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Volumn 219, Issue , 2014, Pages 427-443

β-arrestins: Regulatory role and therapeutic potential in opioid and cannabinoid receptor-mediated analgesia

Author keywords

Analgesia; Antinociception; Arrestin; Cannabinoid; Cannabinoid CB1 receptor; Mu opioid receptor; Opioid; Pain; Tolerance

Indexed keywords

BETA ARRESTIN; BETA ARRESTIN 1; BETA ARRESTIN 2; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HERKINORIN; MORPHINE; MU OPIATE RECEPTOR; MU OPIATE RECEPTOR AGONIST; OPIATE; OPIATE AGONIST; OPIATE RECEPTOR; TRV 130; UNCLASSIFIED DRUG; 1 BUTYL 3 (1 NAPHTHOYL)INDOLE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID; CANNABINOID RECEPTOR AGONIST; ETORPHINE; FENTANYL; G PROTEIN COUPLED RECEPTOR; METHADONE; METHANANDAMIDE; REGULATOR PROTEIN; TV 130; VANILLOID RECEPTOR 1; ANALGESIC AGENT; NARCOTIC ANALGESIC AGENT; RETINA S ANTIGEN;

EID: 84930278822     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-41199-1_22     Document Type: Article
Times cited : (75)

References (95)
  • 1
    • 84875974450 scopus 로고    scopus 로고
    • Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1)
    • Ahn KH, Mahmoud MM, Shim JY, Kendall DA (2013) Distinct roles of β-arrestin 1 and β-arrestin 2 in ORG27569-induced biased signaling and internalization of the cannabinoid receptor 1 (CB1). J Biol Chem 288:9790-9800
    • (2013) J Biol Chem , vol.288 , pp. 9790-9800
    • Ahn, K.H.1    Mahmoud, M.M.2    Shim, J.Y.3    Kendall, D.A.4
  • 3
    • 9444274109 scopus 로고    scopus 로고
    • Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons
    • Bailey CP, Kelly E, Henderson G (2004) Protein kinase C activation enhances morphine-induced rapid desensitization of mu-opioid receptors in mature rat locus ceruleus neurons. Mol Pharmacol 66:1592-1598
    • (2004) Mol Pharmacol , vol.66 , pp. 1592-1598
    • Bailey, C.P.1    Kelly, E.2    Henderson, G.3
  • 5
    • 33750525351 scopus 로고    scopus 로고
    • Opioid receptor signaling: Relevance for gastrointestinal therapy
    • Bohn LM, Raehal KM (2006) Opioid receptor signaling: relevance for gastrointestinal therapy. Curr Opin Pharmacol 6:559-563
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 559-563
    • Bohn, L.M.1    Raehal, K.M.2
  • 7
    • 0034619796 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence
    • Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723
    • (2000) Nature , vol.408 , pp. 720-723
    • Bohn, L.M.1    Gainetdinov, R.R.2    Lin, F.T.3    Lefkowitz, R.J.4    Caron, M.G.5
  • 8
    • 0036895747 scopus 로고    scopus 로고
    • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice
    • Bohn LM, Gainetdinov RR, Caron MJ (2002) Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. J Neurosci 22:10494-10500
    • (2002) J Neurosci , vol.22 , pp. 10494-10500
    • Bohn, L.M.1    Gainetdinov, R.R.2    Caron, M.J.3
  • 9
    • 1642371042 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: Psychostimulant and opiate studies in knockout mice
    • Bohn LM, Gainetdinov RR, Caron MJ (2004) G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. Neuromolecular Med 5:41-50
    • (2004) Neuromolecular Med , vol.5 , pp. 41-50
    • Bohn, L.M.1    Gainetdinov, R.R.2    Caron, M.J.3
  • 10
    • 52449133377 scopus 로고    scopus 로고
    • Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2-/-mice
    • Breivogel CS, Lambert JM, Gerfin S, Huffman JW, Razdan RK (2008) Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2-/-mice. Behav Pharmacol 19:298-307
