메뉴 건너뛰기




Volumn 360, Issue 3, 2015, Pages 723-748

Hereditary barrier-related diseases involving the tight junction: lessons from skin and intestine

Author keywords

Atopic dermatitis; Claudins; Crohn s disease; JAMs; NISCH syndrome; Occludin; Tight junctions

Indexed keywords

CALCIUM; CLAUDIN; CLAUDIN 1; CLAUDIN 12; CLAUDIN 14; CLAUDIN 15; CLAUDIN 18; CLAUDIN 2; CLAUDIN 3; CLAUDIN 4; CLAUDIN 5; CLAUDIN 7; CLAUDIN 8; JUNCTIONAL ADHESION MOLECULE; PROTEIN ZO1; TIGHT JUNCTION PROTEIN; UNCLASSIFIED DRUG;

EID: 84930277386     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-014-2096-1     Document Type: Review
Times cited : (23)

References (198)
  • 1
    • 84867897084 scopus 로고    scopus 로고
    • Activation of TRPV4 strengthens the tight-junction barrier in human epidermal keratinocytes
    • Akazawa Y1, Yuki T, Yoshida H, Sugiyama Y, Inoue S (2013) Activation of TRPV4 strengthens the tight-junction barrier in human epidermal keratinocytes. Skin Pharmacol Physiol 26:15–21
    • (2013) Skin Pharmacol Physiol , vol.26 , pp. 15-21
    • Akazawa, Y.1    Yuki, T.2    Yoshida, H.3    Sugiyama, Y.4    Inoue, S.5
  • 3
    • 79955671365 scopus 로고    scopus 로고
    • Cellular and molecular mechanism of interleukin-1beta modulation of Caco-2 intestinal epithelial tight junction barrier
    • COI: 1:CAS:528:DC%2BC3MXmslWlsLo%3D, PID: 20406328
    • Al-Sadi R, Ye D, Said HM, Ma TY (2011) Cellular and molecular mechanism of interleukin-1beta modulation of Caco-2 intestinal epithelial tight junction barrier. J Cell Mol Med 15:970–982
    • (2011) J Cell Mol Med , vol.15 , pp. 970-982
    • Al-Sadi, R.1    Ye, D.2    Said, H.M.3    Ma, T.Y.4
  • 4
    • 84899722895 scopus 로고    scopus 로고
    • Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene
    • PID: 24662742
    • Al-Sadi R, Ye D, Boivin M, Guo S, Hashimi M, Ereifej L, Ma TY (2014) Interleukin-6 modulation of intestinal epithelial tight junction permeability is mediated by JNK pathway activation of claudin-2 gene. PLoS ONE 9:e85345
    • (2014) PLoS ONE , vol.9 , pp. e85345
    • Al-Sadi, R.1    Ye, D.2    Boivin, M.3    Guo, S.4    Hashimi, M.5    Ereifej, L.6    Ma, T.Y.7
  • 5
    • 0037115724 scopus 로고    scopus 로고
    • Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
    • COI: 1:CAS:528:DC%2BD3sXis1Ojsw%3D%3D, PID: 12432083
    • Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, Fromm M (2002) Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 115:4969–4976
    • (2002) J Cell Sci , vol.115 , pp. 4969-4976
    • Amasheh, S.1    Meiri, N.2    Gitter, A.H.3    Schoneberg, T.4    Mankertz, J.5    Schulzke, J.D.6    Fromm, M.7
  • 8
    • 34547921509 scopus 로고    scopus 로고
    • Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2
    • COI: 1:CAS:528:DC%2BD2sXpt1CjtLk%3D, PID: 17516019
    • Angelow S, Schneeberger EE, Yu AS (2007) Claudin-8 expression in renal epithelial cells augments the paracellular barrier by replacing endogenous claudin-2. J Membr Biol 215:147–159
    • (2007) J Membr Biol , vol.215 , pp. 147-159
    • Angelow, S.1    Schneeberger, E.E.2    Yu, A.S.3
  • 9
    • 54149114711 scopus 로고    scopus 로고
    • Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line
    • COI: 1:CAS:528:DC%2BD1cXht12kurbO, PID: 18786529
    • Aono S, Hirai Y (2008) Phosphorylation of claudin-4 is required for tight junction formation in a human keratinocyte cell line. Exp Cell Res 314:3326–3339
    • (2008) Exp Cell Res , vol.314 , pp. 3326-3339
    • Aono, S.1    Hirai, Y.2
  • 10
    • 33746483878 scopus 로고    scopus 로고
    • Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo
    • COI: 1:CAS:528:DC%2BD28Xns1Cns7c%3D, PID: 16847338
    • Arabzadeh A, Troy TC, Turksen K (2006) Role of the Cldn6 cytoplasmic tail domain in membrane targeting and epidermal differentiation in vivo. Mol Cell Biol 26:5876–5887
    • (2006) Mol Cell Biol , vol.26 , pp. 5876-5887
    • Arabzadeh, A.1    Troy, T.C.2    Turksen, K.3
  • 11
    • 84873249337 scopus 로고    scopus 로고
    • Acute modulations in stratum corneum permeability barrier function affect claudin expression and epidermal tight junction function via changes of epidermal calcium gradient
    • COI: 1:CAS:528:DC%2BC3sXktVGls7s%3D, PID: 23364991
    • Baek JH, Lee SE, Choi KJ, Choi EH, Lee SH (2013) Acute modulations in stratum corneum permeability barrier function affect claudin expression and epidermal tight junction function via changes of epidermal calcium gradient. Yonsei Med J 54:523–528
    • (2013) Yonsei Med J , vol.54 , pp. 523-528
    • Baek, J.H.1    Lee, S.E.2    Choi, K.J.3    Choi, E.H.4    Lee, S.H.5
  • 12
    • 84859884308 scopus 로고    scopus 로고
    • Calcium in epidermis
    • COI: 1:CAS:528:DC%2BC38Xhtlentr%2FN, PID: 22453978
    • Behne MJ, Jensen JM (2012) Calcium in epidermis. Adv Exp Med Biol 740:945–953
    • (2012) Adv Exp Med Biol , vol.740 , pp. 945-953
    • Behne, M.J.1    Jensen, J.M.2
  • 14
    • 84866370562 scopus 로고    scopus 로고
    • Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation
    • COI: 1:CAS:528:DC%2BC38XntlyqsbY%3D, PID: 22622420
    • Bergboer JG, Zeeuwen PL, Schalkwijk J (2012) Genetics of psoriasis: evidence for epistatic interaction between skin barrier abnormalities and immune deviation. J Invest Dermatol 132:2320–2331
    • (2012) J Invest Dermatol , vol.132 , pp. 2320-2331
    • Bergboer, J.G.1    Zeeuwen, P.L.2    Schalkwijk, J.3
  • 19
    • 67349276621 scopus 로고    scopus 로고
    • Tight junctions and tight junction proteins in mammalian epidermis
    • COI: 1:CAS:528:DC%2BD1MXmtVOjt7k%3D, PID: 18775491
    • Brandner JM (2009) Tight junctions and tight junction proteins in mammalian epidermis. Eur J Pharm Biopharm 72:289–294
    • (2009) Eur J Pharm Biopharm , vol.72 , pp. 289-294
    • Brandner, J.M.1
  • 20
    • 0036014853 scopus 로고    scopus 로고
    • Organization and formation of the tight junction system in human epidermis and cultured keratinocytes
    • COI: 1:CAS:528:DC%2BD38Xlt1Kitrg%3D, PID: 12067061
    • Brandner JM, Kief S, Grund C, Rendl M, Houdek P, Kuhn C, Tschachler E, Franke WW, Moll I (2002) Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol 81:253–263
    • (2002) Eur J Cell Biol , vol.81 , pp. 253-263
    • Brandner, J.M.1    Kief, S.2    Grund, C.3    Rendl, M.4    Houdek, P.5    Kuhn, C.6    Tschachler, E.7    Franke, W.W.8    Moll, I.9
  • 21
    • 0141863221 scopus 로고    scopus 로고
    • Expression and localization of tight junction-associated proteins in human hair follicles
    • COI: 1:CAS:528:DC%2BD3sXntVGisLY%3D, PID: 12898148
    • Brandner JM, McIntyre M, Kief S, Wladykowski E, Moll I (2003) Expression and localization of tight junction-associated proteins in human hair follicles. Arch Dermatol Res 295:211–221
    • (2003) Arch Dermatol Res , vol.295 , pp. 211-221
    • Brandner, J.M.1    McIntyre, M.2    Kief, S.3    Wladykowski, E.4    Moll, I.5
  • 23
    • 20444481707 scopus 로고    scopus 로고
    • Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process
    • COI: 1:CAS:528:DC%2BD2MXkvVCrtLk%3D, PID: 15923402
    • Bruewer M, Utech M, Ivanov AI, Hopkins AM, Parkos CA, Nusrat A (2005) Interferon-gamma induces internalization of epithelial tight junction proteins via a macropinocytosis-like process. FASEB J 19:923–933
    • (2005) FASEB J , vol.19 , pp. 923-933
    • Bruewer, M.1    Utech, M.2    Ivanov, A.I.3    Hopkins, A.M.4    Parkos, C.A.5    Nusrat, A.6
  • 24
    • 33144473772 scopus 로고    scopus 로고
    • Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation?
