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Volumn 29, Issue 9, 2012, Pages 1098-1107

Dorothy Hodgkin Lecture 2012 Non-alcoholic fatty liver disease, insulin resistance and ectopic fat: A new problem in diabetes management

Author keywords

Insulin resistance; Non alcoholic steatohepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HEMOGLOBIN A1C; METFORMIN; POLYUNSATURATED FATTY ACID; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

EID: 84865120793     PISSN: 07423071     EISSN: 14645491     Source Type: Journal    
DOI: 10.1111/j.1464-5491.2012.03732.x     Document Type: Review
Times cited : (89)

References (65)
  • 1
    • 84858818014 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments
    • Scorletti E, Calder PC, Byrne CD. Non-alcoholic fatty liver disease and cardiovascular risk: metabolic aspects and novel treatments. Endocrine 2011; 40: 332-343.
    • (2011) Endocrine , vol.40 , pp. 332-343
    • Scorletti, E.1    Calder, P.C.2    Byrne, C.D.3
  • 3
    • 84861417701 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor?
    • Bhatia LS, Curzen NP, Calder PC, Byrne CD. Non-alcoholic fatty liver disease: a new and important cardiovascular risk factor? Eur Heart J 2012; 33: 1190-1200.
    • (2012) Eur Heart J , vol.33 , pp. 1190-1200
    • Bhatia, L.S.1    Curzen, N.P.2    Calder, P.C.3    Byrne, C.D.4
  • 4
    • 77957375969 scopus 로고    scopus 로고
    • Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease
    • Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010; 363: 1341-1350.
    • (2010) N Engl J Med , vol.363 , pp. 1341-1350
    • Targher, G.1    Day, C.P.2    Bonora, E.3
  • 5
    • 7044274423 scopus 로고    scopus 로고
    • Elevated alanine aminotransferase predicts new-onset type2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study
    • Sattar N, Scherbakova O, Ford I, O'Reilly DS, Stanley A, Forrest E et al. Elevated alanine aminotransferase predicts new-onset type2 diabetes independently of classical risk factors, metabolic syndrome, and C-reactive protein in the West of Scotland Coronary Prevention Study. Diabetes 2004; 53: 2855-2860.
    • (2004) Diabetes , vol.53 , pp. 2855-2860
    • Sattar, N.1    Scherbakova, O.2    Ford, I.3    O'Reilly, D.S.4    Stanley, A.5    Forrest, E.6
  • 6
    • 77956631214 scopus 로고    scopus 로고
    • Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data
    • Ghouri N, Preiss D, Sattar N. Liver enzymes, nonalcoholic fatty liver disease, and incident cardiovascular disease: a narrative review and clinical perspective of prospective data. Hepatology 2010; 52: 1156-1161.
    • (2010) Hepatology , vol.52 , pp. 1156-1161
    • Ghouri, N.1    Preiss, D.2    Sattar, N.3
  • 8
    • 77956266803 scopus 로고    scopus 로고
    • Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type1 diabetes
    • Targher G, Bertolini L, Padovani R, Rodella S, Zoppini G, Pichiri I et al. Prevalence of non-alcoholic fatty liver disease and its association with cardiovascular disease in patients with type1 diabetes. J Hepatol 2010; 53: 713-718.
    • (2010) J Hepatol , vol.53 , pp. 713-718
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Zoppini, G.5    Pichiri, I.6
  • 9
    • 31444437104 scopus 로고    scopus 로고
    • Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects
    • Holt HB, Wild SH, Wood PJ, Zhang J, Darekar AA, Dewbury K et al. Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects. Diabetologia 2006; 49: 141-148.
    • (2006) Diabetologia , vol.49 , pp. 141-148
    • Holt, H.B.1    Wild, S.H.2    Wood, P.J.3    Zhang, J.4    Darekar, A.A.5    Dewbury, K.6
  • 10
    • 79957922310 scopus 로고    scopus 로고
    • Hepatic fatty acid partitioning
    • Hodson L, Frayn KN. Hepatic fatty acid partitioning. Curr Opin Lipidol 2011; 22: 216-224.
    • (2011) Curr Opin Lipidol , vol.22 , pp. 216-224
    • Hodson, L.1    Frayn, K.N.2
  • 11
    • 0028824216 scopus 로고
    • Decreased non esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance
    • Byrne CD, Wareham NJ, Day NE, McLeish R, Williams DRR, Hales CN. Decreased non esterified fatty acid suppression and features of the insulin resistance syndrome occur in a sub-group of individuals with normal glucose tolerance. Diabetologia 1995; 38: 1358-1366.
