The role of β-arrestin2 in the mechanism of morphine tolerance in the mouse and guinea pig gastrointestinal tract

Journal of Pharmacology and Experimental Therapeutics

Volumn 340, Issue 3, 2012, Pages 567-576

  Kang, Minho ^a   Maguma, Hercules T ^a   Smith, Tricia H ^a   Ross, Gracious R ^a   Dewey, William L ^a   Akbarali, Hamid I ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 2; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GASTROINTESTINAL TRACT; GUINEA PIG; IN VITRO STUDY; IN VIVO STUDY; KNOCKOUT MOUSE; MALE; MORPHINE TOLERANCE; MOUSE; MUSCLE CONTRACTION; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WESTERN BLOTTING;

ANALGESICS, OPIOID; ANIMALS; ARRESTINS; DRUG TOLERANCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GASTROINTESTINAL TRACT; GUINEA PIGS; MALE; MICE; MICE, KNOCKOUT; MORPHINE; MYENTERIC PLEXUS;

EID: 84857349362     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.186320     Document Type: Article

References (32)

1. Bailey CP, Smith FL, Kelly E, Dewey WL, and Henderson G (2006) How important is protein kinase C in mu-opioid receptor desensitization and morphine tolerance? Trends Pharmacol Sci 27:558-565. (Pubitemid 44572396)
2. Bohn LM, Gainetdinov RR, Lin FT, Lefkowitz RJ, and Caron MG (2000) Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence. Nature 408:720-723. (Pubitemid 32015987)
3. Bohn LM, Lefkowitz RJ, Gainetdinov RR, Peppel K, Caron MG, and Lin FT (1999) Enhanced morphine analgesia in mice lacking beta-arrestin 2. Science 286:2495-2498.
4. Collier HO, Cuthbert NJ, and Francis DL (1981) Model of opiate dependence in the guinea-pig isolated ileum. Br J Pharmacol 73:921-932. (Pubitemid 11033779)
5. Connor M, Osborne PB, and Christie MJ (2004) Mu-opioid receptor desensitization: is morphine different? Br J Pharmacol 143:685-696. (Pubitemid 39611604)
6. DeWire SM, Ahn S, Lefkowitz RJ, and Shenoy SK (2007) Beta-arrestins and cell signaling. Annu Rev Physiol 69:483-510.
7. Droney J, Ross J, Gretton S, Welsh K, Sato H, and Riley J (2008) Constipation in cancer patients on morphine. Support Care Cancer 16:453-459.
8. Furukawa K, Taylor GS, and Bywater RA (1986) An intracellular study of myenteric neurons in the mouse colon. J Neurophysiol 55:1395-1406. (Pubitemid 16068474)
9. Goldstein A and Schulz R (1973) Morphine-tolerant longitudinal muscle strip from guinea-pig ileum. Br J Pharmacol 48:655-666.
10. Grider JR and Makhlouf GM (1987a) Role of opioid neurons in the regulation of intestinal peristalsis. Am J Physiol 253:G226-G231.
11. Grider JR and Makhlouf GM (1987b) Suppression of inhibitory neural input to colonic circular muscle by opioid peptides. J Pharmacol Exp Ther 243:205-210. (Pubitemid 17162719)
12. Grond S, Zech D, Diefenbach C, and Bischoff A (1994) Prevalence and pattern of symptoms in patients with cancer pain: a prospective evaluation of 1635 cancer patients referred to a pain clinic. J Pain Symptom Manage 9:372-382. (Pubitemid 24278155)
13. Holzer P, Ahmedzai SH, Niederle N, Leyendecker P, Hopp M, Bosse B, Spohr I, and Reimer K (2009) Opioid-induced bowel dysfunction in cancer-related pain: causes, consequences, and a novel approach for its management. J Opioid Manag 5:145-151.
14. Kang M, Morsy N, Jin X, Lupu F, and Akbarali HI (2004) Protein and gene expression of Ca2+ channel isoforms in murine colon: effect of inflammation. Pflugers Arch 449:288-297. (Pubitemid 40064620)