    • COI: 1:CAS:528:DC%2BD28Xis1Sjsbw%3D, PID: 16000642
    • Buhner S, Buning C, Genschel J, Kling K, Herrmann D, Dignass A, Kuechler I, Krueger S, Schmidt HH, Lochs H (2006) Genetic basis for increased intestinal permeability in families with Crohn’s disease: role of CARD15 3020insC mutation? Gut 55:342–347
    • (2006) Gut , vol.55 , pp. 342-347
    • Buhner, S.1    Buning, C.2    Genschel, J.3    Kling, K.4    Herrmann, D.5    Dignass, A.6    Kuechler, I.7    Krueger, S.8    Schmidt, H.H.9    Lochs, H.10
  • 31
    • 0346993780 scopus 로고    scopus 로고
    • Impaired trafficking of the desmoplakins in cultured Darier’s disease keratinocytes
    • COI: 1:CAS:528:DC%2BD2cXhtValtA%3D%3D, PID: 14675181
    • Dhitavat J, Cobbold C, Leslie N, Burge S, Hovnanian A (2003) Impaired trafficking of the desmoplakins in cultured Darier’s disease keratinocytes. J Invest Dermatol 121:1349–1355
    • (2003) J Invest Dermatol , vol.121 , pp. 1349-1355
    • Dhitavat, J.1    Cobbold, C.2    Leslie, N.3    Burge, S.4    Hovnanian, A.5
  • 32
    • 3042823935 scopus 로고    scopus 로고
    • Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease
    • COI: 1:CAS:528:DC%2BD2cXlt1Kgur0%3D, PID: 15149492
    • Dhitavat J, Fairclough RJ, Hovnanian A, Burge SM (2004) Calcium pumps and keratinocytes: lessons from Darier’s disease and Hailey-Hailey disease. Br J Dermatol 150:821–828
    • (2004) Br J Dermatol , vol.150 , pp. 821-828
    • Dhitavat, J.1    Fairclough, R.J.2    Hovnanian, A.3    Burge, S.M.4
  • 34
    • 0030838044 scopus 로고    scopus 로고
    • Identification of tissue transglutaminase as the autoantigen of celiac disease
    • COI: 1:CAS:528:DyaK2sXkt1Kqtrc%3D, PID: 9212111
    • Dieterich W, Ehnis T, Bauer M, Donner P, Volta U, Riecken EO, Schuppan D (1997) Identification of tissue transglutaminase as the autoantigen of celiac disease. Nat Med 3:797–801
    • (1997) Nat Med , vol.3 , pp. 797-801
    • Dieterich, W.1    Ehnis, T.2    Bauer, M.3    Donner, P.4    Volta, U.5    Riecken, E.O.6    Schuppan, D.7
  • 36
    • 84856210973 scopus 로고    scopus 로고
    • Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice
    • COI: 1:CAS:528:DC%2BC38XhsVOmu7g%3D, PID: 22044670
    • Ding L, Lu Z, Foreman O, Tatum R, Lu Q, Renegar R, Cao J, Chen YH (2012) Inflammation and disruption of the mucosal architecture in claudin-7-deficient mice. Gastroenterology 142:305–315
    • (2012) Gastroenterology , vol.142 , pp. 305-315
    • Ding, L.1    Lu, Z.2    Foreman, O.3    Tatum, R.4    Lu, Q.5    Renegar, R.6    Cao, J.7    Chen, Y.H.8
  • 37
    • 0031253623 scopus 로고    scopus 로고
    • Responses to self and non-self intestinal microflora in health and inflammatory bowel disease
    • COI: 1:STN:280:DyaK1c3kvVamsQ%3D%3D, PID: 9588839
    • Duchmann R, Neurath MF, Meyer zum Buschenfelde KH (1997) Responses to self and non-self intestinal microflora in health and inflammatory bowel disease. Res Immunol 148:589–594
    • (1997) Res Immunol , vol.148 , pp. 589-594
    • Duchmann, R.1    Neurath, M.F.2    Meyer zum Buschenfelde, K.H.3
  • 38
    • 0346025727 scopus 로고    scopus 로고
    • Junctional adhesion molecules (JAMs): more molecules with dual functions?
    • COI: 1:CAS:528:DC%2BD2cXks1Cks7s%3D, PID: 14657270
    • Ebnet K, Suzuki A, Ohno S, Vestweber D (2004) Junctional adhesion molecules (JAMs): more molecules with dual functions? J Cell Sci 117:19–29
    • (2004) J Cell Sci , vol.117 , pp. 19-29
    • Ebnet, K.1    Suzuki, A.2    Ohno, S.3    Vestweber, D.4
  • 39
    • 14744270867 scopus 로고    scopus 로고
    • Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells
    • COI: 1:CAS:528:DC%2BD2MXit1SqtLo%3D, PID: 15389642
    • Escaffit F, Boudreau F, Beaulieu JF (2005) Differential expression of claudin-2 along the human intestine: Implication of GATA-4 in the maintenance of claudin-2 in differentiating cells. J Cell Physiol 203:15–26
    • (2005) J Cell Physiol , vol.203 , pp. 15-26
    • Escaffit, F.1    Boudreau, F.2    Beaulieu, J.F.3
  • 42
    • 84871356016 scopus 로고    scopus 로고
    • Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis
    • COI: 1:CAS:528:DC%2BC3sXlsVOjsQ%3D%3D, PID: 23284964
    • Fujita H, Hamazaki Y, Noda Y, Oshima M, Minato N (2012) Claudin-4 deficiency results in urothelial hyperplasia and lethal hydronephrosis. PLoS ONE 7:e52272
    • (2012) PLoS ONE , vol.7 , pp. e52272
    • Fujita, H.1    Hamazaki, Y.2    Noda, Y.3    Oshima, M.4    Minato, N.5
  • 43
    • 0027744129 scopus 로고
    • Occludin: a novel integral membrane protein localizing at tight junctions
    • COI: 1:CAS:528:DyaK2cXisFynsQ%3D%3D, PID: 8276896
    • Furuse M, Hirase T, Itoh M, Nagafuchi A, Yonemura S, Tsukita S (1993) Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 123:1777–1788
    • (1993) J Cell Biol , vol.123 , pp. 1777-1788
    • Furuse, M.1    Hirase, T.2    Itoh, M.3    Nagafuchi, A.4    Yonemura, S.5    Tsukita, S.6
  • 44
    • 0032577975 scopus 로고    scopus 로고
    • Claudin-1 and -2: Novel integral membrane proteins localizing at Tight Junctions with no sequence similarity to occludin
    • Furuse M, Fujita K, Hiiragi T, Fujimoto K, Tsukita S (1998) Claudin-1 and -2: Novel integral membrane proteins localizing at Tight Junctions with no sequence similarity to occludin. J Cell Biol 141:1539–1550
    • (1998) J Cell Biol , vol.141 , pp. 1539-1550
    • Furuse, M.1    Fujita, K.2    Hiiragi, T.3    Fujimoto, K.4    Tsukita, S.5
  • 45
    • 0033571047 scopus 로고    scopus 로고
    • Manner of interaction of heterogeneous claudin species within and between tight junction strands
    • COI: 1:CAS:528:DyaK1MXnsFSqtbo%3D, PID: 10562289
    • Furuse M, Sasaki H, Tsukita S (1999) Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 147:891–903
    • (1999) J Cell Biol , vol.147 , pp. 891-903
    • Furuse, M.1    Sasaki, H.2    Tsukita, S.3
  • 46
    • 0035897412 scopus 로고    scopus 로고
    • Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby Canine Kidney I cells
    • COI: 1:CAS:528:DC%2BD3MXivFOiuro%3D, PID: 11309408
    • Furuse M, Furuse K, Sasaki H, Tsukita S (2001) Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby Canine Kidney I cells. J Cell Biol 153:263–272
    • (2001) J Cell Biol , vol.153 , pp. 263-272
    • Furuse, M.1    Furuse, K.2    Sasaki, H.3    Tsukita, S.4
  • 47
    • 0037128938 scopus 로고    scopus 로고
    • Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
    • COI: 1:CAS:528:DC%2BD38Xit1KisLo%3D, PID: 11889141
    • Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S (2002) Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 156:1099–1111
    • (2002) J Cell Biol , vol.156 , pp. 1099-1111
    • Furuse, M.1    Hata, M.2    Furuse, K.3    Yoshida, Y.4    Haratake, A.5    Sugitani, Y.6    Noda, T.7    Kubo, A.8    Tsukita, S.9
  • 48
    • 34047189274 scopus 로고    scopus 로고
    • Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation
    • COI: 1:CAS:528:DC%2BD2sXjs12jsrw%3D, PID: 17351639
    • Gareus R, Huth M, Breiden B, Nenci A, Rosch N, Haase I, Bloch W, Sandhoff K, Pasparakis M (2007) Normal epidermal differentiation but impaired skin-barrier formation upon keratinocyte-restricted IKK1 ablation. Nat Cell Biol 9:461–469
    • (2007) Nat Cell Biol , vol.9 , pp. 461-469
    • Gareus, R.1    Huth, M.2    Breiden, B.3    Nenci, A.4    Rosch, N.5    Haase, I.6    Bloch, W.7    Sandhoff, K.8    Pasparakis, M.9
  • 49
    • 0035210487 scopus 로고    scopus 로고
    • Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging
    • COI: 1:STN:280:DC%2BD3Mnot1OisQ%3D%3D, PID: 11729111
    • Gitter AH, Wullstein F, Fromm M, Schulzke JD (2001) Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging. Gastroenterology 121:1320–1328
    • (2001) Gastroenterology , vol.121 , pp. 1320-1328
    • Gitter, A.H.1    Wullstein, F.2    Fromm, M.3    Schulzke, J.D.4
  • 51
    • 84870615198 scopus 로고    scopus 로고
    • Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model
    • COI: 1:CAS:528:DC%2BC3sXisF2ltrk%3D, PID: 23157658
    • Gschwandtner M, Mildner M, Mlitz V, Gruber F, Eckhart L, Werfel T, Gutzmer R, Elias PM, Tschachler E (2013) Histamine suppresses epidermal keratinocyte differentiation and impairs skin barrier function in a human skin model. Allergy 68:37–47
    • (2013) Allergy , vol.68 , pp. 37-47
    • Gschwandtner, M.1    Mildner, M.2    Mlitz, V.3    Gruber, F.4    Eckhart, L.5    Werfel, T.6    Gutzmer, R.7    Elias, P.M.8    Tschachler, E.9
  • 52
    • 39849103311 scopus 로고    scopus 로고
    • The cytoplasmic plaque of tight junctions: a scaffolding and signalling center
    • COI: 1:CAS:528:DC%2BD1cXjtVSqt78%3D, PID: 18339298
    • Guillemot L, Paschoud S, Pulimeno P, Foglia A, Citi S (2008) The cytoplasmic plaque of tight junctions: a scaffolding and signalling center. Biochim Biophys Acta 1778:601–613
    • (2008) Biochim Biophys Acta , vol.1778 , pp. 601-613
    • Guillemot, L.1    Paschoud, S.2    Pulimeno, P.3    Foglia, A.4    Citi, S.5
  • 53
    • 84861966218 scopus 로고    scopus 로고
    • Claudins and other tight junction proteins
    • PID: 23723025
