-
1
-
-
84875974450
-
Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)
-
Ahn KH, Mahmoud MM, Shim JY, Kendall DA (2013) Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1). J Biol Chem 288:9790-9800
-
(2013)
J Biol Chem
, vol.288
, pp. 9790-9800
-
-
Ahn, K.H.1
Mahmoud, M.M.2
Shim, J.Y.3
Kendall, D.A.4
-
2
-
-
0026730336
-
Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family
-
Attramadal H, Arriza JL, Aoki C, Dawson TM, Codina J, Kwatra MM, Snyder SH, Caron MG, Lefkowitz RJ (1992) Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family. J Biol Chem 267:17882-17890
-
(1992)
J Biol Chem
, vol.267
, pp. 17882-17890
-
-
Attramadal, H.1
Arriza, J.L.2
Aoki, C.3
Dawson, T.M.4
Codina, J.5
Kwatra, M.M.6
Snyder, S.H.7
Caron, M.G.8
Lefkowitz, R.J.9
-
3
-
-
9444274109
-
Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons
-
Bailey CP, Kelly E, Henderson G (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 66:1592-1598
-
(2004)
Mol Pharmacol
, vol.66
, pp. 1592-1598
-
-
Bailey, C.P.1
Kelly, E.2
Henderson, G.3
-
4
-
-
69249213486
-
Involvement of PKC alpha and G-proteincoupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons
-
Bailey CP, Oldfield S, Llorent J, Caunt CH, Teschemacher AG, Roberts L, McArdle CA, Smith FL, Dewy WL, Kelly E, Henderson G (2009) Involvement of PKC alpha and G-proteincoupled receptor kinase 2 in agonist-selective desensitization of mu-opioid receptors in mature brain neurons. Br J Pharmacol 158:157-164
-
(2009)
Br J Pharmacol
, vol.158
, pp. 157-164
-
-
Bailey, C.P.1
Oldfield, S.2
Llorent, J.3
Caunt, C.H.4
Teschemacher, A.G.5
Roberts, L.6
McArdle, C.A.7
Smith, F.L.8
Dewy, W.L.9
Kelly, E.10
Henderson, G.11
-
5
-
-
33750525351
-
Opioid receptor signaling: Relevance for gastrointestinal therapy
-
Bohn LM, Raehal KM (2006) Opioid receptor signaling: relevance for gastrointestinal therapy. Curr Opin Pharmacol 6:559-563
-
(2006)
Curr Opin Pharmacol
, vol.6
, pp. 559-563
-
-
Bohn, L.M.1
Raehal, K.M.2
-
6
-
-
0033601341
-
Enhanced morphine analgesia in mice lacking beta-arrestin 2
-
Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, Lin FT (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286:2495-2498
-
(1999)
Science
, vol.286
, pp. 2495-2498
-
-
Bohn, L.M.1
Lefkowitz, R.J.2
Gainetdinov, R.R.3
Peppel, K.4
Caron, M.G.5
Lin, F.T.6
-
7
-
-
0034619796
-
Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
-
Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723
-
(2000)
Nature
, vol.408
, pp. 720-723
-
-
Bohn, L.M.1
Gainetdinov, R.R.2
Lin, F.T.3
Lefkowitz, R.J.4
Caron, M.G.5
-
8
-
-
0036895747
-
Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice
-
Bohn LM, Gainetdinov RR, Caron MJ (2002) Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci 22:10494-10500
-
(2002)
J Neurosci
, vol.22
, pp. 10494-10500
-
-
Bohn, L.M.1
Gainetdinov, R.R.2
Caron, M.J.3
-
9
-
-
1642371042
-
G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: Psychostimulant and opiate studies in knockout mice
-
Bohn LM, Gainetdinov RR, Caron MJ (2004) G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. Neuromolecular Med 5:41-50
-
(2004)
Neuromolecular Med
, vol.5
, pp. 41-50
-
-
Bohn, L.M.1
Gainetdinov, R.R.2
Caron, M.J.3
-
10
-
-
52449133377
-
Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2-/-mice
-
Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK (2008) Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2-/-mice. Behav Pharmacol 19:298-307
-
(2008)
Behav Pharmacol
, vol.19
, pp. 298-307
-
-
Breivogel, C.S.1
Lambert, J.M.2
Gerfin, S.3
Huffman, J.W.4
Razdan, R.K.5
-
11
-
-
34250860086
-
Pain management: A fundamental human right
-
Brennan F, Carr DB, Cousins M (2007) Pain management: a fundamental human right. Anesth Analg 105:205-221
-
(2007)
Anesth Analg
, vol.105
, pp. 205-221
-
-
Brennan, F.1
Carr, D.B.2
Cousins, M.3
-
12
-
-
84876444777
-
Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
-
doi:10.1371/journal.pone.0048912
-
Bychkov E, Zurkovsky L, Garret MB, Ahmed MR, Gurevich EV (2012) Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum. PLoS One 7:e48912. doi:10.1371/journal.pone. 0048912
