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Volumn 112, Issue 14, 2004, Pages 1341-1346

Application of benzo(a)pyrene and coal tar tumor dose-response data to a modified benchmark dose method of guideline development

Author keywords

7 H benzo(c)fluorene; Benzo(a)pyrene; Cancer risk assessment; Dose response modeling; Modified benchmark dose method; PAH; Soil carcinogens

Indexed keywords

BENZO[A]PYRENE; COAL TAR; FLUORENE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON;

EID: 6344258983     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6427     Document Type: Article
Times cited : (28)

References (48)
  • 2
    • 0003446920 scopus 로고
    • ANZECC and NHMRC. Canberra, Australia:Australia and New Zealand Environment Conservation Council, and National Health and Medical Research Council
    • ANZECC and NHMRC. 1992. Australian and New Zealand Guidelines for the Assessment and Management of Contaminated Sites. Canberra, Australia:Australia and New Zealand Environment Conservation Council, and National Health and Medical Research Council.
    • (1992) Australian and New Zealand Guidelines for the Assessment and Management of Contaminated Sites
  • 3
    • 0030872306 scopus 로고    scopus 로고
    • Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons
    • Boffetta P, Jourenkova N, Gustavsson P. 1997. Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons. Cancer Causes Control 8:444-472.
    • (1997) Cancer Causes Control , vol.8 , pp. 444-472
    • Boffetta, P.1    Jourenkova, N.2    Gustavsson, P.3
  • 5
    • 0036085639 scopus 로고    scopus 로고
    • Cancer risk assessment, indicators and guidelines for polycyclic aromatic hydrocarbons in the ambient air
    • Boström C-E, Gerde P, Hanberg A, Jernström B, Johansson C, Kyrklund T, et al. 2002. Cancer risk assessment, indicators and guidelines for polycyclic aromatic hydrocarbons in the ambient air. Environ Health Perspect 110(suppl 3):451-489.
    • (2002) Environ. Health Perspect. , vol.110 , Issue.SUPPL. 3 , pp. 451-489
    • Boström, C.-E.1    Gerde, P.2    Hanberg, A.3    Jernström, B.4    Johansson, C.5    Kyrklund, T.6
  • 7
    • 0019790919 scopus 로고
    • Investigation of the tumorigenic response to benzo(a)pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats
    • Brune H, Deutsch-Wenzel RP, Habs M, Ivankovic S, Schmähl D. 1981. Investigation of the tumorigenic response to benzo(a pyrene in aqueous caffeine solution applied orally to Sprague-Dawley rats. J Cancer Res Clin Oncol 102:153-157.
    • (1981) J. Cancer Res. Clin. Oncol. , vol.102 , pp. 153-157
    • Brune, H.1    Deutsch-Wenzel, R.P.2    Habs, M.3    Ivankovic, S.4    Schmähl, D.5
  • 8
    • 77957180789 scopus 로고
    • A now method for determining allowable daily intakes
    • Crump K. 1984. A now method for determining allowable daily intakes. Fundam Appl Toxicol 4:854-891.
    • (1984) Fundam. Appl. Toxicol. , vol.4 , pp. 854-891
    • Crump, K.1
  • 9
    • 0028898956 scopus 로고
    • Calculation of benchmark doses from continuous data
    • Crump K. 1995. Calculation of benchmark doses from continuous data. Risk Anal 15:79-89.
    • (1995) Risk Anal. , vol.15 , pp. 79-89
    • Crump, K.1
  • 10
    • 0031869266 scopus 로고    scopus 로고
    • A comparison of the tumors induced by coal tar and benzo[a]pyrene in a 2-year bioassay
    • Culp SJ , Gaylor DW, Winslow GS, Goldstein LS, Beland FA. 1998. A comparison of the tumors induced by coal tar and benzo[a pyrene in a 2-year bioassay. Carcinogenesis 19(4):117-124.
