Evidence for proprotein convertase activity in the endoplasmic reticulum/early Golgi

FEBS Letters

Volumn 579, Issue 25, 2005, Pages 5621-5625

  Salvas, Alexandre ^a   Benjannet, Suzanne ^a   Reudelhuber, Timothy L ^a   Chrétien, Michel ^b   Seidah, Nabil G ^a  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

Author keywords

Endoplasmic reticulum; Furin; PC1; PC7; Proprotein convertase; Prosegment

Indexed keywords

PROTEIN PRECURSOR; SERINE PROTEINASE;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FEMALE; GOLGI COMPLEX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SECRETORY GRANULE;

AMINO ACID SEQUENCE; ANIMALS; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; FURIN; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTATION; PROPROTEIN CONVERTASE 1; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SECRETORY VESICLES; SUBTILISINS; TRANS-GOLGI NETWORK;

EID: 26844560128     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2005.09.029     Document Type: Article

References (24)

1. N.G. Seidah Celllar limited proteolysis of precursor proteins and peptides R.E. Dalbey D.S. Sigman Co- and Post-translational Proteolysis of Proteins 2002 Academic Press San Diego 237 259
2. G. Thomas Furin at the cutting edge: from protein traffic to embryogenesis and disease Nat. Rev. Mol. Cell Biol. 3 2002 753 766
3. N.G. Seidah, and A. Prat Precursor convertases in the secretory pathway, cytosol and extracellular milieu Essays Biochem. 38 2002 79 94
4. M. Zhong, J.S. Munzer, A. Basak, S. Benjannet, S.J. Mowla, E. Decroly, M. Chretien, and N.G. Seidah The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity J. Biol. Chem. 274 1999 33913 33920
5. I. Jutras, N.G. Seidah, and T.L. Reudelhuber A predicted alpha -helix mediates targeting of the proprotein convertase PC1 to the regulated secretory pathway J. Biol. Chem. 275 2000 40337 40343
6. I. Jutras, N.G. Seidah, T.L. Reudelhuber, and V. Brechler Two activation states of the prohormone convertase PC1 in the secretory pathway J. Biol. Chem. 272 1997 15184 15188
7. J. Bass, C. Turck, M. Rouard, and D.F. Steiner Furin-mediated processing in the early secretory pathway: sequential cleavage and degradation of misfolded insulin receptors Proc. Natl. Acad. Sci. USA 97 2000 11905 11909
8. N.G. Seidah, M. Marcinkiewicz, S. Benjannet, L. Gaspar, G. Beaubien, M.G. Mattei, C. Lazure, M. Mbikay, and M. Chretien Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2 Mol. Endocrinol. 5 1991 111 122
9. S. Benjannet, D. Savaria, A. Laslop, J.S. Munzer, M. Chretien, M. Marcinkiewicz, and N.G. Seidah Alpha1-antitrypsin Portland inhibits processing of precursors mediated by proprotein convertases primarily within the constitutive secretory pathway J. Biol. Chem. 272 1997 26210 26218
10. S. Benjannet, N. Rondeau, L. Paquet, A. Boudreault, C. Lazure, M. Chretien, and N.G. Seidah Comparative biosynthesis, covalent post-translational modifications and efficiency of prosegment cleavage of the prohormone convertases PC1 and PC2: glycosylation, sulphation and identification of the intracellular site of prosegment cleavage of PC1 and PC2 Biochem. J. 294 Pt 3 1993 735 743
11. A. Boudreault, D. Gauthier, and C. Lazure Proprotein convertase PC1/3-related peptides are potent slow tight-binding inhibitors of murine PC1/3 and Hfurin J. Biol. Chem. 273 1998 31574 31580
12. N.G. Seidah, L. Gaspar, P. Mion, M. Marcinkiewicz, M. Mbikay, and M. Chretien cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases DNA Cell Biol. 9 1990 415 424
13. A. Boudreault, D. Gauthier, N. Rondeau, D. Savaria, N.G. Seidah, M. Chretien, and C. Lazure Molecular characterization, enzymatic analysis, and purification of murine proprotein convertase-1/3 (PC1/PC3) secreted from recombinant baculovirus-infected insect cells Protein Expr. Purif. 14 1998 353 366
14. N.G. Seidah, and M. Chretien Proprotein and prohormone convertases: a family of subtilases generating diverse bioactive polypeptides Brain Res. 848 1999 45 62
15. J. Lippincott-Schwartz, L. Yuan, C. Tipper, M. Amherdt, L. Orci, and R.D. Klausner Brefeldin A's effects on endosomes, lysosomes, and the TGN suggest a general mechanism for regulating organelle structure and membrane traffic Cell 67 1991 601 616
16. E.D. Anderson, S.S. Molloy, F. Jean, H. Fei, S. Shimamura, and G. Thomas The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation J. Biol. Chem. 277 2002 12879 12890
17. S. Munro, and H.R. Pelham A C-terminal signal prevents secretion of luminal ER proteins Cell 48 1987 899 907
18. A.A. Scheel, and H.R. Pelham Purification and characterization of the human KDEL receptor Biochemistry 35 1996 10203 10209
19. Y. Qian, L.A. Devi, N. Mzhavia, S. Munzer, N.G. Seidah, and L.D. Fricker The C-terminal region of proSAAS is a potent inhibitor of prohormone convertase 1 J. Biol. Chem. 275 2000 23596 23601
20. M. Mbikay, N.G. Seidah, and M. Chretien Neuroendocrine secretory protein 7B2: structure expression and functions Biochem. J. 357 2001 329 342
21. Y. Fortenberry, J. Liu, and I. Lindberg The role of the 7B2 CT peptide in the inhibition of prohormone convertase 2 in endocrine cell lines J. Neurochem. 73 1999 994 1003
22. S.N. Lee, E. Prodhomme, and I. Lindberg Prohormone convertase 1 (PC1) processing and sorting: effect of PC1 propeptide and proSAAS J. Endocrinol. 182 2004 353 364
23. L. Bissonnette, G. Charest, J.M. Longpre, P. Lavigne, and R. Leduc Identification of furin pro-region determinants involved in folding and activation Biochem. J. 379 2004 757 763
24. A. Zhou, L. Paquet, and R.E. Mains Structural elements that direct specific processing of different mammalian subtilisin-like prohormone convertases J. Biol. Chem. 270 1995 21509 21516