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Volumn 19, Issue 7, 2014, Pages 1113-1127

Lymphocyte-derived microparticles induce apoptosis of airway epithelial cells through activation of p38 MAPK and production of arachidonic acid

Author keywords

Airway epithelial cell; Apoptosis; Arachidonic acid; Lymphocyte derived microparticles; p38 MAPK

Indexed keywords

ACETYLCYSTEINE; ARACHIDONIC ACID; CASPASE 3; GLUTATHIONE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; SCAVENGER;

EID: 84902549318     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-014-0993-0     Document Type: Article
Times cited : (23)

References (51)
  • 1
    • 0642345203 scopus 로고    scopus 로고
    • Apoptosis in the normal and inflamed airway epithelium: Role of zinc in epithelial protection and procaspase-3 regulation
    • Truong-Tran AQ, Grosser D, Ruffin RE, Murgia C, Zalewski PD (2003) Apoptosis in the normal and inflamed airway epithelium: role of zinc in epithelial protection and procaspase-3 regulation. Biochem Pharmacol 66(8):1459-1468
    • (2003) Biochem Pharmacol , vol.66 , Issue.8 , pp. 1459-1468
    • Truong-Tran, A.Q.1    Grosser, D.2    Ruffin, R.E.3    Murgia, C.4    Zalewski, P.D.5
  • 2
    • 77449112330 scopus 로고    scopus 로고
    • Apoptosis-regulatory factors as potential drug targets in the epithelium of normal and inflamed airways
    • Zalewski PD, Ruffin RE (2008) Apoptosis-regulatory factors as potential drug targets in the epithelium of normal and inflamed airways. Curr Mol Pharm 1(1):38-49
    • (2008) Curr Mol Pharm , vol.1 , Issue.1 , pp. 38-49
    • Zalewski, P.D.1    Ruffin, R.E.2
  • 3
    • 53949083274 scopus 로고    scopus 로고
    • Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium
    • doi:10.1016/j.febslet.2008.09.030
    • Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D (2008) Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. FEBS Lett 582(25-26):3601-3606. doi:10.1016/j.febslet.2008. 09.030
    • (2008) FEBS Lett , vol.582 , Issue.25-26 , pp. 3601-3606
    • Kamdar, O.1    Le, W.2    Zhang, J.3    Ghio, A.J.4    Rosen, G.D.5    Upadhyay, D.6
  • 4
    • 79952740357 scopus 로고    scopus 로고
    • Mechanisms of altered cell immunity and cytotoxicity in COPD
    • Tsoumakidou M, Tsiligianni I, Tzanakis N (2011) Mechanisms of altered cell immunity and cytotoxicity in COPD. Curr Drug Targets 12(4):450-459
    • (2011) Curr Drug Targets , vol.12 , Issue.4 , pp. 450-459
    • Tsoumakidou, M.1    Tsiligianni, I.2    Tzanakis, N.3
  • 5
    • 33644781601 scopus 로고    scopus 로고
    • Oxidant and antioxidant balance in the airways and airway diseases
    • doi:10.1016/j.ejphar.2005.12.087
    • Rahman I, Biswas SK, Kode A (2006) Oxidant and antioxidant balance in the airways and airway diseases. Eur J Pharmacol 533(1-3):222-239. doi:10.1016/j.ejphar.2005.12.087
    • (2006) Eur J Pharmacol , vol.533 , Issue.1-3 , pp. 222-239
    • Rahman, I.1    Biswas, S.K.2    Kode, A.3
  • 7
    • 0034983085 scopus 로고    scopus 로고
    • Arachidonic acid as a bioactive molecule
    • doi:10.1172/JCI13210
    • Brash AR (2001) Arachidonic acid as a bioactive molecule. J Clin Invest 107(11):1339-1345. doi:10.1172/JCI13210
    • (2001) J Clin Invest , vol.107 , Issue.11 , pp. 1339-1345
    • Brash, A.R.1
  • 8
    • 77449105263 scopus 로고    scopus 로고
    • Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species
    • Dymkowska D, Wojtczak L (2009) Arachidonic acid-induced apoptosis in rat hepatoma AS-30D cells is mediated by reactive oxygen species. Acta Biochim Pol 56(4):711-715