    • (2008) Behav Pharmacol , vol.19 , pp. 298-307
    • Breivogel, C.S.1    Lambert, J.M.2    Gerfin, S.3    Huffman, J.W.4    Razdan, R.K.5
  • 11
    • 34250860086 scopus 로고    scopus 로고
    • Pain management: A fundamental human right
    • Brennan F, Carr DB, Cousins M (2007) Pain management: a fundamental human right. Anesth Analg 105:205-221
    • (2007) Anesth Analg , vol.105 , pp. 205-221
    • Brennan, F.1    Carr, D.B.2    Cousins, M.3
  • 12
    • 84876444777 scopus 로고    scopus 로고
    • Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum
    • doi:10.1371/journal.pone.0048912
    • Bychkov E, Zurkovsky L, Garret MB, Ahmed MR, Gurevich EV (2012) Distinct cellular and subcellular distributions of G protein-coupled receptor kinase and arrestin isoforms in the striatum. PLoS One 7:e48912. doi:10.1371/journal.pone. 0048912
    • (2012) PLoS One , vol.7
    • Bychkov, E.1    Zurkovsky, L.2    Garret, M.B.3    Ahmed, M.R.4    Gurevich, E.V.5
  • 13
    • 0035895932 scopus 로고    scopus 로고
    • Threonine 180 is required for G-protein-coupled receptor kinase 3-and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in xenopus oocytes
    • Celver JP, Lowe J, Kovoor A, Gurevich VV, Chavkin C (2001) Threonine 180 is required for G-protein-coupled receptor kinase 3-and beta-arrestin 2-mediated desensitization of the mu-opioid receptor in xenopus oocytes. J Biol Chem 276:4894-4900
    • (2001) J Biol Chem , vol.276 , pp. 4894-4900
    • Celver, J.P.1    Lowe, J.2    Kovoor, A.3    Gurevich, V.V.4    Chavkin, C.5
  • 14
    • 1342265799 scopus 로고    scopus 로고
    • Distinct domains of the mu-opioid receptor control uncoupling and internalization
    • Celver J, Xu M, Jin W, Lowe J, Chavkin C (2004) Distinct domains of the mu-opioid receptor control uncoupling and internalization. Mol Pharmacol 65:528-537
    • (2004) Mol Pharmacol , vol.65 , pp. 528-537
    • Celver, J.1    Xu, M.2    Jin, W.3    Lowe, J.4    Chavkin, C.5
  • 15
    • 84875469202 scopus 로고    scopus 로고
    • Recent developments in the study of opioid receptors
    • Cox BM (2012) Recent developments in the study of opioid receptors. Mol Pharm 83:723-728
    • (2012) Mol Pharm , vol.83 , pp. 723-728
    • Cox, B.M.1
  • 16
    • 0027939554 scopus 로고
    • Cone arrestin identified by targeting expression of a functional family
    • Craft CM, Whitmore DH, Wiechmann AF (1994) Cone arrestin identified by targeting expression of a functional family. J Biol Chem 269:4613-4619
    • (1994) J Biol Chem , vol.269 , pp. 4613-4619
    • Craft, C.M.1    Whitmore, D.H.2    Wiechmann, A.F.3
  • 17
    • 37349043924 scopus 로고    scopus 로고
    • Rapid CB1 cannabinoid receptor desensitization defined the time course of ERK1/2 MAP kinase signaling
    • Daigle TL, Kearn CS, Mackie K (2008) Rapid CB1 cannabinoid receptor desensitization defined the time course of ERK1/2 MAP kinase signaling. Neuropharmacology 54:36-44
    • (2008) Neuropharmacology , vol.54 , pp. 36-44
    • Daigle, T.L.1    Kearn, C.S.2    Mackie, K.3
  • 18
    • 63849297063 scopus 로고    scopus 로고
    • Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons
    • Dang VC, Napier IA, Christie MJ (2009) Two distinct mechanisms mediate acute μ-opioid receptor desensitization in native neurons. J Neurosci 29:3322-3327
    • (2009) J Neurosci , vol.29 , pp. 3322-3327
    • Dang, V.C.1    Napier, I.A.2    Christie, M.J.3
  • 19
    • 79956302829 scopus 로고    scopus 로고
    • Cellular morphine tolerance produced by βarresitn-2-dependent impairment of μ-opioid receptor resensitization
