Claudins 1, 2, 3, 4, 5 and 7 in solar keratosis and squamocellular carcinoma of the skin

International Journal of Clinical and Experimental Pathology

Volumn 6, Issue 12, 2013, Pages 2855-2863

  Hintsala, Hanna Riikka ^a   Siponen, Maria ^b   Haapasaari, Kirsi Maria ^a   Karihtala, Peeter ^a   Soini, Ylermi ^b  

^a OULU UNIVERSITY HOSPITAL   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

Actinic keratosis; Claudins; Dysplasia; Squamocellular carcinoma; Tight junction

Indexed keywords

CLAUDIN; CLAUDIN 1; CLAUDIN 3; CLAUDIN 4; CLAUDIN 5; CLDN1 PROTEIN, HUMAN; CLDN2 PROTEIN, HUMAN; CLDN3 PROTEIN, HUMAN; CLDN4 PROTEIN, HUMAN; CLDN5 PROTEIN, HUMAN; CLDN7 PROTEIN, HUMAN;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CASE CONTROL STUDY; CHEMISTRY; COMPARATIVE STUDY; DYSPLASIA; FEMALE; HUMAN; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PRECANCER; SKIN; SKIN TUMOR; SQUAMOCELLULAR CARCINOMA; SQUAMOUS CELL CARCINOMA; TIGHT JUNCTION; VERY ELDERLY;

ACTINIC KERATOSIS; CLAUDINS; DYSPLASIA; SQUAMOCELLULAR CARCINOMA; TIGHT JUNCTION;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CLAUDIN-1; CLAUDIN-3; CLAUDIN-4; CLAUDIN-5; CLAUDINS; FEMALE; HUMANS; KERATOSIS, ACTINIC; MALE; MIDDLE AGED; PRECANCEROUS CONDITIONS; SKIN; SKIN NEOPLASMS;