-
(2012)
PLoS One
, vol.7
-
-
Bychkov, E.1
Zurkovsky, L.2
Garret, M.B.3
Ahmed, M.R.4
Gurevich, E.V.5
-
13
-
-
0035895932
-
Threonine 180 is required for G-protein-coupled receptor kinase 3-and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in xenopus oocytes
-
Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C (2001) Threonine 180 is required for G-protein-coupled receptor kinase 3-and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in xenopus oocytes. J Biol Chem 276:4894-4900
-
(2001)
J Biol Chem
, vol.276
, pp. 4894-4900
-
-
Celver, J.P.1
Lowe, J.2
Kovoor, A.3
Gurevich, V.V.4
Chavkin, C.5
-
14
-
-
1342265799
-
Distinct domains of the mu-opioid receptor control uncoupling and internalization
-
Celver J, Xu M, Jin W, Lowe J, Chavkin C (2004) Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol 65:528-537
-
(2004)
Mol Pharmacol
, vol.65
, pp. 528-537
-
-
Celver, J.1
Xu, M.2
Jin, W.3
Lowe, J.4
Chavkin, C.5
-
15
-
-
84875469202
-
Recent developments in the study of opioid receptors
-
Cox BM (2012) Recent developments in the study of opioid receptors. Mol Pharm 83:723-728
-
(2012)
Mol Pharm
, vol.83
, pp. 723-728
-
-
Cox, B.M.1
-
16
-
-
0027939554
-
Cone arrestin identified by targeting expression of a functional family
-
Craft CM, Whitmore DH, Wiechmann AF (1994) Cone arrestin identified by targeting expression of a functional family. J Biol Chem 269:4613-4619
-
(1994)
J Biol Chem
, vol.269
, pp. 4613-4619
-
-
Craft, C.M.1
Whitmore, D.H.2
Wiechmann, A.F.3
-
17
-
-
37349043924
-
Rapid CB1 cannabinoid receptor desensitization defined the time course of ERK1/2 MAP kinase signaling
-
Daigle TL, Kearn CS, Mackie K (2008) Rapid CB1 cannabinoid receptor desensitization defined the time course of ERK1/2 MAP kinase signaling. Neuropharmacology 54:36-44
-
(2008)
Neuropharmacology
, vol.54
, pp. 36-44
-
-
Daigle, T.L.1
Kearn, C.S.2
Mackie, K.3
-
18
-
-
63849297063
-
Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons
-
Dang VC, Napier IA, Christie MJ (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J Neurosci 29:3322-3327
-
(2009)
J Neurosci
, vol.29
, pp. 3322-3327
-
-
Dang, V.C.1
Napier, I.A.2
Christie, M.J.3
-
19
-
-
79956302829
-
Cellular morphine tolerance produced by βarresitn-2-dependent impairment of μ-opioid receptor resensitization
-
Dang VC, Chieng B, Azriel Y, Christie MJ (2011) Cellular morphine tolerance produced by βarresitn-2-dependent impairment of μ-opioid receptor resensitization. J Neurosci 31:7122-7130
-
(2011)
J Neurosci
, vol.31
, pp. 7122-7130
-
-
Dang, V.C.1
Chieng, B.2
Azriel, Y.3
Christie, M.J.4
-
20
-
-
84874406899
-
A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine
-
DeWire SM, Yamashita DS, Rominger DH, Liu G, Cowan CL, Graczyk TM, Chen XT, Pitis PM, Gotchev D, Yuan C, Koblish M, Lark MW, Violin JD (2013) A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther 344:708-717
-
(2013)
J Pharmacol Exp Ther
, vol.344
, pp. 708-717
-
-
Dewire, S.M.1
Yamashita, D.S.2
Rominger, D.H.3
Liu, G.4
Cowan, C.L.5
Graczyk, T.M.6
Chen, X.T.7
Pitis, P.M.8
Gotchev, D.9
Yuan, C.10
Koblish, M.11
Lark, M.W.12
Violin, J.D.13
-
21
-
-
34548096786
-
Napthlalen-11-yl-(4-pentyloxynapthalen-1-yl) methanone: A potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration
-
Dziaduleqicz EK, Bevan SJ, Brain CT, Coote PR, Culshaw AG, Davis AJ, Edwards LJ, Fisher AJ, Fox AJ, Gentry C, Vecchia L, Loong Y, Lyothier I, McNair KO, Farrell C, Peacoc M, Portmann R, Schopfer U, Yaqoob M, Zadrobilek J (2007) Napthlalen-11-yl-(4-pentyloxynapthalen-1-yl) methanone: a potent, orally bioavailable human CB1/CB2 dual agonist with antihyperalgesic properties and restricted central nervous system penetration. J Med Chem 50:3851-3856
-
(2007)
J Med Chem
, vol.50
, pp. 3851-3856
-
-
Dziaduleqicz, E.K.1
Bevan, S.J.2
Brain, C.T.3
Coote, P.R.4
Culshaw, A.G.5
Davis, A.J.6
Edwards, L.J.7
Fisher, A.J.8
Fox, A.J.9
Gentry, C.10
Vecchia, L.11
Loong, Y.12
Lyothier, I.13
McNair, K.O.14
Farrell, C.15
Peacoc, M.16
Portmann, R.17
Schopfer, U.18
Yaqoob, M.19
Zadrobilek, J.20
more..