    • (1998) Carcinogenesis , vol.19 , Issue.4 , pp. 117-124
    • Culp, S.J.1    Gaylor, D.W.2    Winslow, G.S.3    Goldstein, L.S.4    Beland, F.A.5
  • 11
    • 0033948673 scopus 로고    scopus 로고
    • DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo(a)pyrene
    • Culp SJ, Warbritton AR, Smith BA, Li EE, Beland FA. 2000. DNA adduct measurements, cell proliferation and tumor mutation induction in relation to tumor formation in B6C3F1 mice fed coal tar or benzo(a pyrene. Carcinogenesis 21:1433-1440.
    • (2000) Carcinogenesis , vol.21 , pp. 1433-1440
    • Culp, S.J.1    Warbritton, A.R.2    Smith, B.A.3    Li, E.E.4    Beland, F.A.5
  • 12
    • 0029803289 scopus 로고    scopus 로고
    • Evolution of science-based uncertainty factors in noncancer risk assessment
    • Dourson ML, Felter SP, Robinson D. 1996. Evolution of science-based uncertainty factors in noncancer risk assessment. Regul Toxicol Pharmacol 24:108-120.
    • (1996) Regul. Toxicol. Pharmacol. , vol.24 , pp. 108-120
    • Dourson, M.L.1    Felter, S.P.2    Robinson, D.3
  • 13
    • 6344243576 scopus 로고
    • Setting response levels for polycyclic aromatic hydrocarbons (PAHs)
    • (El Saadi O, Langley A, eds). Adelaide, Australia:South Australian Health Commission
    • Fitzgerald DJ. 1991. Setting response levels for polycyclic aromatic hydrocarbons (PAHs). In: The Health Risk Assessment and Management of Contaminated Sites (El Saadi O, Langley A, eds). Adelaide, Australia:South Australian Health Commission, 153-161.
    • (1991) The Health Risk Assessment and Management of Contaminated Sites , pp. 153-161
    • Fitzgerald, D.J.1
  • 14
    • 6344270205 scopus 로고
    • Carcinogenic soil contaminants: An Australian approach
    • (Langley. A, van Alphen M, eds). Contaminated Sites Monograph No. 2. Adelaide, Australia:South Australian Health Commission
    • Fitzgerald DJ. 1993. Carcinogenic soil contaminants: an Australian approach, ln: The Health Risk Assessment and Management of Contaminated Sites II (Langley A, van Alphen M, eds). Contaminated Sites Monograph No. 2. Adelaide, Australia:South Australian Health Commission, 51-64.
    • (1993) The Health Risk Assessment and Management of Contaminated Sites II , pp. 51-64
    • Fitzgerald, D.J.1
  • 15
    • 6344255068 scopus 로고    scopus 로고
    • The benchmark dose approach and health-based investigation level for polycyclic aromatic hydrocarbons (PAHs)
    • (Langley A, Imray P, Lock W, Hill H, eds). Contaminated Sites Monograph No. 7. Adelaide, Australia:South Australian Health Commission
    • Fitzgerald J. 1998. The benchmark dose approach and health-based investigation level for polycyclic aromatic hydrocarbons (PAHs). In: The Health Risk Assessment and Management of Contaminated Sites IV (Langley A, Imray P, Lock W, Hill H, eds). Contaminated Sites Monograph No. 7. Adelaide, Australia:South Australian Health Commission, 81-92.
    • (1998) The Health Risk Assessment and Management of Contaminated Sites IV , pp. 81-92
    • Fitzgerald, J.1
  • 16
    • 0001879402 scopus 로고    scopus 로고
    • Environmental health risk assessment: Theory and practice
    • (Ballantyne B, Marrs TC, Syversen T, eds). 2nd ad. London:Macmillan
    • Gargas ML, Finley BL, Paustenbach DJ, Long TF. 2000. Environmental health risk assessment: theory and practice. In: General and Applied Toxicology (Ballantyne B, Marrs TC, Syversen T, eds). 2nd ad. London:Macmillan, 1749-1809.
