Mechanism of Clostridium perfringens enterotoxin interaction with claudin-3/-4 protein suggests structural modifications of the toxin to target specific claudins

Journal of Biological Chemistry

Volumn 287, Issue 3, 2012, Pages 1698-1708

  Veshnyakova, Anna ^a   Piontek, Jor̈g ^a   Protze, Jonas ^a   Waziri, Negar ^a   Heise, Ivonne ^a   Krause, Gerd ^a  

^a LEIBNIZ INSTITUT FÜR MOLEKULARE PHARMAKOLOGIE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ASSAYS; BINDING CAVITY; CLAUDIN; CLOSTRIDIUM PERFRINGENS; ENTEROTOXIN; EXTRACELLULAR LOOPS; HELIX-TURN-HELIX MOTIFS; IN-LINE; INTERACTION MODES; SEQUENCE VARIATIONS; STRUCTURAL MODIFICATIONS; STRUCTURE-BASED; TIGHT JUNCTIONS;

CLOSTRIDIUM; DRUG DELIVERY; LIVING SYSTEMS STUDIES;

CRYSTAL ORIENTATION;

ARGININE; ASPARAGINE; ASPARTIC ACID; CLAUDIN 3; CLAUDIN 4; CLOSTRIDIUM PERFRINGENS ENTEROTOXIN; CLOSTRIDIUM TOXIN; ISOLEUCINE; LEUCINE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING; STRUCTURE ACTIVITY RELATION; TOXIN STRUCTURE;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; CELL LINE; CLAUDINS; CLOSTRIDIUM PERFRINGENS; DOGS; ENTEROTOXINS; HUMANS; MICE; MUTATION, MISSENSE; PROTEIN PROCESSING, POST-TRANSLATIONAL;

CLOSTRIDIUM PERFRINGENS;

EID: 84855849580     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.312165     Document Type: Article

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