-
22
-
-
0036894714
-
Chronic morphine treatment inhibits opioid receptor desensitization and internalization
-
Eisinger DA, Ammer H, Schulz R (2002) Chronic morphine treatment inhibits opioid receptor desensitization and internalization. J Neurosci 22:10192-10200
-
(2002)
J Neurosci
, vol.22
, pp. 10192-10200
-
-
Eisinger, D.A.1
Ammer, H.2
Schulz, R.3
-
23
-
-
8144229133
-
Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
-
Elmes SJR, Jhaveri MD, Smart D, Kendall DA, Chapman V (2004) Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci 20:2311-2320
-
(2004)
Eur J Neurosci
, vol.20
, pp. 2311-2320
-
-
Elmes, S.J.R.1
Jhaveri, M.D.2
Smart, D.3
Kendall, D.A.4
Chapman, V.5
-
24
-
-
3042789578
-
State-dependent opioid control of pain
-
Fields H (2004) State-dependent opioid control of pain. Nat Rev Neurosci 5:565-575
-
(2004)
Nat Rev Neurosci
, vol.5
, pp. 565-575
-
-
Fields, H.1
-
25
-
-
1642292051
-
Desensitization of G protein-coupled receptors and neuronal functions
-
Gainetdinov RR, Premont RT, Bohn LM, Lefkowitz RJ, Caron MG (2004) Desensitization of G protein-coupled receptors and neuronal functions. Annu Rev Neurosci 27:107-144
-
(2004)
Annu Rev Neurosci
, vol.27
, pp. 107-144
-
-
Gainetdinov, R.R.1
Premont, R.T.2
Bohn, L.M.3
Lefkowitz, R.J.4
Caron, M.G.5
-
26
-
-
33846456218
-
An opioid agonist that does not induced mu-opioid receptor/arrestin interactions or receptor internalization
-
Groer CE, Tidgewll K, Moyer RA, Harding WW, Rothman RB, Prisinzano TE, Bohn LM (2007) An opioid agonist that does not induced mu-opioid receptor/arrestin interactions or receptor internalization. Mol Pharmacol 71:549-557
-
(2007)
Mol Pharmacol
, vol.71
, pp. 549-557
-
-
Groer, C.E.1
Tidgewll, K.2
Moyer, R.A.3
Harding, W.W.4
Rothman, R.B.5
Prisinzano, T.E.6
Bohn, L.M.7
-
27
-
-
80052416572
-
Agonist-directed interactions with specific beta-arrestins determines mu-opioid receptor trafficking, ubiquitination, and dephosphorylation
-
Groer CE, Schmid CL, Jaeger AM, Bohn LM (2011) Agonist-directed interactions with specific beta-arrestins determines mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. J Biol Chem 286:31731-31741
-
(2011)
J Biol Chem
, vol.286
, pp. 31731-31741
-
-
Groer, C.E.1
Schmid, C.L.2
Jaeger, A.M.3
Bohn, L.M.4
-
28
-
-
0034006773
-
Arrestin: Mutagenesis, expression, purification, and functional characterization
-
Gurevich VV, Benovic JL (2000) Arrestin: mutagenesis, expression, purification, and functional characterization. Methods Enzymol 315:422-437
-
(2000)
Methods Enzymol
, vol.315
, pp. 422-437
-
-
Gurevich, V.V.1
Benovic, J.L.2
-
29
-
-
0041333148
-
The new face of active receptor bound arrestin attracts new partners
-
Gurevich VV, Gurevich EV (2003) The new face of active receptor bound arrestin attracts new partners. Structure 11:1037-1042
-
(2003)
Structure
, vol.11
, pp. 1037-1042
-
-
Gurevich, V.V.1
Gurevich, E.V.2
-
30
-
-
0037074928
-
Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development
-
Gurevich EV, Benovic JL, Gurevich VV (2002) Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109:421-436
-
(2002)
Neuroscience
, vol.109
, pp. 421-436
-
-
Gurevich, E.V.1
Benovic, J.L.2
Gurevich, V.V.3
-
31
-
-
0001962932
-
Opioid analgesics
-
Hardman JG, Limbird LE, Gilman AG (eds) 10th edn McGraw Hill, New York
-
Gutstein HB, Akil H (2001) Opioid analgesics. In: Hardman JG, Limbird LE, Gilman AG (eds) Goodman and Gilman's The pharmacological basis of therapeutics, 10th edn. McGraw Hill, New York, pp 569-620
-
(2001)
Goodman and Gilman's the Pharmacological Basis of Therapeutics
, pp. 569-620
-
-
Gutstein, H.B.1
Akil, H.2
-
32
-
-
23944437411
-
Morphine promotes rapid, arrestindependent endocytosis of mu-opioid receptors in striatal neurons
-
Haberstock-Debic H, Kin KA, Yu YJ, von Zastrow (2005) Morphine promotes rapid, arrestindependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci 25:7847-7857
-
(2005)
J Neurosci
, vol.25
, pp. 7847-7857
-
-
Haberstock-Debic, H.1
Kin, K.A.2
Yu, Y.J.3
Von, Zastrow.4
-
33
-
-
84866028189
-
Regulation of endocytic clathrin dynamics by cargo ubiquitination
-
Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von ZastrowM(2012) Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell 23:519-532
-
(2012)
Dev Cell
, vol.23
, pp. 519-532
-
-
Henry, A.G.1
Hislop, J.N.2
Grove, J.3
Thorn, K.4
Marsh, M.5