    • (2000) General and Applied Toxicology , pp. 1749-1809
    • Gargas, M.L.1    Finley, B.L.2    Paustenbach, D.J.3    Long, T.F.4
  • 17
    • 0034125275 scopus 로고    scopus 로고
    • Cancer risk estimation for mixtures of coal tar and benzo(a)pyrene
    • Gaylor DW, Culp SJ, Goldstein LS, Beland FA. 2000. Cancer risk estimation for mixtures of coal tar and benzo(a)pyrene. Risk Anal 20:81-85.
    • (2000) Risk Anal. , vol.20 , pp. 81-85
    • Gaylor, D.W.1    Culp, S.J.2    Goldstein, L.S.3    Beland, F.A.4
  • 18
    • 0032451386 scopus 로고    scopus 로고
    • Recent bioassay results on coal tars and benzo(a)pyrene: Implications for risk assessment
    • Gaylor DW, Moolgavkar S, Krewski D, Goldstein LS. 1998. Recent bioassay results on coal tars and benzo(a)pyrene: implications for risk assessment. Regul Toxicol Pharmacol 28:178-179.
    • (1998) Regul. Toxicol. Pharmacol. , vol.28 , pp. 178-179
    • Gaylor, D.W.1    Moolgavkar, S.2    Krewski, D.3    Goldstein, L.S.4
  • 19
    • 0034802596 scopus 로고    scopus 로고
    • To BaP or not to BaP? That is the question
    • [Editorial]
    • Goldstein LS. 2001. To BaP or not to BaP? That is the question [Editorial]. Environ Health Perspect 109:A356-A357.
    • (2001) Environ. Health Perspect. , vol.109
    • Goldstein, L.S.1
  • 20
    • 0032449434 scopus 로고    scopus 로고
    • Tumors and DNA adducts in mice exposed to benzo[a]pyrene and coal tars: Implications for risk assessment
    • Goldstein LS, Weyand EH, Safe S, Steinberg M, Culp SJ, Gaylor DW, et al. 1998. Tumors and DNA adducts in mice exposed to benzo[a pyrene and coal tars: implications for risk assessment. Environ Health Perspect 106(suppl 6):1325-1330.
    • (1998) Environ. Health Perspect. , vol.106 , Issue.SUPPL. 6 , pp. 1325-1330
    • Goldstein, L.S.1    Weyand, E.H.2    Safe, S.3    Steinberg, M.4    Culp, S.J.5    Gaylor, D.W.6
  • 22
    • 0023110661 scopus 로고
    • Cell and species differences in metabolic activation of chemical carcinogens
    • Hsu IC, Harris CC, Lipsky MM, Snyder S, Trump BF. 1987. Cell and species differences in metabolic activation of chemical carcinogens. Mutat Res 177:1-7.
    • (1987) Mutat. Res. , vol.177 , pp. 1-7
    • Hsu, I.C.1    Harris, C.C.2    Lipsky, M.M.3    Snyder, S.4    Trump, B.F.5
  • 23
    • 18844440431 scopus 로고
    • Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42
    • IARC
    • IARC. 1987. Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42. Monogr Eval Carcinog Risks Hum (Suppl 7).
    • (1987) Monogr. Eval. Carcinog. Risks Hum. , Issue.SUPPL. 7
  • 24
    • 0035054201 scopus 로고    scopus 로고
    • Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study
    • Kazerouni N, Sinha R, Hsu C-H, Greenberg A, Rothman N. 2001. Analysis of 200 food items for benzo[a]pyrene and estimation of its intake in an epidemiologic study. Food Chem Toxicol 39:423-436.
