Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

Neuroscience Letters

Volumn 548, Issue , 2013, Pages 190-195

  Chang, Chongwang ^a   Lang, Hongjuan ^a   Geng, Ning ^a   Wang, Jing ^a   Li, Nan ^a   Wang, Xuelian ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Alpha synuclein; Exosome; Microglia; Parkinson's disease

Indexed keywords

ALPHA SYNUCLEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CENTRIFUGATION; CONTROLLED STUDY; ELECTRON MICROSCOPY; EXOSOME; FLOW CYTOMETRY; MICROGLIA; MOUSE; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PARKINSON DISEASE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; ULTRACENTRIFUGATION; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANTIGEN-PRESENTING CELLS; APCS; CM; CULTURE MEDIUM; EXOSOME; FLOW CYTOMETRY WASH BUFFER; FWB; LBS; LEWY BODIES; MICROGLIA; PARKINSON'S DISEASE; PD; TACE; TNF-Α CONVERTING ENZYME;

ALPHA-SYNUCLEIN; ANIMALS; APOPTOSIS; CELL LINE; EXOSOMES; MICE; MICROGLIA; NERVE DEGENERATION; PARKINSON DISEASE;

EID: 84880135337     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2013.06.009     Document Type: Article

References (30)

1. Alvarez-Erviti L., Seow Y., Schapira A.H., Gardiner C., Sargent I.L., Wood M.J.A., Cooper J.M. Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission. Neurobiol. Dis. 2011, 42:360-367.
2. Beal M.F. Experimental models of Parkinson's disease. Nat. Rev. Neurosci. 2001, 2:325-334.
3. Castano A., Herrera A., Cano J., Machado A. Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J. Neurochem. 1998, 70:1584-1592.
4. Chen W., Wang J., Shao C., Liu S., Yu Y., Wang Q., Cao X. Efficient induction of antitumor T cell immunity by exosomes derived from heat-shocked lymphoma cells. Eur. J. Immunol. 2006, 36:1598-1607.
5. Clayton A., Turkes A., Dewitt S., Steadman R., Mason M.D., Hallett M.B. Adhesion and signaling by B cell-derived exosomes: the role of integrins. FASEB J. 2004, 18:977-979.
6. De Lella Ezcurra A.L., Chertoff M., Ferrari C., Graciarena M., Pitossi F. Chronic expression of low levels of tumor necrosis factor-[alpha] in the substantia nigra elicits progressive neurodegeneration, delayed motor symptoms and microglia/macrophage activation. Neurobiol. Dis. 2010, 37:630-640.
7. Emmanouilidou E., Melachroinou K., Roumeliotis T., Garbis S.D., Ntzouni M., Margaritis L.H., Stefanis L., Vekrellis K. Cell-produced a-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival. J. Neurosci. 2010, 30:6838-6851.
8. Fellner L., Jellinger K.A., Wenning G.K., Stefanova N. Glial dysfunction in the pathogenesis of α-synucleinopathies: emerging concepts. Acta Neuropathol. 2011, 121:1-19.
9. György B., Szabá T.G., Pásztó M., Pál Z., Misják P., Aradi B., László V., Pállinger É., Kittel PapÁ.E. Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles. Cell. Mol. Life Sci. 2011, 68:1-22.
10. Halliday G.M., Stevens C.H. Glia: initiators and progressors of pathology in Parkinson's disease. Movement Disord. 2011, 26:6-17.
11. Hirsch S. Hunot E.C. Neuroinflammation in Parkinson's disease: a target for neuroprotection?. Lancet Neurol. 2009, 8:382-397.
12. Karlsson M., Lundin S., Dahlgren U., Kahu H., Pettersson I., Telemo E. "Tolerosomes" are produced by intestinal epithelial cells. Eur. J. Immunol. 2001, 31:2892-2900.
13. Khandelwal P.J., Herman A.M., Moussa C.E.H. Inflammation in the early stages of neurodegenerative pathology. J. Neuroimmunol. 2011, 238:1-11.
14. Lee V.M.Y., Trojanowski J.Q. Mechanisms of Parkinson's disease linked to pathological α-synuclein: new targets for drug discovery. Neuron 2006, 52:33-38.
15. McCoy M.K., Tansey M.G. TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease. J. Neuroinflamm. 2008, 5:1-13.
16. McGeer P., McGeer E. Inflammatory processes in amyotrophic lateral sclerosis. Muscle Nerve 2002, 26:459-470.
17. Nakamura K., Nemani V.M., Azarbal F., Skibinski G., Levy J.M., Egami K., Munishkina L., Zhang J., Gardner B., Wakabayashi J. Direct membrane association drives mitochondrial fission by the Parkinson disease-associated protein α-synuclein. J. Biol. Chem. 2011, 286:20710-20726.
18. O'Neill H.C., Quah B.J.C. Exosomes secreted by bacterially infected macrophages are proinflammatory. Sci. STKE 2008, 1:8-17.
19. Orr C.F., Rowe D.B., Mizuno Y., Mori H., Halliday G.M. A possible role for humoral immunity in the pathogenesis of Parkinson's disease. Brain 2005, 128:2665-2674.
20. Potolicchio I., Carven G.J., Xu X., Stipp C., Riese R.J., Stern L.J., Santambrogio L. Proteomic analysis of microglia-derived exosomes: metabolic role of the aminopeptidase CD13 in neuropeptide catabolism. J. Immunol. 2005, 175:2237-2243.
21. Saijo K., Winner B., Carson C.T., Collier J.G., Boyer L., Rosenfeld M.G., Gage F.H., Glass C.K. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 2009, 137:47-59.
22. Schulz J.B., Falkenburger B.H. Neuronal pathology in Parkinson's disease. Cell Tissue Res. 2004, 318:135-147.
23. Simi A., Tsakiri N., Wang P., Rothwell N. Interleukin-1 and inflammatory neurodegeneration. Biochem. Soc. Trans. 2007, 35:1122-1126.
24. Spillantini M.G., Schmidt M.L., Lee V.M.Y., Trojanowski J.Q., Jakes R., Goedert M. α-Synuclein in Lewy bodies. Nature 1997, 388:839-840.
25. Taylor D.D., Gercel-Taylor C. MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 2008, 110:13-21.
26. Théry C., Ostrowski M., Segura E. Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 2009, 9:581-593.
27. Théry C., Zitvogel L., Amigorena S. Exosomes: composition, biogenesis and function. Nat. Rev. Immunol. 2002, 2:569-579.
28. Valadi H., Ekström K., Bossios A., Sjöstrand M., Lee J.J., Lötvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9:654-659.
29. Zhang H.G., Liu C., Su K., Yu S., Zhang L., Zhang S., Wang J., Cao X., Grizzle W., Kimberly R.P. A membrane form of TNF-α presented by exosomes delays T cell activation-induced cell death. J. Immunol. 2006, 176:7385-7393.
30. Zhang W., Wang T., Pei Z., Miller D.S., Wu X., Block M.L., Wilson B., Zhou J.S., Hong Y. Aggregated α-synuclein activates microglia: a process leading to disease progression in Parkinson's disease. FASEB J. 2005, 19:533-542.