    • (1995) Diabetologia , vol.38 , pp. 1358-1366
    • Byrne, C.D.1    Wareham, N.J.2    Day, N.E.3    McLeish, R.4    Williams, D.R.R.5    Hales, C.N.6
  • 12
    • 0028017978 scopus 로고
    • Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids
    • Byrne CD, Wareham NJ, Brown DC, Clark PM, Cox LJ, Day NE et al. Hypertriglyceridaemia in subjects with normal and abnormal glucose tolerance: relative contributions of insulin secretion, insulin resistance and suppression of plasma non-esterified fatty acids. Diabetologia 1994; 37: 889-896.
    • (1994) Diabetologia , vol.37 , pp. 889-896
    • Byrne, C.D.1    Wareham, N.J.2    Brown, D.C.3    Clark, P.M.4    Cox, L.J.5    Day, N.E.6
  • 13
    • 73249128357 scopus 로고    scopus 로고
    • The metabolic syndrome: common origins of a multifactorial disorder
    • Bruce KD, Byrne CD. The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J 2009; 85: 614-621.
    • (2009) Postgrad Med J , vol.85 , pp. 614-621
    • Bruce, K.D.1    Byrne, C.D.2
  • 14
    • 73149107279 scopus 로고    scopus 로고
    • Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    • Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 2009; 50: 1796-1808.
    • (2009) Hepatology , vol.50 , pp. 1796-1808
    • Bruce, K.D.1    Cagampang, F.R.2    Argenton, M.3    Zhang, J.4    Ethirajan, P.L.5    Burdge, G.C.6
  • 15
    • 68049099023 scopus 로고    scopus 로고
    • Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis
    • Basciano H, Miller AE, Naples M, Baker C, Kohen R, Xu E et al. Metabolic effects of dietary cholesterol in an animal model of insulin resistance and hepatic steatosis. Am J Physiol Endocrinol Metab 2009; 297: E462-E473.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Basciano, H.1    Miller, A.E.2    Naples, M.3    Baker, C.4    Kohen, R.5    Xu, E.6
  • 16
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van NM, Behling C, Contos MJ, Cummings OW et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van, N.M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 17
    • 33750312195 scopus 로고    scopus 로고
    • Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease
    • Guha IN, Parkes J, Roderick PR, Harris S, Rosenberg WM. Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease. Gut 2006; 55: 1650-1660.
    • (2006) Gut , vol.55 , pp. 1650-1660
    • Guha, I.N.1    Parkes, J.2    Roderick, P.R.3    Harris, S.4    Rosenberg, W.M.5
  • 19
    • 34247384560 scopus 로고    scopus 로고
    • The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD
    • Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007; 45: 846-854.
    • (2007) Hepatology , vol.45 , pp. 846-854
    • Angulo, P.1    Hui, J.M.2    Marchesini, G.3    Bugianesi, E.4    George, J.5    Farrell, G.C.6
  • 20
    • 30344434151 scopus 로고    scopus 로고
    • Non-alcoholic steatatohepatitis and metabolic syndrome
    • Byrne C, Wild S, eds. Chichester: John Wiley and Sons
    • Ahmed MH BC. Non-alcoholic steatatohepatitis and metabolic syndrome. In: Byrne C, Wild S, eds. Metabolic Syndrome. Chichester: John Wiley and Sons, 2005: 279-305.
    • (2005) Metabolic Syndrome , pp. 279-305
    • Ahmed, M.B.1
  • 21
    • 59349119385 scopus 로고    scopus 로고
    • Metabolic syndrome, diabetes and CHD risk
    • Packard CJ, ed. Oxford: Clinical Publishing
    • Ahmed MH BC. Metabolic syndrome, diabetes and CHD risk. In: Packard CJ, ed. The Year in Lipid Disorders. Oxford: Clinical Publishing, 2007: 3-26.
    • (2007) The Year in Lipid Disorders , pp. 3-26
    • Ahmed, M.B.1
  • 22
    • 21344449292 scopus 로고    scopus 로고
    • Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos Nutrition and Liver Study
    • Bedogni G, Miglioli L, Masutti F, Tiribelli C, Marchesini G, Bellentani S. Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos Nutrition and Liver Study. Hepatology 2005; 42: 44-52.
