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Volumn 55, Issue 10, 2012, Pages 2741-2746

Regulation of plasma ceramide levels with fatty acid oversupply: Evidence that the liver detects and secretes de novo synthesised ceramide

Author keywords

De novo ceramide synthesis; Ex vivo SPT activity; HepG2 liver cells; Lipid infusion; Liver; Myriocin

Indexed keywords

CERAMIDE; FATTY ACID; INSULIN; PALMITIC ACID; SERINE PALMITOYLTRANSFERASE; THERMOZYMOCIDIN;

EID: 84866058762     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-012-2649-3     Document Type: Article
Times cited : (84)

References (14)
  • 1
    • 79959746261 scopus 로고    scopus 로고
    • Sphingolipids: Agents provocateurs in the pathogenesis of insulin resistance
    • 21468641 10.1007/s00125-011-2127-3 1:CAS:528:DC%2BC3MXntFGrsLc%3D
    • Lipina C, Hundal HS (2011) Sphingolipids: agents provocateurs in the pathogenesis of insulin resistance. Diabetologia 54:1596-1607
    • (2011) Diabetologia , vol.54 , pp. 1596-1607
    • Lipina, C.1    Hundal, H.S.2
  • 2
    • 63249117466 scopus 로고    scopus 로고
    • Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance
    • 19008343 10.2337/db08-1228 1:CAS:528:DC%2BD1MXhslersLY%3D
    • Haus JM, Kashyap SR, Kasumov T et al (2009) Plasma ceramides are elevated in obese subjects with type 2 diabetes and correlate with the severity of insulin resistance. Diabetes 58:337-343
    • (2009) Diabetes , vol.58 , pp. 337-343
    • Haus, J.M.1    Kashyap, S.R.2    Kasumov, T.3
  • 3
    • 70949101414 scopus 로고    scopus 로고
    • Link between plasma ceramides, inflammation and insulin resistance: Association with serum IL-6 concentration in patients with coronary heart disease
    • 19669729 10.1007/s00125-009-1482-9 1:CAS:528:DC%2BD1MXhsVWls7vL
    • de Mello VD, Lankinen M, Schwab U et al (2009) Link between plasma ceramides, inflammation and insulin resistance: association with serum IL-6 concentration in patients with coronary heart disease. Diabetologia 52:2612-2615
    • (2009) Diabetologia , vol.52 , pp. 2612-2615
    • De Mello, V.D.1    Lankinen, M.2    Schwab, U.3
  • 5
    • 64349124701 scopus 로고    scopus 로고
    • Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry
    • 18832345 10.1194/jlr.D800028-JLR200 1:CAS:528:DC%2BD1MXitlCqtbg%3D
    • Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G (2009) Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 50:574-585
    • (2009) J Lipid Res , vol.50 , pp. 574-585
    • Wiesner, P.1    Leidl, K.2    Boettcher, A.3    Schmitz, G.4    Liebisch, G.5
  • 6
    • 0029031099 scopus 로고
    • Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion
    • 7775441 10.1074/jbc.270.23.13834 1:CAS:528:DyaK2MXmt1yqsLs%3D
    • Merrill AH Jr, Lingrell S, Wang E, Nikolova-Karakashian M, Vales TR, Vance DE (1995) Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. J Biol Chem 270:13834-13841
    • (1995) J Biol Chem , vol.270 , pp. 13834-13841
    • Merrill, Jr.A.H.1    Lingrell, S.2    Wang, E.3    Nikolova-Karakashian, M.4    Vales, T.R.5    Vance, D.E.6
  • 7
    • 33847332202 scopus 로고    scopus 로고
    • Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance
    • 17339025 10.1016/j.cmet.2007.01.002 1:CAS:528:DC%2BD2sXjsF2qtL8%3D
    • Holland WL, Brozinick JT, Wang LP et al (2007) Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab 5:167-179
    • (2007) Cell Metab , vol.5 , pp. 167-179
    • Holland, W.L.1    Brozinick, J.T.2    Wang, L.P.3
  • 8