Von Zastrow, M.6
-
34
-
-
1642498189
-
Selecitve activation of cannabinoid CB2 receptors suppresses hyperalgeisa evoked by intradermal capsaicin
-
Hohmann AG, Farthing JN, Zvonok AM, Makriyannis A (2004) Selecitve activation of cannabinoid CB2 receptors suppresses hyperalgeisa evoked by intradermal capsaicin. J Pharmacol Exp Ther 308:446-453
-
(2004)
J Pharmacol Exp Ther
, vol.308
, pp. 446-453
-
-
Hohmann, A.G.1
Farthing, J.N.2
Zvonok, A.M.3
Makriyannis, A.4
-
35
-
-
21344444379
-
An endocannabinoid mechanism for stress-induced analgesia
-
Hohmann AG, Suplita RL, Bolton NM, Neely MH, Fegley D, Mangieri R, Krey JF, Walker JM, Holmes PV, Crystal JD, Duranti A, Tontinin A, Mor M, Tarzia G, Piomelli D (2005) An endocannabinoid mechanism for stress-induced analgesia. Nature 435:1108-1112
-
(2005)
Nature
, vol.435
, pp. 1108-1112
-
-
Hohmann, A.G.1
Suplita, R.L.2
Bolton, N.M.3
Neely, M.H.4
Fegley, D.5
Mangieri, R.6
Krey, J.F.7
Walker, J.M.8
Holmes, P.V.9
Crystal, J.D.10
Duranti, A.11
Tontinin, A.12
Mor, M.13
Tarzia, G.14
Piomelli, D.15
-
36
-
-
18444376760
-
International union of pharmacology. XXVII. Classification of cannabinoid receptorss
-
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
-
(2002)
Pharmacol Rev
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
Devane, W.A.6
Felder, C.C.7
Herkenham, M.8
Mackie, K.9
Martin, B.R.10
Mechoulam, R.11
Pertwee, R.G.12
-
37
-
-
33646062552
-
CB2 cannabinoid receptor mediation of nociception
-
Ibrahim MM, Rude ML, Stagg NJ, Mata HP, Lai J, Vanderah TW, Porreca F, Buckley NE, Makriyannis A, Malan TP (2006) CB2 cannabinoid receptor mediation of nociception. Pain 122:36-42
-
(2006)
Pain
, vol.122
, pp. 36-42
-
-
Ibrahim, M.M.1
Rude, M.L.2
Stagg, N.J.3
Mata, H.P.4
Lai, J.5
Vanderah, T.W.6
Porreca, F.7
Buckley, N.E.8
Makriyannis, A.9
Malan, T.P.10
-
38
-
-
0031776783
-
The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 recpetor agonist palmitoylethanolamine in visceral and somatic inflammatory pain
-
Jaggar SI, Hasnie FS, Sellaturay S, Rice ASC (1998) The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 recpetor agonist palmitoylethanolamine in visceral and somatic inflammatory pain. Pain 76:189-199
-
(1998)
Pain
, vol.76
, pp. 189-199
-
-
Jaggar, S.I.1
Hasnie, F.S.2
Sellaturay, S.3
Rice, A.S.C.4
-
39
-
-
33646494493
-
Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray
-
Jiang B, Shi Y, Li H, Kang L, Ma L (2006) Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray. Neurosci Lett 400:150-153
-
(2006)
Neurosci Lett
, vol.400
, pp. 150-153
-
-
Jiang, B.1
Shi, Y.2
Li, H.3
Kang, L.4
Ma, L.5
-
40
-
-
0033562607
-
Distinct domains of the CB1 cannaniboid receptor mediate desensitizaiton and internalization
-
Jin W, Brown S, Roche JP, Hsieh C, Celver JP, Kovoor A, Chavkin C, Mackie K (1999) Distinct domains of the CB1 cannaniboid receptor mediate desensitizaiton and internalization. J Neurosci 15:3773-3780
-
(1999)
J Neurosci
, vol.15
, pp. 3773-3780
-
-
Jin, W.1
Brown, S.2
Roche, J.P.3
Hsieh, C.4
Celver, J.P.5
Kovoor, A.6
Chavkin, C.7
Mackie, K.8
-
41
-
-
84857349362
-
The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guina pig gastrointestinal tract
-
Kang M, Maguma HT, Smith TH, Ross GR, Dewy WL, Akbarali HI (2012) The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guina pig gastrointestinal tract. J Pharmacol Exp Ther 340:567-576
-
(2012)
J Pharmacol Exp Ther
, vol.340
, pp. 567-576
-
-
Kang, M.1
Maguma, H.T.2
Smith, T.H.3
Ross, G.R.4
Dewy, W.L.5
Akbarali, H.I.6
-
42
-
-
0034747415
-
Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo
-
Kelly S, Chapman V (2001) Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. J Neurophysiol 86:3061-3064
-
(2001)
J Neurophysiol
, vol.86
, pp. 3061-3064
-
-
Kelly, S.1
Chapman, V.2
-
43
-
-
0033013383
-
Opioids: First lessons from knockout mice
-
Kieffer BL (1999) Opioids: first lessons from knockout mice. Trends Pharmacol Sci 20:19-26
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 19-26
-
-
Kieffer, B.L.1
-
44
-
-
0036095186
-
Exploring the opioid system by gene knockout
-
Kieffer BL, Gaveriaux-Ruff C (2002) Exploring the opioid system by gene knockout. Prog Neurobiol 66:285-306
-
(2002)
Prog Neurobiol
, vol.66
, pp. 285-306
-
-
Kieffer, B.L.1
Gaveriaux-Ruff, C.2
-
45
-
-
0942287665
-
Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization
-
