Nonadditive effects of PAHs on early vertebrate development: Mechanisms and implications for risk assessment

Toxicological Sciences

Volumn 105, Issue 1, 2008, Pages 5-23

  Billiard, Sonya M ^b,d   Meyer, Joel N ^b   Wassenberg, Deena M ^c   Hodson, Peter V ^d   Di Giulio, Richard T ^a,b  

^a Health Canada and World Health Organization Collaborating Center for Standardization and Evaluation of Biologicals   (Canada)

^b DUKE UNIVERSITY   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

AHR; CYP1A; Developmental toxicity; DLCs; PAHs; Risk assessment; Synergism

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ALPHA TOCOPHEROL; AROMATIC HYDROCARBON RECEPTOR; BENZO[A]PYRENE; CARBAZOLE DERIVATIVE; CARBON TETRACHLORIDE; CHRYSENE; CYTOCHROME P450; CYTOCHROME P450 1A; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DIBENZOTHIOPHENE DERIVATIVE; DIOXIN; ETHOXYRESORUFIN DEETHYLASE; FLUORANTHENE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; MANGANESE SUPEROXIDE DISMUTASE; PARAQUAT; PHENANTHRENE; POLYCYCLIC AROMATIC HYDROCARBON; VASCULOTROPIN;

BIOTRANSFORMATION; CARCINOGENICITY; CARDIOMYOPATHY; CARDIOTOXICITY; DEVELOPMENTAL DISORDER; ECOTOXICITY; EMBRYOTOXICITY; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; FISH; GENE EXPRESSION PROFILING; GENOTOXICITY; HEART DISEASE; HUMAN; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; REVIEW; RISK ASSESSMENT; RISK MANAGEMENT; SIGNAL TRANSDUCTION; TERATOGENICITY; TOXICOGENETICS; TOXICOKINETICS;

ANIMALS; CARDIOVASCULAR SYSTEM; CYTOCHROME P-450 CYP1A1; DIOXINS; EMBRYONIC DEVELOPMENT; HUMANS; NECROSIS; OXIDATIVE STRESS; POLYCYCLIC HYDROCARBONS, AROMATIC; RECEPTORS, ARYL HYDROCARBON; RISK ASSESSMENT;

VERTEBRATA;

EID: 49249120076     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfm303     Document Type: Review

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