 2741-2746

  Watt, M J ^a   Barnett, A C ^a   Bruce, C R ^a,b   Schenk, S ^c,d   Horowitz, J F ^c   Hoy, A J ^a,e  

^a MONASH UNIVERSITY   (Australia)

^b BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^c UNIVERSITY OF MICHIGAN   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SYDNEY   (Australia)

Author keywords

De novo ceramide synthesis; Ex vivo SPT activity; HepG2 liver cells; Lipid infusion; Liver; Myriocin

Indexed keywords

CERAMIDE; FATTY ACID; INSULIN; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE; THERMOZYMOCIDIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRAIN HEPG2; CERAMIDE BLOOD LEVEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN EXPERIMENT; INSULIN RESISTANCE; LEAN BODY WEIGHT; LIPID ANALYSIS; LIPID BLOOD LEVEL; LIPOGENESIS; LIVER FUNCTION; MOUSE; NONHUMAN; NORMAL HUMAN; OBESITY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM;

ADULT; ANIMALS; CERAMIDES; DISEASE MODELS, ANIMAL; FATTY ACIDS; FEMALE; HEP G2 CELLS; HUMANS; INSULIN RESISTANCE; LIVER; MALE; MICE; MICE, OBESE; MODELS, ANIMAL; OBESITY; RATS; RATS, WISTAR; SERINE C-PALMITOYLTRANSFERASE;

EID: 84866058762     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2649-3     Document Type: Article

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