    • (2009) Acta Biochim Pol , vol.56 , Issue.4 , pp. 711-715
    • Dymkowska, D.1    Wojtczak, L.2
  • 9
    • 79958710208 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase pathways in asthma and COPD
    • doi:10.1378/chest.10-1914
    • Chung KF (2011) p38 mitogen-activated protein kinase pathways in asthma and COPD. Chest 139(6):1470-1479. doi:10.1378/chest.10-1914
    • (2011) Chest , vol.139 , Issue.6 , pp. 1470-1479
    • Chung, K.F.1
  • 11
    • 84873302890 scopus 로고    scopus 로고
    • Cell-derived microparticles and vascular pregnancy complications: A systematic and comprehensive review
    • doi:10.1016/j.fertnstert.2012.10.009
    • Alijotas-Reig J, Palacio-Garcia C, Llurba E, Vilardell-Tarres M (2013) Cell-derived microparticles and vascular pregnancy complications: a systematic and comprehensive review. Fertil Steril 99(2):441-449. doi:10.1016/j.fertnstert. 2012.10.009
    • (2013) Fertil Steril , vol.99 , Issue.2 , pp. 441-449
    • Alijotas-Reig, J.1    Palacio-Garcia, C.2    Llurba, E.3    Vilardell-Tarres, M.4
  • 12
    • 84869239786 scopus 로고    scopus 로고
    • Increased circulating endothelial microparticles in COPD patients: A potential biomarker for COPD exacerbation susceptibility
    • doi:10.1136/thoraxjnl-2011-201395
    • Takahashi T, Kobayashi S, Fujino N, Suzuki T, Ota C, He M, Yamada M, Suzuki S, Yanai M, Kurosawa S, Yamaya M, Kubo H (2012) Increased circulating endothelial microparticles in COPD patients: a potential biomarker for COPD exacerbation susceptibility. Thorax 67(12):1067-1074. doi:10.1136/thoraxjnl- 2011-201395
    • (2012) Thorax , vol.67 , Issue.12 , pp. 1067-1074
    • Takahashi, T.1    Kobayashi, S.2    Fujino, N.3    Suzuki, T.4    Ota, C.5    He, M.6    Yamada, M.7    Suzuki, S.8    Yanai, M.9    Kurosawa, S.10    Yamaya, M.11    Kubo, H.12
  • 13
    • 84883159414 scopus 로고    scopus 로고
    • Neutrophil intercellular communication in acute lung injury: Emerging roles of microparticles and gap junctions
    • doi:10.1165/rcmb.2012-0472PS
    • Dengler V, Downey GP, Tuder RM, Eltzschig HK, Schmidt EP (2013) Neutrophil intercellular communication in acute lung injury: emerging roles of microparticles and gap junctions. Am J Respir Cell Mol Biol. doi:10.1165/rcmb.2012-0472PS
    • (2013) Am J Respir Cell Mol Biol
    • Dengler, V.1    Downey, G.P.2    Tuder, R.M.3    Eltzschig, H.K.4    Schmidt, E.P.5
  • 14
    • 33746214732 scopus 로고    scopus 로고
    • Monocyte/macrophage-derived microparticles up-regulate inflammatory mediator synthesis by human airway epithelial cells
    • Cerri C, Chimenti D, Conti I, Neri T, Paggiaro P, Celi A (2006) Monocyte/macrophage-derived microparticles up-regulate inflammatory mediator synthesis by human airway epithelial cells. J Immunol 177(3):1975-1980
    • (2006) J Immunol , vol.177 , Issue.3 , pp. 1975-1980
    • Cerri, C.1    Chimenti, D.2    Conti, I.3    Neri, T.4    Paggiaro, P.5    Celi, A.6
  • 16
    • 84877594660 scopus 로고    scopus 로고
    • Lymphocyte-derived microparticles induce bronchial epithelial cells' pro-inflammatory cytokine production and apoptosis
    • doi:10.1016/j.molimm.2013.01.017
    • Qiu Q, Xiong W, Yang C, Gagnon C, Hardy P (2013) Lymphocyte-derived microparticles induce bronchial epithelial cells' pro-inflammatory cytokine production and apoptosis. Mol Immunol 55(3-4):220-230. doi:10.1016/j.molimm. 2013.01.017
    • (2013) Mol Immunol , vol.55 , Issue.3-4 , pp. 220-230
    • Qiu, Q.1    Xiong, W.2    Yang, C.3    Gagnon, C.4    Hardy, P.5
  • 18
    • 1842455359 scopus 로고    scopus 로고
    • Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression
    • doi:10.1161/01.CIR.0000124065.31211.6E
    • Martin S, Tesse A, Hugel B, Martinez MC, Morel O, Freyssinet JM, Andriantsitohaina R (2004) Shed membrane particles from T lymphocytes impair endothelial function and regulate endothelial protein expression. Circulation 109(13):1653-1659. doi:10.1161/01.CIR.0000124065.31211.6E
    • (2004) Circulation , vol.109 , Issue.13 , pp. 1653-1659
    • Martin, S.1    Tesse, A.2    Hugel, B.3    Martinez, M.C.4    Morel, O.5    Freyssinet, J.M.6    Andriantsitohaina, R.7
  • 21
    • 77956469863 scopus 로고    scopus 로고
    • Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
    • doi:10.1186/1476-4598-9-239
    • Mondal S, Mandal C, Sangwan R, Chandra S (2010) Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer 9:239. doi:10.1186/1476-4598-9-239
    • (2010) Mol Cancer , vol.9 , pp. 239
    • Mondal, S.1    Mandal, C.2    Sangwan, R.3    Chandra, S.4
  • 22
    • 84865488724 scopus 로고    scopus 로고
    • Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-kappaB pathways
    • doi:10.1016/j.bcp.2012.07.004
    • Wang J, Zhao B, Yi Y, Zhang W, Wu X, Zhang L, Shen Y (2012) Mycoepoxydiene, a fungal polyketide inhibits MCF-7 cells through simultaneously targeting p53 and NF-kappaB pathways. Biochem Pharmacol 84(7):891-899. doi:10.1016/j.bcp.2012.07.004
    • (2012) Biochem Pharmacol , vol.84 , Issue.7 , pp. 891-899
    • Wang, J.1    Zhao, B.2    Yi, Y.3    Zhang, W.4    Wu, X.5    Zhang, L.6    Shen, Y.7
  • 23
    • 84862846889 scopus 로고    scopus 로고
    • Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress
    • doi:10.1016/j.biochi.2012.03.024
    • Wang X, Gu C, He W, Ye X, Chen H, Zhang X, Hai C (2012) Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: the central role of oxidative stress. Biochimie 94(8):1705-1717. doi:10.1016/j.biochi.2012.03.024
    • (2012) Biochimie , vol.94 , Issue.8 , pp. 1705-1717
    • Wang, X.1    Gu, C.2    He, W.3    Ye, X.4    Chen, H.5    Zhang, X.6    Hai, C.7
  • 24
    • 0033950664 scopus 로고    scopus 로고
    • A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1)
    • Peskin AV, Winterbourn CC (2000) A microtiter plate assay for superoxide dismutase using a water-soluble tetrazolium salt (WST-1). Clin Chim Acta Int J Clin Chem 293(1-2):157-166
    • (2000) Clin Chim Acta Int J Clin Chem , vol.293 , Issue.1-2 , pp. 157-166
    • Peskin, A.V.1    Winterbourn, C.C.2
  • 25
    • 49749094092 scopus 로고    scopus 로고
    • Development of an in vitro batch-type closed gas exposure device with an alveolar epithelial cell line, A549, for toxicity evaluations of gaseous compounds
    • Komori K, Murai K, Miyajima S, Fujii T, Mohri S, Ono Y, Sakai Y (2008) Development of an in vitro batch-type closed gas exposure device with an alveolar epithelial cell line, A549, for toxicity evaluations of gaseous compounds. Anal Sci Int J Jpn Soc Anal Chem 24(8):957-962
    • (2008) Anal Sci Int J Jpn Soc Anal Chem , vol.24 , Issue.8 , pp. 957-962
    • Komori, K.1    Murai, K.2    Miyajima, S.3    Fujii, T.4    Mohri, S.5    Ono, Y.6    Sakai, Y.7
  • 27
    • 0034929314 scopus 로고    scopus 로고
    • The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition
    • doi:10.1078/0065-1281-00601
    • Van Noorden CJ (2001) The history of Z-VAD-FMK, a tool for understanding the significance of caspase inhibition. Acta Histochem 103(3):241-251. doi:10.1078/0065-1281-00601
    • (2001) Acta Histochem , vol.103 , Issue.3 , pp. 241-251
    • Van Noorden, C.J.1
  • 28
    • 84881150548 scopus 로고    scopus 로고
    • Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin) EtOH] in a human osteosarcoma model: The role of oxidative stress and apoptosis
    • doi:10.1039/c3dt50524c
    • Leon IE, Di Virgilio AL, Porro V, Muglia CI, Naso LG, Williams PA, Bollati-Fogolin M, Etcheverry SB (2013) Antitumor properties of a vanadyl(iv) complex with the flavonoid chrysin [VO(chrysin) EtOH] in a human osteosarcoma model: the role of oxidative stress and apoptosis. Dalton Trans. doi:10.1039/c3dt50524c
    • (2013) Dalton Trans
    • Leon, I.E.1    Di Virgilio, A.L.2    Porro, V.3    Muglia, C.I.4    Naso, L.G.5    Williams, P.A.6    Bollati-Fogolin, M.7    Etcheverry, S.B.8
  • 29
    • 60549095158 scopus 로고    scopus 로고
    • Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells
    • doi:10.1152/ajprenal.90437.2008
    • Zimpelmann J, Burns KD (2009) Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells. Am J Physiol Renal Physiol 296(2):F337-F346. doi:10.1152/ajprenal.90437.2008
    • (2009) Am J Physiol Renal Physiol , vol.296 , Issue.2
    • Zimpelmann, J.1    Burns, K.D.2
  • 30
    • 0033621711 scopus 로고    scopus 로고
    • Effect of phospholipase A2 inhibitors on the release of arachidonic acid and cell viability in cold-stored hepatocytes
    • doi:10.1006/cryo.1999.2217
    • Kim JS, Southard JH (2000) Effect of phospholipase A2 inhibitors on the release of arachidonic acid and cell viability in cold-stored hepatocytes. Cryobiology 40(1):27-35. doi:10.1006/cryo.1999.2217
    • (2000) Cryobiology , vol.40 , Issue.1 , pp. 27-35
    • Kim, J.S.1    Southard, J.H.2
  • 31
    • 34250197133 scopus 로고    scopus 로고
    • CD8?T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice
    • Maeno T, Houghton AM, Quintero PA, Grumelli S, Owen CA, Shapiro SD (2007) CD8?T Cells are required for inflammation and destruction in cigarette smoke-induced emphysema in mice. J Immunol 178(12):8090-8096
    • (2007) J Immunol , vol.178 , Issue.12 , pp. 8090-8096
    • Maeno, T.1    Houghton, A.M.2    Quintero, P.A.3    Grumelli, S.4    Owen, C.A.5    Shapiro, S.D.6
  • 32
    • 78349285166 scopus 로고    scopus 로고
    • Microparticles: Protagonists of a novel communication network for intercellular information exchange
    • doi:10.1161/CIRCRESAHA.110.226456
    • Mause SF, Weber C (2010) Microparticles: protagonists of a novel communication network for intercellular information exchange. Circ Res 107(9):1047-1057. doi:10.1161/CIRCRESAHA.110.226456
    • (2010) Circ Res , vol.107 , Issue.9 , pp. 1047-1057
    • Mause, S.F.1    Weber, C.2
  • 33
    • 77957148097 scopus 로고    scopus 로고
    • Low density lipoprotein receptor mediates anti-VEGF effect of lymphocyte T-derived microparticles in Lewis lung carcinoma cells
    • Yang C, Gagnon C, Hou X, Hardy P (2010) Low density lipoprotein receptor mediates anti-VEGF effect of lymphocyte T-derived microparticles in Lewis lung carcinoma cells. Cancer Biol Ther 10(5):448-456
    • (2010) Cancer Biol Ther , vol.10 , Issue.5 , pp. 448-456
    • Yang, C.1    Gagnon, C.2    Hou, X.3    Hardy, P.4
  • 34
  • 35
    • 16644382118 scopus 로고    scopus 로고
    • Regulatory mechanism and physiological role of cytosolic phospholipase A2
    • Hirabayashi T, Murayama T, Shimizu T (2004) Regulatory mechanism and physiological role of cytosolic phospholipase A2. Biol Pharm Bull 27(8):1168-1173
    • (2004) Biol Pharm Bull , vol.27 , Issue.8 , pp. 1168-1173
    • Hirabayashi, T.1    Murayama, T.2    Shimizu, T.3
  • 37
    • 0038249029 scopus 로고    scopus 로고
    • Arachidonic acid cytotoxicity: Can arachidonic acid be a physiological mediator of cell death?