    • Günzel D, Fromm M (2012) Claudins and other tight junction proteins. Compr Physiol 2:1819–1852
    • (2012) Compr Physiol , vol.2 , pp. 1819-1852
    • Günzel, D.1    Fromm, M.2
  • 54
    • 84878506887 scopus 로고    scopus 로고
    • Claudins and the modulation of tight junction permeability
    • PID: 23589827
    • Gunzel D, Yu AS (2013) Claudins and the modulation of tight junction permeability. Physiol Rev 93:525–569
    • (2013) Physiol Rev , vol.93 , pp. 525-569
    • Gunzel, D.1    Yu, A.S.2
  • 56
    • 84855695526 scopus 로고    scopus 로고
    • IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion
    • COI: 1:CAS:528:DC%2BC38Xjt1Wksb0%3D, PID: 22229441
    • Gutowska-Owsiak D, Schaupp AL, Salimi M, Selvakumar TA, McPherson T, Taylor S, Ogg GS (2012) IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion. Exp Dermatol 21:104–110
    • (2012) Exp Dermatol , vol.21 , pp. 104-110
    • Gutowska-Owsiak, D.1    Schaupp, A.L.2    Salimi, M.3    Selvakumar, T.A.4    McPherson, T.5    Taylor, S.6    Ogg, G.S.7
  • 57
    • 63249098521 scopus 로고    scopus 로고
    • Tight junctions as targets of infectious agents
    • COI: 1:CAS:528:DC%2BD1MXktFahurw%3D, PID: 19059200
    • Guttman JA, Finlay BB (2009) Tight junctions as targets of infectious agents. Biochim Biophys Acta 1788:832–841
    • (2009) Biochim Biophys Acta , vol.1788 , pp. 832-841
    • Guttman, J.A.1    Finlay, B.B.2
  • 59
  • 60
    • 0015090964 scopus 로고
    • Intercellular spaces of the human epidermis as demonstrated with lanthanum
    • COI: 1:STN:280:DyaE3M3jvVyltw%3D%3D, PID: 4104141
    • Hashimoto K (1971) Intercellular spaces of the human epidermis as demonstrated with lanthanum. J Invest Dermatol 57:17–31
    • (1971) J Invest Dermatol , vol.57 , pp. 17-31
    • Hashimoto, K.1
  • 61
    • 84936162311 scopus 로고    scopus 로고
    • Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F (2014) The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol (in press)
    • Hattori F, Kiatsurayanon C, Okumura K, Ogawa H, Ikeda S, Okamoto K, Niyonsaba F (2014) The antimicrobial protein S100A7/psoriasin enhances expression of keratinocyte differentiation markers and strengthens the skin tight junction barrier. Br J Dermatol (in press)
  • 65
    • 84888808251 scopus 로고    scopus 로고
    • Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin
    • PID: 24294371
    • Hintsala HR, Siponen M, Haapasaari KM, Karihtala P, Soini Y (2013) Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin. Int J Clin Exp Pathol 6:2855–2863
    • (2013) Int J Clin Exp Pathol , vol.6 , pp. 2855-2863
    • Hintsala, H.R.1    Siponen, M.2    Haapasaari, K.M.3    Karihtala, P.4    Soini, Y.5
  • 67
    • 84868529347 scopus 로고    scopus 로고
    • Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: comparisons of normal skin and chronologically aged skin
    • COI: 1:CAS:528:DC%2BC38XhsVemtr%2FN, PID: 23026054
    • Hung CF, Fang CL, Al-Suwayeh SA, Yang SY, Fang JY (2012) Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: comparisons of normal skin and chronologically aged skin. J Dermatol Sci 68:135–148
    • (2012) J Dermatol Sci , vol.68 , pp. 135-148
    • Hung, C.F.1    Fang, C.L.2    Al-Suwayeh, S.A.3    Yang, S.Y.4    Fang, J.Y.5
  • 69
    • 29144533473 scopus 로고    scopus 로고
    • Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells
    • COI: 1:CAS:528:DC%2BD2MXhtlequ7fP, PID: 16365161
    • Ikenouchi J, Furuse M, Furuse K, Sasaki H, Tsukita S, Tsukita S (2005) Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells. J Cell Biol 171:939–945
    • (2005) J Cell Biol , vol.171 , pp. 939-945
    • Ikenouchi, J.1    Furuse, M.2    Furuse, K.3    Sasaki, H.4    Tsukita, S.5    Tsukita, S.6
  • 70
    • 58149279832 scopus 로고    scopus 로고
    • Loss of occludin affects tricellular localization of tricellulin
    • COI: 1:CAS:528:DC%2BD1cXhtlKqsbbE, PID: 18768749
    • Ikenouchi J, Sasaki H, Tsukita S, Furuse M (2008) Loss of occludin affects tricellular localization of tricellulin. Mol Biol Cell 19:4687–4693
    • (2008) Mol Biol Cell , vol.19 , pp. 4687-4693
    • Ikenouchi, J.1    Sasaki, H.2    Tsukita, S.3    Furuse, M.4
  • 72
    • 84856655907 scopus 로고    scopus 로고
    • Lamellar granule secretion starts before the establishment of tight junction barrier for paracellular tracers in mammalian epidermis
    • COI: 1:CAS:528:DC%2BC38XisFyrsbY%3D, PID: 22328942
    • Ishida-Yamamoto A, Kishibe M, Murakami M, Honma M, Takahashi H, Iizuka H (2012) Lamellar granule secretion starts before the establishment of tight junction barrier for paracellular tracers in mammalian epidermis. PLoS ONE 7:e31641
    • (2012) PLoS ONE , vol.7 , pp. e31641
    • Ishida-Yamamoto, A.1    Kishibe, M.2    Murakami, M.3    Honma, M.4    Takahashi, H.5    Iizuka, H.6
  • 73
    • 0033552629 scopus 로고    scopus 로고
    • Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH-termini of claudins
    • COI: 1:CAS:528:DyaK1MXotVGqurc%3D, PID: 10601346
    • Itoh M, Furuse M, Morita K, Kubota K, Saitou M, Tsukita S (1999) Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2 and ZO-3, with the COOH-termini of claudins. J Cell Biol 147:1351–1363
    • (1999) J Cell Biol , vol.147 , pp. 1351-1363
    • Itoh, M.1    Furuse, M.2    Morita, K.3    Kubota, K.4    Saitou, M.5    Tsukita, S.6
  • 74
    • 19644382735 scopus 로고    scopus 로고
    • Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex
    • COI: 1:CAS:528:DC%2BD2MXkvFGhtLs%3D, PID: 15800060
    • Ivanov AI, Hunt D, Utech M, Nusrat A, Parkos CA (2005) Differential roles for actin polymerization and a myosin II motor in assembly of the epithelial apical junctional complex. Mol Biol Cell 16:2636–2650
    • (2005) Mol Biol Cell , vol.16 , pp. 2636-2650
    • Ivanov, A.I.1    Hunt, D.2    Utech, M.3    Nusrat, A.4    Parkos, C.A.5
  • 78
    • 84878783791 scopus 로고    scopus 로고
    • Dietary glucosylceramide enhances tight junction function in skin epidermis via induction of claudin-1
    • COI: 1:CAS:528:DC%2BC3sXnsV2mu70%3D, PID: 23563543
    • Kawada C, Hasegawa T, Watanabe M, Nomura Y (2013) Dietary glucosylceramide enhances tight junction function in skin epidermis via induction of claudin-1. Biosci Biotechnol Biochem 77:867–869
    • (2013) Biosci Biotechnol Biochem , vol.77 , pp. 867-869
    • Kawada, C.1    Hasegawa, T.2    Watanabe, M.3    Nomura, Y.4
  • 80
    • 84904501812 scopus 로고    scopus 로고
    • Host defense (antimicrobial) peptide, human beta-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes
    • COI: 1:CAS:528:DC%2BC2cXmtlSruro%3D, PID: 24633129
    • Kiatsurayanon C, Niyonsaba F, Smithrithee R, Akiyama T, Ushio H, Hara M, Okumura K, Ikeda S, Ogawa H (2014) Host defense (antimicrobial) peptide, human beta-defensin-3, improves the function of the epithelial tight-junction barrier in human keratinocytes. J Invest Dermatol 134:2163–2173
    • (2014) J Invest Dermatol , vol.134 , pp. 2163-2173
    • Kiatsurayanon, C.1    Niyonsaba, F.2    Smithrithee, R.3    Akiyama, T.4    Ushio, H.5    Hara, M.6    Okumura, K.7    Ikeda, S.8    Ogawa, H.9
  • 82
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • COI: 1:CAS:528:DC%2BD3cXktlaitbY%3D, PID: 10833473
    • Kinugasa T, Sakaguchi T, Gu X, Reinecker HC (2000) Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118:1001–1011
    • (2000) Gastroenterology , vol.118 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.C.4
  • 83
    • 84929940993 scopus 로고    scopus 로고
    • Novel mutation in the CLDN1 gene in a Turkish family with neonatal ichthyosis sclerosing cholangitis (NISCH) syndrome
    • COI: 1:STN:280:DC%2BC2crkslOjtA%3D%3D, PID: 24641442
    • Kirchmeier P, Sayar E, Hotz A, Hausser I, Islek A, Yilmaz A, Artan R, Fischer J (2014) Novel mutation in the CLDN1 gene in a Turkish family with neonatal ichthyosis sclerosing cholangitis (NISCH) syndrome. Br J Dermatol 170:976–978
    • (2014) Br J Dermatol , vol.170 , pp. 976-978
    • Kirchmeier, P.1    Sayar, E.2    Hotz, A.3    Hausser, I.4    Islek, A.5    Yilmaz, A.6    Artan, R.7    Fischer, J.8
  • 84
    • 84861974838 scopus 로고    scopus 로고
    • Barriers and more: functions of tight junction proteins in the skin
    • COI: 1:CAS:528:DC%2BC38XhtFOhsbzE, PID: 22671602
    • Kirschner N, Brandner JM (2012) Barriers and more: functions of tight junction proteins in the skin. Ann N Y Acad Sci 1257:158–166
    • (2012) Ann N Y Acad Sci , vol.1257 , pp. 158-166
    • Kirschner, N.1    Brandner, J.M.2
  • 85
    • 70349257315 scopus 로고    scopus 로고
    • Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines
    • COI: 1:CAS:528:DC%2BD1MXhtF2isb3I, PID: 19661441
    • Kirschner N, Poetzl C, von den Driesch P, Wladykowski E, Moll I, Behne MJ, Brandner JM (2009) Alteration of tight junction proteins is an early event in psoriasis: putative involvement of proinflammatory cytokines. Am J Pathol 175:1095–1106
    • (2009) Am J Pathol , vol.175 , pp. 1095-1106
    • Kirschner, N.1    Poetzl, C.2    von den Driesch, P.3    Wladykowski, E.4    Moll, I.5    Behne, M.J.6    Brandner, J.M.7
  • 86
    • 77955550706 scopus 로고    scopus 로고
    • Tight junctions: is there a role in dermatology?