    • (2001) Food Chem. Toxicol. , vol.39 , pp. 423-436
    • Kazerouni, N.1    Sinha, R.2    Hsu, C.-H.3    Greenberg, A.4    Rothman, N.5
  • 25
    • 6344231870 scopus 로고    scopus 로고
    • Application of lung deposition model in carcinogenic risk assessment of polyaromatic hydrocarbons
    • Khalili NR, Thomas S. 2001. Application of lung deposition model in carcinogenic risk assessment of polyaromatic hydrocarbons. Environ Health 1:18-31.
    • (2001) Environ. Health , vol.1 , pp. 18-31
    • Khalili, N.R.1    Thomas, S.2
  • 26
    • 0035387495 scopus 로고    scopus 로고
    • Comparative analysis of PAH:DNA adducts formed in lung of mice exposed to neat coal tar and soils contaminated with coal tar
    • Koganti A, Singh R, Ma B-L, Weyand EH. 2001. Comparative analysis of PAH:DNA adducts formed in lung of mice exposed to neat coal tar and soils contaminated with coal tar. Environ Sci Technol 35:2704-2709.
    • (2001) Environ. Sci. Technol. , vol.35 , pp. 2704-2709
    • Koganti, A.1    Singh, R.2    Ma, B.-L.3    Weyand, E.H.4
  • 28
    • 2042452229 scopus 로고    scopus 로고
    • Tumorigenic Effects in Wistar Rats Orally Administered Benzo[a]pyrene for Two Years (Gavage Studies). Implications for Human Cancer Risks Associated with Oral Exposure to Polycyclic Aromatic Hydrocarbons
    • RIVM Report no. 658603010. Bilthoven, Netherlands:National Institute of Public Health and the Environment
    • Kroese ED, Muller JJA, Mohn GR, Dortant PM, Wester PW. 2001. Tumorigenic Effects in Wistar Rats Orally Administered Benzo[a pyrene for Two Years (Gavage Studies). Implications for Human Cancer Risks Associated with Oral Exposure to Polycyclic Aromatic Hydrocarbons. RIVM Report no. 658603010. Bilthoven, Netherlands:National Institute of Public Health and the Environment.
    • (2001)
    • Kroese, E.D.1    Muller, J.J.A.2    Mohn, G.R.3    Dortant, P.M.4    Wester, P.W.5
  • 29
    • 0002854753 scopus 로고    scopus 로고
    • Chemical carcinogens
    • (Hester RE, Harrison RM, eds). Cambridge, UK:Royal Society of Chemistry
    • Larsen JC, Larsen PB. 1998. Chemical carcinogens. In: Air Pollution and Health (Hester RE, Harrison RM, eds). Cambridge, UK:Royal Society of Chemistry, 33-56.
    • (1998) Air Pollution and Health , pp. 33-56
    • Larsen, J.C.1    Larsen, P.B.2
  • 30
    • 0025092413 scopus 로고
    • A new approach to deriving community exposure guidelines from "no-observed-adverse-effect levels"
    • Lewis SC, Lynch JR, Nikiforov AI. 1990. A new approach to deriving community exposure guidelines from " no-observed-adverse-effect levels." Regul Toxicol Pharmacol 11:314-330.
    • (1990) Regul. Toxicol. Pharmacol. , vol.11 , pp. 314-330
    • Lewis, S.C.1    Lynch, J.R.2    Nikiforov, A.I.3
  • 31
    • 0004306597 scopus 로고    scopus 로고
    • National Environment Protection (Assessment of Site Contamination) Measure 1999: Schedule B (7a) Guideline on Health-Based Investigation Levels
    • National Environment Protection Council. Soil Series No. 1. 3rd ed. Available: [accessed 23 July 2004]. National Environmental Health Forum Monographs
    • National Environment Protection Council. 1999. National Environment Protection (Assessment of Site Contamination) Measure 1999: Schedule B (7a) Guideline on Health-Based Investigation Levels. National Environmental Health Forum Monographs. Soil Series No. 1. 3rd ed. Available: http://www.ephc.gov.au/pdf/cs/cs_07a_health_based_inv.pdf [accessed 23 July 2004].