Koch T, Brandenburg LO, Liang Y, Schulz S, Beyer A, Schröder H, Höllt V (2004) Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization. J Neurochem 88:680-688
-
(2004)
J Neurochem
, vol.88
, pp. 680-688
-
-
Koch, T.1
Brandenburg, L.O.2
Liang, Y.3
Schulz, S.4
Beyer, A.5
Schröder, H.6
Höllt, V.7
-
46
-
-
0030736086
-
Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arresitn2 in xenopus oocytes
-
Kovoor A, Nappey V, Kieffer BL, Chavkin C (1997) Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arresitn2 in xenopus oocytes. J Biol Chem 272:27605-27611
-
(1997)
J Biol Chem
, vol.272
, pp. 27605-27611
-
-
Kovoor, A.1
Nappey, V.2
Kieffer, B.L.3
Chavkin, C.4
-
47
-
-
0031726194
-
Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
-
Kovoor A, Celver JP, Wu A, Chavkin C (1998) Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol Pharmacol 54:704-711
-
(1998)
Mol Pharmacol
, vol.54
, pp. 704-711
-
-
Kovoor, A.1
Celver, J.P.2
Wu, A.3
Chavkin, C.4
-
48
-
-
28544440521
-
Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain
-
LaBuda CJ, Koblish M, Little PH (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol 527:172-174
-
(2005)
Eur J Pharmacol
, vol.527
, pp. 172-174
-
-
Labuda, C.J.1
Koblish, M.2
Little, P.H.3
-
49
-
-
79953863397
-
Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2
-
Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W (2011) Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2. Mol Pain 7:24
-
(2011)
Mol Pain
, vol.7
, pp. 24
-
-
Lam, H.1
Maga, M.2
Pradhan, A.3
Evans, C.J.4
Maidment, N.T.5
Hales, T.G.6
Walwyn, W.7
-
50
-
-
84857142520
-
Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology
-
Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE (2012) Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology. Drug Alcohol Depend 121:181-188
-
(2012)
Drug Alcohol Depend
, vol.121
, pp. 181-188
-
-
Lamb, K.1
Tidgewell, K.2
Simpson, D.S.3
Bohn, L.M.4
Prisinzano, T.E.5
-
51
-
-
84995353254
-
Molecular mechanisms and regulation of opioid receptor
-
Law PY, Wong YH, Loh HH (2000) Molecular mechanisms and regulation of opioid receptor. J Biol Chem 277:15729-15735
-
(2000)
J Biol Chem
, vol.277
, pp. 15729-15735
-
-
Law, P.Y.1
Wong, Y.H.2
Loh, H.H.3
-
52
-
-
63449097594
-
Improvement of morphine-mediated analgesia by inhibition of beta-arrestin 2 expression in mice periaqueductal gray matter
-
Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C (2009) Improvement of morphine-mediated analgesia by inhibition of beta-arrestin 2 expression in mice periaqueductal gray matter. Int J Mol Sci 10:954-963
-
(2009)
Int J Mol Sci
, vol.10
, pp. 954-963
-
-
Li, Y.1
Liu, X.2
Liu, C.3
Kang, J.4
Yang, J.5
Pei, G.6
Wu, C.7
-
53
-
-
0025352299
-
Beta-arrestin: A protein that regulates beta-adrenergic receptor function
-
Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (1990) Beta-arrestin: a protein that regulates beta-adrenergic receptor function. Science 248:1547-1550
-
(1990)
Science
, vol.248
, pp. 1547-1550
-
-
Lohse, M.J.1
Benovic, J.L.2
Codina, J.3
Caron, M.G.4
Lefkowitz, R.J.5
-
54
-
-
0037013307
-
Mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin
-
Lowe JD, Celver JP, Gurevich VV, Chavkin C (2002) mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin. J Biol Chem 277:15729-15735
-
(2002)
J Biol Chem
, vol.277
, pp. 15729-15735
-
-
Lowe, J.D.1
Celver, J.P.2
Gurevich, V.V.3
Chavkin, C.4
-
55
-
-
33845958896
-
Mu opioid receptor activation of ERK 1/2 is GRK3 and arrestin dependent in striatal neurons
-
Macey TA, Lowe JD, Chavkin C (2006) Mu opioid receptor activation of ERK 1/2 is GRK3 and arrestin dependent in striatal neurons. J Biol Chem 281:34515-34524
-
(2006)
J Biol Chem
, vol.281
, pp. 34515-34524
-
-
Macey, T.A.1
Lowe, J.D.2
Chavkin, C.3
-
56
-
-
0034886018
-
CB2 cannabinoid receptor-mediated peripheral antinociception
-
Malan TP, Ibrahim MM, Deng JF, Liu A, Mata HP, Vanderah T, Porreca R, Makriyannis A (2001) CB2 cannabinoid receptor-mediated peripheral antinociception. Pain 93:239-245
-
(2001)
Pain
, vol.93
, pp. 239-245
-
-
Malan, T.P.1
Ibrahim, M.M.2
Deng, J.F.3
Liu, A.4
Mata, H.P.5
Vanderah, T.6
Porreca, R.7
Makriyannis, A.8
-
57
-
-
84858609378
-
Novel roles for the E3 ubiquitin ligase atrophininteracting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling
-