    • COI: 1:CAS:528:DC%2BC3cXpsFOls7k%3D, PID: 20563589
    • Kirschner N, Bohner C, Rachow S, Brandner JM (2010a) Tight junctions: is there a role in dermatology? Arch Dermatol Res 302:483–493
    • (2010) Arch Dermatol Res , vol.302 , pp. 483-493
    • Kirschner, N.1    Bohner, C.2    Rachow, S.3    Brandner, J.M.4
  • 87
    • 77956612570 scopus 로고    scopus 로고
    • Tight junctions form a barrier in human epidermis
    • COI: 1:CAS:528:DC%2BC3cXhtFGjs7nM, PID: 20732726
    • Kirschner N, Houdek P, Fromm M, Moll I, Brandner JM (2010b) Tight junctions form a barrier in human epidermis. Eur J Cell Biol 89:839–842
    • (2010) Eur J Cell Biol , vol.89 , pp. 839-842
    • Kirschner, N.1    Houdek, P.2    Fromm, M.3    Moll, I.4    Brandner, J.M.5
  • 89
    • 84857753766 scopus 로고    scopus 로고
    • Tight junctions and differentiation–a chicken or the egg question?
    • COI: 1:CAS:528:DC%2BC38Xlt1Grsrg%3D, PID: 22379962
    • Kirschner N, Rosenthal R, Gunzel D, Moll I, Brandner JM (2012) Tight junctions and differentiation–a chicken or the egg question? Exp Dermatol 21:171–175
    • (2012) Exp Dermatol , vol.21 , pp. 171-175
    • Kirschner, N.1    Rosenthal, R.2    Gunzel, D.3    Moll, I.4    Brandner, J.M.5
  • 90
    • 84876672147 scopus 로고    scopus 로고
    • Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes
    • COI: 1:CAS:528:DC%2BC3sXisVSku7o%3D, PID: 23407391
    • Kirschner N, Rosenthal R, Furuse M, Moll I, Fromm M, Brandner JM (2013) Contribution of tight junction proteins to ion, macromolecule, and water barrier in keratinocytes. J Invest Dermatol 133:1161–1169
    • (2013) J Invest Dermatol , vol.133 , pp. 1161-1169
    • Kirschner, N.1    Rosenthal, R.2    Furuse, M.3    Moll, I.4    Fromm, M.5    Brandner, J.M.6
  • 92
    • 69949110857 scopus 로고    scopus 로고
    • Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability
    • COI: 1:CAS:528:DC%2BD1MXhsVClt7rN, PID: 19535456
    • Krug SM, Amasheh S, Richter JF, Milatz S, Gunzel D, Westphal JK, Huber O, Schulzke JD, Fromm M (2009) Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability. Mol Biol Cell 20:3713–3724
    • (2009) Mol Biol Cell , vol.20 , pp. 3713-3724
    • Krug, S.M.1    Amasheh, S.2    Richter, J.F.3    Milatz, S.4    Gunzel, D.5    Westphal, J.K.6    Huber, O.7    Schulzke, J.D.8    Fromm, M.9
  • 93
    • 73949120263 scopus 로고    scopus 로고
    • External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
    • COI: 1:CAS:528:DC%2BD1MXhs1Wlsb3K, PID: 19995951
    • Kubo A, Nagao K, Yokouchi M, Sasaki H, Amagai M (2009) External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers. J Exp Med 206:2937–2946
    • (2009) J Exp Med , vol.206 , pp. 2937-2946
    • Kubo, A.1    Nagao, K.2    Yokouchi, M.3    Sasaki, H.4    Amagai, M.5
  • 95
    • 77955039293 scopus 로고    scopus 로고
    • Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function
    • COI: 1:CAS:528:DC%2BC3cXpt1Kktb0%3D, PID: 20654784
    • Kuroda S, Kurasawa M, Mizukoshi K, Maeda T, Yamamoto T, Oba A, Kishibe M, Ishida-Yamamoto A (2010) Perturbation of lamellar granule secretion by sodium caprate implicates epidermal tight junctions in lamellar granule function. J Dermatol Sci 59:107–114
    • (2010) J Dermatol Sci , vol.59 , pp. 107-114
    • Kuroda, S.1    Kurasawa, M.2    Mizukoshi, K.3    Maeda, T.4    Yamamoto, T.5    Oba, A.6    Kishibe, M.7    Ishida-Yamamoto, A.8
  • 97
    • 0036690912 scopus 로고    scopus 로고
    • Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom
    • COI: 1:CAS:528:DC%2BD38XotFGqu7o%3D, PID: 12234014
    • Langbein L, Grund C, Kuhn C, Praetzel S, Kartenbeck J, Brandner JM, Moll I, Franke WW (2002) Tight junctions and compositionally related junctional structures in mammalian stratified epithelia and cell cultures derived therefrom. Eur J Cell Biol 81:419–435
    • (2002) Eur J Cell Biol , vol.81 , pp. 419-435
    • Langbein, L.1    Grund, C.2    Kuhn, C.3    Praetzel, S.4    Kartenbeck, J.5    Brandner, J.M.6    Moll, I.7    Franke, W.W.8
  • 99
    • 67349282678 scopus 로고    scopus 로고
    • Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey-Hailey and Darier epidermis
    • COI: 1:CAS:528:DC%2BD1MXlslGitrg%3D, PID: 19052563
    • Leinonen PT, Hagg PM, Peltonen S, Jouhilahti EM, Melkko J, Korkiamaki T, Oikarinen A, Peltonen J (2009) Reevaluation of the normal epidermal calcium gradient, and analysis of calcium levels and ATP receptors in Hailey-Hailey and Darier epidermis. J Invest Dermatol 129:1379–1387
    • (2009) J Invest Dermatol , vol.129 , pp. 1379-1387
    • Leinonen, P.T.1    Hagg, P.M.2    Peltonen, S.3    Jouhilahti, E.M.4    Melkko, J.5    Korkiamaki, T.6    Oikarinen, A.7    Peltonen, J.8
  • 101
    • 74549133965 scopus 로고    scopus 로고
    • Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development
    • Lichtenberger BM, Tan PK, Niederleithner H, Ferrara N, Petzelbauer P, Sibilia M (2013) Autocrine VEGF signaling synergizes with EGFR in tumor cells to promote epithelial cancer development. Cell 140:268–279
    • (2013) Cell , vol.140 , pp. 268-279
    • Lichtenberger, B.M.1    Tan, P.K.2    Niederleithner, H.3    Ferrara, N.4    Petzelbauer, P.5    Sibilia, M.6
  • 103
    • 0023949917 scopus 로고
    • Functional coupling of tight junctions and microfilaments in T84 monolayers
    • COI: 1:CAS:528:DyaL1cXmtVyqtr0%3D, PID: 3279816
    • Madara JL, Stafford J, Barenberg D, Carlson S (1988) Functional coupling of tight junctions and microfilaments in T84 monolayers. Am J Physiol 254:G416–423
    • (1988) Am J Physiol , vol.254 , pp. G416-G423
    • Madara, J.L.1    Stafford, J.2    Barenberg, D.3    Carlson, S.4
  • 104
    • 16844368294 scopus 로고    scopus 로고
    • The JAM family of proteins
    • COI: 1:CAS:528:DC%2BD2MXivFKhsLg%3D, PID: 15820556
    • Mandell KJ, Parkos CA (2005) The JAM family of proteins. Adv Drug Deliv Rev 57:857–867
    • (2005) Adv Drug Deliv Rev , vol.57 , pp. 857-867
    • Mandell, K.J.1    Parkos, C.A.2
  • 106
    • 0942268163 scopus 로고    scopus 로고
    • Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity
    • COI: 1:CAS:528:DC%2BD2cXntVGnsA%3D%3D, PID: 14751232
    • Mankertz J, Hillenbrand B, Tavalali S, Huber O, Fromm M, Schulzke JD (2004) Functional crosstalk between Wnt signaling and Cdx-related transcriptional activation in the regulation of the claudin-2 promoter activity. Biochem Biophys Res Commun 314:1001–1007
    • (2004) Biochem Biophys Res Commun , vol.314 , pp. 1001-1007
    • Mankertz, J.1    Hillenbrand, B.2    Tavalali, S.3    Huber, O.4    Fromm, M.5    Schulzke, J.D.6
  • 107
  • 109
    • 77952536060 scopus 로고    scopus 로고
    • Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine
    • COI: 1:CAS:528:DC%2BC3cXjtlGhsb0%3D
    • Markov AG, Veshnyakova A, Fromm M, Amasheh M, Amasheh S (2010) Segmental expression of claudin proteins correlates with tight junction barrier properties in rat intestine. J Comp Physiol B, Biochem, Syst Environ Physiol 180:591–598
    • (2010) J Comp Physiol B, Biochem, Syst Environ Physiol , vol.180 , pp. 591-598
    • Markov, A.G.1    Veshnyakova, A.2    Fromm, M.3    Amasheh, M.4    Amasheh, S.5
  • 111
    • 34547698923 scopus 로고    scopus 로고
    • Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis
    • COI: 1:CAS:528:DC%2BD2sXptFGqsbk%3D, PID: 17515853
    • Mazzon E, Cuzzocrea S (2007a) Absence of functional peroxisome proliferator-activated receptor-alpha enhanced ileum permeability during experimental colitis. Shock 28:192–201
    • (2007) Shock , vol.28 , pp. 192-201
    • Mazzon, E.1    Cuzzocrea, S.2
  • 112
    • 38149087653 scopus 로고    scopus 로고
    • Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation
    • PID: 17971210
    • Mazzon E, Cuzzocrea S (2007b) Role of TNF-alpha in lung tight junction alteration in mouse model of acute lung inflammation. Respir Res 8:75
    • (2007) Respir Res , vol.8 , pp. 75
    • Mazzon, E.1    Cuzzocrea, S.2
  • 113