    • (2005) Hepatology , vol.42 , pp. 44-52
    • Bedogni, G.1    Miglioli, L.2    Masutti, F.3    Tiribelli, C.4    Marchesini, G.5    Bellentani, S.6
  • 25
    • 18244385511 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association
    • Pagano G, Pacini G, Musso G, Gambino R, Mecca F, Depetris N et al. Nonalcoholic steatohepatitis, insulin resistance, and metabolic syndrome: further evidence for an etiologic association. Hepatology 2002; 35: 367-372.
    • (2002) Hepatology , vol.35 , pp. 367-372
    • Pagano, G.1    Pacini, G.2    Musso, G.3    Gambino, R.4    Mecca, F.5    Depetris, N.6
  • 26
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC, Holmes-Walker J, Hui JM, Fung C et al. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3    Holmes-Walker, J.4    Hui, J.M.5    Fung, C.6
  • 27
    • 84862075971 scopus 로고    scopus 로고
    • Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for Type2 diabetes
    • Sung KC, Jeong WS, Wild SH, Byrne CD. Combined influence of insulin resistance, overweight/obesity, and fatty liver as risk factors for Type2 diabetes. Diabetes Care 2012; 35: 717-722.
    • (2012) Diabetes Care , vol.35 , pp. 717-722
    • Sung, K.C.1    Jeong, W.S.2    Wild, S.H.3    Byrne, C.D.4
  • 28
    • 66149119340 scopus 로고    scopus 로고
    • Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population
    • Gastaldelli A, Kozakova M, Hojlund K, Flyvbjerg A, Favuzzi A, Mitrakou A et al. Fatty liver is associated with insulin resistance, risk of coronary heart disease, and early atherosclerosis in a large European population. Hepatology 2009; 49: 1537-1544.
    • (2009) Hepatology , vol.49 , pp. 1537-1544
    • Gastaldelli, A.1    Kozakova, M.2    Hojlund, K.3    Flyvbjerg, A.4    Favuzzi, A.5    Mitrakou, A.6
  • 29
    • 67650912354 scopus 로고    scopus 로고
    • Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans
    • Yun KE, Shin CY, Yoon YS, Park HS. Elevated alanine aminotransferase levels predict mortality from cardiovascular disease and diabetes in Koreans. Atherosclerosis 2009; 205: 533-537.
    • (2009) Atherosclerosis , vol.205 , pp. 533-537
    • Yun, K.E.1    Shin, C.Y.2    Yoon, Y.S.3    Park, H.S.4
  • 30
    • 34547673500 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type2 diabetic patients
    • Targher G, Bertolini L, Rodella S, Tessari R, Zenari L, Lippi G et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type2 diabetic patients. Diabetes Care 2007; 30: 2119-2121.
    • (2007) Diabetes Care , vol.30 , pp. 2119-2121
    • Targher, G.1    Bertolini, L.2    Rodella, S.3    Tessari, R.4    Zenari, L.5    Lippi, G.6
  • 31
    • 75449088414 scopus 로고    scopus 로고
    • Decreased survival of subjects with elevated liver function tests during a 28-year follow-up
    • Soderberg C, Stal P, Askling J, Glaumann H, Lindberg G, Marmur J et al. Decreased survival of subjects with elevated liver function tests during a 28-year follow-up. Hepatology 2010; 51: 595-602.
    • (2010) Hepatology , vol.51 , pp. 595-602
    • Soderberg, C.1    Stal, P.2    Askling, J.3    Glaumann, H.4    Lindberg, G.5    Marmur, J.6
  • 32
    • 33947169979 scopus 로고    scopus 로고
    • Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study
    • Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ et al. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis 2007; 191: 391-396.
    • (2007) Atherosclerosis , vol.191 , pp. 391-396
    • Schindhelm, R.K.1    Dekker, J.M.2    Nijpels, G.3    Bouter, L.M.4    Stehouwer, C.D.5    Heine, R.J.6
  • 33
    • 26944453966 scopus 로고    scopus 로고
    • Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163944 Austrian adults
    • Ruttmann E, Brant LJ, Concin H, Diem G, Rapp K, Ulmer H. Gamma-glutamyltransferase as a risk factor for cardiovascular disease mortality: an epidemiological investigation in a cohort of 163944 Austrian adults. Circulation 2005; 112: 2130-2137.