Malik R, Soh UJ, Trejo J, Marchese A (2012) Novel roles for the E3 ubiquitin ligase atrophininteracting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem 287:9013-9027
-
(2012)
J Biol Chem
, vol.287
, pp. 9013-9027
-
-
Malik, R.1
Soh, U.J.2
Trejo, J.3
Marchese, A.4
-
58
-
-
0029852678
-
Loss of morphineinduced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioidreceptor gene
-
Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, LeMeur M, Dollé P, Tzavara E, Hanoune J, Roques BP, Kieffer BL (1996) Loss of morphineinduced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioidreceptor gene. Nature 383:819-823
-
(1996)
Nature
, vol.383
, pp. 819-823
-
-
Matthes, H.W.1
Maldonado, R.2
Simonin, F.3
Valverde, O.4
Slowe, S.5
Kitchen, I.6
Befort, K.7
Dierich, A.8
Lemeur, M.9
Dollé, P.10
Tzavara, E.11
Hanoune, J.12
Roques, B.P.13
Kieffer, B.L.14
-
59
-
-
77957221089
-
μ-opioid receptors: Correlation of agonist efficacy for signaling with ability to activate internalization
-
McPherson J, Rivero G, Baptist M, Lorente J, Al-Sabah S, Krasel C, Dewey WL, Bailey COP, Rosethorne EM, Charlton SJ, Henderson G, Kelly E (2010) μ-opioid receptors: correlation of agonist efficacy for signaling with ability to activate internalization. Mol Pharmacol 78:756-766
-
(2010)
Mol Pharmacol
, vol.78
, pp. 756-766
-
-
McPherson, J.1
Rivero, G.2
Baptist, M.3
Lorente, J.4
Al-Sabah, S.5
Krasel, C.6
Dewey, W.L.7
Bailey, C.O.P.8
Rosethorne, E.M.9
Charlton, S.J.10
Henderson, G.11
Kelly, E.12
-
60
-
-
84862315506
-
Evidence that behavioral phenotypes of morphine in β-arrs-/-mice are due to the unmaking of JNK signaling
-
Mittal N, Tan M, Egbuta O, Desai N, Crawford C, Xie CW, Evans C, WalwynW(2012) Evidence that behavioral phenotypes of morphine in β-arrs-/-mice are due to the unmaking of JNK signaling. Neuropscyhopharmacology 37:1953-1962
-
(2012)
Neuropscyhopharmacology
, vol.37
, pp. 1953-1962
-
-
Mittal, N.1
Tan, M.2
Egbuta, O.3
Desai, N.4
Crawford, C.5
Xie, C.W.6
Evans, C.7
Walwyn, W.8
-
61
-
-
77951221698
-
Morphine-like opiates selectively antagonize receptor-arrestin interactions
-
Molinari P, Vezzi V, Sbraccia M, Gró C, Riitano D, Ambrosio C, Casella I, Costa T (2010) Morphine-like opiates selectively antagonize receptor-arrestin interactions. J Biol Chem 285:12522-12535
-
(2010)
J Biol Chem
, vol.285
, pp. 12522-12535
-
-
Molinari, P.1
Vezzi, V.2
Sbraccia, M.3
Gró, C.4
Riitano, D.5
Ambrosio, C.6
Casella, I.7
Costa, T.8
-
62
-
-
0027332380
-
X-arrestin: A new retinal arrestin mapping to the X chromosome
-
Murakami A, Yajima T, Sakuma H, McLaren MJ, Inana G (1993) X-arrestin: a new retinal arrestin mapping to the X chromosome. FEBS Lett 334:203-209
-
(1993)
FEBS Lett
, vol.334
, pp. 203-209
-
-
Murakami, A.1
Yajima, T.2
Sakuma, H.3
McLaren, M.J.4
Inana, G.5
-
63
-
-
84859099308
-
β-arrestin2 regulated cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner
-
Nguyen PT, Schmid CL, Raehal KM, Selley DE, Bohn LM, Sim-Selley LJ (2012) β-arrestin2 regulated cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner. Biol Psychiatry 71:714-724
-
(2012)
Biol Psychiatry
, vol.71
, pp. 714-724
-
-
Nguyen, P.T.1
Schmid, C.L.2
Raehal, K.M.3
Selley, D.E.4
Bohn, L.M.5
Sim-Selley, L.J.6
-
64
-
-
77957268985
-
The role of cannabinoid receptor in the descending modulation of pain
-
Palazzo E, Livio L, de Novellis V, Rossi F, Maione S (2010) The role of cannabinoid receptor in the descending modulation of pain. Pharmaceuticals 3:2661-2673
-
(2010)
Pharmaceuticals
, vol.3
, pp. 2661-2673
-
-
Palazzo, E.1
Livio, L.2
De Novellis, V.3
Rossi, F.4
Maione, S.5
-
65
-
-
19344375070
-
Molecular biology of opioid analgesia
-
Pasternak GW (2013) Molecular biology of opioid analgesia. J Pain Symptom Manage 29:2-9
-
(2013)
J Pain Symptom Manage
, vol.29
, pp. 2-9
-
-
Pasternak, G.W.1
-
66
-
-
79251565243
-
Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation
-
Patierno S, Anselmi L, Jaramill I, Scott D, Garcia R, Sternini C (2011) Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology 140:618-626
-
(2011)
Gastroenterology
, vol.140
, pp. 618-626
-
-
Patierno, S.1
Anselmi, L.2
Jaramill, I.3
Scott, D.4
Garcia, R.5
Sternini, C.6
-
67
-
-
33644804271
-
The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
-
Pertwee RG (2005) The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 7:E625-654
-
(2005)
AAPS J
, vol.7
-
-
Pertwee, R.G.1
-
68
-
-
84868218099
