β-Arrestin2 regulates cannabinoid CB 1 receptor signaling and adaptation in a central nervous system region-dependent manner

Biological Psychiatry

Volumn 71, Issue 8, 2012, Pages 714-724

  Nguyen, Peter T ^a   Schmid, Cullen L ^b   Raehal, Kirsten M ^b   Selley, Dana E ^a   Bohn, Laura M ^b   Sim Selley, Laura J ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Beta arrestin; cannabinoid receptors; GPCR; statistical parametric mapping; tolerance

Indexed keywords

BETA ARRESTIN 2; CANNABINOID 1 RECEPTOR; CANNABIS; DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; AUTORADIOGRAPHY; BRAIN CORTEX; BRAIN MAPPING; BRAIN REGION; CATALEPSY; CENTRAL NERVOUS SYSTEM; CEREBELLUM; CONTROLLED STUDY; DRUG DEPENDENCE; DRUG TOLERANCE; GLOBUS PALLIDUS; HYPOTHALAMUS; HYPOTHERMIA; INTERNALIZATION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; RECEPTOR DOWN REGULATION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPINAL CORD; SUBSTANTIA NIGRA; WILD TYPE;

ANIMALS; ARRESTINS; AUTORADIOGRAPHY; CATALEPSY; CENTRAL NERVOUS SYSTEM; DOWN-REGULATION; DRUG TOLERANCE; G-PROTEIN-COUPLED RECEPTOR KINASES; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HYPOTHERMIA; MICE; MICE, KNOCKOUT; NOCICEPTION; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION; SULFUR RADIOISOTOPES; TETRAHYDROCANNABINOL;

EID: 84859099308     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2011.11.027     Document Type: Article

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