    • (2005) Circulation , vol.112 , pp. 2130-2137
    • Ruttmann, E.1    Brant, L.J.2    Concin, H.3    Diem, G.4    Rapp, K.5    Ulmer, H.6
  • 34
    • 33748760084 scopus 로고    scopus 로고
    • Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28838 middle-aged men and women
    • Lee DH, Silventoinen K, Hu G, Jacobs DR Jr, Jousilahti P, Sundvall J et al. Serum gamma-glutamyltransferase predicts non-fatal myocardial infarction and fatal coronary heart disease among 28838 middle-aged men and women. Eur Heart J 2006; 27: 2170-2176.
    • (2006) Eur Heart J , vol.27 , pp. 2170-2176
    • Lee, D.H.1    Silventoinen, K.2    Hu, G.3    Jacobs Jr, D.R.4    Jousilahti, P.5    Sundvall, J.6
  • 35
    • 72949097025 scopus 로고    scopus 로고
    • Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels
    • Haring R, Wallaschofski H, Nauck M, Dorr M, Baumeister SE, Volzke H. Ultrasonographic hepatic steatosis increases prediction of mortality risk from elevated serum gamma-glutamyl transpeptidase levels. Hepatology 2009; 50: 1403-1411.
    • (2009) Hepatology , vol.50 , pp. 1403-1411
    • Haring, R.1    Wallaschofski, H.2    Nauck, M.3    Dorr, M.4    Baumeister, S.E.5    Volzke, H.6
  • 37
    • 36349033483 scopus 로고    scopus 로고
    • Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis
    • Fraser A, Harris R, Sattar N, Ebrahim S, Smith GD, Lawlor DA. Gamma-glutamyltransferase is associated with incident vascular events independently of alcohol intake: analysis of the British Women's Heart and Health Study and Meta-Analysis. Arterioscler Thromb Vasc Biol 2007; 27: 2729-2735.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2729-2735
    • Fraser, A.1    Harris, R.2    Sattar, N.3    Ebrahim, S.4    Smith, G.D.5    Lawlor, D.A.6
  • 38
    • 50649094716 scopus 로고    scopus 로고
    • Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study
    • Dunn W, Xu R, Wingard DL, Rogers C, Angulo P, Younossi ZM et al. Suspected nonalcoholic fatty liver disease and mortality risk in a population-based cohort study. Am J Gastroenterol 2008; 103: 2263-2271.
    • (2008) Am J Gastroenterol , vol.103 , pp. 2263-2271
    • Dunn, W.1    Xu, R.2    Wingard, D.L.3    Rogers, C.4    Angulo, P.5    Younossi, Z.M.6
  • 40
    • 59349107500 scopus 로고    scopus 로고
    • Current treatment of non-alcoholic fatty liver disease
    • Ahmed MH, Byrne CD. Current treatment of non-alcoholic fatty liver disease. Diabetes Obes Metab 2009; 11: 188-195.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 188-195
    • Ahmed, M.H.1    Byrne, C.D.2
  • 41
    • 77952561547 scopus 로고    scopus 로고
    • The role of non-alcoholic fatty liver disease in cardiovascular disease
    • Perseghin G. The role of non-alcoholic fatty liver disease in cardiovascular disease. Dig Dis 2010; 28: 210-213.
    • (2010) Dig Dis , vol.28 , pp. 210-213
    • Perseghin, G.1
  • 42
    • 79960549297 scopus 로고    scopus 로고
    • The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study
    • Bhala N, Angulo P, van der Poorten D, Lee E, Hui JM, Saracco G et al. The natural history of nonalcoholic fatty liver disease with advanced fibrosis or cirrhosis: an international collaborative study. Hepatology 2011; 54: 1208-1216.
    • (2011) Hepatology , vol.54 , pp. 1208-1216
    • Bhala, N.1    Angulo, P.2    van der Poorten, D.3    Lee, E.4    Hui, J.M.5    Saracco, G.6
  • 43
    • 62649107835 scopus 로고    scopus 로고
    • The severity of nonalcoholic fatty liver disease is associated with increased cardiovascular risk in a large cohort of non-obese Asian subjects
    • Sung KC, Ryan MC, Wilson AM. The severity of nonalcoholic fatty liver disease is associated with increased cardiovascular risk in a large cohort of non-obese Asian subjects. Atherosclerosis 2009; 203: 581-586.