EID: 84888808251     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Balda MS and Matter K. Tight junctions. J Cell Sci 1998; 111: 541-547.
2. Mitic LL, Van Itallie CM and Anderson JM. Molecular Physiology and Pathophysiology of Tight Junctions I. Tight junction structure and function: lessons from mutant animals and proteins. Am J Physiol Gastrointest Liver Physiol 2000; 279: G250-254.
3. Findley MK and Koval M. Regulation and roles for claudin-family tight junction proteins. IUBMB Life 2009; 61: 431-437.
4. Mineta K, Yamamoto Y, Yamazaki Y, Tanaka H, Tada Y, Saito K, Tamura A, Igarashi M, Endo T, Takeuchi K and Tsukita S. Predicted expansion of the claudin multigene family. FEBS Lett 2011; 585: 606-612.
5. Reyes JL, Lamas M, Martin D, del Carmen Namorado M, Islas S, Luna J, Tauc M and Gonzalez-Mariscal L. The renal segmental distribution of claudins changes with development. Kidney Int 2002; 62: 476-487.
6. Hou J and Goodenough DA. Claudin-16 and claudin-19 function in the thick ascending limb. Curr Opin Nephrol Hypertens 2010; 19: 483-488.
7. Tamura A, Hayashi H, Imasato M, Yamazaki Y, Hagiwara A, Wada M, Noda T, Watanabe M, Suzuki Y and Tsukita S. Loss of Claudin-15, but Not Claudin-2, Causes Na+ deficiency and glucose malabsorption in mouse small intestine. Gastroenterology 2011; 140: 913-923.
8. Turksen K and Troy TC. Junctions gone bad: claudins and loss of the barrier in cancer. Biochim Biophys Acta 2011; 1816: 73-79.
9. Feigin ME and Muthuswamy SK. Polarity proteins regulate mammalian cell-cell junctions and cancer pathogenesis. Curr Opin Cell Biol 2009; 21: 694-700.
10. Sawada N, Murata M, Kikuchi K, Osanai M, Tobioka H, Kojima T and Chiba H. Tight junctions and human diseases. Med Electron Microsc 2003; 36: 147-156.
11. Tsapara A, Matter K and Balda MS. The heat-shock protein Apg-2 binds to the tight junction protein ZO-1 and regulates transcriptional activity of ZONAB. Mol Biol Cell 2006; 17: 1322-1330.
12. Matter K and Balda MS. Epithelial tight junctions, gene expression and nucleo-junctional interplay. J Cell Sci 2007; 120: 1505-1511.
13. Singh AB, Sharma A and Dhawan P. Claudin Family of Proteins and Cancer: An Overview. J Oncol 2010; 2010: 541957.
14. Balda MS and Matter K. Tight junctions and the regulation of gene expression. Biochim Biophys Acta 2009; 1788: 761-767.
15. Ikenouchi J, Matsuda M, Furuse M and Tsukita S. Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by Snail. J Cell Sci 2003; 116: 1959-1967.
16. Venkov CD, Link AJ, Jennings JL, Plieth D, Inoue T, Nagai K, Xu C, Dimitrova YN, Rauscher FJ and Neilson EG. A proximal activator of transcription in epithelial-mesenchymal transition. J Clin Invest 2007; 117: 482-491.
17. Martinez-Estrada OM, Culleres A, Soriano FX, Peinando H, Bolos V, Martinez FO, Reina M, Cano A, Fabre M and Vilaro S. The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem J 2006; 394: 449-457.
18. Soini Y. Expression of claudins 1, 2, 3, 4, 5 and 7 in various types of tumours. Histopathology 2005; 46: 551-560.
19. Billings SD, Walsh SV, Fisher C, Nusrat A, Weiss SW and Folpe AL. Aberrant expression of tight junction-related proteins ZO-1, claudin-1 and occludin in synovial sarcoma: an immunohistochemical study with ultrastructural correlation. Mod Pathol 2004; 17: 141-149.
20. Folpe AL, Billings SD, McKenney JK, Walsh SV, Nusrat A and Weiss SW. Expression of claudin-1, a recently described tight junction-associated protein, distinguishes soft tissue perineurioma from potential mimics. Am J Surg Pathol 2002; 26: 1620-1626.
21. Kirchner N, Bohner C, Rachow S and Brandner JM. Tight junctions: is there a role in dermatology?. Arch Dermatol Res 2010; 302: 483-493.
22. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A and Tsukita S. Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 2002; 156: 1099-1111.
23. Arabzadeh A, Troy TC and Turksen K. Changes in the distribution pattern of Claudin tight junction proteins during the progression of mouse skin tumorigenesis. BMC Cancer 2007; 7: 196.
24. Langbein L, Pape UF, Grund C, Kuhn C, Praetzel S, Moll I, Moll R and Franke WW. Tight junction-related structures in the absence of a lumen: occludin, claudins and tight junction plaque proteins in densely packed cell formations of stratified epithelia and squamous cell carcinomas. Eur J Cell Biol 2003; 82: 385-400.
25. Takala H, Saarnio J, Wiik H, and Soini Y. Claudins 1, 3, 4, 5 and 7 in esophageal cancer: loss of claudin 3 and 4 expression is associat ed with metastatic behavior. APMIS 2007; 115: 838-847.
26. Bello IO, Vilen ST, Niinimaa A, Kantola S, Soini Y and Salo T. Expression of claudins 1, 4, 5 and 7 and occludin, and relationship with prognosis in squamous cell carcinoma of the tongue. Hum Pathol 2008; 39: 1212-1223.
27. Benjamin CL and Ananthaswamy HN. p53 and the Pathogenesis of Skin Cancer. Toxicol Appl Pharmacol 2007; 224: 241-248.
28. Roewert-Huber J, Stockfleth E and Kerl H. Pathology and pathobiology of actinic (solar) keratosis - an update. Br J Dermatol 2007; 157: 18-20.
29. Mortier L, Marchetti P, Delaporte E, Martin de Lassalle E, Thomas P, Piette F, Formstecher P, Polakowska R and Danze PM. Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor. Cancer Lett 2002; 176: 205-214.
30. Wheedon D, LeBoit P, Burg G and Sarasin A. Pathology and Genetics of Tumours of the Skin. WHO International Classification of Tumours. Lyon, France: IARC 2005.
31. Kress S, Sutter C, Strickland PT, Mukhtar H, Schweizer J and Schwarz M. Carcinogen-specific mutational pattern in the p53 gene in ultraviolet B radiation-induced squamous cell carcinomas of mouse skin. Cancer Res 1992; 52: 6400-6403.