    • doi:10.1002/cbf.1012
    • Pompeia C, Lima T, Curi R (2003) Arachidonic acid cytotoxicity: can arachidonic acid be a physiological mediator of cell death? Cell Biochem Funct 21(2):97-104. doi:10.1002/cbf.1012
    • (2003) Cell Biochem Funct , vol.21 , Issue.2 , pp. 97-104
    • Pompeia, C.1    Lima, T.2    Curi, R.3
  • 38
    • 33750022367 scopus 로고    scopus 로고
    • Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices
    • doi:10.1016/j.cbi.2006.08.005
    • Wang ZJ, Liang CL, Li GM, Yu CY, Yin M (2006) Neuroprotective effects of arachidonic acid against oxidative stress on rat hippocampal slices. Chem Biol Interact 163(3):207-217. doi:10.1016/j.cbi.2006.08.005
    • (2006) Chem Biol Interact , vol.163 , Issue.3 , pp. 207-217
    • Wang, Z.J.1    Liang, C.L.2    Li, G.M.3    Yu, C.Y.4    Yin, M.5
  • 40
    • 0022578848 scopus 로고
    • Diacylglycerol lipase pathway is a minor source of released arachidonic acid in thrombin-stimulated human platelets
    • Mahadevappa VG, Holub BJ (1986) Diacylglycerol lipase pathway is a minor source of released arachidonic acid in thrombin-stimulated human platelets. Biochem Biophys Res Commun 134(3):1327-1333
    • (1986) Biochem Biophys Res Commun , vol.134 , Issue.3 , pp. 1327-1333
    • Mahadevappa, V.G.1    Holub, B.J.2
  • 41
    • 0021719169 scopus 로고
    • Differential effects of trifluoperazine on arachidonate liberation, secretion and myosin phosphorylation in intact platelets
    • Holmsen H, Daniel JL, Dangelmaier CA, Molish I, Rigmaiden M, Smith JB (1984) Differential effects of trifluoperazine on arachidonate liberation, secretion and myosin phosphorylation in intact platelets. Thromb Res 36(5):419-428
    • (1984) Thromb Res , vol.36 , Issue.5 , pp. 419-428
    • Holmsen, H.1    Daniel, J.L.2    Dangelmaier, C.A.3    Molish, I.4    Rigmaiden, M.5    Smith, J.B.6
  • 42
    • 0025879195 scopus 로고
    • Possible role of calmodulin in the secretion of Entamoeba histolytica electron-dense granules containing collagenase
    • Munoz Mde L, Moreno MA, Perez-Garcia JN, Tovar GR, Hernandez VI (1991) Possible role of calmodulin in the secretion of Entamoeba histolytica electron-dense granules containing collagenase. Mol Microbiol 5(7):1707-1714
    • (1991) Mol Microbiol , vol.5 , Issue.7 , pp. 1707-1714
    • Munoz Mde, L.1    Moreno, M.A.2    Perez-Garcia, J.N.3    Tovar, G.R.4    Hernandez, V.I.5
  • 43
    • 46449087496 scopus 로고    scopus 로고
    • Fatty acids as modulators of the cellular production of reactive oxygen species
    • doi:10.1016/j.freeradbiomed.2008.04.029
    • Schonfeld P, Wojtczak L (2008) Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radical Biol Med 45(3):231-241. doi:10.1016/j.freeradbiomed.2008.04.029
    • (2008) Free Radical Biol Med , vol.45 , Issue.3 , pp. 231-241
    • Schonfeld, P.1    Wojtczak, L.2
  • 44
    • 0037591839 scopus 로고    scopus 로고
    • Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: SPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release
