Claudin 2 mRNA and protein are present in human keratinocytes and may be regulated by all-trans-retinoic acid

Skin Pharmacology and Physiology

Volumn 21, Issue 4, 2008, Pages 211-217

  Telgenhoff, D ^a,b   Ramsay, S ^a   Hilz, S ^a   Slusarewicz, P ^a   Shroot, B ^a  

^a Central Research Division   (United States)

^b DFB Pharmaceuticals   (United States)

Author keywords

Claudin 2; Epidermis; Keratinocytes; Retinoids; Tight junction

Indexed keywords

ACTIN; CATION CHANNEL; CLAUDIN; CLAUDIN 2; COMPLEMENTARY DNA; MESSENGER RNA; OCCLUDIN; RETINOIC ACID;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL MEMBRANE PERMEABILITY; EPIDERMIS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA PERMEABILITY; KERATINOCYTE; KIDNEY EPITHELIUM; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SKIN DISEASE; SKIN FUNCTION; TIGHT JUNCTION; WESTERN BLOTTING;

ADULT; ANIMALS; BLOTTING, WESTERN; CELLS, CULTURED; DOGS; EPIDERMIS; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; KERATINOCYTES; MEMBRANE PROTEINS; PERMEABILITY; POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIGHT JUNCTIONS; TRETINOIN;

EID: 47249125248     PISSN: 16605527     EISSN: None     Source Type: Journal    
DOI: 10.1159/000135637     Document Type: Article

References (28)

1. Furuse M, Sasaki H, Tsukita S: Manner of interaction of heterogeneous claudin species within and between tight junction strands. J Cell Biol 1999;147:891-903.
2. Chen Y, Lu Q, Schneeberger EE, Goodenough DA: Restoration of tight junction structure and barrier function by down-regulation of the mitogen-activated protein kinase pathway in Ras-transformed Madin-Darby canine kidney cells. Mol Biol Cell 2000;11:849-862.
3. Turksen K, Troy TC: Barriers built on claudins. J Cell Sci 2004;117:2435-2447.
4. Brandner JM, Kief S, Grund C, Rendl M, Houdek P, Kuhn C, Tschachler E, Franke WW, Moll I: Organization and formation of the tight junction system in human epidermis and cultured keratinocytes. Eur J Cell Biol 2002;81:253-263.
5. Furuse M, Hata M, Furuse K, Yoshida Y, Haratake A, Sugitani Y, Noda T, Kubo A, Tsukita S: Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice. J Cell Biol 2002;156:1099-1111.
6. Schneeberger EE, Lynch RD: Structure, function, and regulation of cellular tight junctions. Am J Physiol 1992;262:L647-L661.
7. Gumbiner BM: Breaking through the tight junction barrier. J Cell Biol 1993;123:1631-1633.
8. Anderson JM, Van Itallie CM: Tight junctions: closing in on the seal. Curr Biol 1999;9:R922-R924.
9. Amasheh S, Meiri N, Gitter AH, Schoneberg T, Mankertz J, Schulzke JD, Fromm M: Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci 2002;115:4969-4976.
10. Tang VW, Goodenough DA: Paracellular ion channel at the tight junction. Biophys J 2003;84:1660-1673.
11. Lipschutz JH, Li S, Arisco A, Balkovetz DF: Extracellular signal-regulated kinases 1/2 control claudin-2 expression in Madin-Darby canine kidney strain I and II cells. J Biol Chem 2005;280:3780-3788.
12. Enck AH, Berger UV, Yu AS: Claudin-2 is selectively expressed in proximal nephron in mouse kidney. Am J Physiol Renal Physiol 2001;281:F966-F974.
13. Furuse M, Furuse K, Sasaki H, Tsukita S: Conversion of zonulae occludentes from tight to leaky strand type by introducing claudin-2 into Madin-Darby canine kidney I cells. J Cell Biol 2001;153:263-272.
14. Baltes S, Nau H, Lampen A: All-trans-retinoic acid enhances differentiation and influences permeability of intestinal Caco-2 cells under serum-free conditions. Dev Growth Differ 2004;46:503-514.
15. Madison KC: Barrier function of the skin: 'la raison d'être' of the epidermis. J Invest Dermatol 2003;121:231-241.
16. Lee SH, Jeong SK, Ahn SK: An update of the defensive barrier function of skin. Yonsei Med J 2006;47:293-306.
17. Telgenhoff D, Shroot B: Further evidence of multifunctionality in the keratinocyte: The endothelial protein c receptor. J Invest Dermatol 2005;125:xviii-xix.
18. Elias P: Stratum corneum defensive functions: an integrated view. J Invest Dermatol 2005;125:183-200.
19. Bikle DD, Ng D, Tu CL, Oda Y, Xie Z: Calcium-and vitamin D-regulated keratinocyte differentiation. Mol Cell Endocrinol 2001;177:161-171.
20. Benoit S, Toksoy A, Ahlmann M, Schmidt M, Sunderkotter C, Foell D, Pasparakis M, Roth J, Goebeler M: Elevated serum levels of calcium-binding S100 proteins A8 and A9 reflect disease activity and abnormal differentiation of keratinocytes in psoriasis. Br J Dermatol 2006;155:62-66.
21. Hwang SM, Ahn SK, Menon GK, Choi EH, Lee SH: Basis of occlusive therapy in psoriasis: correcting defects in permeability barrier and calcium gradient. Int J Dermatol 2001;40:223-231.
22. Lee SH, Choi EH, Feingold KR, Jiang S, Ahn SK: Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol 1998;111:39-43.
23. Baron JM, Heise R, Blaner WS, Neis M, Joussen S, Dreuw A, Marquardt Y, Saurat JH, Merk HF, Bickers DR, Jugert FK: Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol 2005;125:143-153.
24. Njar VC, Gediya L, Purushottamachar P, Chopra P, Belosay A, Patel JB: Retinoids in clinical use. Med Chem 2006;2:431-438.
25. Kang S: The mechanism of action of topical retinoids. Cutis 2005;75:10-13, discussion 13.
26. Winterfield L, Cather J, Cather J, Menter A: Changing paradigms in dermatology: nuclear hormone receptors. Clin Dermatol 2003;21:447-454.
27. Njar VC: Cytochrome p450 retinoic acid 4-hydroxylase inhibitors: potential agents for cancer therapy. Mini Rev Med Chem 2002;2:261-269.
28. Peltonen S, Riehokainen J, Pummi K, Peltonen J: Tight junction components occludin, zo-1, and claudins-1, -4, and -5 in active and healing psoriasis; in Lindblad WJ (ed): 36th Annual European Society for Dermatological Research Meeting. Paris, Blackwell Synergy, 2006, vol 126, pp S1-S116.