    • (2009) Atherosclerosis , vol.203 , pp. 581-586
    • Sung, K.C.1    Ryan, M.C.2    Wilson, A.M.3
  • 44
    • 58149378362 scopus 로고    scopus 로고
    • Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type2 diabetes: the Diabetes Heart Study
    • McKimmie RL, Daniel KR, Carr JJ, Bowden DW, Freedman BI, Register TC et al. Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type2 diabetes: the Diabetes Heart Study. Am J Gastroenterol 2008; 103: 3029-3035.
    • (2008) Am J Gastroenterol , vol.103 , pp. 3029-3035
    • McKimmie, R.L.1    Daniel, K.R.2    Carr, J.J.3    Bowden, D.W.4    Freedman, B.I.5    Register, T.C.6
  • 46
    • 77956189968 scopus 로고    scopus 로고
    • The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk
    • Alkhouri N, Tamimi TA, Yerian L, Lopez R, Zein NN, Feldstein AE. The inflamed liver and atherosclerosis: a link between histologic severity of nonalcoholic fatty liver disease and increased cardiovascular risk. Dig Dis Sci 2010; 55: 2644-2650.
    • (2010) Dig Dis Sci , vol.55 , pp. 2644-2650
    • Alkhouri, N.1    Tamimi, T.A.2    Yerian, L.3    Lopez, R.4    Zein, N.N.5    Feldstein, A.E.6
  • 48
    • 4344628555 scopus 로고    scopus 로고
    • The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease
    • viii.
    • McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8: 521-533, viii.
    • (2004) Clin Liver Dis , vol.8 , pp. 521-533
    • McCullough, A.J.1
  • 49
    • 11144307888 scopus 로고    scopus 로고
    • Narrative review: hepatobiliary disease in type2 diabetes mellitus
    • Tolman KG, Fonseca V, Tan MH, Dalpiaz A. Narrative review: hepatobiliary disease in type2 diabetes mellitus. Ann Intern Med 2004; 141: 946-956.
    • (2004) Ann Intern Med , vol.141 , pp. 946-956
    • Tolman, K.G.1    Fonseca, V.2    Tan, M.H.3    Dalpiaz, A.4
  • 50
    • 0033853134 scopus 로고    scopus 로고
    • Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke
    • Jousilahti P, Rastenyte D, Tuomilehto J. Serum gamma-glutamyl transferase, self-reported alcohol drinking, and the risk of stroke. Stroke 2000; 31: 1851-1855.
    • (2000) Stroke , vol.31 , pp. 1851-1855
    • Jousilahti, P.1    Rastenyte, D.2    Tuomilehto, J.3
  • 51
    • 0029086625 scopus 로고
    • Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes
    • Wannamethee G, Ebrahim S, Shaper AG. Gamma-glutamyltransferase: determinants and association with mortality from ischemic heart disease and all causes. Am J Epidemiol 1995; 142: 699-708.
    • (1995) Am J Epidemiol , vol.142 , pp. 699-708
    • Wannamethee, G.1    Ebrahim, S.2    Shaper, A.G.3
  • 52
    • 33947169979 scopus 로고    scopus 로고
    • Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study
    • Schindhelm RK, Dekker JM, Nijpels G, Bouter LM, Stehouwer CD, Heine RJ et al. Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study. Atherosclerosis 2007; 191: 391-396.
    • (2007) Atherosclerosis , vol.191 , pp. 391-396
    • Schindhelm, R.K.1    Dekker, J.M.2    Nijpels, G.3    Bouter, L.M.4    Stehouwer, C.D.5    Heine, R.J.6
  • 53
    • 38749102436 scopus 로고    scopus 로고
    • Liver enzymes and risk of diabetes and cardiovascular disease: results of the Firenze Bagno a Ripoli (FIBAR) study
    • Monami M, Bardini G, Lamanna C, Pala L, Cresci B, Francesconi P et al. Liver enzymes and risk of diabetes and cardiovascular disease: results of the Firenze Bagno a Ripoli (FIBAR) study. Metabolism 2008; 57: 387-392.
    • (2008) Metabolism , vol.57 , pp. 387-392
    • Monami, M.1    Bardini, G.2    Lamanna, C.3    Pala, L.4    Cresci, B.5    Francesconi, P.6
  • 54
    • 34247605492 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type2 diabetic patients
    • Targher G, Bertolini L, Padovani R, Rodella S, Tessari R, Zenari L et al. Prevalence of nonalcoholic fatty liver disease and its association with cardiovascular disease among type2 diabetic patients. Diabetes Care 2007; 30: 1212-1218.