    • 84861975912 scopus 로고    scopus 로고
    • Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2
    • COI: 1:CAS:528:DC%2BC38XhtFOhsb%2FI, PID: 22671596
    • McCole DF (2012) Regulation of epithelial barrier function by the inflammatory bowel disease candidate gene, PTPN2. Ann N Y Acad Sci 1257:108–114
    • (2012) Ann N Y Acad Sci , vol.1257 , pp. 108-114
    • McCole, D.F.1
  • 114
    • 25444486668 scopus 로고    scopus 로고
    • The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex
    • COI: 1:CAS:528:DC%2BD2MXhtVKnsbrK, PID: 16186252
    • Mertens AE, Rygiel TP, Olivo C, van der Kammen R, Collard JG (2005) The Rac activator Tiam1 controls tight junction biogenesis in keratinocytes through binding to and activation of the Par polarity complex. J Cell Biol 170:1029–1037
    • (2005) J Cell Biol , vol.170 , pp. 1029-1037
    • Mertens, A.E.1    Rygiel, T.P.2    Olivo, C.3    van der Kammen, R.4    Collard, J.G.5
  • 115
    • 33744999597 scopus 로고    scopus 로고
    • Tiam1 takes PARt in cell polarity
    • COI: 1:CAS:528:DC%2BD28XlvF2is7Y%3D, PID: 16650994
    • Mertens AE, Pegtel DM, Collard JG (2006) Tiam1 takes PARt in cell polarity. Trends Cell Biol 16:308–316
    • (2006) Trends Cell Biol , vol.16 , pp. 308-316
    • Mertens, A.E.1    Pegtel, D.M.2    Collard, J.G.3
  • 116
    • 67249162901 scopus 로고    scopus 로고
    • Cadherin-mediated regulation of tight junctions in stratifying epithelia
    • COI: 1:CAS:528:DC%2BD1MXot1Ghu70%3D, PID: 19538302
    • Michels C, Aghdam SY, Niessen CM (2009) Cadherin-mediated regulation of tight junctions in stratifying epithelia. Ann N Y Acad Sci 1165:163–168
    • (2009) Ann N Y Acad Sci , vol.1165 , pp. 163-168
    • Michels, C.1    Aghdam, S.Y.2    Niessen, C.M.3
  • 117
    • 79751530994 scopus 로고    scopus 로고
    • Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes
    • COI: 1:CAS:528:DC%2BC3cXhtFGhurvN, PID: 20655293
    • Milatz S, Krug SM, Rosenthal R, Gunzel D, Muller D, Schulzke JD, Amasheh S, Fromm M (2010) Claudin-3 acts as a sealing component of the tight junction for ions of either charge and uncharged solutes. Biochim Biophys Acta 1798:2048–2057
    • (2010) Biochim Biophys Acta , vol.1798 , pp. 2048-2057
    • Milatz, S.1    Krug, S.M.2    Rosenthal, R.3    Gunzel, D.4    Muller, D.5    Schulzke, J.D.6    Amasheh, S.7    Fromm, M.8
  • 119
    • 77954008878 scopus 로고    scopus 로고
    • Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype
    • COI: 1:STN:280:DC%2BC3cnoslOluw%3D%3D, PID: 20645982
    • Nagtzaam IF, van Geel M, Driessen A, Steijlen PM, van Steensel MA (2010) Bile duct paucity is part of the neonatal ichthyosis-sclerosing cholangitis phenotype. Br J Dermatol 163:205–207
    • (2010) Br J Dermatol , vol.163 , pp. 205-207
    • Nagtzaam, I.F.1    van Geel, M.2    Driessen, A.3    Steijlen, P.M.4    van Steensel, M.A.5
  • 120
    • 84865256473 scopus 로고    scopus 로고
    • Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies
    • COI: 1:CAS:528:DC%2BC38XhsFSns7vF, PID: 22796440
    • Nakai K, Yoneda K, Hosokawa Y, Moriue T, Presland RB, Fallon PG, Kabashima K, Kosaka H, Kubota Y (2012) Reduced expression of epidermal growth factor receptor, E-cadherin, and occludin in the skin of flaky tail mice is due to filaggrin and loricrin deficiencies. Am J Pathol 181:969–977
    • (2012) Am J Pathol , vol.181 , pp. 969-977
    • Nakai, K.1    Yoneda, K.2    Hosokawa, Y.3    Moriue, T.4    Presland, R.B.5    Fallon, P.G.6    Kabashima, K.7    Kosaka, H.8    Kubota, Y.9
  • 122
    • 22244491607 scopus 로고    scopus 로고
    • JAM-A expression during embryonic development
    • COI: 1:CAS:528:DC%2BD2MXnvVWrtbY%3D, PID: 15977176
    • Parris JJ, Cooke VG, Skarnes WC, Duncan MK, Naik UP (2005) JAM-A expression during embryonic development. Dev Dyn 233:1517–1524
    • (2005) Dev Dyn , vol.233 , pp. 1517-1524
    • Parris, J.J.1    Cooke, V.G.2    Skarnes, W.C.3    Duncan, M.K.4    Naik, U.P.5
  • 123
    • 33846976467 scopus 로고    scopus 로고
    • Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis
    • COI: 1:CAS:528:DC%2BD2sXjvVKksL4%3D, PID: 17300235
    • Peltonen S, Riehokainen J, Pummi K, Peltonen J (2007) Tight junction components occludin, ZO-1, and claudin-1, -4 and -5 in active and healing psoriasis. Br J Dermatol 156:466–472
    • (2007) Br J Dermatol , vol.156 , pp. 466-472
    • Peltonen, S.1    Riehokainen, J.2    Pummi, K.3    Peltonen, J.4
  • 124
    • 77953021608 scopus 로고    scopus 로고
    • Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules
    • COI: 1:CAS:528:DC%2BC3cXmsFyrtbY%3D, PID: 20333434
    • Piehl C, Piontek J, Cording J, Wolburg H, Blasig IE (2010) Participation of the second extracellular loop of claudin-5 in paracellular tightening against ions, small and large molecules. Cell Mol Life Sci 67:2131–2140
    • (2010) Cell Mol Life Sci , vol.67 , pp. 2131-2140
    • Piehl, C.1    Piontek, J.2    Cording, J.3    Wolburg, H.4    Blasig, I.E.5
  • 125
  • 127
    • 56349089597 scopus 로고    scopus 로고
    • The skin: an indispensable barrier
    • PID: 19043850
    • Proksch E, Brandner JM, Jensen JM (2008) The skin: an indispensable barrier. Exp Dermatol 17:1063–1072
    • (2008) Exp Dermatol , vol.17 , pp. 1063-1072
    • Proksch, E.1    Brandner, J.M.2    Jensen, J.M.3
  • 128
    • 0035725214 scopus 로고    scopus 로고
    • Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes
    • COI: 1:CAS:528:DC%2BD38XhtFOlsQ%3D%3D, PID: 11710912
    • Pummi K, Malminen M, Aho H, Karvonen S-L, Peltonen J, Peltonen S (2001) Epidermal tight junctions: ZO-1 and occludin are expressed in mature, developing, and affected skin and in vitro differentiating keratinocytes. J Investig Dermatol 117:1050–1058
    • (2001) J Investig Dermatol , vol.117 , pp. 1050-1058
    • Pummi, K.1    Malminen, M.2    Aho, H.3    Karvonen, S.-L.4    Peltonen, J.5    Peltonen, S.6
  • 131
    • 84863778992 scopus 로고    scopus 로고
    • Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes
    • COI: 1:CAS:528:DC%2BC38XhtlKqtbfN, PID: 22639968
    • Raiko L, Siljamaki E, Mahoney MG, Putaala H, Suominen E, Peltonen J, Peltonen S (2012) Hailey-Hailey disease and tight junctions: Claudins 1 and 4 are regulated by ATP2C1 gene encoding Ca(2+) /Mn(2+) ATPase SPCA1 in cultured keratinocytes. Exp Dermatol 21:586–591
    • (2012) Exp Dermatol , vol.21 , pp. 586-591
    • Raiko, L.1    Siljamaki, E.2    Mahoney, M.G.3    Putaala, H.4    Suominen, E.5    Peltonen, J.6    Peltonen, S.7
  • 133
    • 84880633970 scopus 로고    scopus 로고
    • beta-Catenin protects the epidermis from mechanical stresses
    • COI: 1:CAS:528:DC%2BC3sXhtFalur7M, PID: 23816618
    • Ray S, Foote HP, Lechler T (2013) beta-Catenin protects the epidermis from mechanical stresses. J Cell Biol 202:45–52
    • (2013) J Cell Biol , vol.202 , pp. 45-52
    • Ray, S.1    Foote, H.P.2    Lechler, T.3
  • 135
    • 0037379915 scopus 로고    scopus 로고
    • TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells
    • COI: 1:CAS:528:DC%2BD3sXjsFOju7k%3D, PID: 12671897
    • Rosenstiel P, Fantini M, Brautigam K, Kuhbacher T, Waetzig GH, Seegert D, Schreiber S (2003) TNF-alpha and IFN-gamma regulate the expression of the NOD2 (CARD15) gene in human intestinal epithelial cells. Gastroenterology 124:1001–1009
    • (2003) Gastroenterology , vol.124 , pp. 1001-1009
    • Rosenstiel, P.1    Fantini, M.2    Brautigam, K.3    Kuhbacher, T.4    Waetzig, G.H.5    Seegert, D.6    Schreiber, S.7
  • 137
    • 84875444792 scopus 로고    scopus 로고
    • The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study
    • COI: 1:CAS:528:DC%2BC3sXks1Gjtrs%3D, PID: 23136956
    • Ross-Hansen K, Linneberg A, Johansen JD, Hersoug LG, Brasch-Andersen C, Menne T, Thyssen JP (2013) The role of glutathione S-transferase and claudin-1 gene polymorphisms in contact sensitization: a cross-sectional study. Br J Dermatol 168:762–770
    • (2013) Br J Dermatol , vol.168 , pp. 762-770