32. Hung CF, Fang CL, Al-Suwayeh SA, Yang SY and Fang JY. Evaluation of drug and sunscreen permeation via skin irradiated with UVA and UVB: Comparisons of normal skin and chronologically aged skin. J Dermatol Sci 2012; 68: 135-148.
33. Matsumoto-Okazaki Y, Furuse M and Kajiya K. Claudin-5 haploinsufficiency exacerbates UVB-induced oedema formation by inducing lymphatic vessel leakage. Exp Dermatol 2012; 21: 557-559.
34. Troy TC and Turksen K. The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities. Mol Biotechnol 2007; 36: 166-174.
35. Lopardo T, Lo Iacono N, Marinari B, Giustizieri ML, Cyr DG, Merlo G, Crosti F, Costanzo A and Guerrini L. Claudin-1 is a p63 target gene with a crucial role in epithelial development. PLoS One 2008; 3: e2715.
36. Martinez-Estrada OM, Culleres A, Soriano FX, Peinado H, Bolos V, Martinez FO, Reina M, Cano A, Fabre M and Vilaro S. The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem J 2006; 394: 449-457.
37. Olmeda D, Montes A, Moreno-Bueno G, Flores JM, Portillo F and Cano A. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene 2008; 27: 4690-4701.
38. Sobel G, Paska C, Szabo I, Kiss A, Kadar A and SchaffZ. Increased expression of claudins in cervical squamous intraepithelial neoplasia and invasive carcinoma. Hum Pathol 2005; 36: 162-169.
39. Harris HJ, Farquhar MJ, Mee CJ, Davis C, Reynolds GM, Jennings A, Hu K, Yuan F, Deng H, Hubscher SG, Han JH, Balfe P and McKeating JA. CD81 and claudin 1 coreceptor association: role in hepatitis C virus entry. J Virol 2008; 82: 5007-5020.
40. Kondoh A, Takano K, Kojima T, Ohkuni T, Kamekura R, Ogasawara N, Go M, Sawada N and Himi T. Altered expression of claudin-1, claudin-7, and tricellulin regardless of human papilloma virus infection in human tonsillar squamous cell carcinoma. Acta Otolaryngol 2011; 131: 861-868.
41. French AD, Fiori JL, Camilli TC, Leotlela PD, O'Connell MP, Frank BP, Subaran S, Indig FE, Taub DD and Weeraratna AT. PKC and PKA phosphorylation affect the subcellular localization of claudin-1 in melanoma cells. Int J Med Sci 2009; 6: 93-101.
42. Lee JW, Hsiao WT, Chen HY, Hsu LP, Chen PR, Lin MD, Chiu SJ, Shih WL and Hsu YC. Upregulated claudin-1 expression confers resistance to cell death of nasopharyngeal carcinoma cells. Int J Cancer 2010; 126: 1353-1366.
43. Xin S, Huixin C, Benchang S, Aiping B, Jinhui W, Xiaoyan L, Yu WB, Minhu C. Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis. Oncology 2007; 73: 357-365.
44. Weber CR, Nalle SC, Tretiakova M, Rubin DT and Turner JR. Claudin-1 and claudin-2 expression is elevated in inflammatory bowel disease and may contribute to early neoplastic transformation. Lab Invest 2008; 88: 1110-1120.
45. Montgomery E, Mamelak AJ, Gibson M, Maitra A, Sheikh S, Amr SS, Yang S, Brock M, Forastiere A, Zhang S, Murphy KM and Berg KD. Overexpression of claudin proteins in esophageal adenocarcinoma and its precursor lesions. Appl Immunohistochem Mol Morphol 2006; 14: 24-30.
46. Adams L, Roth MJ, Abnet CC, Dawsey SP, Qiao YL, Wang GQ, Wei WQ, Lu N, Dawsey SM and Woodson K. Promoter methylation in cytology specimens as an early detection marker for esophageal squamous dysplasia and early esophageal squamous cell carcinoma. Cancer Prev Res (Phila) 2008; 1: 357-361.
47. Turunen M, Talvensaari-Mattila A, Soini Y and Santala M. Claudin-5 overexpression correlates with aggressive behavior in serous ovarian adenocarcinoma. Anticancer Res 2009; 29: 5185-5189.
48. Cunningham SC, Kamangar F, Kim MP, Hammoud S, Haque R, Iacobuzio-Donahue CA, Maitra A, Ashfaq R, Hustinx S, Heitmiller RE, Choti MA, Lillemoe KD, Cameron JL, Yeo CJ, Schulick RD and Montgomery E. Claudin-4, mitogen-activated protein kinase kinase 4, and stratifin are markers of gastric adenocarcinoma precursor lesions. Cancer Epidemiol Biomarkers Prev 2006; 15: 281-287.
49. Cao D, Polyak K, Halushka MK, Nassar H, Kouprina N, Iacobuzio-Donahue C, Wu X, Sukumar S, Hicks J, De Marzo A and Argani P. Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9. Breast Cancer Res 2008; 10: R91.
50. Bornholdt J, Friis S, Godiksen S, Poulsen SS, Santoni-Rugiu E, Bisgaard HC, Lothe IM, Ikdahl T, Tveit KM, Johnson E, Kure EH and Vogel LK. The level of claudin-7 is reduced as an early event in colorectal carcinogenesis. BMC Cancer 2011; 11: 65.
51. Johnson AH, Frierson HF, Zaika A, Powell SM, Roche J, Crowe S, Moskaluk CA and El-Rifai W. Expression of tight-junction protein claudin-7 is an early event in gastric tumorigenesis. Am J Pathol 2005; 167: 577-584.
52. Wrone DA, Yoo S, Chipps LK and Moy RL. The expression of p63 in actinic keratoses, seborrheic keratosis, and cutaneous squamous cell carcinomas. Dermatol Surg 2004; 30: 1299-1302.
53. De Benedetto A, Rafaels NM, McGirt LY, Ivanov AI, Georas SN, Cheadle C, Berger AE, Zhang K, Vidyasagar S, Yoshida T, Boguniewicz M, Hata T, Schneider LC, Hanifin JM, Gallo RL, Novak N, Weidinger S, Beaty TH, Leung DY, Barnes KC and Beck LA. Tight junction defects in patients with atopic dermatitis. J Allergy Clin Immunol 2011; 127: 773-786.
54. Itoh K, Kawasaki S, Kawamoto S, Seishima M, Chiba H, Michibata H, Wakimoto K, Imai Y, Minesaki Y, Otsuji M and Okubo K. Identification of differentially expressed genes in psoriasis using expression profiling approaches. Exp Dermatol 2005; 14: 667-674.
55. Troy TC and Turksen K. The targeted overexpression of a Claudin mutant in the epidermis of transgenic mice elicits striking epidermal and hair follicle abnormalities. Mol Biotechnol 2007; 36: 166-174.