    • (1999)
  • 32
    • 0014175994 scopus 로고
    • Gastric tumors in mice fed benzo[a]pyrene: A quantitative study
    • Neal J, Rigdon RH. 1967. Gastric tumors in mice fed benzo[ a]pyrene: a quantitative study. Texas Rep Biol Med 25:553-557.
    • (1967) Texas Rep. Biol. Med. , vol.25 , pp. 553-557
    • Neal, J.1    Rigdon, R.H.2
  • 33
    • 0003996920 scopus 로고    scopus 로고
    • NHMRC. Canberra, Australia:National Health and Medical Research Council. Available: [accessed 9 June 2004]
    • NHMRC. 1999. Toxicity Assessment for Carcinogenic Soil Contaminants. Canberra, Australia:National Health and Medical Research Council. Available: http://www.health.gov.au:80/nhmrc/publications/synopses/eh21syn.htm [accessed 9 June 2004].
    • (1999) Toxicity Assessment for Carcinogenic Soil Contaminants
  • 34
    • 0027094098 scopus 로고
    • Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs)
    • Nisbet ICT, LaGoy PK. 1992. Toxic equivalency factors (TEFs) for polycyclic aromatic hydrocarbons (PAHs). Regul Toxicol Pharmacol 16:290-300.
    • (1992) Regul. Toxicol. Pharmacol. , vol.16 , pp. 290-300
    • Nisbet, I.C.T.1    LaGoy, P.K.2
  • 35
    • 0017786950 scopus 로고
    • Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites
    • Oesch F, Raphael D, Schwind H, Glatt HR. 1977. Species differences in activating and inactivating enzymes related to the control of mutagenic metabolites. Arch Toxicol 39:97-108.
    • (1977) Arch. Toxicol. , vol.39 , pp. 97-108
    • Oesch, F.1    Raphael, D.2    Schwind, H.3    Glatt, H.R.4
  • 36
    • 0035870182 scopus 로고    scopus 로고
    • Impacts of aging on in vivo and in vitro measurements of soil-bound polycyclic aromatic hydrocarbon availability
    • Reeves WR, McDonald TJ, Bordelon NR, George SE, Donnelly KC. 2001. Impacts of aging on in vivo and in vitro measurements of soil-bound polycyclic aromatic hydrocarbon availability. Environ Sci Technol 35:1637-1643.
    • (2001) Environ. Sci. Technol. , vol.35 , pp. 1637-1643
    • Reeves, W.R.1    McDonald, T.J.2    Bordelon, N.R.3    George, S.E.4    Donnelly, K.C.5
  • 37
    • 0027340356 scopus 로고
    • 32P-postlabeling analysis of benzo[a]pyrene-DNA adducts formed in vitro upon activation of benzo[a]pyrene by human, rabbit and rodent liver microsomes
    • 32P-postlabeling analysis of benzo[a]pyrene-DNA adducts formed in vitro upon activation of benzo[a]pyrene by human, rabbit and rodent liver microsomes. Carcinogenesis 14:1945-1950.
    • (1993) Carcinogenesis , vol.14 , pp. 1945-1950
    • Roggeband, R.1    Wolterbeek, A.P.M.2    Rutten, A.A.J.J.L.3    Baan, R.A.4
  • 38
    • 6344278645 scopus 로고
    • Contaminants in Soil: Collation of Toxicological Data and Intake Values for Humans. Polycyclic Aromatic Hydrocarbons
    • RPS. Project No. EPC/1/6/11. Report to the U.K. Department of the Environment. London:RPS
    • RPS. 1995. Contaminants in Soil: Collation of Toxicological Data and Intake Values for Humans. Polycyclic Aromatic Hydrocarbons. Project No. EPC/1/6/11. Report to the U.K. Department of the Environment. London:RPS.