    • Ross-Hansen, K.1    Linneberg, A.2    Johansen, J.D.3    Hersoug, L.G.4    Brasch-Andersen, C.5    Menne, T.6    Thyssen, J.P.7
  • 138
    • 0033635344 scopus 로고    scopus 로고
    • Complex phenotype of mice lacking occludin, a component of tight junction strands
    • COI: 1:CAS:528:DC%2BD3cXovFansLo%3D, PID: 11102513
    • Saitou M, Furuse M, Sasaki H, Schulzke JD, Fromm M, Takano H, Noda T, Tsukita S (2000) Complex phenotype of mice lacking occludin, a component of tight junction strands. Mol Biol Cell 11:4131–4142
    • (2000) Mol Biol Cell , vol.11 , pp. 4131-4142
    • Saitou, M.1    Furuse, M.2    Sasaki, H.3    Schulzke, J.D.4    Fromm, M.5    Takano, H.6    Noda, T.7    Tsukita, S.8
  • 139
    • 0037077248 scopus 로고    scopus 로고
    • Cloning of the human claudin-2 5’-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha
    • COI: 1:CAS:528:DC%2BD38XkslyqtL4%3D, PID: 11934881
    • Sakaguchi T, Gu X, Golden HM, Suh E, Rhoads DB, Reinecker HC (2002) Cloning of the human claudin-2 5’-flanking region revealed a TATA-less promoter with conserved binding sites in mouse and human for caudal-related homeodomain proteins and hepatocyte nuclear factor-1alpha. J Biol Chem 277:21361–21370
    • (2002) J Biol Chem , vol.277 , pp. 21361-21370
    • Sakaguchi, T.1    Gu, X.2    Golden, H.M.3    Suh, E.4    Rhoads, D.B.5    Reinecker, H.C.6
  • 140
    • 77955550521 scopus 로고    scopus 로고
    • Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer
    • University of, Heidelberg, Heidelberg
    • Schlüter H (2006) Schlussleisten (Zonulae occludentes) und biochemisch verwandte Strukturen: Tight Junction-Proteine und -Funktionen in mehrschichtigen Epithelien, mit besonderer. PhD dissertation, University of Heidelberg, Heidelberg
    • (2006) PhD dissertation
    • Schlüter, H.1
  • 141
    • 12344274098 scopus 로고    scopus 로고
    • Sealing the live part of the skin: the integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis
    • PID: 15679110
    • Schlüter H, Wepf R, Moll I, Franke WW (2004) Sealing the live part of the skin: the integrated meshwork of desmosomes, tight junctions and curvilinear ridge structures in the cells of the uppermost granular layer of the human epidermis. Eur J Cell Biol 83:655–665
    • (2004) Eur J Cell Biol , vol.83 , pp. 655-665
    • Schlüter, H.1    Wepf, R.2    Moll, I.3    Franke, W.W.4
  • 142
    • 36049008482 scopus 로고    scopus 로고
    • The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia
    • Schlüter H, Moll I, Wolburg H, Franke WW (2007) The different structures containing tight junction proteins in epidermal and other stratified epithelial cells, including squamous cell metaplasia. Eur J Cell Biol 86:645–655
    • (2007) Eur J Cell Biol , vol.86 , pp. 645-655
    • Schlüter, H.1    Moll, I.2    Wolburg, H.3    Franke, W.W.4
  • 146
    • 33745193296 scopus 로고    scopus 로고
    • Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure
    • COI: 1:CAS:528:DC%2BD28XmtFSmurg%3D, PID: 16638813
    • Shen L, Black ED, Witkowski ED, Lencer WI, Guerriero V, Schneeberger EE, Turner JR (2006) Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structure. J Cell Sci 119:2095–2106
    • (2006) J Cell Sci , vol.119 , pp. 2095-2106
    • Shen, L.1    Black, E.D.2    Witkowski, E.D.3    Lencer, W.I.4    Guerriero, V.5    Schneeberger, E.E.6    Turner, J.R.7
  • 147
    • 84896736512 scopus 로고    scopus 로고
    • p38delta mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes
    • COI: 1:CAS:528:DC%2BC2cXivF2rt7Y%3D, PID: 23856837
    • Siljamaki E, Raiko L, Toriseva M, Nissinen L, Nareoja T, Peltonen J, Kahari VM, Peltonen S (2014) p38delta mitogen-activated protein kinase regulates the expression of tight junction protein ZO-1 in differentiating human epidermal keratinocytes. Arch Dermatol Res 306:131–141
    • (2014) Arch Dermatol Res , vol.306 , pp. 131-141
    • Siljamaki, E.1    Raiko, L.2    Toriseva, M.3    Nissinen, L.4    Nareoja, T.5    Peltonen, J.6    Kahari, V.M.7    Peltonen, S.8
  • 150
    • 77953316839 scopus 로고    scopus 로고
    • The TRPV4 channel contributes to intercellular junction formation in keratinocytes
    • Sokabe T, Fukumi-Tominaga T, Yonemura S, Mizuno A, Tominaga M (2010) The TRPV4 channel contributes to intercellular junction formation in keratinocytes. J Biol Chem 285:18749–18758
    • (2010) J Biol Chem , vol.285 , pp. 18749-18758
    • Sokabe, T.1    Fukumi-Tominaga, T.2    Yonemura, S.3    Mizuno, A.4    Tominaga, M.5
  • 151
    • 0033523773 scopus 로고    scopus 로고
    • Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier
    • PID: 10508866
    • Sonoda N, Furuse M, Sasaki H, Yonemura S, Katahira J, Horiguchi Y, Tsukita S (1999) Clostridium perfringens enterotoxin fragment removes specific claudins from tight junction strands: Evidence for direct involvement of claudins in tight junction barrier. J Cell Biol 147:195–204
    • (1999) J Cell Biol , vol.147 , pp. 195-204
    • Sonoda, N.1    Furuse, M.2    Sasaki, H.3    Yonemura, S.4    Katahira, J.5    Horiguchi, Y.6    Tsukita, S.7
  • 152
    • 0016140812 scopus 로고
    • Strucutre and function of intercellular junctions
    • COI: 1:STN:280:DyaE2M%2FlvFOmuw%3D%3D
    • Staehelin LA (1974) Strucutre and function of intercellular junctions. Annu Rev Cytol 39:191–283
    • (1974) Annu Rev Cytol , vol.39 , pp. 191-283
    • Staehelin, L.A.1
  • 153
    • 77249110786 scopus 로고    scopus 로고
    • Dynamics and functions of tight junctions
    • COI: 1:CAS:528:DC%2BC3cXisFemu78%3D, PID: 20061152
    • Steed E, Balda MS, Matter K (2010) Dynamics and functions of tight junctions. Trends Cell Biol 20:142–149
    • (2010) Trends Cell Biol , vol.20 , pp. 142-149
    • Steed, E.1    Balda, M.S.2    Matter, K.3
  • 154
    • 78651401370 scopus 로고    scopus 로고
    • Resolved psoriasis lesions retain expression of a subset of disease-related genes
    • COI: 1:CAS:528:DC%2BC3MXlsFWktw%3D%3D, PID: 20861854
    • Suarez-Farinas M, Fuentes-Duculan J, Lowes MA, Krueger JG (2011) Resolved psoriasis lesions retain expression of a subset of disease-related genes. J Invest Dermatol 131:391–400
    • (2011) J Invest Dermatol , vol.131 , pp. 391-400
    • Suarez-Farinas, M.1    Fuentes-Duculan, J.2    Lowes, M.A.3    Krueger, J.G.4
  • 156
    • 84875808184 scopus 로고    scopus 로고
    • Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice
    • COI: 1:CAS:528:DC%2BC3sXivVGqtr0%3D, PID: 23433550
    • Sugawara T, Iwamoto N, Akashi M, Kojima T, Hisatsune J, Sugai M, Furuse M (2013) Tight junction dysfunction in the stratum granulosum leads to aberrant stratum corneum barrier function in claudin-1-deficient mice. J Dermatol Sci 70:12–18
    • (2013) J Dermatol Sci , vol.70 , pp. 12-18
    • Sugawara, T.1    Iwamoto, N.2    Akashi, M.3    Kojima, T.4    Hisatsune, J.5    Sugai, M.6    Furuse, M.7
  • 157
    • 84869145834 scopus 로고    scopus 로고
    • Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation
    • Sumigray KD, Foote HP, Lechler T (2014) Noncentrosomal microtubules and type II myosins potentiate epidermal cell adhesion and barrier formation. J Cell Biol 199:513–525
    • (2014) J Cell Biol , vol.199 , pp. 513-525
    • Sumigray, K.D.1    Foote, H.P.2    Lechler, T.3
  • 158
    • 80052400212 scopus 로고    scopus 로고
    • Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium
    • COI: 1:CAS:528:DC%2BC3MXhtFaitLfM, PID: 21771795
    • Suzuki T, Yoshinaga N, Tanabe S (2011) Interleukin-6 (IL-6) regulates claudin-2 expression and tight junction permeability in intestinal epithelium. J Biol Chem 286:31263–31271
    • (2011) J Biol Chem , vol.286 , pp. 31263-31271
    • Suzuki, T.1    Yoshinaga, N.2    Tanabe, S.3
  • 161
    • 84906937391 scopus 로고    scopus 로고
    • Tatari MN, De Craene B, Soen B, Taminau J, Vermassen P, Goossens S, Haigh K, Cazzola S, Lambert J, Huylebroeck D, Haigh JJ, Berx G (2014) ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins. Cell Mol Life Sci (in press)