-
β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel
-
Por ED, Bierbower SM, Berg KA, Gomez R, Akopian AN, Wetsel WC, Jeske NA (2012) β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. J Biol Chem 287:37552-37563
-
(2012)
J Biol Chem
, vol.287
, pp. 37552-37563
-
-
Por, E.D.1
Bierbower, S.M.2
Berg, K.A.3
Gomez, R.4
Akopian, A.N.5
Wetsel, W.C.6
Jeske, N.A.7
-
69
-
-
84875194289
-
Phosphorylation regulates TRPV1 association with β-arrestin-2
-
Por ED, Gomez R, Akopian AN, Jeske NA (2013) Phosphorylation regulates TRPV1 association with β-arrestin-2. Biochem J 451:101-109
-
(2013)
Biochem J
, vol.451
, pp. 101-109
-
-
Por, E.D.1
Gomez, R.2
Akopian, A.N.3
Jeske, N.A.4
-
70
-
-
0037036192
-
Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat
-
Przewlocka B, Sieja A, Starowicz K, Maj M, Bilecki W, Przewlocki R (2002) Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat. Neurosci Lett 325:107-110
-
(2002)
Neurosci Lett
, vol.325
, pp. 107-110
-
-
Przewlocka, B.1
Sieja, A.2
Starowicz, K.3
Maj, M.4
Bilecki, W.5
Przewlocki, R.6
-
71
-
-
0141814986
-
Mu-opioid receptor desensitization: Role of receptor phosphorylation, internalization and representation
-
Qiu Y, Law PY, Loh HH (2003) Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization and representation. J Biol Chem 278:36733-36739
-
(2003)
J Biol Chem
, vol.278
, pp. 36733-36739
-
-
Qiu, Y.1
Law, P.Y.2
Loh, H.H.3
-
72
-
-
79953003987
-
Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone
-
Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT (2011) Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone. J Neurosci 31:4434-4443
-
(2011)
J Neurosci
, vol.31
, pp. 4434-4443
-
-
Quillinan, N.1
Lau, E.K.2
Virk, M.3
Von Zastrow, M.4
Williams, J.T.5
-
73
-
-
84995303705
-
The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
-
Raehal KM, Bohn LM (2011) The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology 63:1001-1019
-
(2011)
Neuropharmacology
, vol.63
, pp. 1001-1019
-
-
Raehal, K.M.1
Bohn, L.M.2
-
74
-
-
23944485741
-
Morphine side effects in beta-arresitn2 knockout mice
-
Raehal KM, Walker JK, Bohn LM (2005) Morphine side effects in beta-arresitn2 knockout mice. J Pharmacol Exp Ther 314:1195-1201
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 1195-1201
-
-
Raehal, K.M.1
Walker, J.K.2
Bohn, L.M.3
-
75
-
-
80053588007
-
Functional selectivity at the μ-opioid receptor: Implications for understanding opioid analgesia and tolerance
-
Raehal KM, Schmid CL, Groer CE, Bohn LM (2011) Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacol Rev 63 (4):1001-1019
-
(2011)
Pharmacol Rev
, vol.63
, Issue.4
, pp. 1001-1019
-
-
Raehal, K.M.1
Schmid, C.L.2
Groer, C.E.3
Bohn, L.M.4
-
76
-
-
35648993556
-
Supraspinal modulation of pain by cannabinoids: The role of GABA and glutamate
-
Rea K, Roche M, Finn DP (2007) Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. Br J Pharmacol 152:633-648
-
(2007)
Br J Pharmacol
, vol.152
, pp. 633-648
-
-
Rea, K.1
Roche, M.2
Finn, D.P.3
-
77
-
-
0032078392
-
Mu-opioid receptor-knockout mice: The role of mu-opioid receptor in gastrointestinal transit
-
Roy S, Liu HC, Loh HH (1998) Mu-opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res 56:281-283
-
(1998)
Brain Res
, vol.56
, pp. 281-283
-
-
Roy, S.1
Liu, H.C.2
Loh, H.H.3
-
78
-
-
0141568089
-
The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins
-
Schmidlin F, Roosterman D, Bunnett NW (2003) The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Am J Physiol Cell Physiol 285:C945-C958
-
(2003)
Am J Physiol Cell Physiol
, vol.285
-
-
Schmidlin, F.1
Roosterman, D.2
Bunnett, N.W.3
-
79
-
-
0023433192
-
Primary and secondary structure of bovine retinal S antigen (48-kDa protein)
-
Shinohara T, Dietzschold B, Craft CM, Wistow G, Early JJ, Donoso LA, Horwitz J, Tao R (1987) Primary and secondary structure of bovine retinal S antigen (48-kDa protein). Proc Natl Acad Sci USA 84:6975-6979
-
(1987)
Proc Natl Acad Sci USA
, vol.84
, pp. 6975-6979
-
-
Shinohara, T.1
Dietzschold, B.2
Craft, C.M.3
Wistow, G.4
Early, J.J.5
Donoso, L.A.6
Horwitz, J.7
Tao, R.8
-
81
-
-
77952643387
-
Cannabinoid CB1 receptor-interacting proteins: Novel targets for central nervous system drug discovery?
-
Smith TH, Sim-Selley LJ, Selley DE (2010) Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? Br J Pharmacol 160):454-66.