    • Dang VC, Chieng B, Azriel Y, Christie MJ (2011) Cellular morphine tolerance produced by βarresitn-2-dependent impairment of μ-opioid receptor resensitization. J Neurosci 31:7122-7130
    • (2011) J Neurosci , vol.31 , pp. 7122-7130
    • Dang, V.C.1    Chieng, B.2    Azriel, Y.3    Christie, M.J.4
  • 22
    • 0036894714 scopus 로고    scopus 로고
    • Chronic morphine treatment inhibits opioid receptor desensitization and internalization
    • Eisinger DA, Ammer H, Schulz R (2002) Chronic morphine treatment inhibits opioid receptor desensitization and internalization. J Neurosci 22:10192-10200
    • (2002) J Neurosci , vol.22 , pp. 10192-10200
    • Eisinger, D.A.1    Ammer, H.2    Schulz, R.3
  • 23
    • 8144229133 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain
    • Elmes SJR, Jhaveri MD, Smart D, Kendall DA, Chapman V (2004) Cannabinoid CB2 receptor activation inhibits mechanically evoked responses of wide dynamic range dorsal horn neurons in naïve rats and in rat models of inflammatory and neuropathic pain. Eur J Neurosci 20:2311-2320
    • (2004) Eur J Neurosci , vol.20 , pp. 2311-2320
    • Elmes, S.J.R.1    Jhaveri, M.D.2    Smart, D.3    Kendall, D.A.4    Chapman, V.5
  • 24
    • 3042789578 scopus 로고    scopus 로고
    • State-dependent opioid control of pain
    • Fields H (2004) State-dependent opioid control of pain. Nat Rev Neurosci 5:565-575
    • (2004) Nat Rev Neurosci , vol.5 , pp. 565-575
    • Fields, H.1
  • 27
    • 80052416572 scopus 로고    scopus 로고
    • Agonist-directed interactions with specific beta-arrestins determines mu-opioid receptor trafficking, ubiquitination, and dephosphorylation
    • Groer CE, Schmid CL, Jaeger AM, Bohn LM (2011) Agonist-directed interactions with specific beta-arrestins determines mu-opioid receptor trafficking, ubiquitination, and dephosphorylation. J Biol Chem 286:31731-31741
    • (2011) J Biol Chem , vol.286 , pp. 31731-31741
    • Groer, C.E.1    Schmid, C.L.2    Jaeger, A.M.3    Bohn, L.M.4
  • 28
    • 0034006773 scopus 로고    scopus 로고
    • Arrestin: Mutagenesis, expression, purification, and functional characterization
    • Gurevich VV, Benovic JL (2000) Arrestin: mutagenesis, expression, purification, and functional characterization. Methods Enzymol 315:422-437
    • (2000) Methods Enzymol , vol.315 , pp. 422-437
    • Gurevich, V.V.1    Benovic, J.L.2
  • 29
    • 0041333148 scopus 로고    scopus 로고
    • The new face of active receptor bound arrestin attracts new partners
    • Gurevich VV, Gurevich EV (2003) The new face of active receptor bound arrestin attracts new partners. Structure 11:1037-1042
    • (2003) Structure , vol.11 , pp. 1037-1042
    • Gurevich, V.V.1    Gurevich, E.V.2
  • 30
    • 0037074928 scopus 로고    scopus 로고
    • Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development
    • Gurevich EV, Benovic JL, Gurevich VV (2002) Arrestin2 and arrestin3 are differentially expressed in the rat brain during postnatal development. Neuroscience 109:421-436
    • (2002) Neuroscience , vol.109 , pp. 421-436
    • Gurevich, E.V.1    Benovic, J.L.2    Gurevich, V.V.3
  • 32
    • 23944437411 scopus 로고    scopus 로고
    • Morphine promotes rapid, arrestindependent endocytosis of mu-opioid receptors in striatal neurons
    • Haberstock-Debic H, Kin KA, Yu YJ, von Zastrow (2005) Morphine promotes rapid, arrestindependent endocytosis of mu-opioid receptors in striatal neurons. J Neurosci 25:7847-7857
    • (2005) J Neurosci , vol.25 , pp. 7847-7857
    • Haberstock-Debic, H.1    Kin, K.A.2    Yu, Y.J.3    Von, Zastrow.4