    • Tatari MN, De Craene B, Soen B, Taminau J, Vermassen P, Goossens S, Haigh K, Cazzola S, Lambert J, Huylebroeck D, Haigh JJ, Berx G (2014) ZEB2-transgene expression in the epidermis compromises the integrity of the epidermal barrier through the repression of different tight junction proteins. Cell Mol Life Sci (in press)
  • 163
    • 47249125248 scopus 로고    scopus 로고
    • Claudin 2 mRNA and protein are present in human keratinocytes and may be regulated by all-trans-retinoic acid
    • COI: 1:CAS:528:DC%2BD1cXotlCnsLs%3D, PID: 18509255
    • Telgenhoff D, Ramsay S, Hilz S, Slusarewicz P, Shroot B (2008) Claudin 2 mRNA and protein are present in human keratinocytes and may be regulated by all-trans-retinoic acid. Skin Pharmacol Physiol 21:211–217
    • (2008) Skin Pharmacol Physiol , vol.21 , pp. 211-217
    • Telgenhoff, D.1    Ramsay, S.2    Hilz, S.3    Slusarewicz, P.4    Shroot, B.5
  • 165
    • 0019202695 scopus 로고
    • Clinical features and genetics of the ichthyosis vulgaris group
    • COI: 1:STN:280:DyaL38%2FgsFKjtQ%3D%3D, PID: 7274918
    • Traupe H, Happle R (1980) Clinical features and genetics of the ichthyosis vulgaris group. Fortschr Med 98:1809–1815
    • (1980) Fortschr Med , vol.98 , pp. 1809-1815
    • Traupe, H.1    Happle, R.2
  • 166
    • 20444416411 scopus 로고    scopus 로고
    • Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice
    • COI: 1:CAS:528:DC%2BD2MXltFCqtL4%3D, PID: 15908185
    • Troy TC, Rahbar R, Arabzadeh A, Cheung RM, Turksen K (2005) Delayed epidermal permeability barrier formation and hair follicle aberrations in Inv-Cldn6 mice. Mech Dev 122:805–819
    • (2005) Mech Dev , vol.122 , pp. 805-819
    • Troy, T.C.1    Rahbar, R.2    Arabzadeh, A.3    Cheung, R.M.4    Turksen, K.5
  • 167
    • 34848913802 scopus 로고    scopus 로고
    • Claudin immunolocalization in neonatal mouse epithelial tissues
    • COI: 1:CAS:528:DC%2BD2sXhtFSrtr%2FO, PID: 17828607
    • Troy TC, Arabzadeh A, Yerlikaya S, Turksen K (2007) Claudin immunolocalization in neonatal mouse epithelial tissues. Cell Tissue Res 330:381–388
    • (2007) Cell Tissue Res , vol.330 , pp. 381-388
    • Troy, T.C.1    Arabzadeh, A.2    Yerlikaya, S.3    Turksen, K.4
  • 168
    • 70649095272 scopus 로고    scopus 로고
    • Dermatitis and aging-related barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant
    • PID: 19915705
    • Troy TC, Arabzadeh A, Lariviere NM, Enikanolaiye A, Turksen K (2009) Dermatitis and aging-related barrier dysfunction in transgenic mice overexpressing an epidermal-targeted claudin 6 tail deletion mutant. PLoS ONE 4:e7814
    • (2009) PLoS ONE , vol.4 , pp. e7814
    • Troy, T.C.1    Arabzadeh, A.2    Lariviere, N.M.3    Enikanolaiye, A.4    Turksen, K.5
  • 169
    • 17144431742 scopus 로고    scopus 로고
    • E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions
    • COI: 1:CAS:528:DC%2BD2MXjsVejs7s%3D, PID: 15775979
    • Tunggal JA, Helfrich I, Schmitz A, Schwarz H, Gunzel D, Fromm M, Kemler R, Krieg T, Niessen CM (2005) E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctions. EMBO J 24:1146–1156
    • (2005) EMBO J , vol.24 , pp. 1146-1156
    • Tunggal, J.A.1    Helfrich, I.2    Schmitz, A.3    Schwarz, H.4    Gunzel, D.5    Fromm, M.6    Kemler, R.7    Krieg, T.8    Niessen, C.M.9
  • 170
    • 0036336486 scopus 로고    scopus 로고
    • Permeability barrier dysfunction in transgenic mice overexpressing claudin 6
    • COI: 1:CAS:528:DC%2BD38Xjt1eit7c%3D, PID: 11923212
    • Turksen K, Troy TC (2002) Permeability barrier dysfunction in transgenic mice overexpressing claudin 6. Development 129:1775–1784
    • (2002) Development , vol.129 , pp. 1775-1784
    • Turksen, K.1    Troy, T.C.2
  • 171
    • 0019474380 scopus 로고
    • Hyperlinear palms: association with ichthyosis and atopic dermatitis
    • COI: 1:STN:280:DyaL3M3lsVyhsQ%3D%3D, PID: 7259244
    • Uehara M, Hayashi S (1981) Hyperlinear palms: association with ichthyosis and atopic dermatitis. Arch Dermatol 117:490–491
    • (1981) Arch Dermatol , vol.117 , pp. 490-491
    • Uehara, M.1    Hayashi, S.2
  • 173
    • 0035013499 scopus 로고    scopus 로고
    • Regulated expression of claudin 4 decreases paracellular conductance through a selective decrease in sodium permeability
    • PID: 11375422
    • van Itallie C, Rahner C, Anderson JM (2001) Regulated expression of claudin 4 decreases paracellular conductance through a selective decrease in sodium permeability. J Clin Invest 107:1319–1327
    • (2001) J Clin Invest , vol.107 , pp. 1319-1327
    • van Itallie, C.1    Rahner, C.2    Anderson, J.M.3
  • 174
    • 2942659788 scopus 로고    scopus 로고
    • The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability
    • PID: 15366421
    • Van Itallie CM, Colegio OR, Anderson JM (2004) The cytoplasmic tails of claudins can influence tight junction barrier properties through effects on protein stability. J Membr Biol 199:29–38
    • (2004) J Membr Biol , vol.199 , pp. 29-38
    • Van Itallie, C.M.1    Colegio, O.R.2    Anderson, J.M.3
  • 175
    • 84872188573 scopus 로고    scopus 로고
    • Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes
    • PID: 22825868
    • van Itallie CM, Tietgens AJ, LoGrande K, Aponte A, Gucek M, Anderson JM (2012) Phosphorylation of claudin-2 on serine 208 promotes membrane retention and reduces trafficking to lysosomes. J Cell Sci 125:4902–4912
    • (2012) J Cell Sci , vol.125 , pp. 4902-4912
    • van Itallie, C.M.1    Tietgens, A.J.2    LoGrande, K.3    Aponte, A.4    Gucek, M.5    Anderson, J.M.6
  • 176
    • 84855849580 scopus 로고    scopus 로고
    • Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins
    • COI: 1:CAS:528:DC%2BC38XmtlGmtA%3D%3D, PID: 22128179
    • Veshnyakova A, Piontek J, Protze J, Waziri N, Heise I, Krause G (2012) Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins. J Biol Chem 287:1698–1708
    • (2012) J Biol Chem , vol.287 , pp. 1698-1708
    • Veshnyakova, A.1    Piontek, J.2    Protze, J.3    Waziri, N.4    Heise, I.5    Krause, G.6
  • 177
    • 79952112171 scopus 로고    scopus 로고
    • Somatostatin regulates tight junction function and composition in human keratinocytes
    • COI: 1:CAS:528:DC%2BC3cXhsVSksrbE, PID: 20629740
    • Vockel M, Breitenbach U, Kreienkamp HJ, Brandner JM (2010) Somatostatin regulates tight junction function and composition in human keratinocytes. Exp Dermatol 19:888–894
    • (2010) Exp Dermatol , vol.19 , pp. 888-894
    • Vockel, M.1    Breitenbach, U.2    Kreienkamp, H.J.3    Brandner, J.M.4
  • 178
    • 33644849605 scopus 로고    scopus 로고
    • NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2
    • COI: 1:CAS:528:DC%2BD28XmtlKmuw%3D%3D, PID: 16319062
    • Voss E, Wehkamp J, Wehkamp K, Stange EF, Schroder JM, Harder J (2006) NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem 281:2005–2011
    • (2006) J Biol Chem , vol.281 , pp. 2005-2011
    • Voss, E.1    Wehkamp, J.2    Wehkamp, K.3    Stange, E.F.4    Schroder, J.M.5    Harder, J.6
  • 179
    • 0034823910 scopus 로고    scopus 로고
    • Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia
    • COI: 1:CAS:528:DC%2BD3MXntVKnsb8%3D, PID: 11522741
    • Walsh SV, Hopkins AM, Chen J, Narumiya S, Parkos CA, Nusrat A (2001) Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia. Gastroenterology 121:566–579
    • (2001) Gastroenterology , vol.121 , pp. 566-579
    • Walsh, S.V.1    Hopkins, A.M.2    Chen, J.3    Narumiya, S.4    Parkos, C.A.5    Nusrat, A.6
  • 181
    • 77950588683 scopus 로고    scopus 로고
    • Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity
    • COI: 1:CAS:528:DC%2BC3cXksVGlurk%3D, PID: 20177070
    • Weber CR, Raleigh DR, Su L, Shen L, Sullivan EA, Wang Y, Turner JR (2010) Epithelial myosin light chain kinase activation induces mucosal interleukin-13 expression to alter tight junction ion selectivity. J Biol Chem 285:12037–12046