    • (1995)
  • 39
    • 0035681327 scopus 로고    scopus 로고
    • Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: A bio-historical perspective with updates
    • Rubin H. 2001. Synergistic mechanisms in carcinogenesis by polycyclic aromatic hydrocarbons and by tobacco smoke: a bio-historical perspective with updates. Carcinogenesis 22:1903-1930.
    • (2001) Carcinogenesis , vol.22 , pp. 1903-1930
    • Rubin, H.1
  • 40
    • 0033647479 scopus 로고    scopus 로고
    • Daily soil ingestion estimates for children at a Superfund site
    • Stanek EJ III, Calabrese EJ. 2000. Daily soil ingestion estimates for children at a Superfund site. Risk Anal 20:627-635.
    • (2000) Risk Anal. , vol.20 , pp. 627-635
    • Stanek III, E.J.1    Calabrese, E.J.2
  • 42
    • 0003788952 scopus 로고
    • The Use of the Benchmark Dose Approach in Health Risk Assessment
    • U.S. EPA. EPA/630/R-94-007. Washington, DC:U.S. Environmental Protection Agency
    • U.S. EPA. 1995. The Use of the Benchmark Dose Approach in Health Risk Assessment. Risk Assessment Forum. EPA/630/R-94-007. Washington, DC:U.S. Environmental Protection Agency.
    • (1995) Risk Assessment Forum
  • 43
    • 18744384846 scopus 로고    scopus 로고
    • U.S. EPA. Washington, DC:U.S. Environmental Protection Agency. Available: [accessed 9 September 2003]
    • U.S. EPA. 2003. Benchmark Dose Software. Washington, DC:U.S. Environmental Protection Agency. Available: http://cfpub.epa.gov/ncea/cfm/recordisplay.cfm [accessed 9 September 2003].
    • (2003) Benchmark Dose Software
  • 44
    • 0037162669 scopus 로고    scopus 로고
    • Synthesis of suspected carcinogenic metabolites of 7H-benzo[c]fluorene, a coal tar component implicated in causation of lung tumors
    • Wang JQ, Weyand EH, Harvey RG. 2002. Synthesis of suspected carcinogenic metabolites of 7H-benzo[c]fluorene, a coal tar component implicated in causation of lung tumors. J Org Chem 67:6216-6219.
    • (2002) J. Org. Chem. , vol.67 , pp. 6216-6219
    • Wang, J.Q.1    Weyand, E.H.2    Harvey, R.G.3
  • 45
    • 0028788319 scopus 로고
    • Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: Benzo(a)pyrene vs manufactured gas plant residue
    • Weyand EH, Chen Y-C, Wu Y, Koganti A, Dunsford HA, Rodriguez LV. 1995. Differences in the tumorigenic activity of a pure hydrocarbon and a complex mixture following ingestion: benzo(a)pyrene vs manufactured gas plant residue. Chem Res Toxicol 8:949-954.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 949-954
    • Weyand, E.H.1    Chen, Y.-C.2    Wu, Y.3    Koganti, A.4    Dunsford, H.A.5    Rodriguez, L.V.6
  • 47
    • 0028892109 scopus 로고
    • Covalent binding of polycyclic aromatic hydrocarbon components of manufactured gas plant residue to mouse lung and forestomach DNA
    • Weyand EH, Wu Y. 1995. Covalent binding of polycyclic aromatic hydrocarbon components of manufactured gas plant residue to mouse lung and forestomach DNA. Chem Res Toxicol 8:955-962.
    • (1995) Chem. Res. Toxicol. , vol.8 , pp. 955-962
    • Weyand, E.H.1    Wu, Y.2
  • 48
    • 6344239246 scopus 로고
    • Guidance Values for Human Exposure Limits
    • WHO. Geneva:International Programme on Chemical Safety, World Health Organization
    • WHO. 1994. Guidance Values for Human Exposure Limits. Environmental Health Criteria 170. Geneva:International Programme on Chemical Safety, World Health Organization.
    • (1994) Environmental Health Criteria 170


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