P2X7 receptor is critical in α-synuclein-mediated microglial NADPH oxidase activation

Neurobiology of Aging

Volumn 36, Issue 7, 2015, Pages 2304-2318

  Jiang, Tianfang ^a   Hoekstra, Jake ^b   Heng, Xin ^a   Kang, Wenyan ^a   Ding, Jianqing ^a   Liu, Jun ^a   Chen, Shengdi ^a,c   Zhang, Jing ^b,d  

^a SHANGHAI SECOND MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF WASHINGTON   (United States)

^c Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^d PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

Microglia; P2X7 receptor; Parkinson's disease; PI3K AKT signaling; Synuclein

Indexed keywords

ALPHA SYNUCLEIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; CYBB PROTEIN, HUMAN; MEMBRANE PROTEIN; NEUTROPHIL CYTOSOLIC FACTOR 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL DAMAGE; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; MICROGLIA; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DEATH; DOPAMINERGIC NERVE CELL; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; MUTATION; PATHOLOGY; PHYSIOLOGY;

ALPHA-SYNUCLEIN; ANIMALS; CELL DEATH; CELLS, CULTURED; DOPAMINERGIC NEURONS; ENZYME ACTIVATION; MALE; MEMBRANE GLYCOPROTEINS; MICE, INBRED C57BL; MICROGLIA; MOLECULAR TARGETED THERAPY; MUTATION; NADPH OXIDASE; OXIDATIVE STRESS; PARKINSON DISEASE; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, PURINERGIC P2X7; SIGNAL TRANSDUCTION;

EID: 84930086236     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2015.03.015     Document Type: Article

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