  • 34
    • 1642498189 scopus 로고    scopus 로고
    • Selecitve activation of cannabinoid CB2 receptors suppresses hyperalgeisa evoked by intradermal capsaicin
    • Hohmann AG, Farthing JN, Zvonok AM, Makriyannis A (2004) Selecitve activation of cannabinoid CB2 receptors suppresses hyperalgeisa evoked by intradermal capsaicin. J Pharmacol Exp Ther 308:446-453
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 446-453
    • Hohmann, A.G.1    Farthing, J.N.2    Zvonok, A.M.3    Makriyannis, A.4
  • 38
    • 0031776783 scopus 로고    scopus 로고
    • The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 recpetor agonist palmitoylethanolamine in visceral and somatic inflammatory pain
    • Jaggar SI, Hasnie FS, Sellaturay S, Rice ASC (1998) The anti-hyperalgesic actions of the cannabinoid anandamide and the putative CB2 recpetor agonist palmitoylethanolamine in visceral and somatic inflammatory pain. Pain 76:189-199
    • (1998) Pain , vol.76 , pp. 189-199
    • Jaggar, S.I.1    Hasnie, F.S.2    Sellaturay, S.3    Rice, A.S.C.4
  • 39
    • 33646494493 scopus 로고    scopus 로고
    • Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray
    • Jiang B, Shi Y, Li H, Kang L, Ma L (2006) Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray. Neurosci Lett 400:150-153
    • (2006) Neurosci Lett , vol.400 , pp. 150-153
    • Jiang, B.1    Shi, Y.2    Li, H.3    Kang, L.4    Ma, L.5
  • 41
    • 84857349362 scopus 로고    scopus 로고
    • The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guina pig gastrointestinal tract
    • Kang M, Maguma HT, Smith TH, Ross GR, Dewy WL, Akbarali HI (2012) The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guina pig gastrointestinal tract. J Pharmacol Exp Ther 340:567-576
    • (2012) J Pharmacol Exp Ther , vol.340 , pp. 567-576
    • Kang, M.1    Maguma, H.T.2    Smith, T.H.3    Ross, G.R.4    Dewy, W.L.5    Akbarali, H.I.6
  • 42
    • 0034747415 scopus 로고    scopus 로고
    • Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo
    • Kelly S, Chapman V (2001) Selective cannabinoid CB1 receptor activation inhibits spinal nociceptive transmission in vivo. J Neurophysiol 86:3061-3064
    • (2001) J Neurophysiol , vol.86 , pp. 3061-3064
    • Kelly, S.1    Chapman, V.2
  • 43
    • 0033013383 scopus 로고    scopus 로고
    • Opioids: First lessons from knockout mice
    • Kieffer BL (1999) Opioids: first lessons from knockout mice. Trends Pharmacol Sci 20:19-26
    • (1999) Trends Pharmacol Sci , vol.20 , pp. 19-26
    • Kieffer, B.L.1
  • 44
    • 0036095186 scopus 로고    scopus 로고
    • Exploring the opioid system by gene knockout
    • Kieffer BL, Gaveriaux-Ruff C (2002) Exploring the opioid system by gene knockout. Prog Neurobiol 66:285-306
    • (2002) Prog Neurobiol , vol.66 , pp. 285-306
    • Kieffer, B.L.1    Gaveriaux-Ruff, C.2
  • 45
    • 0942287665 scopus 로고    scopus 로고
    • Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization
    • Koch T, Brandenburg LO, Liang Y, Schulz S, Beyer A, Schröder H, Höllt V (2004) Phospholipase D2 modulates agonist-induced mu-opioid receptor desensitization and resensitization. J Neurochem 88:680-688
    • (2004) J Neurochem , vol.88 , pp. 680-688
    • Koch, T.1    Brandenburg, L.O.2    Liang, Y.3    Schulz, S.4    Beyer, A.5    Schröder, H.6    Höllt, V.7
  • 46
    • 0030736086 scopus 로고    scopus 로고
    • Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arresitn2 in xenopus oocytes