    • doi:10.1074/jbc.M300424200
    • Han WK, Sapirstein A, Hung CC, Alessandrini A, Bonventre JV (2003) Cross-talk between cytosolic phospholipase A2 alpha (cPLA2 alpha) and secretory phospholipase A2 (sPLA2) in hydrogen peroxide-induced arachidonic acid release in murine mesangial cells: sPLA2 regulates cPLA2 alpha activity that is responsible for arachidonic acid release. J Biol Chem 278(26):24153-24163. doi:10.1074/jbc.M300424200
    • (2003) J Biol Chem , vol.278 , Issue.26 , pp. 24153-24163
    • Han, W.K.1    Sapirstein, A.2    Hung, C.C.3    Alessandrini, A.4    Bonventre, J.V.5
  • 46
    • 44449106129 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells
    • Mostefai HA, Agouni A, Carusio N, Mastronardi ML, Heymes C, Henrion D, Andriantsitohaina R, Martinez MC (2008) Phosphatidylinositol 3-kinase and xanthine oxidase regulate nitric oxide and reactive oxygen species productions by apoptotic lymphocyte microparticles in endothelial cells. J Immunol 180(7):5028-5035
    • (2008) J Immunol , vol.180 , Issue.7 , pp. 5028-5035
    • Mostefai, H.A.1    Agouni, A.2    Carusio, N.3    Mastronardi, M.L.4    Heymes, C.5    Henrion, D.6    Andriantsitohaina, R.7    Martinez, M.C.8
  • 47
    • 84902551256 scopus 로고    scopus 로고
    • Roles of phosphorylated JNK in esophageal squamous cell carcinomas of Kazakh ethnic
    • doi:10.1002/mc.22004
    • Qin X, Zheng S, Liu T, Liu Q, Liang M, Li X, Ilyar S, Lu X (2013) Roles of phosphorylated JNK in esophageal squamous cell carcinomas of Kazakh ethnic. Mol Carcinog. doi:10.1002/mc.22004
    • (2013) Mol Carcinog
    • Qin, X.1    Zheng, S.2    Liu, T.3    Liu, Q.4    Liang, M.5    Li, X.6    Ilyar, S.7    Lu, X.8
  • 48
    • 70349469564 scopus 로고    scopus 로고
    • Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells
    • doi:10.1016/j.abb.2009.08.011
    • Cheng Y, Qiu F, Ye YC, Tashiro S, Onodera S, Ikejima T (2009) Oridonin induces G2/M arrest and apoptosis via activating ERK-p53 apoptotic pathway and inhibiting PTK-Ras-Raf-JNK survival pathway in murine fibrosarcoma L929 cells. Arch Biochem Biophys 490(1):70-75. doi:10.1016/j.abb.2009.08.011
    • (2009) Arch Biochem Biophys , vol.490 , Issue.1 , pp. 70-75
    • Cheng, Y.1    Qiu, F.2    Ye, Y.C.3    Tashiro, S.4    Onodera, S.5    Ikejima, T.6
  • 49
    • 84880041457 scopus 로고    scopus 로고
    • Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line
    • doi:10.1016/j.mrgentox.2013.04.015
    • Sun Y, Tang S, Jin X, Zhang C, Zhao W, Xiao X (2013) Opposite effects of JNK and p38 MAPK signaling pathways on furazolidone-stimulated S phase cell cycle arrest of human hepatoblastoma cell line. Mutat Res 755(1):24-29. doi:10.1016/j.mrgentox.2013.04.015
    • (2013) Mutat Res , vol.755 , Issue.1 , pp. 24-29
    • Sun, Y.1    Tang, S.2    Jin, X.3    Zhang, C.4    Zhao, W.5    Xiao, X.6


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