    • (2010) J Biol Chem , vol.285 , pp. 12037-12046
    • Weber, C.R.1    Raleigh, D.R.2    Su, L.3    Shen, L.4    Sullivan, E.A.5    Wang, Y.6    Turner, J.R.7
  • 182
    • 36849042673 scopus 로고    scopus 로고
    • Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4
    • COI: 1:CAS:528:DC%2BD2sXhsVent7rK, PID: 17640674
    • Wisner DM, Harris LR 3rd, Green CL, Poritz LS (2008) Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4. J Surg Res 144:1–7
    • (2008) J Surg Res , vol.144
    • Wisner, D.M.1    Harris, L.R.2    Green, C.L.3    Poritz, L.S.4
  • 184
    • 49549104243 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity
    • COI: 1:CAS:528:DC%2BD1cXhtFGhsbbL, PID: 18363837
    • Ye D, Ma TY (2008) Cellular and molecular mechanisms that mediate basal and tumour necrosis factor-alpha-induced regulation of myosin light chain kinase gene activity. J Cell Mol Med 12:1331–1346
    • (2008) J Cell Mol Med , vol.12 , pp. 1331-1346
    • Ye, D.1    Ma, T.Y.2
  • 185
    • 0035007387 scopus 로고    scopus 로고
    • Altered expression of occludin and tight junction formation in psoriasis
    • COI: 1:STN:280:DC%2BD3Mzks1OjtQ%3D%3D, PID: 11409568
    • Yoshida Y, Morita K, Mizoguchi A, Ide C, Miyachi Y (2001) Altered expression of occludin and tight junction formation in psoriasis. Arch Dermatol Res 293:239–244
    • (2001) Arch Dermatol Res , vol.293 , pp. 239-244
    • Yoshida, Y.1    Morita, K.2    Mizoguchi, A.3    Ide, C.4    Miyachi, Y.5
  • 186
    • 84880325086 scopus 로고    scopus 로고
    • Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis
    • PID: 23712060
    • Yoshida K, Yokouchi M, Nagao K, Ishii K, Amagai M, Kubo A (2013) Functional tight junction barrier localizes in the second layer of the stratum granulosum of human epidermis. J Dermatol Sci 71:89–99
    • (2013) J Dermatol Sci , vol.71 , pp. 89-99
    • Yoshida, K.1    Yokouchi, M.2    Nagao, K.3    Ishii, K.4    Amagai, M.5    Kubo, A.6
  • 187
    • 84879884533 scopus 로고    scopus 로고
    • Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition
    • COI: 1:CAS:528:DC%2BC3sXos12qs7s%3D, PID: 23685254
    • Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O’Neill CA, O’Shaughnessy RF (2013) Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition. Dev Biol 380:274–285
    • (2013) Dev Biol , vol.380 , pp. 274-285
    • Youssef, G.1    Gerner, L.2    Naeem, A.S.3    Ralph, O.4    Ono, M.5    O’Neill, C.A.6    O’Shaughnessy, R.F.7
  • 188
    • 0037930880 scopus 로고    scopus 로고
    • Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation
    • COI: 1:CAS:528:DC%2BD3sXjsVKmsLY%3D, PID: 12615928
    • Yu AS, Enck AH, Lencer WI, Schneeberger EE (2003) Claudin-8 expression in Madin-Darby canine kidney cells augments the paracellular barrier to cation permeation. J Biol Chem 278:17350–17359
    • (2003) J Biol Chem , vol.278 , pp. 17350-17359
    • Yu, A.S.1    Enck, A.H.2    Lencer, W.I.3    Schneeberger, E.E.4
  • 189
    • 33749524559 scopus 로고    scopus 로고
    • The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4
    • COI: 1:CAS:528:DC%2BD28XhtVygsb7M, PID: 16949565
    • Yu Z, Lin KK, Bhandari A, Spencer JA, Xu X, Wang N, Lu Z, Gill GN, Roop DR, Wertz P, Andersen B (2006) The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4. Dev Biol 299:122–136
    • (2006) Dev Biol , vol.299 , pp. 122-136
    • Yu, Z.1    Lin, K.K.2    Bhandari, A.3    Spencer, J.A.4    Xu, X.5    Wang, N.6    Lu, Z.7    Gill, G.N.8    Roop, D.R.9    Wertz, P.10    Andersen, B.11
  • 190
    • 60549090106 scopus 로고    scopus 로고
    • Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site
    • COI: 1:CAS:528:DC%2BD1MXhslWjuro%3D, PID: 19114638
    • Yu AS, Cheng MH, Angelow S, Gunzel D, Kanzawa SA, Schneeberger EE, Fromm M, Coalson RD (2009) Molecular basis for cation selectivity in claudin-2-based paracellular pores: identification of an electrostatic interaction site. J Gen Physiol 133:111–127
    • (2009) J Gen Physiol , vol.133 , pp. 111-127
    • Yu, A.S.1    Cheng, M.H.2    Angelow, S.3    Gunzel, D.4    Kanzawa, S.A.5    Schneeberger, E.E.6    Fromm, M.7    Coalson, R.D.8
  • 191
    • 77952391850 scopus 로고    scopus 로고
    • MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function
    • COI: 1:CAS:528:DC%2BC3cXmtVKgtrs%3D, PID: 20404178
    • Yu D, Marchiando AM, Weber CR, Raleigh DR, Wang Y, Shen L, Turner JR (2010) MLCK-dependent exchange and actin binding region-dependent anchoring of ZO-1 regulate tight junction barrier function. Proc Natl Acad Sci U S A 107:8237–8241
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 8237-8241
    • Yu, D.1    Marchiando, A.M.2    Weber, C.R.3    Raleigh, D.R.4    Wang, Y.5    Shen, L.6    Turner, J.R.7
  • 192
    • 33947095510 scopus 로고    scopus 로고
    • Tight junction proteins in keratinocytes: localization and contribution to barrier function
    • COI: 1:CAS:528:DC%2BD2sXlt1Krs74%3D, PID: 17359339
    • Yuki T, Haratake A, Koishikawa H, Morita K, Miyachi Y, Inoue S (2007) Tight junction proteins in keratinocytes: localization and contribution to barrier function. Exp Dermatol 16:324–330
    • (2007) Exp Dermatol , vol.16 , pp. 324-330
    • Yuki, T.1    Haratake, A.2    Koishikawa, H.3    Morita, K.4    Miyachi, Y.5    Inoue, S.6
  • 194
    • 84873569974 scopus 로고    scopus 로고
    • Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing
    • COI: 1:CAS:528:DC%2BC38XhvFWgsrrM, PID: 23273645
    • Yuki T, Komiya A, Kusaka A, Kuze T, Sugiyama Y, Inoue S (2013) Impaired tight junctions obstruct stratum corneum formation by altering polar lipid and profilaggrin processing. J Dermatol Sci 69:148–158
    • (2013) J Dermatol Sci , vol.69 , pp. 148-158
    • Yuki, T.1    Komiya, A.2    Kusaka, A.3    Kuze, T.4    Sugiyama, Y.5    Inoue, S.6
  • 195
    • 33845995125 scopus 로고    scopus 로고
    • Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
    • COI: 1:CAS:528:DC%2BD2sXhtF2qsLo%3D, PID: 16822808
    • Zeissig S, Burgel N, Gunzel D, Richter J, Mankertz J, Wahnschaffe U, Kroesen AJ, Zeitz M, Fromm M, Schulzke JD (2007) Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease. Gut 56:61–72
    • (2007) Gut , vol.56 , pp. 61-72
    • Zeissig, S.1    Burgel, N.2    Gunzel, D.3    Richter, J.4    Mankertz, J.5    Wahnschaffe, U.6    Kroesen, A.J.7    Zeitz, M.8    Fromm, M.9    Schulzke, J.D.10
  • 196
    • 84885065385 scopus 로고    scopus 로고
    • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation
    • COI: 1:CAS:528:DC%2BC3sXhs1SqurzL, PID: 24043783
    • Zhou K, Muroyama A, Underwood J, Leylek R, Ray S, Soderling SH, Lechler T (2013) Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. Proc Natl Acad Sci U S A 110:E3820–3829
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. E3820-E3829
    • Zhou, K.1    Muroyama, A.2    Underwood, J.3    Leylek, R.4    Ray, S.5    Soderling, S.H.6    Lechler, T.7
  • 197
    • 37249092435 scopus 로고    scopus 로고
    • Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome)
    • COI: 1:CAS:528:DC%2BD1cXisVynsr0%3D, PID: 18095941
    • Zimmerli SC, Kerl K, Hadj-Rabia S, Hohl D, Hauser C (2008) Human epidermal Langerhans cells express the tight junction protein claudin-1 and are present in human genetic claudin-1 deficiency (NISCH syndrome). Exp Dermatol 17:20–23
    • (2008) Exp Dermatol , vol.17 , pp. 20-23
    • Zimmerli, S.C.1    Kerl, K.2    Hadj-Rabia, S.3    Hohl, D.4    Hauser, C.5
  • 198
    • 33846894974 scopus 로고    scopus 로고
    • Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair
    • COI: 1:CAS:528:DC%2BD2sXivV2is7k%3D, PID: 17087734
    • Zyrek AA, Cichon C, Helms S, Enders C, Sonnenborn U, Schmidt MA (2007) Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 9:804–816
    • (2007) Cell Microbiol , vol.9 , pp. 804-816
    • Zyrek, A.A.1    Cichon, C.2    Helms, S.3    Enders, C.4    Sonnenborn, U.5    Schmidt, M.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.