-
(2010)
Br J Pharmacol
, vol.160
, pp. 454-466
-
-
Smith, T.H.1
Sim-Selley, L.J.2
Selley, D.E.3
-
82
-
-
0037966402
-
Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of CB2 receptors in anaesthetized rats
-
Sokal DM, Elmes SJR, Kendall DA, Chapman V (2003) Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of CB2 receptors in anaesthetized rats. Neuropharmacol 45:404-411
-
(2003)
Neuropharmacol
, vol.45
, pp. 404-411
-
-
Sokal, D.M.1
Elmes, S.J.R.2
Kendall, D.A.3
Chapman, V.4
-
83
-
-
0031030042
-
Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia
-
Sora I, Takahashi N, Funada M, Ujike H, Revay RS, Donovan DM, Miner LL, Uhl GR (1997) Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci USA 94:1544-1549
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1544-1549
-
-
Sora, I.1
Takahashi, N.2
Funada, M.3
Ujike, H.4
Revay, R.S.5
Donovan, D.M.6
Miner, L.L.7
Uhl, G.R.8
-
84
-
-
31844433721
-
Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
-
Suplita RL 2nd, Gutierrez T, Fegley D, Piomelli D, Hohmann AG (2006) Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacol 50:372-379
-
(2006)
Neuropharmacol
, vol.50
, pp. 372-379
-
-
Suplita II, R.L.1
Gutierrez, T.2
Fegley, D.3
Piomelli, D.4
Hohmann, A.G.5
-
85
-
-
48749103773
-
Cannabinoid receptor 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review
-
SvÍzenská I, Dubový P, Sulcová A (2008) Cannabinoid receptor 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures-a short review. Pharmacol Biochem Behav 90:501-511
-
(2008)
Pharmacol Biochem Behav
, vol.90
, pp. 501-511
-
-
Svízenská, I.1
Dubový, P.2
Sulcová, A.3
-
86
-
-
33748765783
-
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
-
Walwyn WM, Wei W, Xie CW, Chiu K, Kieffer BL, Evans CJ, Maidment NT (2006) Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons. Neuroscience 142:493-503
-
(2006)
Neuroscience
, vol.142
, pp. 493-503
-
-
Walwyn, W.M.1
Wei, W.2
Xie, C.W.3
Chiu, K.4
Kieffer, B.L.5
Evans, C.J.6
Maidment, N.T.7
-
87
-
-
34248382512
-
Beat-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
-
Walwyn W, Evans CJ, Hales TG (2007) Beat-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. J Neurosci 27:5092-5104
-
(2007)
J Neurosci
, vol.27
, pp. 5092-5104
-
-
Walwyn, W.1
Evans, C.J.2
Hales, T.G.3
-
88
-
-
0032544061
-
Morphine-activated opioid receptor eludes desensitization by beta-arrestin
-
Whistler JL, von Zastrow M (1998) Morphine-activated opioid receptor eludes desensitization by beta-arrestin. Proc Natl Acad Sci USA 95:9914-9919
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 9914-9919
-
-
Whistler, J.L.1
Von Zastrow, M.2
-
89
-
-
0033179904
-
Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
-
Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23:737-746
-
(1999)
Neuron
, vol.23
, pp. 737-746
-
-
Whistler, J.L.1
Chuang, H.H.2
Chu, P.3
Jan, L.Y.4
Von Zastrow, M.5
-
90
-
-
84874290339
-
Regulation of μ-opioid receptors: Desensitization, phosphorylation, internalization, and tolerance
-
Williams JT, Ingram SL, Henderson G, Chavkin C, von Zastrow M, Schulz S, Koch T, Evans CJ, Christie MJ (2013) Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance. Pharmacol Rev 65:223-254
-
(2013)
Pharmacol Rev
, vol.65
, pp. 223-254
-
-
Williams, J.T.1
Ingram, S.L.2
Henderson, G.3
Chavkin, C.4
Von Zastrow, M.5
Schulz, S.6
Koch, T.7
Evans, C.J.8
Christie, M.J.9
-
92
-
-
80054114499
-
Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats
-
Yang CH, Huang HW, Chen KH, Chen YS, Sheen-Chen SM, Lin CR (2011) Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats. Br J Anaesth 107:774-781
-
(2011)
Br J Anaesth
, vol.107
, pp. 774-781
-
-
Yang, C.H.1
Huang, H.W.2
Chen, K.H.3
Chen, Y.S.4
Sheen-Chen, S.M.5
Lin, C.R.6
-
93
-
-
0032499738
-
Roler for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness
-
Zhang J, Ferguson SS, Barak LS, Bodduluri SR, Laporte SA, Law PY, Caron MG (1998) Roler for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness. Proc Natl Acad Sci USA 95:7157-7162
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7157-7162
-
-
Zhang, J.1
Ferguson, S.S.2
Barak, L.S.3
Bodduluri, S.R.4
Laporte, S.A.5
Law, P.Y.6
Caron, M.G.7
-
94
-
-
59049089275
-
Src phosphorylation of μ-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal
-
Zhang L, Zhao H, Qui Y, Loh HH, Law PY (2008) Src phosphorylation of μ-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem 284:1990-2000
-
(2008)
J Biol Chem
, vol.284
, pp. 1990-2000
-
-
Zhang, L.1
Zhao, H.2
Qui, Y.3
Loh, H.H.4
Law, P.Y.5
-
95
-
-
0033545866
-
Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
-
Zimmer A, Zimmer AM, Hohmann AG, Herkenhan M, Bonner TI (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96:5780-5785
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5780-5785
-
-
Zimmer, A.1
Zimmer, A.M.2
Hohmann, A.G.3
Herkenhan, M.4
Bonner, T.I.5
|