Neurotoxicity may be an overlooked consequence of benzo[a]pyrene exposure that is relevant to human health risk assessment

Mutation Research - Reviews in Mutation Research

Volumn 764, Issue , 2015, Pages 64-89

  Chepelev, Nikolai L ^a   Moffat, Ivy D ^a   Bowers, Wayne J ^a   Yauk, Carole L ^a  

^a HEALTH CANADA   (Canada)

Author keywords

Benchmark dose; Carcinogens; Environmental pollutant; Mode of action; Point of departure; Polycyclic aromatic hydrocarbon

Indexed keywords

AMINE OXIDASE (FLAVIN CONTAINING); AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; DOPAMINE; MALONALDEHYDE; N METHYL DEXTRO ASPARTIC ACID; NORADRENALIN; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SEROTONIN; TRYPTOPHAN HYDROXYLASE; TYROSINE;

BLOOD BRAIN BARRIER; BRAIN BIOCHEMISTRY; CARCINOGENICITY; COGNITION; DNA DAMAGE; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; FORESTOMACH; GENE EXPRESSION; GENOTOXICITY; HEALTH HAZARD; HUMAN; LIPOPHILICITY; LOCOMOTION; LONG TERM POTENTIATION; MEMORY; METABOLIC ACTIVATION; MORRIS WATER MAZE TEST; NERVOUS SYSTEM DEVELOPMENT; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; REVIEW; RISK ASSESSMENT; SPATIAL LEARNING; STOMACH CANCER; STOMACH CARCINOGENESIS; TOXICOKINETICS; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; GENETICS; LEARNING; METABOLISM; NEOPLASM; PATHOLOGY; TOXICITY AND INTOXICATION;

RODENTIA;

ANIMALS; BENZO(A)PYRENE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LEARNING; NEOPLASMS; NEUROTOXICITY SYNDROMES;

EID: 84930045420     PISSN: 13835742     EISSN: 13882139     Source Type: Journal    
DOI: 10.1016/j.mrrev.2015.03.001     Document Type: Review

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