    • Kovoor A, Nappey V, Kieffer BL, Chavkin C (1997) Mu and delta opioid receptors are differentially desensitized by the coexpression of beta-adrenergic receptor kinase 2 and beta-arresitn2 in xenopus oocytes. J Biol Chem 272:27605-27611
    • (1997) J Biol Chem , vol.272 , pp. 27605-27611
    • Kovoor, A.1    Nappey, V.2    Kieffer, B.L.3    Chavkin, C.4
  • 47
    • 0031726194 scopus 로고    scopus 로고
    • Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy
    • Kovoor A, Celver JP, Wu A, Chavkin C (1998) Agonist induced homologous desensitization of mu-opioid receptors mediated by G protein-coupled receptor kinases is dependent on agonist efficacy. Mol Pharmacol 54:704-711
    • (1998) Mol Pharmacol , vol.54 , pp. 704-711
    • Kovoor, A.1    Celver, J.P.2    Wu, A.3    Chavkin, C.4
  • 48
    • 28544440521 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain
    • LaBuda CJ, Koblish M, Little PH (2005) Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain. Eur J Pharmacol 527:172-174
    • (2005) Eur J Pharmacol , vol.527 , pp. 172-174
    • Labuda, C.J.1    Koblish, M.2    Little, P.H.3
  • 49
    • 79953863397 scopus 로고    scopus 로고
    • Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2
    • Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W (2011) Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2. Mol Pain 7:24
    • (2011) Mol Pain , vol.7 , pp. 24
    • Lam, H.1    Maga, M.2    Pradhan, A.3    Evans, C.J.4    Maidment, N.T.5    Hales, T.G.6    Walwyn, W.7
  • 50
    • 84857142520 scopus 로고    scopus 로고
    • Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: New concepts in mu opioid receptor pharmacology
    • Lamb K, Tidgewell K, Simpson DS, Bohn LM, Prisinzano TE (2012) Antinociceptive effects of herkinorin, a MOP receptor agonist derived from salvinorin A in the formalin test in rats: new concepts in mu opioid receptor pharmacology. Drug Alcohol Depend 121:181-188
    • (2012) Drug Alcohol Depend , vol.121 , pp. 181-188
    • Lamb, K.1    Tidgewell, K.2    Simpson, D.S.3    Bohn, L.M.4    Prisinzano, T.E.5
  • 51
    • 84995353254 scopus 로고    scopus 로고
    • Molecular mechanisms and regulation of opioid receptor
    • Law PY, Wong YH, Loh HH (2000) Molecular mechanisms and regulation of opioid receptor. J Biol Chem 277:15729-15735
    • (2000) J Biol Chem , vol.277 , pp. 15729-15735
    • Law, P.Y.1    Wong, Y.H.2    Loh, H.H.3
  • 52
    • 63449097594 scopus 로고    scopus 로고
    • Improvement of morphine-mediated analgesia by inhibition of beta-arrestin 2 expression in mice periaqueductal gray matter
    • Li Y, Liu X, Liu C, Kang J, Yang J, Pei G, Wu C (2009) Improvement of morphine-mediated analgesia by inhibition of beta-arrestin 2 expression in mice periaqueductal gray matter. Int J Mol Sci 10:954-963
    • (2009) Int J Mol Sci , vol.10 , pp. 954-963
    • Li, Y.1    Liu, X.2    Liu, C.3    Kang, J.4    Yang, J.5    Pei, G.6    Wu, C.7
  • 53
    • 0025352299 scopus 로고
    • Beta-arrestin: A protein that regulates beta-adrenergic receptor function
    • Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (1990) Beta-arrestin: a protein that regulates beta-adrenergic receptor function. Science 248:1547-1550
    • (1990) Science , vol.248 , pp. 1547-1550
    • Lohse, M.J.1    Benovic, J.L.2    Codina, J.3    Caron, M.G.4    Lefkowitz, R.J.5
  • 54
    • 0037013307 scopus 로고    scopus 로고
    • Mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin
    • Lowe JD, Celver JP, Gurevich VV, Chavkin C (2002) mu-Opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin. J Biol Chem 277:15729-15735
    • (2002) J Biol Chem , vol.277 , pp. 15729-15735