    • (2007) Diabetes Care , vol.30 , pp. 1212-1218
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Tessari, R.5    Zenari, L.6
  • 55
    • 33644700376 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and risk of future cardiovascular events among type2 diabetic patients
    • Targher G, Bertolini L, Poli F, Rodella S, Scala L, Tessari R et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type2 diabetic patients. Diabetes 2005; 54: 3541-3546.
    • (2005) Diabetes , vol.54 , pp. 3541-3546
    • Targher, G.1    Bertolini, L.2    Poli, F.3    Rodella, S.4    Scala, L.5    Tessari, R.6
  • 56
    • 77955517684 scopus 로고    scopus 로고
    • Ezetimibe as a potential treatment for non-alcoholic fatty liver disease: is the intestine a modulator of hepatic insulin sensitivity and hepatic fat accumulation?
    • Ahmed MH, Byrne CD. Ezetimibe as a potential treatment for non-alcoholic fatty liver disease: is the intestine a modulator of hepatic insulin sensitivity and hepatic fat accumulation? Drug Discov Today 2010; 15: 590-595.
    • (2010) Drug Discov Today , vol.15 , pp. 590-595
    • Ahmed, M.H.1    Byrne, C.D.2
  • 57
    • 56449087970 scopus 로고    scopus 로고
    • The relationship between the fatty acid composition of immune cells and their function
    • Calder PC. The relationship between the fatty acid composition of immune cells and their function. Prostaglandins Leukot Essent Fatty Acids 2008; 79: 101-108.
    • (2008) Prostaglandins Leukot Essent Fatty Acids , vol.79 , pp. 101-108
    • Calder, P.C.1
  • 58
    • 62749169989 scopus 로고    scopus 로고
    • A systemic review of the roles of n-3 fatty acids in health and disease
    • Riediger ND, Othman RA, Suh M, Moghadasian MH. A systemic review of the roles of n-3 fatty acids in health and disease. J Am Diet Assoc 2009; 109: 668-679.
    • (2009) J Am Diet Assoc , vol.109 , pp. 668-679
    • Riediger, N.D.1    Othman, R.A.2    Suh, M.3    Moghadasian, M.H.4
  • 59
    • 73949087595 scopus 로고    scopus 로고
    • Understanding omega-3 polyunsaturated fatty acids
    • Calder PC, Yaqoob P. Understanding omega-3 polyunsaturated fatty acids. Postgrad Med 2009; 121: 148-157.
    • (2009) Postgrad Med , vol.121 , pp. 148-157
    • Calder, P.C.1    Yaqoob, P.2
  • 60
  • 61
    • 2942706241 scopus 로고    scopus 로고
    • Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease
    • Araya J, Rodrigo R, Videla LA, Thielemann L, Orellana M, Pettinelli P et al. Increase in long-chain polyunsaturated fatty acid n-6/n-3 ratio in relation to hepatic steatosis in patients with non-alcoholic fatty liver disease. Clin Sci (Lond) 2004; 106: 635-643.
    • (2004) Clin Sci (Lond) , vol.106 , pp. 635-643
    • Araya, J.1    Rodrigo, R.2    Videla, L.A.3    Thielemann, L.4    Orellana, M.5    Pettinelli, P.6
  • 62
    • 0035658444 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPAR-α, and steatohepatitis
    • Reddy JK. Nonalcoholic steatosis and steatohepatitis. III. Peroxisomal β-oxidation, PPAR-α, and steatohepatitis. Am J Physiol Gastrointest Liver Physiol 2001; 281: G1333-G1339.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Reddy, J.K.1
  • 63
    • 0035066651 scopus 로고    scopus 로고
    • Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome
    • Clarke SD. Polyunsaturated fatty acid regulation of gene transcription: a molecular mechanism to improve the metabolic syndrome. J Nutr 2001; 131: 1129-1132.
    • (2001) J Nutr , vol.131 , pp. 1129-1132
    • Clarke, S.D.1
  • 64
    • 0034791616 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription
    • Clarke SD. Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. Am J Physiol Gastrointest Liver Physiol 2001; 281: G865-G869.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Clarke, S.D.1
  • 65
    • 4344701247 scopus 로고    scopus 로고
    • The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors
    • Clarke SD. The multi-dimensional regulation of gene expression by fatty acids: polyunsaturated fats as nutrient sensors. Curr Opin Lipidol 2004; 15: 13-18.
    • (2004) Curr Opin Lipidol , vol.15 , pp. 13-18
    • Clarke, S.D.1


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