P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

PLoS ONE

Volumn 8, Issue 6, 2013, Pages

  Massicot, France ^a   Hache, Guillaume ^b   David, Ludivine ^a   Chen, Dominique ^a   Leuxe, Charlotte ^a   Garnier Legrand, Laure ^a   Rat, Patrice ^a   Laprévote, Olivier ^a   Coudoré, François ^b  

^a FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

^b University of Paris XI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; CARDIOLIPIN; CASPASE 3; IBUPROFEN; INTERLEUKIN 6; NITRIC OXIDE SYNTHASE; OXALIPLATIN; PARACETAMOL; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLSERINE; PURINERGIC P2X7 RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; NEUROPROTECTIVE AGENT; PLATINUM COMPLEX;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL FUNCTION; CELL VIABILITY; CHROMATIN CONDENSATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPERALGESIA; IN VIVO STUDY; LIPID PEROXIDATION; MACROPHAGE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NERVE CELL LESION; NEUROBLASTOMA; NEUROPATHIC PAIN; NONHUMAN; OXIDATIVE STRESS; PROTEIN FUNCTION; PROTEIN SECRETION; ANIMAL; BRAIN; C57BL MOUSE; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; MITOCHONDRION; NERVE CELL; PHYSIOLOGY; TUMOR CELL LINE;

MUS;

ANIMALS; APOPTOSIS; BRAIN; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MACROPHAGES; MALE; MICE, INBRED C57BL; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; ORGANOPLATINUM COMPOUNDS; OXIDATIVE STRESS; RECEPTORS, PURINERGIC P2X7;

EID: 84879528499     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0066830     Document Type: Article

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