    • Lowe, J.D.1    Celver, J.P.2    Gurevich, V.V.3    Chavkin, C.4
  • 55
    • 33845958896 scopus 로고    scopus 로고
    • Mu opioid receptor activation of ERK 1/2 is GRK3 and arrestin dependent in striatal neurons
    • Macey TA, Lowe JD, Chavkin C (2006) Mu opioid receptor activation of ERK 1/2 is GRK3 and arrestin dependent in striatal neurons. J Biol Chem 281:34515-34524
    • (2006) J Biol Chem , vol.281 , pp. 34515-34524
    • Macey, T.A.1    Lowe, J.D.2    Chavkin, C.3
  • 57
    • 84858609378 scopus 로고    scopus 로고
    • Novel roles for the E3 ubiquitin ligase atrophininteracting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling
    • Malik R, Soh UJ, Trejo J, Marchese A (2012) Novel roles for the E3 ubiquitin ligase atrophininteracting protein 4 and signal transduction adaptor molecule 1 in G protein-coupled receptor signaling. J Biol Chem 287:9013-9027
    • (2012) J Biol Chem , vol.287 , pp. 9013-9027
    • Malik, R.1    Soh, U.J.2    Trejo, J.3    Marchese, A.4
  • 62
    • 0027332380 scopus 로고
    • X-arrestin: A new retinal arrestin mapping to the X chromosome
    • Murakami A, Yajima T, Sakuma H, McLaren MJ, Inana G (1993) X-arrestin: a new retinal arrestin mapping to the X chromosome. FEBS Lett 334:203-209
    • (1993) FEBS Lett , vol.334 , pp. 203-209
    • Murakami, A.1    Yajima, T.2    Sakuma, H.3    McLaren, M.J.4    Inana, G.5
  • 63
    • 84859099308 scopus 로고    scopus 로고
    • β-arrestin2 regulated cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner
    • Nguyen PT, Schmid CL, Raehal KM, Selley DE, Bohn LM, Sim-Selley LJ (2012) β-arrestin2 regulated cannabinoid CB1 receptor signaling and adaptation in a central nervous system region-dependent manner. Biol Psychiatry 71:714-724
    • (2012) Biol Psychiatry , vol.71 , pp. 714-724
    • Nguyen, P.T.1    Schmid, C.L.2    Raehal, K.M.3    Selley, D.E.4    Bohn, L.M.5    Sim-Selley, L.J.6
  • 64
  • 65
    • 19344375070 scopus 로고    scopus 로고
    • Molecular biology of opioid analgesia
    • Pasternak GW (2013) Molecular biology of opioid analgesia. J Pain Symptom Manage 29:2-9
    • (2013) J Pain Symptom Manage , vol.29 , pp. 2-9
    • Pasternak, G.W.1
  • 66
    • 79251565243 scopus 로고    scopus 로고
    • Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation
    • Patierno S, Anselmi L, Jaramill I, Scott D, Garcia R, Sternini C (2011) Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology 140:618-626
    • (2011) Gastroenterology , vol.140 , pp. 618-626
    • Patierno, S.1    Anselmi, L.2    Jaramill, I.3    Scott, D.4    Garcia, R.5    Sternini, C.6
  • 67
    • 33644804271 scopus 로고    scopus 로고
    • The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids
    • Pertwee RG (2005) The therapeutic potential of drugs that target cannabinoid receptors or modulate the tissue levels or actions of endocannabinoids. AAPS J 7:E625-654
    • (2005) AAPS J , vol.7
    • Pertwee, R.G.1
  • 69
    • 84875194289 scopus 로고    scopus 로고
    • Phosphorylation regulates TRPV1 association with β-arrestin-2
    • Por ED, Gomez R, Akopian AN, Jeske NA (2013) Phosphorylation regulates TRPV1 association with β-arrestin-2. Biochem J 451:101-109
    • (2013) Biochem J , vol.451 , pp. 101-109
    • Por, E.D.1    Gomez, R.2    Akopian, A.N.3    Jeske, N.A.4
  • 70
    • 0037036192 scopus 로고    scopus 로고
    • Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat
    • Przewlocka B, Sieja A, Starowicz K, Maj M, Bilecki W, Przewlocki R (2002) Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat. Neurosci Lett 325:107-110