    • 77956022194 scopus 로고    scopus 로고
    • Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption
    • 20522596 10.2337/db09-1293 1:CAS:528:DC%2BC3cXhsVGhs7nI
    • Ussher JR, Koves TR, Cadete VJ et al (2010) Inhibition of de novo ceramide synthesis reverses diet-induced insulin resistance and enhances whole-body oxygen consumption. Diabetes 59:2453-2464
    • (2010) Diabetes , vol.59 , pp. 2453-2464
    • Ussher, J.R.1    Koves, T.R.2    Cadete, V.J.3
  • 9
    • 33750590489 scopus 로고    scopus 로고
    • Altered adipose and plasma sphingolipid metabolism in obesity: A potential mechanism for cardiovascular and metabolic risk
    • DOI 10.2337/db06-0330
    • Samad F, Hester KD, Yang G, Hannun YA, Bielawski J (2006) Altered adipose and plasma sphingolipid metabolism in obesity: a potential mechanism for cardiovascular and metabolic risk. Diabetes 55:2579-2587 (Pubitemid 44871159)
    • (2006) Diabetes , vol.55 , Issue.9 , pp. 2579-2587
    • Samad, F.1    Hester, K.D.2    Yang, G.3    Hannun, Y.A.4    Bielawski, J.5
  • 10
    • 67649687040 scopus 로고    scopus 로고
    • Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis
    • 19387108
    • Lyn-Cook LE Jr, Lawton M, Tong M et al (2009) Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. J Alzheimers Dis 16:715-729
    • (2009) J Alzheimers Dis , vol.16 , pp. 715-729
    • Lyn-Cook, Jr.L.E.1    Lawton, M.2    Tong, M.3
  • 11
    • 0022970190 scopus 로고
    • Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells
    • Preiss J, Loomis CR, Bishop WR, Stein R, Niedel JE, Bell RM (1986) Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes, and ras- and sis-transformed normal rat kidney cells. J Biol Chem 261:8597-8600 (Pubitemid 17205050)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.19 , pp. 8597-8600
    • Preiss, J.1    Loomis, C.R.2    Bishop, W.R.3
  • 12
    • 33645842245 scopus 로고    scopus 로고
    • Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues
    • 16396984 10.1210/en.2005-1074 1:CAS:528:DC%2BD28XjvFOrtLw%3D
    • Watt MJ, Hevener A, Lancaster GI, Febbraio MA (2006) Ciliary neurotrophic factor prevents acute lipid-induced insulin resistance by attenuating ceramide accumulation and phosphorylation of c-Jun N-terminal kinase in peripheral tissues. Endocrinology 147:2077-2085
    • (2006) Endocrinology , vol.147 , pp. 2077-2085
    • Watt, M.J.1    Hevener, A.2    Lancaster, G.I.3    Febbraio, M.A.4
  • 13
    • 79959434733 scopus 로고    scopus 로고
    • Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase
    • 21464445 10.2337/db10-0845 1:CAS:528:DC%2BC3MXmsVKltbc%3D
    • Borg ML, Andrews ZB, Duh EJ, Zechner R, Meikle PJ, Watt MJ (2011) Pigment epithelium-derived factor regulates lipid metabolism via adipose triglyceride lipase. Diabetes 60:1458-1466
    • (2011) Diabetes , vol.60 , pp. 1458-1466
    • Borg, M.L.1    Andrews, Z.B.2    Duh, E.J.3    Zechner, R.4    Meikle, P.J.5    Watt, M.J.6
  • 14
    • 67650517066 scopus 로고    scopus 로고
    • An improved method to determine serine palmitoyltransferase activity
    • 19181628 10.1194/jlr.D900001-JLR200 1:CAS:528:DC%2BD1MXms1ehtLY%3D
    • Rutti MF, Richard S, Penno A, von Eckardstein A, Hornemann T (2009) An improved method to determine serine palmitoyltransferase activity. J Lipid Res 50:1237-1244
    • (2009) J Lipid Res , vol.50 , pp. 1237-1244
    • Rutti, M.F.1    Richard, S.2    Penno, A.3    Von Eckardstein, A.4    Hornemann, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.