15. Kurz A and Sessler DI (2003) Opioid-induced bowel dysfunction: pathophysiology and potential new therapies. Drugs 63:649-671. (Pubitemid 36408072)
16. Li P, Maguma HT, Thayne K, Davis B, and Taylor DA (2010) Correlation of the time course of development and decay of tolerance to morphine with alterations in sodium pump protein isoform abundance. Biochem Pharmacol 79:1015-1024.
17. Moore RA and McQuay HJ (2005) Prevalence of opioid adverse events in chronic non-malignant pain: systematic review of randomised trials of oral opioids. Arthritis Res Ther 7:R1046-R1051.
18. Muller DL and Unterwald EM (2004) In vivo regulation of extracellular signalregulated protein kinase (ERK) and protein kinase B (Akt) phosphorylation by acute and chronic morphine. J Pharmacol Exp Ther 310:774-782. (Pubitemid 38988924)
19. Pappagallo M (2001) Incidence, prevalence, and management of opioid bowel dysfunction. Am J Surg 182 (5A Suppl):11S-18S.
20. Patierno S, Anselmi L, Jaramillo I, Scott D, Garcia R, and Sternini C (2011) Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation. Gastroenterology 140:618-626.
21. Paton WD (1957) The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemother 12:119-127.
22. Raehal KM, Schmid CL, Groer CE, and Bohn LM (2011) Functional selectivity at the μ-opioid receptor: implications for understanding opioid analgesia and tolerance. Pharmacol Rev 63:1001-1019.
23. Raehal KM, Walker JK, and Bohn LM (2005) Morphine side effects in beta-arrestin 2 knockout mice. J Pharmacol Exp Ther 314:1195-1201. (Pubitemid 41205984)
24. Rezvani A, Huidobro-Toro JP, Hu J, and Way EL (1983) A rapid and simple method for the quantitative determination of tolerance development to opiates in the guinea-pig ileum in vitro. J Pharmacol Exp Ther 225:251-255. (Pubitemid 13091209)
25. Ross GR, Gabra BH, Dewey WL, and Akbarali HI (2008) Morphine tolerance in the mouse ileum and colon. J Pharmacol Exp Ther 327:561-572.
26. Roy S, Liu HC, and Loh HH (1998) mu-Opioid receptor-knockout mice: the role of mu-opioid receptor in gastrointestinal transit. Brain Res Mol Brain Res 56:281-283. (Pubitemid 28271686)
27. Shenoy SK, McDonald PH, Kohout TA, and Lefkowitz RJ (2001) Regulation of receptor fate by ubiquitination of activated beta 2-adrenergic receptor and betaarrestin. Science 294:1307-1313. (Pubitemid 33063090)
28. Shenoy SK, Modi AS, Shukla AK, Xiao K, Berthouze M, Ahn S, Wilkinson KD, Miller WE, and Lefkowitz RJ (2009) Beta-arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2. Proc Natl Acad Sci USA 106: 6650-6655.
29. Smith FL, Gabra BH, Smith PA, Redwood MC, and Dewey WL (2007) Determination of the role of conventional, novel and atypical PKC isoforms in the expression of morphine tolerance in mice. Pain 127:129-139. (Pubitemid 44959434)
30. Sternini C, Patierno S, Selmer IS, and Kirchgessner A (2004) The opioid system in the gastrointestinal tract. Neurogastroenterol Motil 16 (Suppl 2):3-16. (Pubitemid 39468862)
31. Taylor DA and Fleming WW (2001) Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids. J Pharmacol Exp Ther 297:11-18. (Pubitemid 32242558)
32. Tuteja AK, Biskupiak J, Stoddard GJ, and Lipman AG (2010) Opioid-induced bowel disorders and narcotic bowel syndrome in patients with chronic non-cancer pain. Neurogastroenterol Motil 22:424-430, e96.