    • (2002) Neurosci Lett , vol.325 , pp. 107-110
    • Przewlocka, B.1    Sieja, A.2    Starowicz, K.3    Maj, M.4    Bilecki, W.5    Przewlocki, R.6
  • 71
    • 0141814986 scopus 로고    scopus 로고
    • Mu-opioid receptor desensitization: Role of receptor phosphorylation, internalization and representation
    • Qiu Y, Law PY, Loh HH (2003) Mu-opioid receptor desensitization: role of receptor phosphorylation, internalization and representation. J Biol Chem 278:36733-36739
    • (2003) J Biol Chem , vol.278 , pp. 36733-36739
    • Qiu, Y.1    Law, P.Y.2    Loh, H.H.3
  • 72
    • 79953003987 scopus 로고    scopus 로고
    • Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone
    • Quillinan N, Lau EK, Virk M, von Zastrow M, Williams JT (2011) Recovery from μ-opioid receptor desensitization after chronic treatment with morphine and methadone. J Neurosci 31:4434-4443
    • (2011) J Neurosci , vol.31 , pp. 4434-4443
    • Quillinan, N.1    Lau, E.K.2    Virk, M.3    Von Zastrow, M.4    Williams, J.T.5
  • 73
    • 84995303705 scopus 로고    scopus 로고
    • The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
    • Raehal KM, Bohn LM (2011) The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics. Neuropharmacology 63:1001-1019
    • (2011) Neuropharmacology , vol.63 , pp. 1001-1019
    • Raehal, K.M.1    Bohn, L.M.2
  • 74
    • 23944485741 scopus 로고    scopus 로고
    • Morphine side effects in beta-arresitn2 knockout mice
    • Raehal KM, Walker JK, Bohn LM (2005) Morphine side effects in beta-arresitn2 knockout mice. J Pharmacol Exp Ther 314:1195-1201
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 1195-1201
    • Raehal, K.M.1    Walker, J.K.2    Bohn, L.M.3
  • 75
    • 80053588007 scopus 로고    scopus 로고
    • Functional selectivity at the μ-opioid receptor: Implications for understanding opioid analgesia and tolerance
    • Raehal KM, Schmid CL, Groer CE, Bohn LM (2011) Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacol Rev 63 (4):1001-1019
    • (2011) Pharmacol Rev , vol.63 , Issue.4 , pp. 1001-1019
    • Raehal, K.M.1    Schmid, C.L.2    Groer, C.E.3    Bohn, L.M.4
  • 76
    • 35648993556 scopus 로고    scopus 로고
    • Supraspinal modulation of pain by cannabinoids: The role of GABA and glutamate
    • Rea K, Roche M, Finn DP (2007) Supraspinal modulation of pain by cannabinoids: the role of GABA and glutamate. Br J Pharmacol 152:633-648
    • (2007) Br J Pharmacol , vol.152 , pp. 633-648
    • Rea, K.1    Roche, M.2    Finn, D.P.3
  • 77
    • 0032078392 scopus 로고    scopus 로고
    • Mu-opioid receptor-knockout mice: The role of mu-opioid receptor in gastrointestinal transit
    • Roy S, Liu HC, Loh HH (1998) Mu-opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res 56:281-283
    • (1998) Brain Res , vol.56 , pp. 281-283
    • Roy, S.1    Liu, H.C.2    Loh, H.H.3
  • 78
    • 0141568089 scopus 로고    scopus 로고
    • The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins
    • Schmidlin F, Roosterman D, Bunnett NW (2003) The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Am J Physiol Cell Physiol 285:C945-C958
    • (2003) Am J Physiol Cell Physiol , vol.285
    • Schmidlin, F.1    Roosterman, D.2    Bunnett, N.W.3
  • 81
    • 77952643387 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor-interacting proteins: Novel targets for central nervous system drug discovery?
    • Smith TH, Sim-Selley LJ, Selley DE (2010) Cannabinoid CB1 receptor-interacting proteins: novel targets for central nervous system drug discovery? Br J Pharmacol 160):454-66.
    • (2010) Br J Pharmacol , vol.160 , pp. 454-466
    • Smith, T.H.1    Sim-Selley, L.J.2    Selley, D.E.3
  • 82
    • 0037966402 scopus 로고    scopus 로고
    • Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of CB2 receptors in anaesthetized rats
    • Sokal DM, Elmes SJR, Kendall DA, Chapman V (2003) Intraplantar injection of anandamide inhibits mechanically-evoked responses of spinal neurons via activation of CB2 receptors in anaesthetized rats. Neuropharmacol 45:404-411
    • (2003) Neuropharmacol , vol.45 , pp. 404-411
    • Sokal, D.M.1    Elmes, S.J.R.2    Kendall, D.A.3    Chapman, V.4
  • 84
    • 31844433721 scopus 로고    scopus 로고
    • Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia
    • Suplita RL 2nd, Gutierrez T, Fegley D, Piomelli D, Hohmann AG (2006) Endocannabinoids at the spinal level regulate, but do not mediate, nonopioid stress-induced analgesia. Neuropharmacol 50:372-379
    • (2006) Neuropharmacol , vol.50 , pp. 372-379
    • Suplita II, R.L.1    Gutierrez, T.2    Fegley, D.3    Piomelli, D.4    Hohmann, A.G.5
  • 85
    • 48749103773 scopus 로고    scopus 로고
    • Cannabinoid receptor 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review
    • SvÍzenská I, Dubový P, Sulcová A (2008) Cannabinoid receptor 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures-a short review. Pharmacol Biochem Behav 90:501-511
    • (2008) Pharmacol Biochem Behav , vol.90 , pp. 501-511
    • Svízenská, I.1    Dubový, P.2    Sulcová, A.3
  • 87
    • 34248382512 scopus 로고    scopus 로고
    • Beat-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
    • Walwyn W, Evans CJ, Hales TG (2007) Beat-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons. J Neurosci 27:5092-5104
    • (2007) J Neurosci , vol.27 , pp. 5092-5104
    • Walwyn, W.1    Evans, C.J.2    Hales, T.G.3
  • 88
    • 0032544061 scopus 로고    scopus 로고
    • Morphine-activated opioid receptor eludes desensitization by beta-arrestin
    • Whistler JL, von Zastrow M (1998) Morphine-activated opioid receptor eludes desensitization by beta-arrestin. Proc Natl Acad Sci USA 95:9914-9919
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9914-9919
    • Whistler, J.L.1    Von Zastrow, M.2
  • 89
    • 0033179904 scopus 로고    scopus 로고
    • Functional dissociation of mu opioid receptor signaling and endocytosis: Implications for the biology of opiate tolerance and addiction
    • Whistler JL, Chuang HH, Chu P, Jan LY, von Zastrow M (1999) Functional dissociation of mu opioid receptor signaling and endocytosis: implications for the biology of opiate tolerance and addiction. Neuron 23:737-746
    • (1999) Neuron , vol.23 , pp. 737-746
    • Whistler, J.L.1    Chuang, H.H.2    Chu, P.3    Jan, L.Y.4    Von Zastrow, M.5
  • 92
    • 80054114499 scopus 로고    scopus 로고
    • Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats
    • Yang CH, Huang HW, Chen KH, Chen YS, Sheen-Chen SM, Lin CR (2011) Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats. Br J Anaesth 107:774-781
    • (2011) Br J Anaesth , vol.107 , pp. 774-781
    • Yang, C.H.1    Huang, H.W.2    Chen, K.H.3    Chen, Y.S.4    Sheen-Chen, S.M.5    Lin, C.R.6
  • 94
    • 59049089275 scopus 로고    scopus 로고
    • Src phosphorylation of μ-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal
    • Zhang L, Zhao H, Qui Y, Loh HH, Law PY (2008) Src phosphorylation of μ-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal. J Biol Chem 284:1990-2000
    • (2008) J Biol Chem , vol.284 , pp. 1990-2000
    • Zhang, L.1    Zhao, H.2    Qui, Y.3    Loh, H.H.4    Law, P.Y.5
  • 95
    • 0033545866 scopus 로고    scopus 로고
    • Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice
    • Zimmer A, Zimmer AM, Hohmann AG, Herkenhan M, Bonner TI (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci USA 96:5780-5785
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5780-5785
    • Zimmer, A.1    Zimmer, A.M.2    Hohmann, A.G.3    Herkenhan, M.4    Bonner, T.I.5


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